ALADIPTASE: Membrane alanyl dipeptidase (M1) family signature
Seed alignment containing 12 sequences:

                       1         11        21        31        41        51        61        71        81        91        101       111       121       131       141       151       161       171       181       191       201       211       221       231       241       251       261       271       281       291       301       311       321       331       341       351       361       371       381       391       401       411       421       431       441       451       461       471       481       491       501       511       521       531       541       551       561       571       581       591       601       611       621       631       641       651       661       671       681       691       701       711       721       731       741       751       761       771       781       791       801       811       821       831       841       851       861       871       881       891       901       911       921       931       941       951       961       971       981       991       1001      1011      1021      1031 
                       |---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|-
 AMPN_LACDL            ----------------------------------------------------------------------------------------------------------AVKRFYETFHPDHYDLYIDVDRAARSFSGTSTIHGEIQEETVLVHQKYMTISKVTVDGKEVPFTFGDDFEGIKIEAGKTGEAVIAIDYSAPLTDTMMGIYPSYYQVDG--VKKEL---IGTQFETTFAREAFPCVDEPEAKATFSLALKFDEHEGETVLANMPEDRVENGVHY------FKETVRMSSYLVAFAFGEMRSLTTHTKSGVLIG----VYSTQAHTEKELT-FSLDIAKRAIEFYEDFYQTPYPLPQSLQLALPD-FSAGAMENWGLVTYREAYLLLDPDNTTLEMKKLVAT-VVTHELAHQWFGDLVTMEWWDNLWLNESFANMMEYLSVDHLEPNWHIWEMFQTSEAAAALTRDAT-DGVQSVHVEVNDPA------EIDALFDGAIVYAKGSRMLVMVRSLLGDEALRKGLKRYFDKHKFGNAAGDDLWDALSTATDLNIGEIMHT--------WLDQPGYPVVNAFVEDGHLKLTQKQFFIGEGKEVGRKWEIPLNANFKAPKIMSDVELDLGDYQALRAEAGH-------ALRLNVGNNSHFIVKYDQTLMDDIMKEAKDLDP----VSQLQLLQDLRLLAEGKQASYADVVPVLELFKNSESHIVNDALYTTADKLRQFAP-AGSEADKNLRALYNDLSKDQVARLGWLPKAGESDEDIQTRPYVLSASLYGRNADSEKQAHEIYVEYADKLAELSADIRPYVLINEVENYGSSELTDKLIGLYQATSDPSFKMDLEAAIVKSKDEGELKKIVSWFKNAEIVKPQDLRGWFSGVLSNPAGEQLAWDWIRDEWAWLEKTVGGDMEFATFITVISRVFKTKERYDEYNAFFTDKESNMLLNREIKMDRKVIANRVDLIASEQADVNAAVAAALQK  
LKHA_HUMAN ----------------------------------------------------------------------------------------------PEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYK-FIQKVPIPCYLIALVVGALESRQIGPRTL--------VWSEKEQVEKSA--YEFSETESMLKIAEDLGGP-YVWGQYDLLVLPPSFPYGGMENPCLTFVTPT-LLAGDKSLSN---------VIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDI------DPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNA---WLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD
AMPN_PIG ----------------AKGFYISKALGILGILLGVAAVATIIALSVVYAQEKNKNAE-HVPQAPTSPTITTTAAITLDQSKPWNRYRLPTTLLPDSYFVTLRPYLTPNADGLYIFKGKSIVRLLCQEPTDVIIIHSKKLNYTTQGHMVVLRGVGDSQVPEIDRTELVELTEYLVVHLKGSLQPGHMYEMESEFQGE-LADDLAGFYRSEYMEGN--VKKVL---ATTQMQSTDARKSFPCFDEPAMKATFNITLIHPNNLTALSNMPPKGSSTPLAEDPNWSVTEFETTPVMSTYLLAYIVSEFQSVNETAQNGVLIR----IWARPNAIAEGHGMYALNVTGPILNFFANHYNTSYPLPKSDQIALPD-FNAGAMENWGLVTYRENALLFDPQSSSISNKERVVT-VIAHELAHQWFGNLVTLAWWNDLWLNEGFASYVEYLGADHAEPTWNLKDLIVPGDVYRVMAV----DALASSHPLTTPAEEVNTPA-QISEMFDSISYSKGASVIRMLSNFLTEDLFKEGLASYLHAFAYQNTTYLDLWEHLQKAVDAQTSIRLPDTVRAIMDRWTLQMGFPVITVDTKTG--NISQKHFLLDSESNVTRSSAFDYLWIVPISSIKNGVMQDHYWLRDVSQAQNDLFKTASD--DWVLLNVNVTGYFQVNYDEDNWRMIQHQLQTNLSVIPVINRAQVIYDSFNLATAHMVPVTLALDNTLFLNGEKEYMPWQAALSSLSYFSLMFDRSEVYGPMKKYLRKQVEPLFQHFETLTKNWTERPENLMDQYSEINAISTACSNGLPQCENLAKTLFDQWMSDPENNPIHPNLRSTIYCNAIAQGGQDQWDFAWGQLQQAQLVNEADKLRSALACSNEVWLLNRYLGYTLNPDLIRKQDATSTINSIASNVIGQPLAWDFVQSNWKKLFQDYGGGSFSFSNLIQGVTRRFSSEFELQQLEQFKKNNMDVGFGSGTRALEQALEKTKANIKWVKENKEVVLNWFIEHS
YIN7_YEAST -------------------------------------------------------------------------MSDNLLSLENPVVPSHYELRLEIDPKQSSPNFKGSAIIHLKFNPNSTTLASIEDSFTQFKLHSKDLIVLSAHATIGSTKFDLKISQDTGKHLSIFNSESPIQLSNDCPLILSVQYVGKIRDIKTHHDKTFGIFKTNFMDRKTGTANNHV--VATHCQPFSASNIFPCIDEPSNKSTFQLNIATDAQYKAVSNTPVEMVEALDSSQKHLVK--FAKTPLMTTSVFGFSIGDLEFLKTEIKLEGDRTIPVSIYAPWDIANAA---FTLDTVQKYLPLLESYFKCPYPLPKLDFVLLPY-LSDMAMENFGMITIQLNHLLIPPNALANETVREQAQQLIVHELVHQWMGNYISFDSWESLWFNESFATWLACHILEQNGDLSHYWTSEPYLLQQVEPTMCRD-AADVNGRSIFQIAQRNTGIDSQTSDIFDPEAYTKGIIMLRSLQLATGESHLQKGLESVFEDTKTFHARSVKPMDIWNHIGKFLKSQNITNFVSS----WTRTPGLPVVKVEVEEKDGKTQTKLTQHRFINQLSTEEKDQLEDVPYQVPLFGVLPDGKMDTKNVLLTDRTLKFDYPILVINHLAQGYYRVSYESEECYALINDKITEETLSEIDLRKIFLDLSQFIGDEGFQNSIHLHGLFKILNHIASPSTKIASKYWDPLSKGLEVLQTIDRASLTSSKLQSFLKKKIVIPLFNKIDWPHGEFDKSTNPHELKVMSQVLFLNKNSAKCAELCQIYFKHLLQGPRSSVPLELVNSILVVVSQHCANIKQWKKIFDLVKRSSCTGITNHVINMYDQNSSETAMLIQNGAIESLGFCLDSDIVKKTLNFITSNIESEGMELALFGFNYNFKKRLNKNEKPQDQVVRETIWEWYMGNFDQWARKATRKGTTTGDHLHKALRSISLIIFQMFVADEPQKIEKFINLEKEKLGQSLLSLDDIWASVQQDEESRKTIRRDLASLV
AMPN_ECOLI -------------------------------------------------------------------------------------------------------TQQPQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGALVISNLPERFTLK--IINEISPAANTALEGLYQSGDA-----LCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNRVAQGELENGRHWVQ-WQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAP--WAMTSLKNSMKWDEERFGLEYDLDIYMIVAVDF-FNMGAMENKGLNIFNSKYVLARTDTATDKDYLDIER-VIGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAE----DASPMAHPIRPDMVI------EMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGS-AATCDDFVQAMEDASNVDLSHFRR--------WYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQPLHIPFAIELYDNEGKVIPLQKGGHPVNSV-------LNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAVAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDGSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKALA
LKHA_YEAST -------------------------------------------MFLLPFVIRHSSSIYLPTLRFRGLLTVISRNIHISTPHKMLPLSIEQRRPSRSPEYDQSTLSNYKDFAVLHTDLNLSVSFEKSAISGSVTFQLKKLHEGKNKSDELHLDTSYLDVQEVHIDGSKADFQIEQRKEPLGSRLVINNASCNDNFTLNIQFRTTDKCTALQWLNSKQTKGG-KPYVFSQLEAIHARSLFPCFDTPSVKSTFTASIESP--LPVVFSGIRIEDTSKDTNIYR-----FEQKVPIPAYLIGIASGDLSSAPIGPRST--------VYTEPFRLKDCQ--WEFENDVEKFIQTAEKIIFEYEWGTYDILVNVDSYPYGGMESPNMTFATPT-LIAHDRSNID---------VIAHELAHSWSGNLVTNCSWNHFWLNEGWTVYLERRIIGAIHGEPTRHFSALIGWSDLQNSIDSMKDPERFSTLVQNLNDNT-----DPDDAFSTVPYEKGFNLLFHLETILGGKAEFDPFIRHYFKKFAKKSLDTFQFLDTLYEFYPEKKEILDSVDWET---WLYKPGMPPRPHFITALADNVYQLADKWVEMAQHLKTTEDFRSEFNAIDIKDFNSNQLVLFLETLTQNGHSNKKPKDFDWAKFPVASRALLDIYQDNIVKSQNAEVVFKMFKFQIFAKLQEEYKHLADWLGTVGRMKFVRPGYRLLNSVDRRLALATFDKFKDTYHPICKALVKQDLGL
AMPE_HUMAN MNFAEREGSKRYCIQTKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHLPSSTASPSGPPAQDQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGW--LNGSLVGFYRTTYTEN--GRVKSI---AATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKWTRTT---FEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLT----IYVQPEQKHTAE--YAANITKSVFDYFEEYFAMNYSLPKLDKIAIPD-FGTGAMENWGLITYRETNLLYDPKESASSNQQRVAT-VVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPVQED----DSLMSSHPIIVTVTTPD----EITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASRLPVKEVMDT--------WTRQMGYPVLNVNGVK---NITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEKEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFE-DDKELYPMIEEYFQGQVKPIADSLGWNDAGDHVTKLLRSSVLGF--ACKMGDREALNNASSLFEQWLNGTVSLPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTIAEP-FNTELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREWFFNLLESG
AMPN_HAEIN -----------------------------------------------------------------------------------------------------MLAKAKYRKDYKQPDFTVTDIYLDFQLDPKHTVVTAITKFQRLNNEATSLCLDGHSFQFSSIKFNGEPFSDYQQDGESLTLDLKDKSADEFEIE--IVTFLVPAENTSLQGLYQSGEG-----ICTQCEAEGFRQITYMLDRPDVLARYITKITADKTKYPFLLSNGNRIASGELEDGRHWVE-WNDPFPKPSYLFALVAGDFDLLQDKFITKSGREVALELYVDRGNLNRAT--WAMESLKKAMKWDEDRFNLEYDLDIYMIVAVDF-FNMGAMENKGLNIFNSKFVLANPQTATDDDYLAIES-VIAHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDTGSRAVNRINNVKFLRTVQFAE----DASPMSHPIRPEKVI------EMNNFYTVTVYEKGAEVIRMLHTLLGEQGFQKGMQLYIAENDGK-AATCEDFVSAMERANNLDLNQFRR--------WYSQSGTPELLISDAYDEKTHTYRLTVSQSTPPTADQMEKVNLHIPLKVALYDANGTKQMLQHNGELLSDV-------LNVTEKDQVFEFHGIYGRPIPALLCDFSAPVKLDYDYKTEQLLGLLKFADNQFIRWDAAQMLFAQELRRNVVRFQQGEALEISPEILTALSYVLNHYEKDIELATLILTLPKEMEFAESFKTIDPDGISAARAFMQAQIAESLKDDFLRVYTHIRLNDYQVTQQDIALRVMRNLCLTYLAYTNLG--NNLVQKHYNNANNMTDTLAALSVATKAALLCRDVLLADFEQKWQHDGLVMDKWFALQATRPDDNVLEIIQLLMDHPSFNFNNPNRLRSLVGSFANHNLKAFHNVSGSGYRFLTDVLIRLNESNPQVAARLIEPLIRFSRFDAQRQTLMKRALERLSVVENLSKDLFEKIEKALQ
AAP1_YEAST ---------------------------------------------------------------------------------------------MSREVLPNNVTPLHYDITLEPNFRAFTFEGSLKIDLQINDHSINSVQINYLEIDFHSARIEGVNAIEVNKNENQQKATLVFPNGTFENLGPSAKLEIIFSGI--LNDQMAGFYRAKYTDKVTGETKYM---ATTQMEATDARRAFPCFDEPNLKATFAVTLVSESFLTHLSNMDVRNETIKEGKKYTT----FNTTPKMSTYLVAFIVADLRYVESN-NFRIPVR----VYSTPGDEKFGQ--FAANLAARTLRFFEDTFNIEYPLPKMDMVAVHE-FSAGAMENWGLVTYRVIDLLLDIENSSLDRIQRVAE-VIQHELAHQWFGNLVTMDWWEGLWLNEGFATWMSWYSCNKFQPEWKVWEQYVTDNLQRALNL----DSLRSSHPIEVPVNNAD----EINQIFDAISYSKGSSLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTGDLWDALADASGKDVCSVMNI--------WTKRVGFPVLSVKEHKNKITLTQHRYLSTGDVKEEEDTTIYPILLALKDSTGIDNTLVLNEKSATFELKNEE------FFKINGDQSGIFITSYSDERWAKLSKQANLL----SVEDRVGLVADAKALSASGYTSTTNFLNLISNWKNEDSFVVWEQIINSLSALKSTWVFEPEDILNALDKFTLDLVLNKLSELGWNIGEDDSFAIQRLKVTLFSAACTSGNEKMQSIAVEMFEEYANGNKQAIPALFKAVVFNTVARLGGENNYEKIFNIYQNPVSSEEKIIALRALGRFEDKELLERTLSYLLDGTVL-NQDFYIPMQGIRVHKKGIERLWAWMQEHWDEIAKRLQPGSPVLGGVLTLGLTNFTSFEALEKISAFYSRKVTKGFDQTLAQALDTIRSKAQWVSRDREIVATYLREHEYDQ
AMPN_STRLI -----------------------------------------------------------------------------------------------MPGTNLTREEARQRATLLTVDSYEIDLDLTGAQEGGTYRSVTTVRFDVAEGGGESFIDLVAPTVHEVTLNGDALDTAEVFQDSRIALPGLLPGRNILRVVADCAYTNTGEGLHRFVDPVDDQAY-----LYTQFEVPDARRVFASFEQPDLKATFQFTVKAPEGWTVISNSPTPEPKDNVWE--------FEPTPRISSYVTALIVGPYHSVHSVYEKDGQSVPLG-IYCRPSLAEHLDADAIFEVTRQGFDWFQEKFDYAYPFKKYDQLFVPE-FNAGAMENAGAVTIRDQYVFRSKVTDAAYEV-RAA--TILHELAHMWFGDLVTMEWWNDLWLNESFATYAEAACQAAAPGSKWPHSWTTFANQMKTWAYRQ--DQLPSTHPIMADISDLD----DVLVNFDGITYAKGASVLKQLVAYVGEEAFFKGVQAYFKRHAFGNTRLSDLLGALEETSGRDLKTWSKA--------WLETAGINVLRPEIETDADGVITSFAIRQEAPALPAGAKGEPTLRPHRIAIGAYDLDGAGKLVRGDRVELDVDGELTAVPQLVGKARPAVLLLNDDDLSYAKVRLDEQSLAVVTEHLGDFTESLPRALCWASAWDMTRDAELATRDYLALVLSGIGKESDIGVVQSLHRQVKLAIDQYAAPTAREALLTRWTEATLAHLRAAEAGSDHQLAWARAFAATARTPEQLDLLDALLDGTQTIEGLAVDTELRWAFVQRLAAVGRFGGSEIAAEYERDKTAAGERHAATARAARPTEAAKAEAWESVVESDKLPNAVQEAVIAGFVQTDQRELLAAYTERYFEALKDVWASRSHEMAQQIAVGLYPAVQVSQDTLDRTDAWLASAEPNAALRRLVSESRSGIERALRAQAADAAAAE
LKHA_CAVPO ----------------------------------------------------------------------------------------------PEVVDTCSLASPATVCRTKHLHLRCSVDFTRRALTGVAALTIQSQEDNLRSLILDTKDLTIEKVVINGQEVKYALGEKQSYKGSPMEISLPIALSKNQEVVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAFLPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPADPSRKIYK-FSQKVPIPCYLIALVVGALESRKIGPRTL--------VWSEKEQVDKSA--YEFSETESMLKIAEDLGGP-YVWGQYDRLVLPPSFSYGGMENPCLTFVTPT-LLAGDKSLSN---------VIAHEISHTWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNTVKTLGETQAFTKLVVDLTDT------DPDVAYSSVPYEKGFALLFHLEQLLGGPEVFLGFLKAYVEKFSYKSITTDDWKNFLFSHFKDKVDILNQVDWDA---WLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEKDLNTFSATDLKDLSSHQVNEFLAQVLQRAPLPLGHVKRMQEVYNCNAINNSEIRFRWLRLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAIQTYHAHKASMHPVTAMLVGKDLKVE
APE2_YEAST ------------------------------------------------------------------------------------------MTSKTPNREILPDNVVPLHYDLTVEPDFKTFKFEGSVKIELKINNPAIDTVTLNTVDTDIHSAKIGDVTSSEIISEEEQQVTTFAFPKGTMSSFKGNAFLDIKFTGILNDNMAGFYRAKYEDKLTGETKYM---ATTQMEPTDARRAFPCFDEPNLKASFAITLVSDPSLTHLSNMDVKNEYVKDGKKVTL----FNTTPKMSTYLVAFIVAELKYVESKNFRIPVR-----VYATPGNEKHGQ--FAADLTAKTLAFFEKTFGIQYPLPKMDNVAVHE-FSAGAMENWGLVTYRVVDLLLDKDNSTLDRIQRVAE-VVQHELAHQWFGNLVTMDWWEGLWLNEGFATWMSWYSCNEFQPEWKVWEQYVTDTLQHALSL----DSLRSSHPIEVPVKKAD----EINQIFDAISYSKGASLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTEDLWDALADASGKDVRSVMNI--------WTKKVGFPVISVSEDGNGKITFRQNRYLSTADVKPDEDKTIYPVFLALKTKNGVDSSVVLSERSKTIELEDPTFFKVNSEQSGIYITSYTDERWAKLGQQADLLSVEDRVGLVADVKTLSASGYTSTTNFLNLVSKWNNEKSFVVWDQIINSISSMKSTWLFEPKETQDALDNFTKQLISGMTHHLGWEFKSSDSFSTQRLKVTMFGAACAARDADVEKAALKMFTDYCSGNKEAIPALIKPIVFNTVARVGGAENYEKVYKIYLDPISNDEKLAALRSLGRFKEPKLLERTLGYLFDGTVLNQDIYIPMQGMRAHQEGVEALWNWVKKNWDELVKRLPPGLSMLGSVVTLGTSGFTSMQKIDEIKKFFATKSTKGFDQSLAQSLDTITSKAQWG