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 CAN_SCHMA             -------------------------------------------------------------------------------------------------------------------------MGRIQIVYSPDENVSGRTNRPGKEVVDPRTGRIIKVKRETPDDYLNVLKPIKGPKRMEFNPYLPKTLTPKGYAKFKLMMNVASKQYETLVKRLKTERTLWEDPDFPANDKAIGNLPDFRERIE-----WKRPHEINPNAKFFAGGASRFDIEQGALGDCWLLAVVASISGYPQLFDQVVPKDQELKGPE-----YVGVVRFRFWRFGHWVEVLIDDRLPVRQGRNTLVFMHSNDPTEFWSALLEKAYAKLNGCYAHLSGGSQSEAMEDLTGGICLSLELNQKERPSDLIDQLKIYAQRCCLMGCSIDSSVMEQKMDN---------------------------------------------------GLIGSHAYSLTGVYPVNYRGRT--------QWLMRLRNPWGDSHEWKGAWCDGSPQWREISEQEKKNINLSFTADGEFWMSYEDFVTCFSRVEVCHLGLESLEYNQNFHGKRRLDEAIF----SGQWQRNVNAGGCINNRTTYWTSPQFRITVEDPDPDDDD-----NKCSVLIGLMQTDIRKK--VGADFQPIGFMVYNAPDDLNTLLS-RAQLLTRSPIAKS----QFINTREVTAQFRVPPGSYVVIPSTFDPNIEVNFILRVFSQTSITEQELDEDNTNQGLPDDVIEALKLEDTLLDEDQEIEQKFLAIRDPKTNAINAVKLGELLNNSTLQDIPNFQGFNKELCRSMVASVDNNLTGHVELNEFMDLWIQAKGWKHIFIKHDVDQSGYFSAYEFREA------------------------LNDAGYHVSNRLINAIINRYQDPGTDKISFEDFMLCMVRLKTAFETIEAHPKNIEGTSLFSAEDYLRFSVYI  
 MMCALPAIN             --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGPPLKLFKNQKYQELKQECMKDGRLFCDPTFLPENDSLFFNRLLPGKVV-----WKRPQDISDDPHLIVGNISNHQLIQGRLGNKAMISAFSCLAVQESHWTKAIPNHKDQEWDPRKPEKYAGIFHFRFWHFGEWTEVVIDDLLPTINGD--LVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIMDFTGTLAEIIDMQKGRYTDLVEEKYKLFGELYKTFTKGGLICCSIESPSQEEQEVETDW------------------------------------------GLLKGYTYTMTDIRKLRLGERLVEVFSTEKLYMVRLRNPLG-RQEWSGPWSEISEEWQQLTVTDRKNLGLVMSDDGEFWMSLEDFCHNFHKLNVCRNVNNPVFGRKELESVVGCWTVDDD-------PLMNRSGGCYNNRDTFLQNPQYIFTVPEDG-----------HKVIMSLQQKDLRTYRRMGRPDNYIIGFELFKVEMNRRFRLHHLYIQERAGTSTYIDTRTVFLSK-------YLKKGSYVLVPTMFQHGRTSEFLLRIFSEVPVQLRELTLDMPKMSCWNLARGYPKVVTQITVHSAEGLEKKYANETVNPYLIIKCGKEEVRSPVQKNTVHAIFDTQAVFYRRTTDIPIIIQVWNSRKFCDQFLGQVTLDADPSDCRDLKSLYLRKKGGPTAKVKQGHISFKVISSDDLTEL  
 CAN3_CHICK            -------------------------------------------------------------------------------------------------------------------------MPSAINAAVAQQT-------AAGSVPSTTSTTTEGTGGGTGGIYSAIISRNQPIIKVKE------------------------KTYEELHKKCLEENILYEDPDFPPNETSLFYSQKVPIKFE-----WKRPREICENPRFIIGGANRTDICQGELGDCWFLAAIACLTLNKKLLCRVIPHDQSFIQN------YAGIFHFQFWRYGDWVDVIIDDCLPTYNNQ--LVFTKSSQRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVIEFYEIKDAPKDIYKIMKHAIARGS--LMASSIDDNLGFHYGAAPRS-DIGELIARMVKNLENAQMTYSTVDYQGTDERPAWTIMPMQYETRMSCGLVKGHAYSVTAVEETTYKGEKM--------RLVRLRNPWGQ-VEWNGPWSDKSEEWNFIDEEEKIRLQHKIAEDGEFWISLEDFMRHFTKLEICNLTPDTLEADKLQTWTVSVNEGRWVRGC--------SAGGCRNYPDTFWTNPQYRLKLLEEDDDPEDEE---VICSFLVALMQKNRRKERKLGANLYTIGFAIYEVPKEMHGTKH-HLQKDFFLYNASKARSKTYINMREISERFRLPPSEYVIIPSTYEPHQEGEFILRVFSEKRSLSEEVE------------------------------------------------NMIEADRPSKKKKGKPIIFVSDRANSNKELTTDEDAGKDGEKTHVDEKKRSSAKAREKSEEETQFRNIFRQIAGDDMEICREELRNVLNNVV----KKHKDLKTEGFELESSRSMIALMDTDGSGKINFDEFRHLWDKIKSWQKIFKHYDADHSGTINSYEMRNAVKDAGFRLNNQLYDIITMRYADKNMNIDFDSFICCFVRLDAMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA  
 YKR2_CAEE             MAKDLIGGIFDNVVNRKGKKEQDNYGGGGNYGGGGGNQGGGGGGGFNFNDIGGLINSMGGGGGGGQRQGGGGGGFGDILGGIGSLIGGGGGGQYNGGGGNVNPNNLNGGMVNVIGNLIGEAAHRFLGVDPGTGRIIGAVAGNVIMGLGGKDNSLGNIGKVILDNIISGKFRRDVDPFVRPGPDPDRGGGGSGPSPISPRPTTEPQDFYELRDQCLESKRLFEDPQFLANDSSLFFSKRPPKRVE-----WLRPGEITREPQLITEGHSRFDVIQGELGDCWLLAAAANLTLKDELFYRVVPPDQSFTEN------YAGIFHFQFWQYGKWVDVVIDDRLPTSNGE--LLYMHSASNNEFWSALLEKAYAKLFGSYEALKGGTTSEALEDMTGGLTEFIDLKNPPRNLMQMMMRGFEMGS--LFGCSIEADPNVWEAKMSN-------------------------------------------------GLVKGHAYSITGCRIVDGPNGQ--------TCILRIRNPWGNEQEWNGPWSDNSREWRSVPDSVKQDMGLKFDHDGEFWMSFDDFMRNFEKMEICNLGPDVMDEVYQMTGVKAAGMVWAANTHDGAWVRNQTAGGCRNYINTFANNPQFRVQLTDSDPDDDDE-----LCT----------------------------------AGNNRGRLSKQFFAANKSAMRSAAFINLREMTGRFRVPPGNYVVVPSTFEPNEEAEFMLRVYTNGFIESE  
 HSCANPX               --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGPPLKLFKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYFRLLPGKVV-----WKRPQDICDDPHLIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFHFRFWHFGEWTEVVIDDLLPTINGD--LVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEVETDW------------------------------------------GLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLG-RQEWSGPWSEISEEWQQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELESVLGCWTVDDD-------PLMNRSGGCYNNRDTFLQNPQYIFTVPEDG-----------HKVIMSLQQKDLRTYRRMGRPDNYIIGFELFKVEMNRKFRLHHLYIQERAGTSTYIDTRTVFLSK-------YLKKGNYVLVPTMFQHGRTSEFLLRIFSEVPVQLRELTLDMPKMSCWNLARGYPKVVTQITVHSAEDLEKKYANETVNPYLVIKCGKEEVRSPVQKNTVHAIFDTQAIFYRRTTDIPIIVQVWNSRKFCDQFLGQVTLDADPSDCRDLKSLYLRKKGGPTAKVKQGHISFKVISSDDLTEL  
 CAN2_HUMAN            -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAGIAAKLAKDREAAEGLGSHERAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGMRWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQEN------YAGIFHFQFWQYGEWVEVVVDDRLPTKDGE--LLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGS--LLGCSIDITSAADSEAITFQK------------------------------------------------LVKGHAYSVTGAEEVESNGSL--------QKLIRIRNPWG-EVEWTGRWNDNCPSWNTIDPEERERLTRRH-EDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGS--------TAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGE---SGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVD--------DEIEANLEEFDISEDDIDDGVRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWLCFSVL  
 HSNCL3PRT             --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVR-----RKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQ--LIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERM------------------------------------------LKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGER-EWNGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIHKTWEEARLHGAW----TLHEDPRQNRGGGCINHKDTFFQNPQYIFEVKKPEDEVL-------IC-IQQRPKRSTRREGKG---ENLAIGFDIYKVEENRQYRMHSLQHKAASSIYIN--SRSVFLRT-------DQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRELRLDEPPHTCWSSLCGYPQLVTQVHVLGAAGLKDSPTGA--NSYVIIKCEGDKVRSAVQKGTSTPEYNVKGIFYRKKLSQPITVQVWNHRVLKDEFLGQVHLKADPDNLQALHTLHLRDRNSRQPSNLPGTVAVHILSS  
 CAN1_HUMAN            ---------------------------------------------------------------------------------------------------------------------------------------------------------------------MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNG------YAGIFHFQLWQFGEWVDVVVDDLLPIKDGK--LVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGS--LLGCSIDISSVLDMEAITFKK------------------------------------------------LVKGHAYSVTGAKQVNYRGQVVS--------LIRMRNPWG-EVEWTGAWSDSSSEWNNVDPYERDQLRVKM-EDGEFWMSFRDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGS--------TAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRE-SGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSEEEIDEN-------FKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA  
 CAN3_RAT              -------------------------------------------------------------------------------------------------------------------------MPTVISPTVAPRTGAEPRS-PGPVPHPAQGKTTEAGGGHPGGIYSAIISRNFPIIGVKE------------------------KTFEQLHKKCLEKKVLYLDPEFPPDETSLFYSQKFPIQFV-----WKRPPEICENPRFIIGGANRTDICQGDLGDCWLLAAIACLTLNERLLFRVIPHDQSFTEN------YAGIFHFQFWRYGDWVDVVIDDCLPTYNNQ--LVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVTEFFEIKDAPSDMYKIMRKAIERGS--LMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLRDSDLDPRASDDRPSRTIVPVQYETRMACGLVKGHAYSVTGLEEALFKGEKV--------KLVRLRNPWGQ-VEWNGSWSDGWKDWSFVDKDEKARLQHQVTEDGEFWMSYDDFVYHFTKLEICNLTADALESDKLQTWTVSVNEGRWVRGC--------SAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSE---VICSFLVALMQKNRRKDRKLGANLFTIGFAIYEVPKEMHGNKQ-HLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEAE------------------------------------------------NTISVDRPVKKKKNKPIIFVSDRANSNKELGVDQEAEEGKDKTGPDKQGESPQPRPGHTDQESEEQQQFRNIFRQIAGDDMEICADELKNVLNTVVNKHKDLKTQGFTLESCRSMIALMDTDGSGRLNLQEFHHLWKKIKAWQKIFKHYDTDHSGTINSYEMRNAVNDAGFHLNSQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA  
 AF029232              --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGPPLKLFKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVV-----WKRPQDICDDPHLIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFHFRFWHFGEWTEVVIDDLLPTINGD--LVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEVETDW------------------------------------------GLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLG-RQEWSGPWSEISEEWQQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELESVLGCWTVDDD-------PLMNRSGGCYNNRDTFLQNPQYIFTVPEDG-----------HKVIMSLQQKDLRTYRRMGKTDNYIIGFELFKVEMNRKFRLHHLYIQERAGTSTYIDTRTVFLSK-------YLKKGNYVLVPTMFQHGRTSEFLLRIFSEVPVQLRELTLDMPKMSCWNLARGYPKVVTQITVHSAEDLEKKYANETVNPYLVIKCGKEEVRSPVQKNTVHAIFDTQAIFYRRTTDIPIIVQVWNSRKFCDQFLGQVTLDADPSDCRDLKSLYLRKKGGPTAKVKQGHISFKVISSDDLTEL  
 CAN_DROME             -------------------------------------------------------------------------------------------------------------------------MDDLRGFLRQAGQEFLNAAGEAAMGAAKDVVGSVINEIFIKKEADTKRVLPSIKNMRVLGEKSSSLGPYSEV-----------QDYETILNSCLASGSLFEDPLFPASNESLQFSRRPDRHIE-----WLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEEN------YAGIFHFRFWQYGKWVDVIIDDRLPTYNGE--LMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNLFTILQKAAERNS--MMGCSIEPDPNVTEAETPQ-------------------------------------------------GLIRGHAYSITKVCLIDIVTPNRQGK----IPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQHSGKRKWEMSMY----EGEWTPGVTAGGCRNFLDTFWHNPQYIITLVDPDEEDEE-----GQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQGLN--FFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGYGGKADTITPGFPTPKPIDPQKEGLRRLFDSIAGKDMEVDWMELKRILDHSMRDDLPKPVVFNRFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPVTANAIV------------DETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGRVSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETATFTLEEWIERTIYS