1         11        21        31        41        51        61        71        81        91        101       111       121       131       141       151       161       171       181       191       201       211       221       231       241       251       261       271       281       291       301       311       321       331       341       351       361       371       381       391       401       411       421       431       441       451       461       471       481       491       501       511       521       531       541       551       561       571       581       591       601       611       621   
                       |---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|-----
 RATPOLB1              --------------------------------------------------------------------------------------------------------------------MSKRKAPQETLN--GGITDMLVELANFEKNV----------------SQAIHKYNAYRK-------------AASVIAK---------------------------YPHKIKSG-AEAKKLPGVGTKIAEKIDEFLATGKLRKL-EKIRQDDTSSSINFLTRVTGIGPSAARKLV---DEGIKTL-EDLRKNE--DKLN-HHQ-RIGLKYFEDFEKRIPREEMLQMQDIVLNEVKK-LDPEYIATVCGSFRRGAESSGDMDVLLT--HPNFT-SESSKQPKLLHRVVEQLQKVRFITD---TRSKGETKFMGVCQLPSENDENEYPH-------------------------------------------------------------------RRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLG-----------------VTGV-AGEPL--------PVDSEQDIFDYIQWRYREPKDRSE  
 XLY15732              --------------------------------------------------------------------------------------------------------------------MSKRKAPQESPN--EGITDFLVELANYERNV----------------NRAIHKYNAYRK-------------AASVIAK---------------------------YPTKIKSG-TEAKKLDGVGAKIAEKIDEFLATGKLRKL-EKIRQDDTSSSINFLTRVTGIGPAAARKFF---DEGIKTL-DDLRNNE--HKLN-HHQ-KIGLKHFDDFEKRIPRKEMLQMQEIILDKVNN-LDPEYIATVCGSFRRGAESSGDMDILLT--HPDFT-SESAKQPRLLHQVVQCLEDCNFITD---TLVKGDTKFMGVCQLPCES-DQDYPY-------------------------------------------------------------------RRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRTHALEKGFTLNEYTLRPLG-----------------VTGI-AGEPL--------PIDSEKDIFDYIQWKYREPKDRSE  
 DPO4_YEAST            SLKGKFFAFLPNPNTSSNKFFKSILEKKGATIVSSIQNCLQSSRKEVIILIEDSFVDSDMHLTQKDIFQREAGLNDVDEFLGKIEQSGIQCVKTSCITKWVQNDKFAFQKDDLIKFQPSIIVISDNADDGQSSTDKESEISTDVESERNDDSNNKDMIQASKPLKRLLQEDKGRASLVTDKTKYKNNELIIGALKRLTKKYEIEGEKFRARSYRLAKQSMENCDFNVRSGEEAHTKLRNIGPSIAKKIQVILDTGVLPGLNDSVGLED---KLKYFKNCYGIGSEIAKRWN---LLNFESFCVAAKKDP--EEFVSDWTILFGWSYYDDWLCKMSRNECFTHLKKVQKALRG-IDPECQVELQGSYNRGYSKCGDIDLLFF--KP-FC-NDTTELAKIMETLCIKLYKDGYIHCFLQLTPNLEKLFLKRIVERFRTAKIVGYGERKRWYSSEIIKKFFMGVKFSPRELEELKEMKNDEGTLLIEEEEEEETKLNPIDQYMSLNAKDGNYCRRLDFFCCKWDELGAGRIHYTGSKEYNRWIRILAAQKGFK---------------------------LTQH-GLFRNNILL----ESFNERRIFELLNLKYAEPEHRNIEWEKKTA  
 DPOB_HUMAN            ---------------------------------------------------------------------------------------------------------------------SKRKAPQETLN--GGITDMLTELANFEKNV----------------SQAIHKYNAYRK-------------AASVIAK---------------------------YPHKIKSG-AEAKKLPGVGTKIAEKIDEFLATGKLRKL-EKIRQDDTSSSINFLTRVSGIGPSAARKFV---DEGIKTL-EDLRKNE--DKLN-HHQ-RIGLKYFGDFEKRIPREEMLQMQDIVLNEVKK-VDSEYIATVCGSFRRGAESSGDMDVLLT--HPSFT-SESTKQPKLLHQVVEQLQKVHFITD---TLSKGETKFMGVCQLPSKNDEKEYPH-------------------------------------------------------------------RRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLG-----------------VTGV-AGEPL--------PVDSEKDIFDYIQWKYREPKDRSE  
 A55874                --------------------------------------------------------------------------------------------------------------------------------------------MFRRTFLTRGHRENIIRIFQEMADLNNALGEKYKVSSYLR---------SIESLK--------------------------TNLDKPLNTPQDLKAFSGFGAKLLKKAEEIMATGKLEEL-ESKTKPKLKAIQELTQVH---GFGPPRRAALFDREGIFTV-EELLQKADSISSLTDQQ-RVGIKYFYDINEKIPMQESVLHENYLREKCLEVLGKDYTIAISGTYRRRHPFSGDVDALLSRTHDAPPLSEPVAATGVLGNYVEHLEKTNYLE---ATMAQGPLKYMGMGRLPPRIVRDKAGRENTKVYKA-----------------------------------------------------------RRVDIRLIETKSVPTAMLTFTGSKNFNVIMRQAAIAKGYLLNEYGLFRLGTPEEARALYERVGIKGKNAGEELGVPKEELEDKRVDVRSEQDVFDALGMPYAKPENRDP  
 DPOB_RAT              ---------------------------------------------------------------------------------------------------------------------SKRKAPQETLN--GGITDMLVELANFEKNV----------------SQAIHKYNAYRK-------------AASVIAK---------------------------YPHKIKSG-AEAKKLPGVGTKIAEKIDEFLATGKLRKL-EKIRQDDTSSSINFLTRVTGIGPSAARKLV---DEGIKTL-EDLRKNE--DKLN-HHQ-RIGLKYFEDFEKRIPREEMLQMQDIVLNEVKK-LDPEYIATVCGSFRRGAESSGDMDVLLT--HPNFT-SESSKQPKLLHRVVEQLQKVRFITD---TLSKGETKFMGVCQLPSENDENEYPH-------------------------------------------------------------------RRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLG-----------------VTGV-AGEPL--------PVDSEQDIFDYIQWRYREPKDRSE  
 HUMPOLB               --------------------------------------------------------------------------------------------------------------------MSKRKAPQETLN--GGITDMLTELANFEKNV----------------SQAIHKYNAYRK-------------AASVIAK---------------------------YPHKIKSG-AEAKKLPGVGTKIAEKIDEFLATGKLRKL-EKIRQDDTSSSINFLTRVSGIGPSAARKFV---DEGIKTL-EDLRKNE--DKLN-HHQ-RIGLKYFGDFEKRIPREEMLQMQDIVLNEVKK-VDSEYIATVCGSFRRGAESSGDMDVLLT--HPSFT-SESTKQPKLLHQVVEQLQKVHFITD---TRSKGETKFMGVCQLPSKNDEKEYPH-------------------------------------------------------------------RRIDIRLYPKDQYYCGVLYFTGSDIFNKNMRAHAKEKGFTINEYTIRPLG-----------------VTGV-AGEPL--------PVDSEKDIFDYIQWKYREPKDRSE