| GPCRRHODOPSN: | Rhodopsin-like GPCR superfamily signature |
| Seed alignment containing 60 sequences: |
1 11 21 31 41 51 61 71 81 91 101 111 121 131 141 151 161 171 181 191 201 211 221 231 241 251 261 271 281 291 301 311 321 331 341 351 361 371 381 391 401 411 421 431 441 451 461 471 481 491 501 511 521 531 541 551 561 571 581 591 601 611 621 631 641 651 661 671 681 691 701 711 721 731 741 751 761 771 781 791 801 811 821
|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|-------
OPSR_HUMAN ----------------------------------------------------------------MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWMIFVVTASVFTNGLVLAATMKF-KKLRHPLN--------WILVNLAVADLAETVIASTISIV-NQVS-GYFVL------GHPM-CVLEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNV----RFDAKLAIVGIAFSWIWSAVWTAP-PIFG-WSR----YWPHGLKTS-----------------CGPDVFSGSSYPGVQS---------YMIVLMVTCCIIPLAIIMLCYLQVWLAIRAVAKQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QKESESTQKAEKEVTRMVVVMIFAYCVCWGPYTFFACFAAANPGYAFHPL----------MAALPAYFAKSATIYNPVIYVFMNRQFRNCILQLFGKKVDDGSELSSASKTEVSSVSSVSPA
OPSD_SHEEP --------------------------------------------------------------------------------MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQH-KKLRTPLN--------YILLNLAVADLFMV-FG-GFTTTLYTSLHGYFVF------GPTG-CNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNF----RFGENHAIMGVAFTWVMALACAAP-PLVG-WSR----YIPQGMQCS-----------------CGALYFTLKPEINNES---------FVIYMFVVHFSIPLIVIFFCYGQLVFTVKEAAAQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPI----------FMTIPAFFAKSSSVYNPVIYIMMNKQFRNCMLTTLCCGKNPLGDDEASTTVSKTETSQVAPA
GCRB_RAT -----------------------------------------------------------MFPNGTAPSPTSSPSSSPGGCGEGVCSRGPGSGAADGMEEPGRNSSQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRY-AKMKTATN--------IYILNLAIADELLMLSVPFLVTS-TLL--RHWPF------GALL-CRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAAR---YRRPTVAKVVNLGVWVLSLLVILPIVVFSRT----AANSDGTVA-------------------CNMLMPEPAQRWLVG----------FVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQDDAT------------VSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEPVDYYATALKSRAYSVEDFQPENLESGGVFRNGTCASRISTL
B1AR_RAT -----------------------------------------------------------MGAGALALGASEPCNLSSAAPLPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAGMGLLLALIVLLIVVGNVLVIVAIAKT-PRLQTLTN--------LFIMSLASADLVMGLLVVPFGAT-IVVW-GRWEY------GSFF-CELWTSVDVLCVTASIETLCVIALDRYLAITLPFRYQS---LLTRARARALVCTVWAISALVSFL-PILMHWW-----RAESD-EARRCYNDPK----------CCDFVTNRA----------------YAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------IDSCERRFLTGPPRPPSPAPSPSPGPPRPADSLANGRSSKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLV--PDR---------LFVFFNWLGYANSAFNPIIYCRS-PDFRKAFQRLLCCARRAACRRRAAHGDRPRASGCLARAGPPPSPGAPSDDDDDDAGATPPARLLEPWAGCNGGTTTVDSDSSLDEPGRQGFSSESKV
NY1R_RAT ------------------------------------------------------------------------------MNSTLFSRVENYSVHYNVSENSPFLAFENDDCHLPLAVIFTLALAYGAVIILGVSGNLALIIIILKQ-KEMRNVTN--------ILIVNLSFSDLLVAVMCLPFTFV-YTL-MDHWVF------GETM-CKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGW-----RPNNRHAYIGITVIWVLAVASSLPFVIYQILTDEP--FQNVSLAAFKDKYV------------CFDKFPSDSHRLS------------YTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNM----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDKIRDSKYRSSETKRINVMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNL-------LFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKISMNDNEKI
ACM2_RAT ----------------------------------------------------------------------------------------------MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVS-RHLQTVNN--------YFLFSLACADLIIGVFSMNLYTL-YTVI-GYWPL------GPVV-CDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPV---KRTTKMAGMMIAAAWVLSFILWAP-AILF-WQ-----FIVGVRTVEDGE--------------CYIQFFSNAA---------------VTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKK-----------------------------------------------------------EKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTETCVQGEEKESSNDSTSSAAVASNMRDDEITQDENTVSTSLDHSRDDNSKQTCIKIVTKAQKGDVYTPTSTTVELVGSSGQSGDEKQNVVARKIVKMPKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAP-CIPNT----------VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
D2DR_RAT -----------------------------------------------------------------------------------MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSRE-KALQTTTN--------YLIVSLAVADLLVATLVMPWVVY-LEVV-GEWKF------SRIH-CDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTR--YSSKRRVTVMIAIVWVLSFTISCP-LLFG-LNN---T-DQNE---------------------CIIANPA------------------FVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKR---------------------------------------------------------------------------VNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD-CNIPPV----------LYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
OAR_DROME --------MPSADQILFVNVTTTVAAAALTAAAAVSTTKSGNGNAARGYTDSDDDAGMGTEAVANISGSLVEGLTTVTAALSTAQADKDSAGECEGAVEELHASILGLQLAVPEWEALLTALVLSVIIVLTIIGNILVILSVFTY-KPLRIVQN--------FFIVSLAVADLTVALLVLPFNVA-YSIL-GRWEF------GIHL-CKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQ---KRTVGRVLLLISGVWLLSLLISSP-PLIG-WND-----WPDEFTSATP---------------CELTSQRG-----------------YVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRERARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTCCPTNK----------FKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLLGLN
AA1R_RAT ------------------------------------------------------------------------------------------------------------MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVN-QALRDATF--------CFIVSLAVADVAVGALVIPLAIL-INI--GPQTY-------FHT-CLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKT---VVTQRRAAVAIAGCWILSLVVGLT-PMFG-WNNLSVVEQDWRANGSVGEPVIK----------CEFEKVISME--------------YMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVSASSGDPQKYYGKDVKIAKSLALILFLFALSWLPLHILNCITLFCPT-CQKPSI---------LIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIDEDLPEEKAED
AG2R_RAT -----------------------------------------------------------------------------------------MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFY-MKLKTVAS--------VFLLNLALADLCFLL-TLPLWAV-YTAMEYRWPF------GNHL-CKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRL---RRTMLVAKVTCIIIWLMAGLASLP-AVI-HRNV----YFIENTNITV----------------CAFHYESRNSTLPIG----------LGLTKNILGFLFPFLIILTSYTLIWKALKKAYEI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QKNKPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHD-C-KISDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSSAKKPASCFEVE
ACM3_RAT --------------------------------------------------MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVTQLGSYNISQETGNFSSNDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVN-KQLKTVNN--------YFLLSLACADLIIGVISMNLFTT-YIIM-NRWAL------GNLA-CDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRA---KRTTKRAGVMIGLAWVISFVLWAP-AILF-WQ-----YFVGKRTVPPGE--------------CFIQFLSEPT---------------ITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGVKRSSRRKYGRCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSSILNSTKLPSSDNLQVSNEDLGTVDVERNAHKLQAQKSMGDGDNCQKDFTKLPIQLESAVDTGKTSDTNSSADKTTATLPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDS-CIPKT----------YWNLGYWLCYINSTVNPVCYALCNKTFRTTFKTLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
TSHR_RAT ---CNESSIRNLRERKSVNVMRGPVYQEYEEGLGDNHVGYKQNSKFQEGPSNSHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTVCGDNEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSPMALLGNVFVLFVLLTSHYKLTVPR---------FLMCNLAFADFCMGVYLLLIASVDLYTHTEYYNHAIDWQTGPG--CNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDR---KIRLRHAYTIMAGGWVSCFLLALL-PMVGISS-----YAKVSI--------------------CLPMDTDTPLAL-------------AYIALVLLLNVVAFVIVCSCYVKIYITVRNPQYN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRDKDTKIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTN----------SGVLLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGLCKHQAQAYQAQRVCPNNNTGIQIQKIPQDTRQSLPNVQDTYEPLGSSHLTPKLQGRISEEYTQTAL
OLF5_RAT ---------------------------------------------------------------------------------------------MSSTNQSSVTEFLLLGLSRQPQQQQLLFLLFLIMYLATVLGNLLIILAIGTD-SRLHTP--------MYFFLSNLSFVDVCFSSTTVPKVLANHILGSQAISFSG---------CLTQLYFLAVFGNMDNFLLAVMSYDRFVAICHPLHYTT---KMTRQLCVLLVVGSWVVANMNCLLHILLMARLS----FCADNMIPHFF---------------CDGTPLLKLSCSDTHLNEL------MILTEGAVVMVTPFVCILISYIHITCAVLRVSSP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGGWKSFSTCGSHLAVVCLFYGTVIAVYFNPSSSHLAGR----------------DMAAAVMYAVVTPMLNPFIYSLRNSDMKAALRKVLAMRFPSKQ
CANR_RAT MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHS-RSLRCRPS-------YHFIGSLAVADLLGSVIFVYSFV----DFHVFHRKDS----PNVF--LFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKR---IVTRPKAVVAFCLMWTIAIVIAVL-PLLG-WNCK----KLQSV--------------------CSDIFPLIDET-------------YLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKT----------VFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
OPR1_HUMAN ---------------------------------------------------------MASPAGNLSAWPGWGWPPPAALRNLTSSPAPTASPSPAPSWTPSPRPGPAHPFLQPPWAVALWSLAYGAVVAVAVLGNLVVIWIVLAH-KRMRTVTN--------SFLVNLAFADAAMAALNALVNFI-YAL-HGEWYF------GANY-CRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKP-----RLSATATRIVIGSIWILAFLLAFPQCLYSKIK-----VMPGRTL-------------------CYVQWPEGSRQHFT-----------YHMIVIVLVYCFPLLIMGITYTIVGITLWGGEIP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GDTCDKYQEQLKAKRKVVKMMIIVVVTFAICWLPYHIYFILTAIYQQLNRWKYIQQ-------VYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIHVSSYDELELKATRLHPMRQSSLYTVTRMESMSVVFDSNDGDSARSSHQKRGTTRDVGSNVCSRRNSKSTSTTASFVSSSHMSVEEGS
IL8A_HUMAN ------------------------------------------------------------------------------MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYS--RVGRSVTD-------VYLLNLALADLLFAL-TLPIWAA-SKVN-GWIFG--------TFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLT----QKRHLVKFVCLGCWGLSMNLSLP-FFLFR-QA----YHPNNSSPV-----------------CYEVLGNDTAKWRMV----------LRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNNIGR-ALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
RNGNRH ----------------------------------------------------------------------------------MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMW-----NITVQWYA------GEFL-CKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQ-----SKSKLERSMTSLAWILSIVFAGPQLYIFRMI-----YLVDGSGPAVFSQ-------------CVTHCSFPQWWHEAF----------YNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNR------------VSEPVNHFFFLFGFLNPCFDPLIYGYFSL
GRPR_MOUSE ----------------------------------------------------------------------------MAPNNCSHLNLDVDPFLSCNDTFNQSLSPPKMDNWFHPGFIYVIPAVYGLIIVIGLIGNITLIKIFCTV-KSMRNVPN--------LFISSLALGDLLLLVTCAPVDAS-KYLA-DRWLF------GRIG-CKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQA---SHALMKICLKAALIWIVSMLLAIP-EAVFSDLHP---FHVKDTNQTFIS--------------CAP-YPHSNELHPKI----------HSMASFLVFYVIPLAIISVYYYFIARNLIQSAYN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFV------TSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLMNRSHSTGRSTTCMTSFKSTNPSATFSLINRNICHEGYV
MUSSRI1A -----------------------------------------------------------MFPNGTASSPSSSPSPSPGSCGEGACSRGPGSGAADGMEEPGRNASQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRY-AKMKTATN--------IYILNLAIADELLMLSVPFLVTS-TLL--RHWPF------GALL-CRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAAR---YRRPTVAKVVNLGVWVLSLLVILPIVVFSRT----AANSDGTVA-------------------CNMLMPEPAQRWLVG----------FVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQDDAT------------VSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEPVDYYATALKSRAYSVEDFQPENLESGGVFRNGTCASRISTL
HH2R_RAT ---------------------------------------------------------------------------------------------------MEPNGTVHSCCLDSMALKVTISVVLTTLILITIAGNVVVCLAVSLN-RRLRSLTN--------CFIVSLAATDLLLGLLVLPFSAI-YQLS-FTWSF------GHVF-CNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPV---LVTPVRVAISLVFIWVISITLSFLSIHLG-WNS-----RNGTRGGNDTFK-------------CKVQVNEV-----------------YGLVDGLVTFYLPLLIMCVTYYRIFKIAREQAKR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------INHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEA----------VEGIVLWLGYANSALNPILYAALNRDFRTAYQQLFHCKFASHNSHKTSLRLNNSLLPRSQSREGRWQEEKPLKLQVWSGTELTHPQGNPIR
S78653 ------------------------------------------MVWGKICWFSQRAGWTVFAESQISLSCSLCLHSGDQEAQNPNLVSQLCGVFLQNETNETIHMQMSMAVGQQALPLNIIAPKAVLVSLCGVLLNGTVFWLLC---CGATNP--------YMVYILHLVAADVIYLCCSAVGFLQVTLLT-YHGVVF-----FIPD---FLAILSPFSFEVCLCLLVAISTERCVCVLFPIWYRC---HRPKYTSNVVCTLIWGLPFCINIVKSLFLT-------YWKHVKA-------------------CVIFLKLSG----------------LFHAILSLVMCVSSLTLLIRFLCCSQQQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KATRVYAVVQISAPMFLLWALPLSVAPLITDFKMFVT--------------TSYLISLFLIINSSANPIIYFFVGSLRKKRLKESLRVILQRALADKPEVGRNKKAAGIDPMEQPHSTQHVENLLPREHRVDVET
RTA_RAT -------------------------------------------------------------------------MAGNCSWEAHSTNQNKMCPGMSEALELYSRGFLTIEQIATLPPPAVTNYIFLLLCLCGLVGNGLVLWFFG---FSIKRTP-------FSIYFLHLASADGIYLFSKAVIALLNM----GTFLGSF----PDYV-RRVSRIVGLCTFFAGVSLLPAISIERCVSVIFPMWYWR---RRPKRLSAGVCALLWLLSFLVTSIHNYFCMFL-----GHEASGTA------------------CLNMDISLGI---------------LLFFLFCPLMVLPCLALILHVECRARRRQRSAKL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NHVVLAIVSVFLVSSIYLGIDWFLFWVFQIPAPFPEYV--------------------------TDLCICINSSAKPIVYFLAGRDKSQRLWEPLRVVFQRALRDGAEPGDAASSTPNTVTMEMQCPSGNAS
NK3R_RAT ---------------------------------------------MASVPRGENWTDGTVEVGTHTGNLSSALGVTEWLALQAGNFSSALGLPATTQAPSQVRANLTNQFVQPSWRIALWSLAYGLVVAVAVFGNLIVIWIILAH-KRMRTVTN--------YFLVNLAFSDASVAAFNTLINFI-YGL-HSEWYF------GANY-CRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKP-----RLSATATKIVIGSIWILAFLLAFPQCLYSKIK-----VMPGRTL-------------------CYVQWPEGPKQHFT-----------YHIIVIILVYCFPLLIMGVTYTIVGITLWGGEIP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GDTCDKYHEQLKAKRKVVKMMIIVVVTFAICWLPYHVYFILTAIYQQLNRWKYIQQ-------VYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIQVSSYDELELKTTRFHPTRQSSLYTVSRMESVTVLFDPNDGDPTKSSRKKRAVPRDPSANGCSHRGSKSASTTSSFISSPYTSVDEYS
B3AR_RAT -----------------------------------------------------------------------------------MAPWPHKNGSLAFWSDAPTLDPSAANTSGLPGVPWAAALAGALLALATVGGNLLVITAIART-PRLQTITN--------VFVTSLATADLVVGLLVMPPGAT-LALT-GHWPL------GATG-CELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGT---LVTKRRARAAVVLVWIVSATVSFA-PIMSQWW-----RVGADAEAQECHSNPR----------CCSFASNMP----------------YALLSSSVSFYLPLLVMLFVYARVFVVAKRQRRF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------VRRELGRFPPEESPRSPSRSPSPATVGTPTASDGVPSCGRRPARLLPLGEHRALRTLGLIMGIFSLCWLPFFLANVLRALVGPSLVPSG----------VFIALNWLGYANSAFNPLIYCRS-PDFRDAFRRLLCSYGGRGPEEPRVVTFPASPVASRQNSPLNRFDGYEGERPFPT
OPSD_MOUSE --------------------------------------------------------------------------------MNGTEGPNFYVPFSNVTGVGRSPFEQPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQH-KKLRTPLN--------YILLNLAVADLFMV-FG-GFTTTLYTSLHGYFVF------GPTG-CNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNF----RFGENHAIMGVVFTWIMALACAAP-PLVG-WSR----YIPEGMQCS-----------------CGIDYYTLKPEVNNES---------FVIYMFVVHFTIPMIVIFFCYGQLVFTVKEAAAQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QQESATTQKAEKEVTRMVIIMVIFFLICWLPYASVAFYIFTHQGSNFGPI----------FMTLPAFFAKSSSIYNPVIYIMLNKQFRNCMLTTLCCGKNPLGDDDASATASKTETSQVAPA
OPSB_HUMAN -----------------------------------------------------------------------------------MRKMSEEEFYLFKNISSVGPWDGPQYHIAPVWAFYLQAAFMGTVFLIGFPLNAMVLVATLRY-KKLRQPLN--------YILVNVSFGGFLLCIFSVFPVFV-ASCN-GYFVF------GRHV-CALEGFLGTVAGLVTGWSLAFLAFERYIVICKPFGNF----RFSSKHALTVVLATWTIGIGVSIP-PFFG-WSR----FIPEGLQCS-----------------CGPDWYTVGTKYRSES---------YTWFLFIFCFIVPLSLICFSYTQLLRALKAVAAQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QQESATTQKAEREVSRMVVVMVGSFCVCYVPYAAFAMYMVNNRNHGLDLR----------LVTIPSFFSKSACIYNPIIYCFMNKQFQACIMKMVCGKAMTDESDTCSSQKTEVSTVSSTQVGPN
5HTA_RAT ---------------------------------------------------------------------------------MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALE-RSLQNVAN--------YLIGSLAVTDLMVSVLVLPMAAL-YQVL-NKWTL------GQVT-CDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVN---KRTPRRAAALISLTWLIGFLISIP-PMLG-WRTPEDRSDPDA---------------------CTISKDHG-----------------YTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRK--------------------------------------------------------------------------------------------------------------TVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPAL---------LGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
TA2R_HUMAN ---------------------------------------------------------------------------------------------MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLA----GARQGGSHTRSS-FLTFLCGLVLTDFLGLLVT-GTIVVSQHAALFEWHAVD----PGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPA---VASQRRAWATVGLVWAAALALGLL-PLLGVGR-----YTVQYPGSW-----------------CFLTLGAES----------------GDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLWFIAQTVLRNPPAMSPAGQLSRTTEK-ELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
PAFR_CAVPO ------------------------------------------------------------------------------------------------------MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFA----RLYPSKKLNE---IKIFMVNLTVADLLFLITL-PLWIVYY-SNQGNWFL------PKFL-CNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQ---ATTRKRGIALSLVIWVAIVAAASY-FLVMDSTNVV-SNKAGSGNITR----------------CFEHYEKGSKP--------------VLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAIND---AHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
BRB2_RAT -------------------------------------------------------------------------------------MFNITTQALGSAHNGTFSEVNCPDTEWWSWLNAIQAPFLWVLFLLAALENIFVLSVFC-----LHKTNCTV----AEIYLGNLAGADLILAC-GLPFWAI-TIANNFDWLF------GEVL-CRVVNTMIYMNLYSSICFLMLVSIDRYLALVKTMSMGR---MRGVRWAKLYSLVIWSCTLLLSSP-MLVFRTM-KD--YREEGHNVTA----------------CVIVYPSRSWEV------------FTNMLLNLVGFLLPLSIITFCTVRIMQVLRNNEMK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFKEVQTEKKATVLVLAVLGLFVLCWFPFQISTFLDTLLRLGVLSG-CWNERAVDI-VTQISSYVAYSNSCLNPLVYVIVGKRFRKKSREVYQAICRKGGCMGESVQMENSMGTLRTSISVDRQIHKLQDWAGNKQ
NK1R_RAT -------------------------------------------------------------------------------------MDNVLPMDSDLFPNISTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAH-KRMRTVTN--------YFLVNLAFAEACMAAFNTVVNFT-YAV-HNVWYY------GLFY-CKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQP-----RLSATATKVVIFVIWVLALLLAFPQGYYSTTE-----TMPSRVV-------------------CMIEWPEHPNRTYEKA---------YHICVTVLIYFLPLLVIGYAYTVVGITLWASEIP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHVFFLLPYINPDLYLKKFIQQ-------VYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTISTVVGAHEEEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA
NTR_RAT -----------------------------------------------------MHLNSSVPQGTPGEPDAQPFSGPQSEMEATFLALSLSNGSGNTSESDTAGPNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTAFTLARK-KSLQSLQST-----VHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAF------GDAG-CRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKT---LMSRSRTKKFISAIWLASALLAIPMLFTMGLQNRS--GDGTHPGGLV----------------CTPIVDTATVKV-------------VIQVNTFMSFLFPMLVISILNTVIANKLTVMVHQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAEQGRVCTVGTHNGLEHSTFNMTIEPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHY---FYMLTNALFYVSSAINPILYNLVSANFRQVFLSTLACLCPGWRHRRKKRPTFSRKPNSMSSNHAFSTSATRETLY
5HT2_RAT -------------------------------------------MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLE-KKLQNATN--------YFLMSLAIADMLLGFLVMPVSML-TILYGYRWPL------PSKL-CAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSR---FNSRTKAFLKIIAVWTISVGISMPIPVFG-LQDDSKVFKEGS---------------------CLLADDN------------------FVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------CVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGA-------LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
NK2R_RAT ------------------------------------------------------------------------------------MGTRAIVSDANILSGLESNATGVTAFSMPGWQLALWATAYLALVLVAVTGNATVIWIILAH-ERMRTVTN--------YFIINLALADLCMAAFNATFNFI-YAS-HNIWYF------GRAF-CYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQP-----RLSAPSTKAIIAGIWLVALALASPQCFYSTIT-----VDEGATK-------------------CVVAWPNDNGGKMLLL---------YHLVVFVLIYFLPLLVMFGAYSVIGLTLWKRAVP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RHQAHGANLRHLQAKKKFVKAMVLVVLTFAICWLPYHLYFILGTFQEDIYYHKFIQQ-------VYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEEDRLELTHTPSLSRRVNRCHTKETLFMTGDMTHSEATNGQVGSPQDGEPAGPICKAQA
IL8B_HUMAN --------------------------------------------------------------------------MESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYS--RVGRSVTD-------VYLLNLALADLLFAL-TLPIWAA-SKV-NGWIFG--------TFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLT----QKRYLVKFICLSIWGLSLLLALP-VLLFRRTV----YSSN-VSPA-----------------CYEDMGNNTANWRML----------LRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDR-ALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
A1AB_RAT ------------------------------------------------------------------------MNPDLDTGHNTSAPAHWGELKDDNFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACN-RHLRTPTN--------YFIVNLAIADLLLSFTVLPFSAT-LEVL-GYWVL------GRIF-CDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPT---LVTRRKAILALLSVWVLSTVISIG-PLLG-WKE------PAPNDDKE----------------CGVTEEP-----------------FCALFCSLGSFYIPLAVILVMYCRVYIVAKRTTKN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------LEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLK-PPDA---------VFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRGGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGQKRTLPSASPSPGYLGRGTQPPVELCAFPEWKPGALLSLPEPPGRRGRLDSGPLFTFKLLGDPESPGTEATASNGGCDTTTDLANGQPGFKSNMPLGPGHF
MAS_RAT --------------------------------------------------------------------------------------MDQSNMTSFAEEKAMNTSSRNASLGTSHPPIPIVHWVIMSISPLGFVENGILLWFLC---FRMRRNP-------FTVYITHLSIADISLLFCIFILSIDY----ALDYELSS----GHYYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWYRC---HRPKHQSAFVCALLWALSCLVTTM-EYVMCIDS----GEESHSQSD-----------------CRAVI--------------------IFIAILSFLVFTPLMLVSSTILVVKIRKNTWASH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSKLYIVIMVTIIIFLIFAMPMRVLYLLYYEYWSTFGN------------LHNISLLFSTINSSANPFIYFFVGSSKKKRFRESLKVVLTRAFKDEMQPRRQEGNGNTVSIETVV
GASR_CANFA ---------------------------------------------------------------MELLKLNRSAQGSGAGPGASLCRAGGALLNSSGAGNLSCEPPRLRGAGTRELELAIRVTLYAVIFLMSVGGNVLIIVVLGLS-RRLRTVTN--------AFLLSLAVSDLLLAVACMPFTLLPNLMG--TFIF------GTVV-CKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARV---WQTRSHAARVIIATWMLSGLLMVPYPVYTAVQ-------PAGGARALQ---------------CVHRWPSARVRQT------------WSVLLLLLLFFVPGVVMAVAYGLISRELYLGLRF--------------------------------------------------------------------------------------------------------------------------------------------DEDSDSESRVRSQGGLRGGAGPGPAPPNGSCRPEGGLAGEDGDGCYVQLPRSRQTLELSALTAPTPGPGGGPRPYQAKLLAKKRVVRMLLVIVVLFFLCWLPLYSANTWRAFDSSGAHRALSGA-------PISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG
GCRC_MOUSE ----------------------------------------------MKVPPVLLLFLLSSVRATEQPQVVTEHPSMEAALTGPNASSHFWANYTFSDWQNFVGRRRYGAESQNPTVKALLIVAYSFTIVFSLFGNVLVCHVIFKN-QRMHSATS--------LFIVNLAVADIMITLLNTPFTLVRFVNS--TWVF------GKGM-CHVSRFAQYCSLHVSALTLTAIAVDRHQVIMHPLKP-----RISITKGVIYIAVIWVMATFFSLP-HAICQKLFTFK-YSEDIVRSL-----------------CLPDFPEPADLFWK----------YLDLATFILLYLLPLFIISVAYARVAKKLWLCNTI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GDVTTEQYLALRRKKKTTVKMLVLVVVLFALVWCPLNCYVLLLSSKAIHTNNA-----------LYFAFHWFAMSSTCYNPFIYCWLNENFRVELKALLSMCQRPPKPQEDRLPSPVPSFRVAWTEKSHGRRAPLPNHHLPSSQIQSGKTDLSSVEPVVAMS
D3DR_RAT ----------------------------------------------------------------------------------------MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRE-RALQTTTN--------YLVVSLAVADLLVATLVMPWVVY-LEVTGGVWNF------SRIC-CDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCP-LLFG-FNT---TGDPSI---------------------CSISNPD------------------FVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRK-------------------------------------------------------------------------RILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPE----------LYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
UL33_HCMVA ------------------------------------------------------------------------------------------------------------MTGPLFAIRTTEAVLNTFIIFVGGPLNAIVLITQLLTNRVLGYST-------PTIYMTNLYSTNFLTLTVL-PFIVL-----SNQWLLPA----GVAS-CKFLSVIYYSSCTVGFATVALIAADRYRVLHKRTYARQ-----SYRSTYMILLLTWLAGLIFSVPAAVYTTVVM----HHDANDTNNTNGHAT-----------CVLYFVAEEVHTVLLS---------WKVLLTMVWGAAPVIMMTWFYAFFYSTVQRTSQK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRSRTLTFVSVLLISFVALQTPYVSLMIFNSYATTAWPMQCEHLTLRRT--IGTLARVVPHLHCLINPILYALLGHDFLQRMRQCFRGQLLDRRAFLRSQQNQRATAETNLAAGNNSQSVATSLDTNSKNYNQHAKRSVSFNFPSGTWKGGQKTASNDTSTKIPHRLSQSHHNLSGV
B2AR_RAT ------------------------------------------------------------------------------------MEPHGNDSDFLLAPNGSRAPGHDITQERDEAWVVGMAILMSVIVLAIVFGNVLVITAIAKF-ERLQTVTN--------YFITSLACADLVMGLAVVPFGAS-HILM-KMWNF------GNFW-CEFWTSIDVLCVTASIETLCVIAVDRYVAITSPFKYQS---LLTKNKARVVILMVWIVSGLTSFL-PIQMHWY-----RATHK-QAIDCYAKET----------CCDFFTNQA----------------YAIASSIVSFYVPLVVMVFVYSRVFQVAKRQLQK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------IDKSEGRFH---------------AQNLSQVEQDGRSGHGLRSSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIRANLI-PKE----------VYILLNWLGYVNSAFNPLIYCRS-PDFRIAFQELLCLRRSSSKTYGNGYSSNSNGRTDYTGEQSAYQLGQEKENELLCEEAPGMEGFVNCQGTVPSLSIDSQGRNCNTNDSPL
VG74_HSVSA ------------------------------------------------------------------------------MEVKLDFSSEDFSNYSYNYSGDIYYGDVAPCVVNFLISESALAFIYVLMFLCNAIGNSLVLRTFLK--YRAQAQ--------SFDYLMMGFCLNSLFLAGYLLMRLLRM----FEIFM-------NTELCKLEAFFLNLSIYWSPFILVFISVLRCLLIFCATRLW----VKKTLIGQVFLCCSFVLACFGALPHVMVTSY------YEPSS---------------------CIEEDGVLTEQLRTK----------LNTFHTWYSFAGPLFITVICYSMSCYKLFKTKLS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRAEVVTIITMTTLLFIVFCIPYYIMESIDTLLRVGVIEETCAKRSAIVY-GIQCTYMLLVLYYCMLPLMFAMFGSLFRQRMAAWCKTICHC
MUSC5AGPR ------------------------------------------------------------------------------------MNSSFEINYDHYGTMDPNIPADGIHLPKRQPGDVAALIIYSVVFLVGVPGNALVVWVTAFE-PDGPSNAI--------WFL-NLAVADLLSCLA-MPVLFTTVLNH-NYWYF------DATA-CIVLPSLILLNMYASILLLATISADRFLLVFKPIWCQK---VRGTGLAWMACGVAWVLALLLTIP-SFVYREAYKDF-YSEHTV--------------------CGINYGGGSFPKEKA----------VAILRLMVGFVLPLLTLNICYTFLLLRTWSRKAT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSTKTLKVVMAVVICFFIFWLPYQVTGVMIAWLPPSSPTLKRVEK------LNSLCVSLAYINCCVNPIIYVMAGQGFHGRLLRSLPSIIRNALSEDSVGRDSKTFTPSTDDTSPRKSQAV
5HTD_RAT ----------------------------------------------------------------------------------MSLPNQSLEGLPQEASNRSLNATGAWDPEVLQALRISLVVVLSIITLATVLSNAFVLTTILLT-KKLHTPAN--------YLIGSLATTDLLVSILVMPISIA-YTTT-RTWNF------GQIL-CDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSK---RRTAGHAAAMIAAVWAISICISIP-PLF--WRQ--ATAHEEMSD-------------------CLVNTSQIS----------------YTIYSTCGAFYIPSILLIILYGRIYVAARSRILN------------------------------------------------------------------------------------------------------------------------------------------------------------PPSLYGKRFTTAQLITGSAGSSLCSLNPSLHESHTHTVGSPLFFNQVKIKLADSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPA---------LFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQRVVHFRKAS
THRR_RAT --------MGPRRLLLVAVGLSLCGPLLSSRVPMRQPESERMYATPYATPNPRSFFLRNPSEDTFEQFPLGDEEEKNESIPLEGRAVYLNKSRFPPMPPPPFISEDASGYLTSPWLTLFIPSVYTFVFIVSLPLNILAIAVFV---FRMKVKKP------AVVYMLHLAMADVLFVSVL-PFKIS------YYFSGT-DWQFGSGM-CRFATAACYCNMYASIMLMTVISIDRFLAVVYPIQSLS---WRTLGRANFTCVVIWVMAIMGVVP-LLLKEQTTQ----VPGLNITT-----------------CHDVLNETLLHGFYSY---------YFSAFSAIFFLVPLIISTVCYTSIIRCLSSSAVA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NRSKKSRALFLSAAVFCIFIVCFGPTNVLLIVHYLLLSDSPGTETAYF------AYLLCVCVTSVASCIDPLIYYYASSECQKHLYSILCCRESSDSNSCNSTGQLMPSKMDTCSSHLNNSIYKKLLA
ACM5_RAT ----------------------------------------------------------------------------------------MEGESYNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVN-SQLKTVNN--------YYLLSLACADLIIGIFSMNLYTT-YILM-GRWVL------GSLA-CDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRA---KRTPKRAGIMIGLAWLVSFILWAP-AILC-WQ-----YLVGKRTVPPDE--------------CQIQFLSEPT---------------ITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKD-----------LADLQGSDSVAEAKKREPAQRTLLRSFFSCPRPSLAQRERNQASWSSSRRSTSTTGKTTQATDLSADWEKAEQVTTCSSYPSSEDEAKPTTDPVFQMVYKSEAKESPGKESNTQETKETVVNTRTENSDYDTPKYFLSPAAAHRLKSQKCVAYKFRLVVKADGTQETNNGCRKVKIMPCSFPVSKDPSTKGPDPNLSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDK-CVPVT----------LWHLGYWLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKKKKVEEKLYWQGNSKLP
PER3_MOUSE --------------------------------------------------------------------------------------------MASMWAPEHSAEAHSNLSSTTDDCGSVSVAFPITMMVTGFVGNALAMLLVS---RSYRRRESKRKKS-FLLCIGWLALTDLVGQLLTSPVVILV-YLSQRRWEQLD----PSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHWYAS----HMKTRATPVLLGVWLSVLAFALL-PVLGVGR-----YSVQWPGTW-----------------CFISTGPAGNETDPAREP-------GSVAFASAFACLGLLALVVTFACNLATIKALVSR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CRAKAAVSQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSALMWSDQLER
FML2_HUMAN -------------------------------------------------------------------------------------------METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAG---FRMTRTVTT-------ICYLNLALADFSFTA-TLPFLIV-SMAMGEKWPF------GWFL-CKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQN---HRTVSLAMKVIVGPWILALVLTLP-VFLFLTT----VTIPNGDTY------------------CTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDI---LVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANCASPPAETELQAM
B2AR_HUMAN ------------------------------------------------------------------------------------MGQPGNGSAFLLAPNRSHAPDHDVTQQRDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKF-ERLQTVTN--------YFITSLACADLVMGLAVVPFGAA-HILM-KMWTF------GNFW-CEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQS---LLTKNKARVIILMVWIVSGLTSFL-PIQMHWY-----RATHQ-EAINCYANET----------CCDFFTNQA----------------YAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------IDKSEGRFH---------------VQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLI-RKE----------VYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
OLF7_RAT --------------------------------------------------------------------------------------------MERRNHSGRVSEFVLLGFPAPAPLRVLLFFLSLLXYVLVLTENMLIIIAIRNH-PTLHKP--------MYFFLANMSFLEIWYVTVTIPKMLAGFIGSKENHGQL-----ISFEACMTQLYFFLGLGCTECVLLAVMAYDRYVAICHPLHYPV---IVSSRLCVQMAAGSWAGGFGISMVKVFLISRLS----YCGPNTINHFF---------------CDVSPLLNLSCTDMSTAEL------TDFVLAIFILLGPLSVTGASYMAITGAVMRIPSA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGRHKAFSTCASHLTVVIIFYAASIFIYARPKALSAFDT----------------NKLVSVLYAVIVPLFNPIIYCLRNQDVKRALRRTLHLAQDQEANTNKGSKIG
DADR_RAT -----------------------------------------------------------------------------------------------MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRF-RHLRSKVTN-------FFVISLAVSDLLVAVLVMPWKAV-AEIA-GFWPL------GPF--CNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYER---KMTPKAAFILISVAWTLSVLISFI-PVQLSWHKAK-PTWPLDGNFTSLEDTED--------DNCDTRLSRT-----------------YAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSI-----TFDVFVWFGWANSSLNPIIYA-FNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
OPSG_HUMAN ----------------------------------------------------------------MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWMIFVVIASVFTNGLVLAATMKF-KKLRHPLN--------WILVNLAVADLAETVIASTISVV-NQVY-GYFVL------GHPM-CVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNV----RFDAKLAIVGIAFSWIWAAVWTAP-PIFG-WSR----YWPHGLKTS-----------------CGPDVFSGSSYPGVQS---------YMIVLMVTCCITPLSIIVLCYLQVWLAIRAVAKQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QKESESTQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAANPGYPFHPL----------MAALPAFFAKSATIYNPVIYVFMNRQFRNCILQLFGKKVDDGSELSSASKTEVSSVSSVSPA
OLF1_RAT ---------------------------------------------------------------------------------------------MTEENQTVISQFLLLFLPIPSEHQHVFYALFLSMYLTTVLGNLIIIILIHLD-SHLHTP--------MYLFLSNLSFSDLCFSSVTMPKLLQNMQSQVPSIPFAG---------CLTQLYFYLYFADLESFLLVAMAYDRYVAICFPLHYMS---IMSPKLCVSLVVLSWVLTTFHAMLHTLLMARLS----FCADNMIPHFF---------------CDISPLLKLSCSDTHVNEL------VIFVMGGLVIVIPFVLIIVSYARVVASILKVPSV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGIHKIFSTCGSHLSVVSLFYGTIIGLYLCPSANNSTVK----------------ETVMAMMYTVVTPMLNPFIYSLRNRDMKEALIRVLCKKKITFCL
TRFR_MOUSE --------------------------------------------------------------------------------------------MENDTVSEMNQTELQPQAAVALEYQVVTILLVVIICGLGIVGNIMVVLVVMRT-KHMRTPTN--------CYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYV-----GCL--CITYLQ--YLGINASSCSITAFTIERYIAICHPIKAQF---LCTFSRAKKIIIFVWAFTSIYCML-WFFLLDLNIST-YKNAVVVS------------------CGYKISRNYYSP-------------IYLMDFGVFYVVPMILATVLYGFIARILFLNPIP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDPKENSKMWKNDSIHQNKNLNLNATNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENW----------FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKESDRFSTELEDITVTDTYVSTTKVSFDDTCLASEN
FMLR_HUMAN -------------------------------------------------------------------------------------------METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAG---FRMTHTVTT-------ISYLNLAVADFCFTS-TLPFFMV-RKAMGGHWPF------GWFL-CKFLFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQN---HRTVSLAKKVIIGPWVMALLLTLP-VIIRVTT------VPGKTGTVA----------------CTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGM-YKEIGI---AVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVALQAK
ET1R_RAT -------------------------------------MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFDFLGTTLRPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQN-KCMRNGPN--------ALIASLALGDLIYVVIDLPINVF-KLLA-GRWPFDHNDF-GVFL-CKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQG---IGIPLITAIEIVSIWILSFILAIP-EAIGFVMVPFE-YKGEQHRT------------------CMLNATTKFMEFYQDV---------KDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLL-MDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
GCRT_RAT -------------------------------------------------------------------------------------------------------MKANNTTTSALWLQITYITMEAAIGLCAVVGNMLVIWVVKLN-RTLRTTTF--------YFIVSLALADIAVGVLVIPLAIA-SAW--RSRCT-------SMA-CLFMSCVLLVFTHASIMSLLAIAVDRYLRVKLTVRYRT---VTTQRRIWLFLGLCWLVSFLVGLT-PMFG-WNRKVTLELSQNSSTLS----------------CHFRSVVGLD--------------YMVFFSFITWILIPLVVMCIIYLDIFYIIRNKLSQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLTGFRETRAFYGREFKTAKSLFLVLFLFALCWLPLSIINFVSYFNVK--IPEI----------AMCLGILLSHANSMMNPIVYACKIKKFKETYFVILRACRLCQTSDSLDSNLEQTTE
OLF3_RAT ---------------------------------------------------------------------------------------------MDSSNRTRVSEFLLLGFVENKDLQPLIYGLFLSMYLVTVIGNISIIVAIISD-PCLHTP--------MYFFLSNLSFVDICFISTTVPKMLVNIQTQNNVITYAG---------CITQIYFFLLFVELDNFLLTIMAYDRYVAICHPMHYTV---IMNYKLCGFLVLVSWIVSVLHALFQSLMMLALP----FCTHLEIPHYF---------------CEPNQVIQLTCSDAFLNDL------VIYFTLVLLATVPLAGIFYSYFKIVSSICAISSV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HGKYKAFSTCASHLSVVSLFYCTGLGVYLSSAANNSSQA----------------SATASVMYTVVTPMVNPFIYSLRNKDVKSVLKKTLCEEVIRSPPSLLHFFLVLCHLPCFIFCY
DBDR_RAT -------------------------------------------------------------------------------MLPPGRNRTAQPARLGLQRQLAQVDAPAGSATPLGPAQVVTAGLLTLLIVWTLLGNVLVCAAIVRS-RHLRAKMTN-------IFIVSLAVSDLFVALLVMPWKAV-AEVA-GYWPF------GTF--CDIWVAFDIMCSTASILNLCIISVDRYWAISRPFRYER---KMTQRVALVMVGLAWTLSILISFI-PVQLNWHRDKAGSQGQEGLLSNGTPWEEGWELEGRTENCDSSLNRT-----------------YAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISSLERAAEHAQSCRSRGA-------YEPDPSLRASIKKETKVFKTLSMIMGVFVCCWLPFFILNCMVPFCSSGDAEGPKTGFPCVSETTFDIFVWFGWANSSLNPIIYA-FNADFRKVFAQLLGCSHFCFRTPVQTVNISNELISYNQDTVFHKEIATAYVHMIPNAVSSGDREVGEEEEEGPFDHMSQISPTTPDGDLAAESVWELDCEEEVSLGKISPLTPNCFDKTA