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 DPOG_PICPA            ------------------------------------------MIIRR------FVRHLSTSK----SSIRINAVGIQHLAPSLQNQLFG----KSSPRLDEDLINMAKRHLKSNNLIGKKSSLNDPIEIQLPSLQGNTLDEHFYKLGSASLEPYNPLIDELLNL-NIIEPQFEFAFQSGWTRYAPGEPSEKVPY-PLEDSYFFDVETMYKVSQYPVMAVALSDKAWYGWVSPYLTEESTTNDHLIPLNTFETEK------------------FIVGHNVSYDRARALEEYNLKQTKAFWMDTMALHVSVSGMCTRQRGTWIKHNKKEQENTMSVASIKSKVQN--EELQELLDSTSIEDP---MLEDNPWINKSSLNSLERVAEFYCKIKLKKDIRN-SFATEDPDELRGNFDELMQYCAKDVFATGKVFQKVYPKFKKLIPHPVTLAALKDISSCILPTTT-KWEDYIETSERLYQESRRMIEKNLHVICEETVKLKDDPTKPWENDPWLSQLDWTIDPIRLTKKGEIHKNQKLPGYPNWYKQLI--------------------------------------------------------------------------------VKNELKLTTKTRTSPLLLKLAWNGNPLYWIQTQGWCFKVPKNKTEEYEKLNFVMVSLKKLSEDPGFESIRAEDL---KNFTFVKVPHPDGPSARVTNCMTKSCLG----------------------------------------------------------------FFEKGF----------------------------LNSQYPLAKDALQMAVASSYWTSSRERIMNQFVVFEDDM---------------------GYILPQIIPMGTITRRAVENTWLTASNAKKNRLGSELKSLIEAPKGYCFVGADVDSEELWIASLIGDSVFK-IHGGTAIGWMTLEGTKNEGTDLHSKTAKILGISRNEAKIFNYGRIYGAGIKFTTTLLKKFNPALSDAEAKATANALYTATKGISGRYDKKSI-----------------------------------------------WYGGSESIIFNRLEAIAEMAHPKTPVLGAGITAPLQKANLSTNN--FLTSRINWAIQSSGVDYLHLLIISMDYLIKLFDIDARLCITVHDEIRYLVKEEDKFRAAYALQISNLWTRAMFCQQLGINEVPQSCAFFSAVDLDFVLRKEVDLDCVTPSNPDPIPCGKSLDIYQLLQQEDIKG--ADFPRTMHLNDVHYRKRTPVIEMFDKAVDDKTRKFMVSLQIAQDKTEFTKWKRSRGELIVH  
 DPOG_DROME            MQFHLIRK------YASKVSR-EHYASSSVKIFRRVKPPQK-----------VNKPKKPENVENGPTEYAENLVKVQMISRNLHAQLFPQAPRSISEQQVASAKVYKDELRRHGVDIESSAPVSD-VQLKLPALRGANIEEHFHNIAKEQVQPYEELLLPLVQCEQLPKRPKRWAFHTGWTAYDPEDGTATPVDHPLEKGLVFDVEVCVSEGQAPVLATAVSTKRWYSWVSSKLTKHRLSVEKLEPLDVDTDSERPHYTTDELIPLGTTGPGLVVGHNVSYDRARLKEQYLTEDTGTRFVDTMSLHMCVSGVTSYQRAMLKSKKE----------------------PAAEDLGWLEQSSLNSLVELHRLYCGGDT---------------LSKEPRNIFVEGTLEQVRQSFQSLTNYCASDVEATHRILRVLYPLYAERFPHPASLAGMLEMGSAYLPVN-SNWERYIREAQLTY--EDLSIEAKYHLGRRAEEACSLLLDDQYRQNLWLWDEDWSVQELKLK-----------------QPPKRKPLPTVE--LKDSGNTPEERR------LQAKFQHLYDQQALL-PARRPLLPGYPLWYRKLCRKPPAKRADEILEDDEEPWSPGASEISTGMQIAPKLLSLCWEGYPLHYEREQGWGFLVPFRSDS----------------------------EGVDRLPMEQLLAHCPVPEFARLSASKAESDMAFDMLP------GQVEQHLGKRE-------HYKKLSQKQ---QRLETQYQGSGVWCNKVLDDCCFFLKLPHKNGPSFRVGNPLSKDFLNKFAENVLSSGDPSCQAAARVIDIARMMSYWRNNRDRIMGQMVVWLDSQQLPNEFTGEKCQPIA-----YGAICPQVVACGTLTRRAMEPTWMTASNSRPDRLGSELRSMVQAPPGYRLVGADVDSQELWIASVLGDAYACGEHGATPLGWMTLSGSKSNGSDMHSITAKAVGISRDHAKVINYARIYGAGQLFAETLLRQFNPTFSASEAKAKAMKMFSITKGKRVYRLREEFHDELEDRAYSS--YEASRLAIQRNRTLA-EVFHRPK-----------WQGGTESAMFNRLEEIATGSQPRTPFLGGRLSRALEADTGPEQEQRFLPTRINWVVQSGAVDFLHLMLVSMRWL---MGSHVRFCLSFHDELRYLVKEELSPKAALAMHITNLMTRSFCVSRIGLQDLPMSVAFFSSVEVDTVLRKECTMDCKTPSNPHGLRIGYGIQPGQSLSVAEAIEKAGGNDVSQWDWIKKS  
 DPOG_MOUSE            MSRLLWKKVAGAKVASGPVPATEGWVSSSVLAPVPSDGRPP-----------SQMP------SSENGQLRLNPLLIQMLSRGLHEQIFGCGGEMPDEAAVQRS---VEHLQKHGLWGQPATPLPD-VELRLPRLFGGNLDQHFRLLAQKQSLPYLEAAASLLEA-QLPPEPKSWAWAEGWNRYGPE-GEAEPVAIPEERALVFDVEVCLAEGTCPTLAVAISPSAWYSWCSRRLVEERYSW--TSQLSPADLTPLGGSTSASSSTKQDGQEQLVVGHNVSFDRAHIREQYLIQDSRMRFLDTMSMHMAISGLSSFQRSLWMGAKQG-KQQDPAVHKARAEVPEESQWSSDSSWDWMDISSANNLADVHNLYVGGPP---------------LEKEPRELFVKGSMRDIRENFQDLMQYCARDVWATFEVFQQQLPLFLERCPHPVTLAGMLEMGVSYLPVN-QNWERYLTEAQNTY--EELQRDDEEVVVVWLMMPGQLLSGERYKEDPWLWDLEWDLQEFKQKKAKKVKK-PASASKLPIEGAGPFGDP-MD--QEDPGPPSEEEELQRSVTAHNRLQQLRSTTDLL-PKRPQHLPGHPGWYRKLC-----------PRLDDPAWAPGPSLLSLQMRVTPKLMALTWDGFPLHYSDSHGWGYLVPGRRDNLTEPPVSPTVESAAVTCPYRAIESLYRKHCLEQGKQQLEPQEVDLAEEFLLTDSSAMWQTVEELG------CLDVEAEAKMEN---SGLSQPLVLPAACAPKSSQPTYHHGNGPYNDVNIPGC-WFFKLPHKDGNNYNVGSPFAKDFLPK-MEDGTLQAGPGGASGPRALEINKMISFWRNAHKRISSQMVVWLPRSALPRVVTRHPAFDEEG---HYGAILPQVVTAGTITRRAVEPTWLTASNARPDRVGSELKAMVQAPTGYVLVGADVDSQELWIAAVLGDAHLAGMHGCTAFGWMTLQGRKSRGTDLHSKTAATVRIHREHAKIFNYGRIYGAGQSFAERLLMQFNHRLTRQEAAEKAQQMYAVTKGLRRYRLSADGEWLVKQLNLPVDRTEDGWVSLQDLRMIRREASRKSRWKKWEVASERAWTGGTESEMFNKLESIAMSDTPRTPVLGCCISRALE-PSVVQGE--FITSRVNWVVQSSAVDYLHLMLVAMKWLFEEFAIDGRFCISIHDEVRYLVREEDRYRAALALQITNLLTRCMFAYKLGLNDLPQSVAFFSAVDIDQCLRKEVTMDCKTPSNPTGMERRYGIPQGEALDIYQIIELTKGSLEKRKPAWTLALSGGSVFAPVELYWSGAGS  
 DPOG_XENLA            MNRLLQK-------GTSLVPS---WRTRGCRYRRCSYAPQL-----------HAKP-----LEMETSQRRMNPLNIQMLSKGFHEQIFRGKQVQHAEEDVQRS---ITHLKNHELWGQETSTVPD-VELQLPKMYGNNIEEHFQILAQKQSLPYLEAANDLLNC-QLPAMPQTWAWQSGWTRYTAT-GEKELVDFPDEKAMVFDVEVCVTEGCCPTLAVAASPQNWYSWCSRRLIEGRYTW--SKELLLSDLFPLETSMNCNYMTKNNWTERLVVGHNVSFDRAHIKEQYLIKGSKTRFMDTMSMHMAISGLTGFQRTLWMASKYGKKKGLQEVKQHIKKTRSNFSGSPISSWDWVNISSINNLADVHALYVGGPP---------------LEKEARELFVKGSMSDIRTEFQELMRYCALDVQATHEVFQEQFPLFMERCPHPVTLSGMLEMGVSYLPVN-QNWERYLDEAQTSY--EELQKEMKKSLMKLANDACQLLTKDAYKEDPWLWDLEWDIQESKQKKTKISKK-----QKKANEAAESVGNKLVEDHNEDPGPPTEKEE-SRPSMGKLYLEDLKLKTLPLLPKRNQHLPGHPGWYRKLC-----------PKLEDPDWLPGPGLISLQMRLTPKLMRLTWDGYPLHYSEKHGWGYLVPGRKNN--KLNNEEEEE--IIPCPYRAIEDIYAEYSKNKTKDGCLSQHSTIPEEFMLTDDNSMWQKVEELSRTEMDLSSEVPATAKAKK-RNNSSEHPVKLEMEF---DSLPDNHHGNSPCGDVNVSGC-WFYKLPHKDGNANNVGSPFAKDFLPK-MEDGTLQASTGDSSATRALEINKMISFWRNAHKRISSQMVVWMKKNELHRTITRDPEFDEEN---KYGAILAQVVSAGTITRRAVEPTWLTASNARADRVGSELKAMVQVPPGYHLIGADVDSQELWIAAILGEAHFAGIHGCTAFGWMTLQGKKSSGTDLHSKTASTVGISREHAKVFNYGRIYGAGQPFAERLLMQFNHRLTQEQAAEKAKQMYAVTKGIRRYILSKEGEWLVEELGISVERGEENSVNLQDLRKIQKDATKRSRRK-WNLVSRRIWTGGTESQMFNKLETIAMSPSPKTPVLGCRISRALE-PTAVKGE--FITSRVNWVVQSSAVDYLHLMLVAMKWLFEAYDIDGRFCISIHDEVRYLVHSKDRYRAALALQITNLLTRCMFASRLGIQDVPQSVAFFSAVDIDKCLRKEVTMDCSTPSNPNGMEKRYGIPQGEALDIYQILKVTKGVL  
 DPOG_SCHPO            ------------------------MFYKACPSTLTCSKWIHSIIKTKK---FLYCRHYSSKSFIDNAPLRINPVGVQYLSPALQNQVFP----QQNTQISQLHLDLAKFHLAKHQLLNKETIKLPSFNFRLPPLQGKTISEHFYNIGLEFAEPHLSKAIKFSKI-DTPVQPKTWKRQPGWTKYAKDGSISCVPY-PDSDCMVFDVEVLYKVSPFAVVATAVSEDAWYCWLSPWLLGKSENDRQLIPSN--PKGA------------------LFVGHNVSFDRQRIREEYNIKSSRNVFLDTMSLHVATHGMCSRQKPTWFKARKAYIRS----QSTETSEDD---------DSSSFDDDYQNYLKQEPWLAHSSVNSLKDVAKFHCNITLDKSKRD-DFASLEKEPILQKLNELITYCAHDTYSTHQVFKKVFPQFLEVCPHPATFSAMLSLGSVFLPVNH-SWTRYINGVEEQYQQMIQLVDQKLSQYAEKAKDLINTK-DTVLKDPWLRQLDWT--PCNLYRKLKKAT-QEVPVVPKWYKKAYCK------------------------------------------------------------------------------TEKRAVITAKSRLAPILLRLKWKKHPLAWSDTYGWVFSVERTSKDEIEMLLDQGLVPCSREE----DTKLDYNN-----YIFFKVPHKDGPEARCCSPLSKSYHA----------------------------------------------------------------YFEEGI----------------------------LQSDYEVAKKALEMSASCSYWSSARDRIRSQMVVWDKDAELGVPS----------SVDGFGIILPCIIPMGTVTRRAVENTWLTASNSKKNRLGSELKAMIRAPDGYTFVGADVDSEELWIVALMGDSQFR-LHGATALGMMTLEGKKSEGTDLHSKTAAILGVSRDSAKVFNYGRLYGAGLKHTTLLLMQMNPTLKTAEAKELAKKLYASTKGVKSKMSKRLQEMG--------------------------------------LPKLTFWSQGTESFVFNKLEAMAQLPSPRTPVLDAGIQQALSSKNLSKNS--FMTSRVNWAIQSSAVDYLHLLLVSMNHLIKKYYLEARLSLTVHDEVRYLSSDKDKYRVAFALQVANLWTRAFFCQRLGINELPQSVAFFSSVDIDHVLRKDVKMDCVTPSNKVPIPPGEELTIESVLEKLEQSG--QSLEPLEQIQCFVDVKATTSAEITEE--DKKNIAYLKAQAFY  
 DPOG_HUMAN            MSRLLWRKVAGATVGPGPVPAPGRWVSSSVPASDPSDGQRRRQQQQQQQQQQQQQPQQPQVLSSEGGQLRHNPLDIQMLSRGLHEQIFGQGGEMPGEAAVRRS---VEHLQKHGLWGQPAVPLPD-VELRLPPLYGDNLDQHFRLLAQKQSLPYLEAANLLLQA-QLPPKPPAWAWAEGWTRYGPE-GEAVPVAIPEERALVFDVEVCLAEGTCPTLAVAISPSAWYSWCSQRLVEERYSW--TSQLSPADLIPLEVPTGASSPTQRDWQEQLVVGHNVSFDRAHIREQYLIQGSRMRFLDTMSMHMAISGLSSFQRSLWIAAKQGKHKVQPPTKQGQKSQRKARRGPAISSWDWLDISSVNSLAEVHRLYVGGPP---------------LEKEPRELFVKGTMKDIRENFQDLMQYCAQDVWATHEVFQQQLPLFLERCPHPVTLAGMLEMGVSYLPVN-QNWERYLAEAQGTY--EELQREMKKSLMDLANDACQLLSGERYKEDPWLWDLEWDLQEFKQKKAKKVKKEPATASKLPIEGAGAPGDP-MD--QEDLGPCSEEEEFQQDVMARACLQKLKGTTELL-PKRPQHLPGHPGWYRKLC-----------PRLDDPAWTPGPSLLSLQMRVTPKLMALTWDGFPLHYSERHGWGYLVPGRRDNLAKLPTGTTLESAGVVCPYRAIESLYRKHCLEQGKQQLMPQEAGLAEEFLLTDNSAIWQTVEELD------YLEVEAEAKMENLRAAVPGQPLALTARGGPKDTQPSYHHGNGPYNDVDIPGC-WFFKLPHKDGNSCNVGSPFAKDFLPK-MEDGTLQAGPGGASGPRALEINKMISFWRNAHKRISSQMVVWLPRSALPRAVIRHPDYDEEG---LYGAILPQVVTAGTITRRAVEPTWLTASNARPDRVGSELKAMVQAPPGYTLVGADVDSQELWIAAVLGDAHFAGMHGCTAFGWMTLQGRKSRGTDLHSKTATTVGISREHAKIFNYGRIYGAGQPFAERLLMQFNHRLTQQEAAEKAQQMYAATKGLRWYRLSDEGEWLVRELNLPVDRTEGGWISLQDLRKVQRETARKSQWKKWEVVAERAWKGGTESEMFNKLESIATSDIPRTPVLGCCISRALE-PSAVQEE--FMTSRVNWVVQSSAVDYLHLMLVAMKWLFEEFAIDGRFCISIHDEVRYLVREEDRYRAALALQITNLLTRCMFAYKLGLNDLPQSVAFFSAVDIDRCLRKEVTMDCKTPSNPTGMERRYGIPQGEALDIYQIIELTKGSLEKRSQPGP  
 DPOG_YEAST            -----------------------------MTKLMVRSECMLRMVRRRPLRVQFCARWFSTKKNTA-EAPRINPVGIQYLGESLQRQVFGSCGGKDEVEQSDKLMELSKKSLKDHGLWGKKTLITDPISFPLPPLQGRSLDEHFQKIGRFNSEPYKSFCEDKFTE--MVARPAEWLRKPGWVKYVPGMAPVEVAY-PDEELVVFDVETLYNVSDYPTLATALSSTAWYLWCSPFICGG-DDPAALIPLNTLNKEQ------------------VIIGHNVAYDRARVLEEYNFRDSKAFFLDTQSLHIASFGLCSRQRPMFMKNNKKKE------AEVESEVHP----------EISIED-----Y-DDPWLNVSALNSLKDVAKFHCKIDLDKTDRD-FFASTDKSTIIENFQKLVNYCATDVTATSQVFDEIFPVFLKKCPHPVSFAGLKSLSKCILPTKLNDWNDYLNSSESLYQQSKVQIESKIVQIIKDIVLLKDKP-DFYLKDPWLSQLDWTTKPLRLTKKGVPAKCQKLPGFPEWYRQLFPS-----------------------------------------------------------------------------KDTVEPKITIKSRIIPILFKLSWENSPVIWSKESGWCFNVPHEQVETYKAKNYVLADSVSQEE----EEIRTHNLGLQCTGVLFKVPHPNGPTFNCTNLLTKSYNH----------------------------------------------------------------FFEKGV----------------------------LKSESELAHQALQINSSGSYWMSARERIQSQFVVPSCKFPNEFQSLSAKSSLNNEKTNDLAIIIPKIVPMGTITRRAVENAWLTASNAKANRIGSELKTQVKAPPGYCFVGADVDSEELWIASLVGDSIFN-VHGGTAIGWMCLEGTKNEGTDLHTKTAQILGCSRNEAKIFNYGRIYGAGAKFASQLLKRFNPSLTDEETKKIANKLYENTKGKTKRSKLFKK----------------------------------------------FWYGGSESILFNKLESIAEQETPKTPVLGCGITYSLMKKNLRANS--FLPSRINWAIQSSGVDYLHLLCCSMEYIIKKYNLEARLCISIHDEIRFLVSEKDKYRAAMALQISNIWTRAMFCQQMGINELPQNCAFFSQVDIDSVIRKEVNMDCITPSNKTAIPHGEALDINQLLDKSNSKLGKPNLDIDSKVSQYAYNYREPVFEEYNKSYTPEFLKYFLAMQVQSDKRDVNRLEDEYLRECTSKEYARDGNTAEYSLLDYIKDVEKGKRTKVRIMGSNFLDGTKNAKADQRIRLPVNMPDYPTLHKIANDSAIPEKQLLENRRKKENRIDDENKKKLTRKKNTTPMERKYKRVYGGRKAFEAFYECANKPLDYTLETEKQFFNIPIDGVIDDVLNDKSNYKKKPSQARTASSSPIRKTAKAVHSKKLPARKSSTTNRNLVELERDITISREY