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                       |---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|------
 MC4R_HUMAN            --------------------------------MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIIITLLNSTDTDAQ-SFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGT-GAI-RQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY  
 S45708                -------------------------------------MPALGSQRRLLGSLNCTPPATLPFTLAPNRTGPQCLE-VSSLDGLFLSLGLVSLVENVLVVAAIAKNRNLHSPMYYFICCLAVSDLLVSVSNVLETAVMPLLEAGVLATQAAVVQQLDNVIDVLICGSMVSSLCFLGAIAVDRYISIFYALRYHSVVTLPRAWRIIAAIWVASILTSLLFITYYNHKVILLCLVGLFIAMLALMAVLYVHMLARACQHARGIARL-QKRQRPIHQGFGLKGAATLTILLGVFFLCWGPFFLHLSLIVLCPQHPTCGCIFKNFNLFLALIICNAIVDPLIYAFRSQELRKTLQEVLQCSW  
 JC4046                -------------------------------------------------MKHIINSYEHTNDTARNNS--DCPD-VVLPEEIFFTISVIGILENLIVLLAVIKNKNVQSPMYFFICSLAISDMLGSLYKILENILIMFRNMGYLKPRGSFESTADDIIDCMFILSLLGSIFSLSVIAADRYITIFHALQYHSIVTMRRTIITLTIIWMFCTGSGITMVIFSHHIPTVLTFTSLFPLMLVFILCLYIHMFLLA---------RSHARKISTLPRTNMKGAMTLTILLGVFIFCWAPFVLHVLLMTFCPNNPYCVCYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKRMLFCNRY  
 MC5R_HUMAN            ---------------------------------------MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCED-MGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSA--RQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD  
 MSHR_HUMAN            -------------------------------------MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLE-VSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGTNVLETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRAPRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARL-HKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW  
 CHKM1R                ---------------------------------------MSMLAPLRLVREPWNASEGNQSNATAGAGGAWCQG-LDIPNELFLTLGLVSLVENLLVVAAILKNRNLHSPTYYFICCLAVSDMLVSVSNLAKTLFMLLMEHGVLVIRASIVRHMDNVIDMLICSSVVSSLSFLGVIAVDRYITIFYALRYHSIMTLQRAVVTMASVWLASTVSSTVLITYYRNNAILLCLIGFFLFMLVLMLVLYIHMFALACHHVRSISS--QQKQPTIYRTSSLKGAVTLTILLGVFFICWGPFFFHLILIVTCPTNPFCTCFFSYFNLFLILIICNSVVDPLIYAFRSQELRRTLREVVLCSW  
 ACTR_HUMAN            -------------------------------------------------MKHIINSYENINNTARNNS--DCPR-VVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTSLFPLMLVFILCLYVHMFLLA---------RSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW  
 VVMESTHOR             -----------------------------------------------------TSPTTPHFKLAANQTGPRCLE-VSIPDGLFLSLGLVSVVENVLVVAAIAKNRNLHSPMYYFIGCLAVSDLLVSVTNVLETAVMLLVEAGALAAQAAVVQQLDDIIDVLICGSMVSSLCFLGAIAVDRYLSIFYALRYHSIVTLPRAWRAISAIWVASVLSSTLFIAYYNHTAVLLCLVSFFVAMLVLMAVLYVHMLARARQHARGIARL-RKRQHSVHQGFGLKGAATLTILLGIFFLCWGPFFLHLSLMVLCPQHPICGCVFQNFNLFLTLIICNSII  
 MC5R_SHEEP            ---------------------------------------MNSSFHLHFLDLGLNATEGNLSGLSVRNASSPCED-MGIAVEVFLALGLISLLENILVIGAIVRNRNLHIPMYFFVGSLAVADMLVSLSNFWETITIYLLTNKHLVMADASVRHLDNVFDSMICISVVASMCSLLAIAVDRYVTIFCRLRYQRIMTGRRSGAIIAGIWAFCTSCGTVFIVYYESTYVVVCLIAMFLTMLLLMASLYTHMFLLARTHVRRIAALPGHSSV--RQRTGVKGAITLAMLLGVFIICWAPFFLHLILMISCPQNLYCSCFMSHFNMYLILIMCNSVIDPLIYAFRSQEMRKTFKEIVCFQGFRTPCRFPSTY  
 ACTR_BOVIN            -------------------------------------------------MKHILNLYENINSTARNNS--DCPA-VILPEEIFFTVSIVGVLENLMVLLAVAKNKSLQSPMYFFICSLAISDMLGSLYKILENVLIMFKNMGYLEPRGSFESTADDVVDSLFILSLLGSICSLSVIAADRYITIFHALQYHRIMTPHRALVILTVLWAGCTGSGITIVTFSHHVPTVIAFTALFPLMLAFILCLYVHMFLLA---------RSHTRRTPSLPKANMRGAVTLTVLLGVFIFCWAPFVLHVLLMTFCPADPYCACYMSLFQVNGVLIMCNAIIDPFIYAFRSPELRVAFKKMVICNCYQ  
 MC3R_RAT              -------------------------------------MNSSCCPSSSYPTLPNLSQHPAAPSASNRSGSGFC-EQVFIKPEVFLALGIVSLMENILVILAVVRNGNLHSPMYFFLLSLLQADMLVSLSNSLETIMIVVINSDSLTLEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALSLIVAIWVCCGICGVMFIVYSESKMVIVCLITMFFAMVLLMGTLYIHMFLFARLHVQRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFKEILCGCNGMNVG  
 BTU39469              -------------------------------------------------------TATLHFSLAANQTGPQCLE-VSISDGLFLSLGLVSLVENVLVVAAIAKNRNLHSPMYYFICCLAVSDLLVSVSNVLETAVMLLLEAGVLVTQAAVVQQLDNVIDVLICRSMVSSLCFLGAIAVDRYISIFYALRYHSVVTLPRAWRIIAAIWVASILTSLLFITYYNHKVILLCLVGLFIAMLALMAVLYVHMLARACQHARGIARL-QKRQRPIHQGFGLKGAATLTILLGVFFLCWGPFFLQL  
 A46647                -------------------------------------MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLE-VSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGTNVLETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARQAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARL-HKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLH-TLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW  
 MC3R_HUMAN            MSIQKKYLEGDFVFPVSSSSFLRTLLEPQLGSALLTAMNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFC-EQVFIKPEIFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG