EP450I: E-class P450 group I signature
Seed alignment containing 19 sequences:

                       1         11        21        31        41        51        61        71        81        91        101       111       121       131       141       151       161       171       181       191       201       211       221       231       241       251       261       271       281       291       301       311       321       331       341       351       361       371       381       391       401       411       421       431       441       451       461       471       481       491       501       511       521       531       541       551       
                       |---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------
 CPCR_MESAU            ---------------------MDPVLVLVLTLSCLLLFSVWRQSSGRGRLPPGPTPLPLIGNILQIDIKDISKSLAN-FSKVYGPVFTLYFGTKPTVVVHGYEAVKEALEDLGEEFSGRGNFPIVERMNSGLGIIFSNGTK----WKELRRFSLMTLRNFGMGKR-------SIEDCIQEEARCLV--EELRKTNGSPCDPTFFLSCAPSNVICSVVFHNRFDYNDKNFLNLMEKLNENFEILNSPWL----QVCNVIPAFLDYLPGSHNKALKNFAEIKSYILKRVKEHQETLDMNNPRDFIDCFLIKME-------KEKDNPHSEFTTESLMATVADVFVAGSETTSTTLRYGLLLLLKHKEVTAKVQKEIDHVIGRDRSPCMQDRTRMPYT---DAMVHEVQRYVNLIPNNVPHAATCNVKFRNYVIPKGTDLITSLTSVLHDDKEFPNPKIFDPAHFLDENGNF---KKSDYFMPFSIGKRMCMGEALARMELFLLLTTILQNFDLKSLADTKDIDTTPVASTFGCVPPSYQLYFIPR  
CPG1_RAT ----------------MALGGAFSIFMTLCLSCLLILIAWKRTSR-GGKLPPGPTPIPFLGNLLQVRIDATFQSFLK-LQKKYGSVFTVYFGPRPVVILCGHEAVKEALVDQADDFSGRGEMPTLEKNFQGYGLALSNGER----WKILRRFSLTVLRNFGMGKR-------SIEERIQEEAGYLL--EELHKVKGAPIDPTFYLSRTVSNVICSVVFGKRFDYEDQRFRSLMKMINESFVEMSMPWA----QLYDMYWGVIQYFPGRHNRLYNLIEELKDFIASRVKINEASFDPSNPRDFIDCFLIKMY-------QDKSDPHSEFNLKNLVLTTLNLFFAGTETVSSTLRYGFLLLMKYPEVEAKIHEEINQVIGTHRTPRVDDRAKMPYT---DAVIHEIQRLTDIVPLGVPHNVIRDTHFRGYFLPKGTDVYPLIGSVLKDPKYFRYPEAFYPQHFLDEQGRF---KKNDAFVAFSSGKRICVGEALARMELFLYFTSILQRFSLRSLVPPADIDIAHKISGFGNIPPTYELCFMAR
CPDE_BOVIN ---------------------------VALLIFLLLLDLMHRRSRWAPRYPPGPTPLPVLGNLLQVDFEDPRPSFNQ-LRRRFGNVFSLQQVWTPVVVLNGLAAVREALVYRSQDTADRPPPAVYERLGYGPRAEGVILARYGDAWREQRRFSLTTLRNFGLGKK-------SLEQWVTEEASCLC--AAFADQAGRPFSPMGLLNKAVSNVIASLTFGCRFEYNDPRIIKLLDLTEDGLKEEFNLVR----KVVEAVPVLLSIPGLAARVFPAQRAFMALIDGLIAEQKMTRDPTQPPRHLTDAFLDEVK-------EAKGNPESSFNDENLRLVVADLFSAGMVTTSTTLAWALLLMILHPDVQRRVQQEIDEVIGQVRRPEMGDQALMPFT---VAVVHEVQAFADIVPLGLPHMTSRDIEVQGFHIPKGTTLITNLSSVLKDETVWQKPFRFHPEHFLDAQGRF---VKQEAFIPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPAGQPRPSEHGVFAFLVTPAPYQLCAVPR
CPT7_BOVIN -----------------------MWLLLAVFLLTLAYLFWPKTKHSGAKYPRSLPSLPLVGSLPFLPRRGQQHKNFFKLQEKYGPIYSFRLGSKTTVMIGHHQLAREVLLKKGKEFSGRPKVATLDILSDNQKGIAFADHG--AHWQLHRKLALNAFALFKDGNL-------KLEKIINQEANVLC--DFLATQHGEAIDLSEPLSLAVTNIISFICFNFSFKNEDPALKAIQNVNDGILEVLSKEVL------LDIFPVLKIFPSKAMEKMKGCVQTRNELLNEILEKCQENFSSDSITNLLHILIQAKVNADNNNA-GPDQDSKLLSNRHMLATIGDIFGAGVETTTSVIKWIVAYLLHHPSLKKRIQDDIDQIIGFNRTPTISDRNRLVLL---EATIREVLRIRPVAPTLIPHKAVIDSSIGDLTIDKGTDVVVNLWALHHSEKEWQHPDLFMPERFLDPTGTQ-LISPSLSYLPFGAGPRSCVGEMLARQELFLFMSRLLQRFNLEIPDDGKLPSLEGHASLVLQIKPFKVKIEVRQAWKEAQAEGSTP
CP71_PERAE -------------------MAILVSLLFLAIALTFFLLKLNEKREKKPNLPPSPPNLPIIGNLHQLGNL--PHRSLRSLANELGPLILLHLGHIPTLIVSTAEIAEEILKTHDLIFASRPSTTAARRIFYDCTDVAFSPYG--EYWRQVRKICVLELLSIKRVNS--------YRSIREEEVGLMMERISQSCSTGEAVNLSELLLLLSSGTITRVAFGKKYEGEEERKNKFADLATELTTLMGAFFV------GDYFPSFAWVDVLTGMDARLKRNHGELDAFV--DHVIDDHLLSRKANGSDGVEQKDLVDVLLHLQKDSSLGVHLNRNNLKAVILDMFSGGTDTTAVTLEWAMAELIKHPDVMEKAQQEVRRVVGKKAKVEEEDLHQLHYL---KLIIKETLRLHPVAPLLVPRESTRDVVIRGYHIPAKTRVFINAWAIGRDPKSWENAEEFLPERFVNNSVDF--KGQDFQLIPFGAGRRGCPGIAFGISSVEISLANLLYWFNWELPGI
A53790 MATSLSADSPQQLSSLSTQQTTLLLLFSVLAAVHLGQWLLRQWQRKPWSSPPGPFPWPLIGNAAAVGQASHLYFARL--ARRYGDVFQIRLGSCPVVVLNGESAIHQALVQQGSIFADRPPFASFRVVSGGRSLAFGHYSE---HWKTQRRSAYSTMRAFSTRH---PRSRGLLEGHALAEARELVAVLVRRCAGGAFLDPTPPVIVAVANVMSAVCFGCRYNHDDAEFLELLSHNEEFGRTVGAGSLVDVLPWLQLFPNPVRTTFRKFEQLNRNFSNFVL-DKF-LRHRESLVPGAAPRDMTDAFILSAEKKAS---GDPGDDSSGLDLEDVPATITDIGGASQDTLSTALLWLLILFTRYPDVQARVQAELDQVVGRDRLPCMSDQPNLPYV---MAFLYESMRFSSFLPVTIPHATTANTFVLGYYIPKNTVVFVNQWSVNHDPAKWPNPEDFDPARFLDKDGFI-NKALTSSVMIFSVGKRRCIGEELSKMLLFLFISILAHQCNFKANQNESSNMSFSYGLTIKPKSVRIHVSLRESMELLDNAVKKLQTEEGCK
OMU16657 --------------MDVLHILQTNFVSIIIGFVVIILLWMNRGKQSNSRLPPGPAPIPLLGNLLRMDVKAPYKLYME-LSKKYGSVFTVWLGSKPVVVISGYQAIKDAFVTQGEEFSGRANYPVIMTVSKGYGVLVSSGKR----SKDLRRFSLMTLKTFGMGRR-------SIEERVQEEAKMLV--KAFGEYRDSVVNPKELLCNCVGNVICSIVFGHRFENDDPMFQLIQKAVDAYFNVLSSPIG----AMYNMFPRIVWCFPGNHHEMFAIVNKAKVYIQEQAEIRLKTLNISEPQDFIEAFLVKML-------EEKDDPNTEFNNGNMVMTAWSLFAAGTETTSSTLRQSFLMMIKYPHIQESVQKEIDEVIGS-RVPTVDDRVKMPYT---DAVIHEVQRYMDLSPTSVPHKVMRDTEFYNYHIPEGTMVLPLLSSVLVDPKLFKNPDEFDPENFLDENGVF---KKNDGFFAFGVGKRACPGEALARVELFLFFTSVLQRFTFTGTKPPEEINIEPACSSFGRLPRSYDCYIKLRTEK
S45644 ---------MSLIEDILQTSSTVTLLGTVLFLLVLYLRSSGSSSEEQGKEPPGPRPLPLLGNMLQLDLKKPYCTLCE-LSKKYGSIFTVHFGPKKVVVLAGYKTVKQALVNQAEDFGDRDITPVFYDFNQGHGILFANGDS----WKEMRRFALTNLRDFGMGKK-------GSEEKILEEIPYLI--EVFEKHEGKAFDTTQSVLYAVSNIISAIVYGSRFEYTDPLFTGMADRAKESIHLTGSASI----QMYNMFPWLGPWINNLTRLKKNIADMKMEVIELVRGLKETLNPHMC-RGFVDSFLVRKQ-----TLEESGHMDSFYHDDNLVFSVGNLFSAGTDTTGTTLRWGLLLMTKYPHIQDQVQEEISRVIGSRQTL-VEDRKNLPYT---DAVIHETQRLANIVPMSVPHTTSRDVTFQGYFIKKGTSVIPLLTSVLQDDSEWESPNTFNPSHFLDEQGGF---VKRDAFMAFSAGRRVCLGEGLARMELFLFFTSLLQRFRFSPPPGVTEDDLDLTPLLGFTLNPSPHQLCAVSRV
CPB4_RABIT --------------------MEFSLLLLLAFLAGLLLLLFRGHPKAHGRLPPGPSPLPVLGNLLQMDRKGLLRSFLR-LREKYGDVFTVYLGSRPVVVLCGTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGER----WRALRRFSLATMRDFGMGKR-------SVEERIQEEARCLV--EELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFLRLLDLFFQSFSLISSFSS----QVFELFPGFLKHFPGTHRQIYRNLQEINTFIGQSVEKHRATLDPSNPRDFIDVYLLRME-------KDKSDPSSEFHHQNLILTVLSLFFAGTETTSTTLRYGFLLMLKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYT---DAVIHEIQRLGDLIPFGVPHTVTKDTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGAL---KRNEGFMPFSLGKRICLGEGIARTELFLFFTTILQNFSIASPVPPEDIDLTPRESGVGNVPPSYQIRFLAR
CPT7_CHICK ------------------MPPLAVLLLALALLCAWRLSYSQGPTGTGTGRPRSLPALPLVGSLLQLAGHPQLHLRLWRLQGRYGSLYGLWMGSHYVVVVNSYQHAREVLLKKGKAFAGRPRTVTTDLLSRGGKDIAFASYG--PLWKFQRKLVHAALSMFGEGSV-------ALEKIICREAASLC--ETLGAAQDMALDMAPELTRAVTNVVCSLCFNSSYRRGDPEFEAMLEYSQGIVDTVAKESL------VDIFPWLQIFPNRDLALLKRCLKVRDQLLQQKFTEHKEAFCGDTVRDLMDALLQVRLNAENNSPLEPGLEL---TDDHLLMTVGDIFGAGVETTTTVLKWAVLYLLHYPEVQKKIQEEMDQKIGLARHPHLSDRPLLPYL---EATISEGLRIRPVSPLLIPHVSLADTSIGEYSIPKGARVVINLWSVHHDEKEWDKPEEFNPGRFLDEQGQH-IHSPSPSYLPFGAGIRVCLGEVLAKMELFLFLAWVLQRFTLECPQDQPLPSLEGKFGVVLQVQKFRVKARLREAWRGEMVR
CPA1_RAT ------------------MLDTGLLLVVILASLSVMLLVSLWQQKIRGRLPPGPTPLPFIGNYLQLNTKDVYSSITQ-LSERYGPVFTIHLGPRRVVVLYGYDAVKEALVDQAEEFSGRGEQATYNTLFKGYGVAFSSGER----AKQLRRLSIATLRDFGVGKR-------GVEERILEEAGYLI--KMLQGTCGAPIDPTIYLSKTVSNVISSIVFGERFDYEDTEFLSLLQMMGQMNRFAASPTG----QLYDMFHSVMKYLPGPQQQIIKVTQKLEDFMIEKVRQNHSTLDPNSPRNFIDSFLIRMQ-------EEK-NGNSEFHMKNLVMTTLSLFFAGSETVSSTLRYGFLLLMKHPDVEAKVHEEIEQVIGRNRQPQYEDHMKMPYT---QAVINEIQRFSNLAPLGIPRRIIKNTTFRGFFLPKATDVFPILGSLMTDPKFFPSPKDFDPQNFLDDKGQL---KKNAAFLPFSTGKRFCLGDGLAKMELFLLLTTILQNFRFKFPMKLEDINESPKPLGFTRIIPKYTMSFMPI
CPH1_CHICK ------------------MDFLGLPTILLLVCISCLLIAAWRSTSQRGKEPPGPTPIPIIGNVFQLNPWDLMGSFKE-LSKKYGPIFTIHLGPKKIVVLYGYDIVKEALIDNGEAFSGRGILPLIEKLFKGTGIVTSNGET----WRQLRRFALTTLRDFGMGKK-------GIEERIQEEAHFLV--ERIRKTHEEPFNPGKFLIHAVANIICSIVFGDRFDYEDKKFLDLIEMLEENNKYQNRIQT----LLYNFFPTILDSLPGPHKTLIKNTETVDDFIKEIVIAHQESFDASCPRDFIDAFINKME---------QEKENSYFTVESLTRTTLDLFLAGTGTTSTTLRYGLLILLKHPEIEEKMHKEIDRVVGRDRSPCMADRSQLPYT---DAVIHEIQRFIDFLPLNVPHAVIKDTKLRDYFIPKDTMIFPLLSPILQDCKEFPNPEKFDPGHFLNANGTF---RRSDYFMPFSAGKRICAGEGLARMEIFLFLTSILQNFSLKPVKDRKDIDISPIITSLANMPRPYEVSFIPR
A40938 -------MVAALSSLAAALGAGLHPKTLLLGAVAFLFFAYFLKTRRPKNYPPGPWRLPFLGNLFTLDMEKSHLQLQQ-FVKKYGNLFCLDLAGKSIVIVTGLPLIKEVLVHMDQNFINRPVPPIRERSFKKNGLIMSSGQL----WKEQRRFALMTLRNFGLGKK-------SLEERIQEEARHLT--EAMEKEGGQPFDAHFKINNAVSNIICSITFGERFEYHDGQFQELLKLFDEVMYLEASMLC----QLYNIFPWIMKFLPGAHQTLFSNWKKLELFVSRMLENHKKDWNPAETRDFIDAYLKEMS-------KYPGSATSSFNEENLICSTLDLFLAGTETTS-DMRWGLLFMALYPEIQEKVHAEIDSVIGQWQQPSMASRESLPYT---NAVIHEVQRMGNILPLNVPREVTVDTTLAGYHLPKGTVVLTNLTALHKDPEEWATPDTFNPEHFLE-NGQF---KKKEAFIPFSIGKRACLGEQLAKSELFIFFTSLMQKFTFKPPSDEKLTLNFRMGITLSPVKHRICAIPRA
XELCP450 -----------------MDTSWLWTLLLSLLISCILIYSTWNKMYRKRNLPPGPTPIPLFGNVLQIKRGEMVKSLIE-YGKKYGDTYTLYFGPSPVIILCSYRATKEALIDQAEDFSGRGAMPSFDQYFQGYGVVFTNGEE----WKQLRRFSLTTLRNFGMGKR-------GIEERIQEEAQFVV--EEIKSYKKKPFDPTDILVQCVSNVICSVVFGNRFEYDNKDFQNLLSLFQSVFRESSSAWG----QLLNMFPLIMNHIPGPHKKVIRDMNKLEAFVLQRVKENEKTLDSNSPRDIIDSFLIKMQ-------QENENPTSAFHMKNLLATVLSIFFAGTETVSTTLRHGFLILLIYPEIEAKLREEIDRVIGQNRSPTIEDRSKMPYT---DAVIHEIQRFSDVIPMNVPHLVTKDTQFRGYTIPKGTDVYPLLCAVLRDPEKFATPYEFNPNHFLDDNGCF---KSNDGFMPFSTGKRICLGEGLARMELFLFLTNILQHFKLHTESRLIEDDIAPKMNGFANYPTSYQLSFIPR
CPF2_MOUSE --------------------MDGVSTAILLLLLAVISLSLTFSSRGKGQLPPGPKPLPILGNLLQLRSQDLLTSLTK-LSKEYGSVFTVYLGSRPVIVLSGYQTVKEALVDKGEEFSGRGAYPVFFNFTRGNGIAFSDGER----WKILRRFSVQILRNFGMGKR-------SIEERILEEGSFLL--EVLRKMEGKPFDPVFILSRSVSNIICSVVFGSRFDYDDERLLTIIHFINDNFKIMSSPWG----EMYNIFPSVLDWIPGPHKRLFRNFGGMKDLIARSVREHQDSLDPNSPRDFIDCFLTKMA-------QEKQDPLSHFNMDTLLMTTHNLLFGGTETVGTTLRHAFLILMKYPKVQARVQEEIDRVVGRSRMPTLEDRTSMPYT---DAVIHEVQRFADVIPMNLPHRVTRDTPFRGFLIPKGTDVITLLNTVHYDSDQFKTPQEFNPEHFLDDNHSF---KKSPAFMPFSAGRRLCLGEPLARMELFIYFTSILQNFTLQPLVDPEDIDLTPLSSGLGNLPRPFQLCMHIR
CPS1_PIG ------------------MVLVWLLLLTTLKAGARLLWGQWKLRNLHLPPLVPGFLHLLQPNLPIYLLG---------LTQKLGPIYRLRLGLQDVVVLNSKRTIEEALVRKWVDFAGRPQIPSYKLASQHCPDI-SLGDY-SLFWKAHKKLTRS-ALLLGVRS--------SMEPRVCQLTQEFC--ERMRAQAGTPVTIQKEFSVLTCSIICCLTFGDKEDTLVHALHDCVQDLMKTWDHWSIQIL-DMVPFLRFFPSPGLRRLKQAIENRDHLVEKQ-LRRHKESMVAGQWRDMLDYMLQEAGRQRVE-------EGQGQLL----EGHVHMSVVDLFIGGTETTANTLSWAVVYLLHHPEIQWRLQEELDRELGPGAAGSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRATRPSSIFGYDIPEGTVVIPNLQGAILDETVWEQPHEFRPDRFLAPGANP-------SALAFGCGARVCLGEPLARLELFVVLVQLLQAFTLLPPEG-ALPSLQPVPYSGINLKVQPFQVRLQPRGGRGEGPGPR
CP11_ONCMY ------MVLMILPIIGSVSASEGLVAMVTLCLVYMIMKYMHTEIPEGLKRLPGPKPLPIIGNVLEVHNNPHLSLTAM--SERYGSVFQIQIGMRPVVVLSGSETVRQALIKQGEDFAGRPDLYSFKFINDGKSLAFSTDKAG--VWRARRKLAMSALRSFATLEGTTPEYSCALEEHVCKEGEYLVKQLTSVMDVSGSFDPFRHIVVSVANVICGMCFGRRYSHDDQELLGLVNMSDEFGQVVGSGNPADSIPILRYLPNRTMKRFMDINDRFNTFVQNIISEHYESYDKDNIRDITDSLIDHCEDRKLDENA-----------NIQVSDEKIVGIVNDLFGAGFDTISTALSWAVVYLVAYPEIQERLHQELKEKVGMIRTPRLSDKINLPLL---EAFILEIFRHSSFLPFTIPHCTIKDTSLNGYFIPKDTCVFINQWQVNHDPDLWKEPSSFNPDRFLSADGTELNKLEGEKVLVFGMDKRRCIGEAIGRNEVFLFLAILLQRLRFQEKPGHPLDMTPEYGLTMKHKRCQLKASMRPWGQEE
CPE1_HUMAN ------------------MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTR-LAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAF-HAHRDRGIIFNNGPT----WKDIRRFSLTTLRNYGMGKQ-------GNESRIQREAHFLL--EALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWL----QLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEME-------KEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYM---DAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKF---KYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPRS
A43349 -----------------MVLAGLLLLLLTLLAGAHLLWGRWKLRNLHLPPLVPGFLHLLQPNLPIHLLS---------LTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRKWVDFAGRPQIPSYKLVSQRCQDI-SLGDY-SLLWKAHKKLTRS-ALLLGTRS--------SMEPWVEQLTQEFC--ERMRVQAGAPVTIQKEFSLLTCSIICYLTFGDKEDTLVHAFHDCVQDLMKTWDHWSIQIL-DMVPFLRLFPNPGLWRLKKAIENRDHMVEKQ-LRRHKESMVAGQWRDMMDYMLQGVGRQRVE-------EGPGQLL----EGHVHMSVVDLFIGGTETKASTLSWAVAFLLHHPEIQRRLQEELDRELGPGASCSGVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIPEGMVVIPNLQGAHLDETVWEQPHEFRPDRFLEPGANT-------SALAFGCGARVCLGESLARLELFVVLLRLLQAFTLLPPPGGALPSLQPDPYCGVNLKVQPFQVRLQPRGVEAGAWESTSAQ