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                       |---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---
 CBPZ_SIMVI            -------------------------------------------------------------------------------------------------------------------------------------------QYHTLPEIYSWLDRLVQEHPEHVEPVVGGKSYEGREIRGVKVSYKKGN-----PVVMVESNIHAREWITAATTTYLLNELLTSKNST-------IREMAENYDWYIFPVTNPDGYVYTHTTD-----RMWRKTRSPNPDSL---------CAGTDPNRNWNFHWMEQG--TSSRPCTETYGGKKAFSEVETRSFSDFLKTLKGQ-----------IKVYLAFHSYSQLLLFPYGHTCQHTYNHDDLQAIGDAAARSLAQRYGTDYTVGNIYDAIYPASGGSM-------DWAYDTLDIPIAYTYELRPRDGWNGFQLPANQ-IIPTGEETVDSVVTILKESRRLGYFNTSD  
 YHT2_YEAST            --------------------MLHMNSLWGCFLFVLLAVTGAVQGLQEDYSEYAVYRFTSDNYSTLVRDVIAPLTDDYDVWTRSNNFIDIKLPKEIGEQINDGQVIIDNMNELIQNTLPTSQMMAREQAVFENDYDFFFNEYRDLDTIYMWLDLLERSFPSLVAVEHLGRTFEGRELKALHISGNKPESNPEKKTIVITGGIHAREWISVSTVCWALYQLLNRYGSSKK-----ETKYLDDLDFLVIPVFNPDGYAYTWSHD-----RLWRKNRQRTHVPQ---------CLGIDIDHSFGFQWEKAH----THACSEEYSGETPFEAWEASAWYKYINETKGD---------YKIYGYIDMHSYSQEILYPYAYSCDALPRDLENLLELSYGLSKAIRSKSGRNYDVISACKDRGSDIFPGLGAGSALDFMYHHRAHWA-FQLKLRDTGNH--GFLLPPENIKPVGKETYAALKYFCDFLLDPEI  
 CBPM_HUMAN            ---------------------------------------------------------------------------------------------------------------------------GLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVLVVGRFPKEHRIGIPEFKYVANMHGDETVGRELLLHLIDYLVTSDGKDPE-----ITNLINSTRIHIMPSMNPDGFEAVKKPD-----CYYSIGRENYN--------------QYDLNRNFPDAFEY-----------------------------NNVSRQPETVAVMKWLKTETFVLSANLHGGALVASYPFDNGVQATGALYSRSL---TPDDDVFQYLAHTYASRNPNMKKGDECKNKMNFP----NGVTNGYSWYP-LQGGMQDYNYIWAQCFEITLELSCCKYPREEKLPSFWNNNKASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYR----TNKYGEYYLLLLPGSYIINVTVPGHDPHITKVIIPEKSQNFSALKKDILLPFQGQLDSIPVSNPSCPMIPLYRNLPDHSAATKPSLFLFLVSLLHIFFK  
 CBPA_BOVIN            -------------------MQGLLILSVLLGAALGKEDFVGHQVLRITAADEAEVQTVKELEDLEHLQLDFWRGPGQPGSPIDVRVPFPSLQAVKVFLEAHGIRYRIMIEDVQSLLDEEQEQMFASQSRARSTNTFNYATYHTLDEIYDFMDLLVAEHPQLVSKLQIGRSYEGRPIYVLKFSTGGSNR----PAIWIDLGIHSREWITQATGVWFAKKFTEDYGQDPS-----FTAILDSMDIFLEIVTNPDGFAFTHSQN-----RLWRKTRSVTSSSL---------CVGVDANRNWDAGFGKAG--ASSSPCSETYHGKYANSEVEVKSIVDFVKDHGN------------FKAFLSIHSYSQLLLYPYGYTTQSIPDKTELNQVAKSAVEALKSLYGTSYKYGSIITTIYQASGGSI-------DWSYNQGIKYS-FTFELRDTGRY--GFLLPASQIIPTAQETWLGVLTIMEHTLNNLY  
 CBP1_HUMAN            -------------------MRGLLVLSVLLGAVFGKEDFVGHQVLRISVADEAQVQKVKELEDLEHLQLDFWRGPAHPGSPIDVRVPFPSIQAVKIFLESHGISYETMIEDVQSLLDEEQEQMFAFRSRARSTDTFNYATYHTLEEIYDFLDLLVAENPHLVSKIQIGNTYEGRPIYVLKFSTGGSKR----PAIWIDTGIHSREWVTQASGVWFAKKITQDYGQDAA-----FTAILDTLDIFLEIVTNPDGFAFTHSTN-----RMWRKTRSHTAGSL---------CIGVDPNRNWDAGFGLSG--ASSNPCSETYHGKFANSEVEVKSIVDFVKDHGN------------IKAFISIHSYSQLLMYPYGYKTEPVPDQDELDQLSKAAVTALASLYGTKFNYGSIIKAIYQASGSTI-------DWTYSQGIKYS-FTFELRDTGRY--GFLLPASQIIPTAKETWLALLTIMEHTLNHPY  
 CBPH_LOPAM            --------------------------------------------------------------------------------------------------------------MKQICSIVLLGAAVVSLVSAAGSDSEISFEYHRYEELRKALVSVWLQCPTIARIYTIGESFEGRELLVLEMSDNPGTHEPGEPEFKYIANMHGNEAVGRELLIYLAQYLCNQYQQGNET----IIDLIHSTRIHLMPSMNPDGFEKAASQPGEI--KDWFVGRSNAQ--------------GVDLNRNFPDLDRI------IYTNEREGGANNHLLQNMKKAVDENTKLAPETKAVIHWIMEIPFVLSANLHGGDVVANYPYDETRTGSTHEYSASPDDVIFKSLAKAFSIYNPVMSDPQRPPCRKHDDDSSFK----DGITNGGAWYS-VPGGMQDFNYLSSNCFEITLELSCDKFPNEDTLKTYWEQNRNSLVNYIEQVHRGVKGYVRDLQGNPIFNATISVE------GIDHDITTAKDGDYWRLLRQGNYKVAASAPGYLTVIKKVAVPHSPATRVDFELESLMERKEEEREELMDWWKMMSETLNF  
 CBPT_THEVU            ----------------------------------MRKKWLSLSLVLVLIVACVPALGFSQNIENPSIFDLGIKLYKIDGVSTKEQRSAIASTGAAIEEVGKDYVKVLATPSEAKQIKQKGFTATVDTSLTTQDFPSYDSGYHNYNEMVNKINTVASNYPNIVKKFSIGKSYEGRELWAVKISDNVGTDENE-PEVLYTALHHAREHLTVEMALYTLDLFTQNYNLDSR-----ITNLVNNREIYIVFNINPDGGEYDISSGSY---KSWRKNRQPNSGSS---------YVGTDLNRNYGYKWGCCG--GSSGSPSSETYRGRSAFSAPETAAMRDFINSRVVGGKQQ------IKTLITFHTYSELILYPYGYTYTDVPSDMTQDD-FNVFKTMANTMAQTNGYTPQQASDLYITDGDMT-------DWAYGQHKIFA-FTFEMYPTSYNPGFYPPDEVIGRETSRNKEAVLYVAEKADCPYSVIGKSCSTK  
 CBPC_MOUSE            ------------------MRFFLLMAVIYTTLAIAPVHFDREKVFRVKLQNEKHASVLKNLTQSI--ELDFWYPDAIHDIAVNMTVDFRVSEKESQTIQSTLEQHK-IHYEILIHDLQEEIEKQFDVKDEIAGRH-SYAKYNDWDKIVSWTEKMLEKHPEMVSRIKIGSTVEDNPLYVLKIGKKDGER----KAIFMDCGIHAREWISPAFCQWFVYQATKSYGKNKI-----MTKLLDRMNFYVLPVFNVDGYIWSWTQD-----RMWRKNRSRNQNST---------CIGTDLNRNFDVSWDSSP--NTNKPCLNVYRGPAPESEKETKAVTNFIRSHLNS-----------IKAYITFHSYSQMLLIPYGYTFKLPPNHQDLLKVARIATDALSTRYETRYIYGPIASTIYKTSGSSL-------DWVYDLGIKHT-FAFELRDKGKS--GFLLPESRIKPTCKETMLSVKFIAKYILKNTS  
 CBP2_RAT              -------------------MRLTLLLAALLGYIYCQETFVGDQVLEIIPSHEEQIRTLLQLEAEEHLELDFWKSPTIPGETVHVRVPFASIQAVKVFLESQGIDYSIMIEDVQVLLDQEREEMLFNQQRERGG-NFNFEAYHTLEEIYQEMDNLVAENPGLVSKVNLGSSFENRPMNVLKFSTGGDK-----PAIWLDAGIHAREWVTQATALWTANKIASDYGTDPA-----ITSLLNTLDIFLLPVTNPDGYVFSQTTN-----RMWRKTRSKRSGSG---------CVGVDPNRNWDANFGGPG--ASSSPCSDSYHGPKPNSEVEVKSIVDFIKSHGK------------VKAFITLHSYSQLLMFPYGYKCTKPDDFNELDEVAQKAAQALKRLHGTSYKVGPICSVIYQASGGSI-------DWAYDLGIKYS-FAFELRDTAFY--GFLLPAKQILPTAEETWLGLKTIMEHVRDHPY  
 CEW01A85              -----------------------------------------------------------------------------------------------------------------MVRFMKDTTLTRDVNGGARTPFFDLTVYNDWPQFEDYIKGVAHDNPSFVQLKTIGRTREGRPLLGVRIGKPALPGKRK-IAVWLDGGNHAREWPAFHVAVYFIEKLVNGYLSDDK-----ITKYVETLDIYVFPVLNPDGFVYSRTSTRAMI-RQWRKNRAPENCTGTGPFQTDICCEGVDLNRNYDIGFSHKNY-PFNNPCSDEFQGPRPFSEPETRAVRDFIMSSEIYGR---------LYALVSMHTHGQLWILPYNYQKRTYPQDIKDLEILANRAADRVFAYRETKYRVGTAADMLGTATGGAT------DWIKKNTPTKYVYVLELPPDMKTWFAFQVKPHWLIPIGKETWLGIEVIFDQVVEETKNFQPTEPTTNGTSADSRSPRFRQL  
 CBPS_STRCP            ------------------MSPKRRRLMAAALGACVALVLPLHAGSAQPSTAKTPERTVFEVTASTPEARTRVARTGVDVLGQDGDKLTVVAEPRQQWALRATGLRVENLGDYDAQLQALGKVDFTDPQVGTQDFPSGYTGYHNFQETVTELNQTVTDHPNLVRLSSVGKSYQGRDLWMLKLSDNPAVDENE-PEVLFTCNMHAREHLTVEMCLRIIKQYTDGYATNPT-----IKNLVDSREIWIIPMVNPDGVEYDIATGSF---RSWRKNRQPNSTA-----------VGTDPNRNWGYQWGCCG--GSSSSGSSETTAARRRSPPRRSPHPH-FVNTRVVGGVQQ------IKTHIDWHTYSELILWPYGYTYNDTAPGLDAQQ-ASAFSTLGRRMASLNGTRRQQSSDLYITDGTIN-------DWLWGVHKIWS-YTFEMYPKSSSPGFYPRDTVIATQTQRNDSAVELFLSYSDCVPRIIGRTC  
 ACU37559              ---------------------------------------------------------------------------------------------MDTSKMLSQCVLVFAAAVAIVSYQSIEASQDTEENGSKKPESTIFFHHTYEEMVSLMYEVNKACPEVTRIYNLSEPSVEKRNLTVLEITENPGVHVPGKPEFKYVANMHGNEVVGKEMVLYFLVALCEEYKRGDKL----ANFIVSQTRVHVLPSMNPDGWQKAYKELQE---KGEAGWLTGRANAN-----------DVDLNRNFPDLNAQ------IYENEKKHKGRNNHLVKVENTIANDKSLQPETRAVMRWFAEIGFVLSSNLHGGDLVANYPYDETRSGKMQEYTACPDDHTFVYLAKSYAYFHATMADPERPPCDKDGDN--------KPITNGGLWYS-VARGMQDYNYLNTNCFEITLELGCKKFPAASELEKYWLDNAAAIYNYVLQTHIGVKGFVKSVDDTPIANAEIKVRSLATGFPIDHDIVSLEDGDYYRLLGNGYYHIQAKAEGFHPRSKCIRIENNIHVGVPSYDLRPATQMNFTLNPTKLPQESDKKEDYNCERLWNEVQMETQLEDRELLVSVLSYLQPQTKWSLLADQLSTLELYSLLAEALKELNPDQMREVLERLPHAVQEQLELVISAHMSK  
 CBPH_HUMAN            ----------------------------------------------------------------------------------------MAGRGGSALLALCGALAACGWLLGAEAQEPGAPAAGMRRRRRLQQEDGISFEYHRYPELREALVSVWLQCTAISRIYTVGRSFEGRELLVIELSDNPGVHEPGEPEFKYIGNMHGNEAVGRELLIFLAQYLCNEYQKGNET----IVNLIHSTRIHIMPSLNPDGFEKAASQPGEL--KDWFVGRSNAQ--------------GIDLNRNFPDLDRI------VYVNEKEGGPNNHLLKNMKKIVDQNTKLAPETKAVIHWIMDIPFVLSANLHGGDLVANYPYDETRSGSAHEYSSSPDDAIFQSLARAYSSFNPAMSDPNRPPCRKNDDDSSFV----DGTTNGGAWYS-VPGGMQDFNYLSSNCFEITVELSCEKFPPEETLKTYWEDNKNSLISYLEQIHRGVKGFVRDLQGNPIANATISVE------GIDHDVTSAKDGDYWRLLIPGNYKLTASAPGYLAITKKVAVPYSPAAGVDFELESFSERKEEEKEELMEWWKMMSETLNF  
 YQGT_BACSU            -----------------------------------------------------------MMAFITVKPEIKNNLANVAKELKIDEELLKSANRSAQKHQLYCPGYVIEEHSGKELQTIQDIKRFLQPRQLKLSDSWIEQEKIYDDSAVEKEIKKIIDVFPFVSCREIGRSVLGRPIWELKAGGEHAV-----KKVHMNASFHANEWITTSVLLKWFKEYCMSLCCNSPFFGFSPIKLFNSTSLSLVPLVNPDGVDLVLNGSEVMGARRDELERLNEHRPNFNEWKANI--NGVDLNKQFPSLWEIEKYRKPTAPSYRDFPGISPLTEPESIAMYRLITEN-------------PPDRLLALHTQGEEIYWGYKGLEPEESAAVIKEFEELSGNIYKGVRDIDSYAGFRDWFIHHYFKEGYTVELGKGQNPLPFQQFSHIYNATSGILWRALFFHE  
 CPA2_HUMAN            --------------------MRLILFFGALFGHIYCLETFVGDQVLEIVPSNEEQIKNLLQLEAQEHLQLDFWKSPTTPGETAHVRVPFVNVQAVKVFLESQGIAYSIMIEDVQVLLDKENEEMLFNRRRERSGNFNFGAYHTLEEISQEMDNLVAEHPGLVSKVNIGSSFENRPMNVLKFSTGGDK-----PAIWLDAGIHAREWVTQATALWTANKIVSDYGKDPS-----ITSILDALDIFLLPVTNPDGYVFSQTKN-----RMWRKTRSKVSGSL---------CVGVDPNRNWDAGFGGPG--ASSNPCSDSYHGPSANSEVEVKSIVDFIKSHGK------------VKAFIILHSYSQLLMFPYGYKCTKLDDFDELSEVAQKAAQSLRSLHGTKYKVGPICSVIYQASGGSI-------DWSYDYGIKYS-FAFELRDTGRY--GFLLPARQILPTAEETWLGLKAIMEHVRDHPY  
 CEZC4348              MTTKRTRNTLWLLILISAFAINAEIADDKPPKFQVLRAHATDVPQLKALRDIHERTQHDLDFWQTPSKVGHRADIMVDEDRMEWLDSVLKNSNISYDVIIEDVGKLILEKEHGPPRFSNLLFSKRMHNEGGNRARYGFGEYHSYQTICDWMKDIERKYPDKAKVFTMGTTSEGRPIQGIKIGSQVWRNDK--RIFWIDGGIHAREWAAVHTALWFIDRIRLWRKNRAG--------------------------------VVCKK-DRWFRDR---------------CCGGVDLNRNYDWHFGETG--SSTDKCSEIYQGSSAFSEKLNGKIDAFITLHTYSQ----------MWIHPYSHARKSVPADVAELVCVDENNVQRVGRAAVAALENTYGTKYKFGTGSDILYPSAGGSD----------DWAKGTLRIKYVYLLELRPGEDVWDGFILDQHQLIPTAKETWNGIKVVIRAVTEQAGSLSSVFQSRKIFNLHNDFLHDFFFAFSFSVPNSIASTLPPITLPPTPLPTTTTTTTTTTTTTMEPTTTESWATTTAAPFSSIFIVTEPAPITRTTPIHLDASYKLGKRRFKFVSIKTFFPTLPTTPMPTAFPTFSPFSEFSQPQASLFTEPSSPSLPFVTVVGPNENNNAVIDDFEGSSSPRVLPAFVRRPNGSIVRTETHTEVKLQTWLNAQGHPNKLLVAAPARTDRHGVHLGSTPTPESARSRKST  
 CBPB_CANFA            ------------------MAFLILVTLALASAHYSGEHFEGEKVFRVNVEDENHINLLHTLASTT--QIDFWKPDSVTQIKPHSTADFRVKAEDILTVEDFLKQNE-LHYEVLINNLRLVLEGQFGRQVPATGH--SYEKYNRWETIEAWTQQVTSENPDLISRRSIGTTFEGRTIYLLKVGKAGQNK----PAIFMDCGFHAREWISPAFWQWFVREXIRTYGQEIH-----MTELLDKLDFYVLPVGNIDGYVYTWTKN-----RMWRKTRSTQVGTN---------CVGTDPTRNFDAGWCKIG--ASRNPCDETYCGPAAESEKETKALANFIRSNLSS-----------IKAYLTIHSYSQMMLYPYSYDYKLTENNAELNALAKATVKELATLHGTKYTYGPGATTIYPAAGGSD-------DWAYDQGIKYS-FTFELRDKGRY--GFALPESQISPTCEETLLAIKHLARYVLQHLY