| ALADIPTASE: | Membrane alanyl dipeptidase (M1) family signature |
| Seed alignment containing 12 sequences: |
1 11 21 31 41 51 61 71 81 91 101 111 121 131 141 151 161 171 181 191 201 211 221 231 241 251 261 271 281 291 301 311 321 331 341 351 361 371 381 391 401 411 421 431 441 451 461 471 481 491 501 511 521 531 541 551 561 571 581 591 601 611 621 631 641 651 661 671 681 691 701 711 721 731 741 751 761 771 781 791 801 811 821 831 841 851 861 871 881 891 901 911 921 931 941 951 961 971 981 991 1001 1011 1021 1031
|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|-
AMPN_LACDL ----------------------------------------------------------------------------------------------------------AVKRFYETFHPDHYDLYIDVDRAARSFSGTSTIHGEIQEETVLVHQKYMTISKVTVDGKEVPFTFGDDFEGIKIEAGKTGEAVIAIDYSAPLTDTMMGIYPSYYQVDG--VKKEL---IGTQFETTFAREAFPCVDEPEAKATFSLALKFDEHEGETVLANMPEDRVENGVHY------FKETVRMSSYLVAFAFGEMRSLTTHTKSGVLIG----VYSTQAHTEKELT-FSLDIAKRAIEFYEDFYQTPYPLPQSLQLALPD-FSAGAMENWGLVTYREAYLLLDPDNTTLEMKKLVAT-VVTHELAHQWFGDLVTMEWWDNLWLNESFANMMEYLSVDHLEPNWHIWEMFQTSEAAAALTRDAT-DGVQSVHVEVNDPA------EIDALFDGAIVYAKGSRMLVMVRSLLGDEALRKGLKRYFDKHKFGNAAGDDLWDALSTATDLNIGEIMHT--------WLDQPGYPVVNAFVEDGHLKLTQKQFFIGEGKEVGRKWEIPLNANFKAPKIMSDVELDLGDYQALRAEAGH-------ALRLNVGNNSHFIVKYDQTLMDDIMKEAKDLDP----VSQLQLLQDLRLLAEGKQASYADVVPVLELFKNSESHIVNDALYTTADKLRQFAP-AGSEADKNLRALYNDLSKDQVARLGWLPKAGESDEDIQTRPYVLSASLYGRNADSEKQAHEIYVEYADKLAELSADIRPYVLINEVENYGSSELTDKLIGLYQATSDPSFKMDLEAAIVKSKDEGELKKIVSWFKNAEIVKPQDLRGWFSGVLSNPAGEQLAWDWIRDEWAWLEKTVGGDMEFATFITVISRVFKTKERYDEYNAFFTDKESNMLLNREIKMDRKVIANRVDLIASEQADVNAAVAAALQK
LKHA_HUMAN ----------------------------------------------------------------------------------------------PEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYK-FIQKVPIPCYLIALVVGALESRQIGPRTL--------VWSEKEQVEKSA--YEFSETESMLKIAEDLGGP-YVWGQYDLLVLPPSFPYGGMENPCLTFVTPT-LLAGDKSLSN---------VIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDI------DPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNA---WLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD
AMPN_PIG ----------------AKGFYISKALGILGILLGVAAVATIIALSVVYAQEKNKNAE-HVPQAPTSPTITTTAAITLDQSKPWNRYRLPTTLLPDSYFVTLRPYLTPNADGLYIFKGKSIVRLLCQEPTDVIIIHSKKLNYTTQGHMVVLRGVGDSQVPEIDRTELVELTEYLVVHLKGSLQPGHMYEMESEFQGE-LADDLAGFYRSEYMEGN--VKKVL---ATTQMQSTDARKSFPCFDEPAMKATFNITLIHPNNLTALSNMPPKGSSTPLAEDPNWSVTEFETTPVMSTYLLAYIVSEFQSVNETAQNGVLIR----IWARPNAIAEGHGMYALNVTGPILNFFANHYNTSYPLPKSDQIALPD-FNAGAMENWGLVTYRENALLFDPQSSSISNKERVVT-VIAHELAHQWFGNLVTLAWWNDLWLNEGFASYVEYLGADHAEPTWNLKDLIVPGDVYRVMAV----DALASSHPLTTPAEEVNTPA-QISEMFDSISYSKGASVIRMLSNFLTEDLFKEGLASYLHAFAYQNTTYLDLWEHLQKAVDAQTSIRLPDTVRAIMDRWTLQMGFPVITVDTKTG--NISQKHFLLDSESNVTRSSAFDYLWIVPISSIKNGVMQDHYWLRDVSQAQNDLFKTASD--DWVLLNVNVTGYFQVNYDEDNWRMIQHQLQTNLSVIPVINRAQVIYDSFNLATAHMVPVTLALDNTLFLNGEKEYMPWQAALSSLSYFSLMFDRSEVYGPMKKYLRKQVEPLFQHFETLTKNWTERPENLMDQYSEINAISTACSNGLPQCENLAKTLFDQWMSDPENNPIHPNLRSTIYCNAIAQGGQDQWDFAWGQLQQAQLVNEADKLRSALACSNEVWLLNRYLGYTLNPDLIRKQDATSTINSIASNVIGQPLAWDFVQSNWKKLFQDYGGGSFSFSNLIQGVTRRFSSEFELQQLEQFKKNNMDVGFGSGTRALEQALEKTKANIKWVKENKEVVLNWFIEHS
YIN7_YEAST -------------------------------------------------------------------------MSDNLLSLENPVVPSHYELRLEIDPKQSSPNFKGSAIIHLKFNPNSTTLASIEDSFTQFKLHSKDLIVLSAHATIGSTKFDLKISQDTGKHLSIFNSESPIQLSNDCPLILSVQYVGKIRDIKTHHDKTFGIFKTNFMDRKTGTANNHV--VATHCQPFSASNIFPCIDEPSNKSTFQLNIATDAQYKAVSNTPVEMVEALDSSQKHLVK--FAKTPLMTTSVFGFSIGDLEFLKTEIKLEGDRTIPVSIYAPWDIANAA---FTLDTVQKYLPLLESYFKCPYPLPKLDFVLLPY-LSDMAMENFGMITIQLNHLLIPPNALANETVREQAQQLIVHELVHQWMGNYISFDSWESLWFNESFATWLACHILEQNGDLSHYWTSEPYLLQQVEPTMCRD-AADVNGRSIFQIAQRNTGIDSQTSDIFDPEAYTKGIIMLRSLQLATGESHLQKGLESVFEDTKTFHARSVKPMDIWNHIGKFLKSQNITNFVSS----WTRTPGLPVVKVEVEEKDGKTQTKLTQHRFINQLSTEEKDQLEDVPYQVPLFGVLPDGKMDTKNVLLTDRTLKFDYPILVINHLAQGYYRVSYESEECYALINDKITEETLSEIDLRKIFLDLSQFIGDEGFQNSIHLHGLFKILNHIASPSTKIASKYWDPLSKGLEVLQTIDRASLTSSKLQSFLKKKIVIPLFNKIDWPHGEFDKSTNPHELKVMSQVLFLNKNSAKCAELCQIYFKHLLQGPRSSVPLELVNSILVVVSQHCANIKQWKKIFDLVKRSSCTGITNHVINMYDQNSSETAMLIQNGAIESLGFCLDSDIVKKTLNFITSNIESEGMELALFGFNYNFKKRLNKNEKPQDQVVRETIWEWYMGNFDQWARKATRKGTTTGDHLHKALRSISLIIFQMFVADEPQKIEKFINLEKEKLGQSLLSLDDIWASVQQDEESRKTIRRDLASLV
AMPN_ECOLI -------------------------------------------------------------------------------------------------------TQQPQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGALVISNLPERFTLK--IINEISPAANTALEGLYQSGDA-----LCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNRVAQGELENGRHWVQ-WQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAP--WAMTSLKNSMKWDEERFGLEYDLDIYMIVAVDF-FNMGAMENKGLNIFNSKYVLARTDTATDKDYLDIER-VIGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAE----DASPMAHPIRPDMVI------EMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGS-AATCDDFVQAMEDASNVDLSHFRR--------WYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQPLHIPFAIELYDNEGKVIPLQKGGHPVNSV-------LNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAVAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDGSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKALA
LKHA_YEAST -------------------------------------------MFLLPFVIRHSSSIYLPTLRFRGLLTVISRNIHISTPHKMLPLSIEQRRPSRSPEYDQSTLSNYKDFAVLHTDLNLSVSFEKSAISGSVTFQLKKLHEGKNKSDELHLDTSYLDVQEVHIDGSKADFQIEQRKEPLGSRLVINNASCNDNFTLNIQFRTTDKCTALQWLNSKQTKGG-KPYVFSQLEAIHARSLFPCFDTPSVKSTFTASIESP--LPVVFSGIRIEDTSKDTNIYR-----FEQKVPIPAYLIGIASGDLSSAPIGPRST--------VYTEPFRLKDCQ--WEFENDVEKFIQTAEKIIFEYEWGTYDILVNVDSYPYGGMESPNMTFATPT-LIAHDRSNID---------VIAHELAHSWSGNLVTNCSWNHFWLNEGWTVYLERRIIGAIHGEPTRHFSALIGWSDLQNSIDSMKDPERFSTLVQNLNDNT-----DPDDAFSTVPYEKGFNLLFHLETILGGKAEFDPFIRHYFKKFAKKSLDTFQFLDTLYEFYPEKKEILDSVDWET---WLYKPGMPPRPHFITALADNVYQLADKWVEMAQHLKTTEDFRSEFNAIDIKDFNSNQLVLFLETLTQNGHSNKKPKDFDWAKFPVASRALLDIYQDNIVKSQNAEVVFKMFKFQIFAKLQEEYKHLADWLGTVGRMKFVRPGYRLLNSVDRRLALATFDKFKDTYHPICKALVKQDLGL
AMPE_HUMAN MNFAEREGSKRYCIQTKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHLPSSTASPSGPPAQDQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGW--LNGSLVGFYRTTYTEN--GRVKSI---AATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKWTRTT---FEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLT----IYVQPEQKHTAE--YAANITKSVFDYFEEYFAMNYSLPKLDKIAIPD-FGTGAMENWGLITYRETNLLYDPKESASSNQQRVAT-VVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPVQED----DSLMSSHPIIVTVTTPD----EITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASRLPVKEVMDT--------WTRQMGYPVLNVNGVK---NITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEKEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFE-DDKELYPMIEEYFQGQVKPIADSLGWNDAGDHVTKLLRSSVLGF--ACKMGDREALNNASSLFEQWLNGTVSLPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTIAEP-FNTELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREWFFNLLESG
AMPN_HAEIN -----------------------------------------------------------------------------------------------------MLAKAKYRKDYKQPDFTVTDIYLDFQLDPKHTVVTAITKFQRLNNEATSLCLDGHSFQFSSIKFNGEPFSDYQQDGESLTLDLKDKSADEFEIE--IVTFLVPAENTSLQGLYQSGEG-----ICTQCEAEGFRQITYMLDRPDVLARYITKITADKTKYPFLLSNGNRIASGELEDGRHWVE-WNDPFPKPSYLFALVAGDFDLLQDKFITKSGREVALELYVDRGNLNRAT--WAMESLKKAMKWDEDRFNLEYDLDIYMIVAVDF-FNMGAMENKGLNIFNSKFVLANPQTATDDDYLAIES-VIAHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDTGSRAVNRINNVKFLRTVQFAE----DASPMSHPIRPEKVI------EMNNFYTVTVYEKGAEVIRMLHTLLGEQGFQKGMQLYIAENDGK-AATCEDFVSAMERANNLDLNQFRR--------WYSQSGTPELLISDAYDEKTHTYRLTVSQSTPPTADQMEKVNLHIPLKVALYDANGTKQMLQHNGELLSDV-------LNVTEKDQVFEFHGIYGRPIPALLCDFSAPVKLDYDYKTEQLLGLLKFADNQFIRWDAAQMLFAQELRRNVVRFQQGEALEISPEILTALSYVLNHYEKDIELATLILTLPKEMEFAESFKTIDPDGISAARAFMQAQIAESLKDDFLRVYTHIRLNDYQVTQQDIALRVMRNLCLTYLAYTNLG--NNLVQKHYNNANNMTDTLAALSVATKAALLCRDVLLADFEQKWQHDGLVMDKWFALQATRPDDNVLEIIQLLMDHPSFNFNNPNRLRSLVGSFANHNLKAFHNVSGSGYRFLTDVLIRLNESNPQVAARLIEPLIRFSRFDAQRQTLMKRALERLSVVENLSKDLFEKIEKALQ
AAP1_YEAST ---------------------------------------------------------------------------------------------MSREVLPNNVTPLHYDITLEPNFRAFTFEGSLKIDLQINDHSINSVQINYLEIDFHSARIEGVNAIEVNKNENQQKATLVFPNGTFENLGPSAKLEIIFSGI--LNDQMAGFYRAKYTDKVTGETKYM---ATTQMEATDARRAFPCFDEPNLKATFAVTLVSESFLTHLSNMDVRNETIKEGKKYTT----FNTTPKMSTYLVAFIVADLRYVESN-NFRIPVR----VYSTPGDEKFGQ--FAANLAARTLRFFEDTFNIEYPLPKMDMVAVHE-FSAGAMENWGLVTYRVIDLLLDIENSSLDRIQRVAE-VIQHELAHQWFGNLVTMDWWEGLWLNEGFATWMSWYSCNKFQPEWKVWEQYVTDNLQRALNL----DSLRSSHPIEVPVNNAD----EINQIFDAISYSKGSSLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTGDLWDALADASGKDVCSVMNI--------WTKRVGFPVLSVKEHKNKITLTQHRYLSTGDVKEEEDTTIYPILLALKDSTGIDNTLVLNEKSATFELKNEE------FFKINGDQSGIFITSYSDERWAKLSKQANLL----SVEDRVGLVADAKALSASGYTSTTNFLNLISNWKNEDSFVVWEQIINSLSALKSTWVFEPEDILNALDKFTLDLVLNKLSELGWNIGEDDSFAIQRLKVTLFSAACTSGNEKMQSIAVEMFEEYANGNKQAIPALFKAVVFNTVARLGGENNYEKIFNIYQNPVSSEEKIIALRALGRFEDKELLERTLSYLLDGTVL-NQDFYIPMQGIRVHKKGIERLWAWMQEHWDEIAKRLQPGSPVLGGVLTLGLTNFTSFEALEKISAFYSRKVTKGFDQTLAQALDTIRSKAQWVSRDREIVATYLREHEYDQ
AMPN_STRLI -----------------------------------------------------------------------------------------------MPGTNLTREEARQRATLLTVDSYEIDLDLTGAQEGGTYRSVTTVRFDVAEGGGESFIDLVAPTVHEVTLNGDALDTAEVFQDSRIALPGLLPGRNILRVVADCAYTNTGEGLHRFVDPVDDQAY-----LYTQFEVPDARRVFASFEQPDLKATFQFTVKAPEGWTVISNSPTPEPKDNVWE--------FEPTPRISSYVTALIVGPYHSVHSVYEKDGQSVPLG-IYCRPSLAEHLDADAIFEVTRQGFDWFQEKFDYAYPFKKYDQLFVPE-FNAGAMENAGAVTIRDQYVFRSKVTDAAYEV-RAA--TILHELAHMWFGDLVTMEWWNDLWLNESFATYAEAACQAAAPGSKWPHSWTTFANQMKTWAYRQ--DQLPSTHPIMADISDLD----DVLVNFDGITYAKGASVLKQLVAYVGEEAFFKGVQAYFKRHAFGNTRLSDLLGALEETSGRDLKTWSKA--------WLETAGINVLRPEIETDADGVITSFAIRQEAPALPAGAKGEPTLRPHRIAIGAYDLDGAGKLVRGDRVELDVDGELTAVPQLVGKARPAVLLLNDDDLSYAKVRLDEQSLAVVTEHLGDFTESLPRALCWASAWDMTRDAELATRDYLALVLSGIGKESDIGVVQSLHRQVKLAIDQYAAPTAREALLTRWTEATLAHLRAAEAGSDHQLAWARAFAATARTPEQLDLLDALLDGTQTIEGLAVDTELRWAFVQRLAAVGRFGGSEIAAEYERDKTAAGERHAATARAARPTEAAKAEAWESVVESDKLPNAVQEAVIAGFVQTDQRELLAAYTERYFEALKDVWASRSHEMAQQIAVGLYPAVQVSQDTLDRTDAWLASAEPNAALRRLVSESRSGIERALRAQAADAAAAE
LKHA_CAVPO ----------------------------------------------------------------------------------------------PEVVDTCSLASPATVCRTKHLHLRCSVDFTRRALTGVAALTIQSQEDNLRSLILDTKDLTIEKVVINGQEVKYALGEKQSYKGSPMEISLPIALSKNQEVVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAFLPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPADPSRKIYK-FSQKVPIPCYLIALVVGALESRKIGPRTL--------VWSEKEQVDKSA--YEFSETESMLKIAEDLGGP-YVWGQYDRLVLPPSFSYGGMENPCLTFVTPT-LLAGDKSLSN---------VIAHEISHTWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNTVKTLGETQAFTKLVVDLTDT------DPDVAYSSVPYEKGFALLFHLEQLLGGPEVFLGFLKAYVEKFSYKSITTDDWKNFLFSHFKDKVDILNQVDWDA---WLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEKDLNTFSATDLKDLSSHQVNEFLAQVLQRAPLPLGHVKRMQEVYNCNAINNSEIRFRWLRLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAIQTYHAHKASMHPVTAMLVGKDLKVE
APE2_YEAST ------------------------------------------------------------------------------------------MTSKTPNREILPDNVVPLHYDLTVEPDFKTFKFEGSVKIELKINNPAIDTVTLNTVDTDIHSAKIGDVTSSEIISEEEQQVTTFAFPKGTMSSFKGNAFLDIKFTGILNDNMAGFYRAKYEDKLTGETKYM---ATTQMEPTDARRAFPCFDEPNLKASFAITLVSDPSLTHLSNMDVKNEYVKDGKKVTL----FNTTPKMSTYLVAFIVAELKYVESKNFRIPVR-----VYATPGNEKHGQ--FAADLTAKTLAFFEKTFGIQYPLPKMDNVAVHE-FSAGAMENWGLVTYRVVDLLLDKDNSTLDRIQRVAE-VVQHELAHQWFGNLVTMDWWEGLWLNEGFATWMSWYSCNEFQPEWKVWEQYVTDTLQHALSL----DSLRSSHPIEVPVKKAD----EINQIFDAISYSKGASLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTEDLWDALADASGKDVRSVMNI--------WTKKVGFPVISVSEDGNGKITFRQNRYLSTADVKPDEDKTIYPVFLALKTKNGVDSSVVLSERSKTIELEDPTFFKVNSEQSGIYITSYTDERWAKLGQQADLLSVEDRVGLVADVKTLSASGYTSTTNFLNLVSKWNNEKSFVVWDQIINSISSMKSTWLFEPKETQDALDNFTKQLISGMTHHLGWEFKSSDSFSTQRLKVTMFGAACAARDADVEKAALKMFTDYCSGNKEAIPALIKPIVFNTVARVGGAENYEKVYKIYLDPISNDEKLAALRSLGRFKEPKLLERTLGYLFDGTVLNQDIYIPMQGMRAHQEGVEALWNWVKKNWDELVKRLPPGLSMLGSVVTLGTSGFTSMQKIDEIKKFFATKSTKGFDQSLAQSLDTITSKAQWG