| NRIONCHANNEL: | Neurotransmitter-gated ion channel family signature |
| Seed alignment containing 27 sequences: |
1 11 21 31 41 51 61 71 81 91 101 111 121 131 141 151 161 171 181 191 201 211 221 231 241 251 261 271 281 291 301 311 321 331 341 351 361 371 381 391 401 411 421 431 441 451 461 471 481 491 501 511 521 531 541 551 561 571 581 591 601 611 621
|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------
GAC2_BOVIN MSSPNIWSTGSSVYSTPVFSQKMTLWILLLLSLYPGLTRQKSDDDYEDYASNKTWVLTPKVPEG----------DVTVILNNLLEGYDNKLRPDIGVKP-TLIHTDMYVNSIGPVNAINMEYTIDIFFGQTWYDRRLKFNSTIKVLR--LNS-NMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQW---KRSSVEVSDTRSWRLY---------QFSFVGLRNTTEVVKT-TS--GDYVVMTVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWIN----KDAVPARTSLGITTVLTMTTLSTIARK---SLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSN----RKPSKDKDKKKKN-------PLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTG------------------------------------------------------------------------------AWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL
ACHA_BOVIN ----------------------------------------------------MEPRPLLLLLGLCSAGLVLGSEHETRLVAKLFEDYNSVVRPVEDHRQAVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGG--VKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLDY--TGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVVINP----------ESDQPDLSN----FMESGEWVIKESRGWKHWVFYACCPSTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDS-GEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPEW-VRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPP----------------------------------------------------------------------------MGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAEEWKYVAMVMDHILLAVFMLVCIIGTLAVFAGRLIELNQQG
GAB1_HUMAN ---------MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMP------------------------------YVKETVDRLLKGYDIRLRPDFGGPP-VDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLT--LDN-RVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIE---LP---------QFSIVDYKMVSKKVEF-TT--GAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWIN----YDASAARVALGITTVLTMTTISTHLRE---TLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNE----TSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYG--RALDRHGVPSKGRIRRRASQLKVK------------------------------------------------------IPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH
ACHO_CARAU -------------------------------------------MTLAVIGLFTLFTSIIAITPAREFVSLAEREDALLRE--LFQGYQRWVRPVQHANHSVKVRFGLKISQLVDVDEKNQLMTTNVWLWQEWLDYKLRWNPENYGG--ITSIRVPSESIWLPDIVLYENADGRFEGSLMTKAIVRY--NGMITWTPPASYKSACTMDVTFFPFDRQNCSMKFGSWTYDGNMVKLVLINQQVDRSD--------------FFDNGEWEILSATGVKGSRQDSH---LSYPYITYSFILKRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDE-GEKVSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTIFVINVHHRSSATYHPMSPWVRSLFLQRLPHLLCMRGNTDRYHYPELEPHSPDLKPRNKKGPPGPEGEGQALINLLEQATNSVRYISR---------------------------------------------------------------------------------HIKKEHFIREVVQDWKFVAQVLDRIFLWTFLTVSVLGTILIFTPALKMFLRTPPPPSP
GRA2_HUMAN -----------------------------MNRQLVNILTALFAFFLETNHFRTAFCKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPP-VNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDS--LDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLT----LP---------QFILKEEKELGYCTKHYNT--GKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWIN----MDAAPARVALGITTVLTMTTQSSGSRA---SLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRE--------------------------------------------------------------------------------------------------SRFNFSGYGMGHCLQVKDGTAVK----ATPANPLPQPPKDGDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK
GAA2_MOUSE -------------MKTKLSTCNVWSLLLVLLVWDPVRLVLANIQE---------------------DEAKNNITIFTRILDRLLDGYDNRLRPGLGDSI-TEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILR--LNN-LMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGS-RLN---------QYDLLGQSIGKETIKS-ST--GEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLN----RESVPARTVFGVTTVLTMTTLSISARN---SLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKGS-----VMIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAK----------------------------------------------------------------------------------------------KTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYLNREPVLGVSP
ACHB_TORCA ------------------------------------------------MENVRRMALGLVVMMALALSGVGASVMEDTLLSVLFETYNPKVRPAQTVGDKVTVRVGLTLTNLLILNEKIEEMTTNVFLNLAWTDYRLQWDPAAYEG--IKDLRIPSSDVWQPDIVLMNNNDGSFEITLHVNVLVQH--TGAVSWQPSAIYRSSCTIKVMYFPFDWQNCTMVFKSYTYDTSEVTLQHALDAKGEREVKEIVINKDA----FTENGQWSIEHKPSRKNWRSDD----PSYEDVTFYLIIQRKPLFYIVYTIIPCILISILAILVFYLPPDA-GEKMSLSISALLAVTVFLLLLADKVPETSLSVPIIIRYLMFIMILVAFSVILSVVVLNLHHRSPNTHTMPNW-IRQIFIETLPPFLWIQRPVTTPSPDSKPTIISRANDEYFIRKPAGDFVCPVDNARVAVQPERLFSEMKWHLNGLTQPVTL-----------------------------------------------------PQDLKEAVEAIKYIAEQLESASEFDDLKKDWQYVAMVADRLFLYVFFVICSIGTFSIFLDASHNVPPDNPFA
GAA1_BOVIN ------------MKKSPGLSDYLWAWTLFLSTLTGRSYGQPSLQ----------------------DELKDNTTVFTRILDRLLDGYDNRLRPGLGERV-TEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLR--LNN-LMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGS-RLN---------QYDLLGQTVDSGIVQS-ST--GEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLN----RESVPARTVFGVTTVLTMTTLSISARN---SLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKD----PLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPK---------------------------------------------------------------------------------------------KTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
GRA3_RAT ------------------------------MAHVRHFRTLLSGFYFWEAALLLSLVATKETNSARSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPP-VNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDS--LDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLT----LP---------QFLLKEEKDLRYCTKHYNT--GKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWIN----MDAAPARVALGITTVLTMTTQSSGSRA---SLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRKNKTEAFALEKF-------------------------------------------------------------------------------------------YRFSDTDDEVRESRLSFTAYGMGPCLQAKDGVVPKGPNHAVQVMPKSADEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKILRHEDIHHQQD
ACH1_DROME ---------------------------------------------------MGSVLFAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNPDDYGG--VDTLHVPSEHIWHPDIVLYNNADGNYEVTIMTKAILHH--TGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRH-LKQTADSDNIEVGIDLQD----YYISVEWDIMRVPAVRNEKFYSCCE-EPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDS-GEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPW-VQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQAPSLHDQSQPIDILYSKIAKKKFELLKMGSENTL
GRA1_RAT -------------------------------------MGKSPGLLDYLWAWTLFEFPSKEADAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPP-VNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDS--LDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLT----LP---------QFILKEEKDLRYCTKHYNT--GKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWIN----MDAAPARVGLGITTVLTMTTQSSGSRA---SLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKDDEGGEGR---------------------------------------------------------------------------------------------------FNFSAYGMGPACLQAKDGISVKGANNNNTTNPAPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNK
GAC4_CHICK -----------------MPAMVLLLCLALGPALRSARCESTEEYDYDYLSINKTWVLTPKAQET----------DATQILNSLLKNYDNKLRPDIGIKP-TFIDVDIYVNSIGPVSVIQMEYTIDIFFAQTWYDRRLRFNSTLKALT--LNT-NMVSRIWIPDTFFRNSKRADSHWITTPNQLLRIWNDGKVLYTLRLTIEAECLLQLQNFPMDTHSCPLVFSSYGYPREEIVYRW---RRYSIEVSDQRTWRLY---------QFDFTGLRNTSEVLRT-GA--GEYMVMTVSFDLSRRMGYFAIQTYIPCILTVVLSWVSFWIK----RDSTPARTSLGITTVLTMTTLSTISRK---HLPRVSYITAMDLFVSVCFIFVFAALMEYATLNYLVGNKKPLEHSSRKARLPPAGAQVMPSFTAINININNIMHWPPEI------------EEDEDDDPGSPCLEGKECERFFCCIEDCQTG------------------------------------------------------------------------------MWREGRVRIHISRLDSYSRVFFPTAFLLFNIVYWIAYLYL
ACHP_RAT ------------------------------------------------MRGTPLLLVSLFSLLQDGDCRLANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIRLELSLSQLISVNEREQIMTTSIWLKQEWTDYRLAWNSSCYEG--VNILRIPAKRVWLPDIVLYNNADGTYEVSVYTNVIVRS--NGSIQWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDMVLKSPTAIMDD--------------FTPSGEWDIVALPGRRTVNPQD----PSYVDVTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPSDC-GEKMTLCISVLLALTFFLLLISKIVPPTSLDIPLIGKYLLFTMVLVTFSIVTTVCVLNVHHRSPSTHTMASW-VKECFLHKLPTFLFMKRPGLEVSLVRVPHPSQLHLATADTAATSALGPTSPSNLYGSSMYFVNPVPAAPKSAVSSHTAGLPRDARLRSSG-----------------------------------------RFREDLQEALEGVSFIAQHLESDDRDQSVIEDWKFVAMVVDRLFLWVFVFVCILGTMGLFLPPLFQIHAPSKDS
ACHG_MOUSE ------------------------------------------------MQGGQRPHLLLLLLAVCLGAQSRNQEERLLAD--LMRNYDPHLRPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWCDYRLRWDPKDYEG--LWILRVPSTMVWRPDIVLENNVDGVFEVALYCNVLVSP--DGCIYWLPPAIFRSSCSISVTYFPFDWQNCSLIFQSQTYSTSEINLQLSQEDGQAIEWIFIDPEA------FTENGEWAIRHRPAKMLLDSVAPAEEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIYFLPAKAGGQKCTVATNVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLMVVTILIVVNSVVVLNVSLRSPHTHSMARG-VRKLFLRLLPQLLRMHVRPLAPAAVQDARFRLQNGSSSGWPIMAREEGDLCLPRSELLFRQRQRNGLVQAVLEKLENGPEVRQSQEFCGSLKQASPAIQACVDACNLMAR---------------------------------------ARRQQSHFDSGNEEWLLVGRVLDRVCFLAMLSLFICGTAGIFLMAHYNQVPDLPFPGDPRPYLPLPD
GAA6_RAT -----------MLLLLPWLFSLLWIENAQAQLEDEGNFYSENVS---------------------------------RILDNLLEGYDNRLRPGFGGAV-TEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFKGPAEILS--LNN-LMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRLMHNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESS-SLL---------QYDLIGQTVSSETIKS-NT--GEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWIN----KESVPARTVFGITTVLTMTTLSISARH---SLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNL---QSQKAERQAQTAAKP-----PVAKSKTTESLEAEIVVHSDSKYHLKKRISSLTLPIVPSSEASKVLSRTPILPSTP---------------------------------------------------------------------------------VTPPLLLPAIGGTSKIDQYSRILFPVAFAGFNLVYWIVYLSKDTMEVSSTVE
GAA3_HUMAN ---------MIITQTSHCYMTSLGILFLINILPGTTGQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAV-TEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILP--LNN-LLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGS-RLN---------QYDLLGHVVGTEIIRS-ST--GEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLN----RESVPARTVFGVTTVLTMTTLSISARN---SLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWEGKK-VPEALEMKKKTPAAPAKKTSTTFNIVGTTYPINLAKDTEFSTISKGAA-PSASSTPTIIASPKATYVQDSPTET------------------------------------------------------------------------------------KTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRESAIKGMIRKQ
GAB3_CHICK ---------MWGFGGGRIFGIFSAPVLVAVVCCAQSVNDPGNMS------------------------------FVKETVDKLLKGYDIRLRPDFGGPP-VCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYAGIPLNLT--LDN-RVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDNAVTGVERIE---LP---------QFSIVEYRLVSKNVVF-AT--GAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWIN----YDASAARVALGITTVLTMTTINTHLRE---TLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGKGPQRQKKLAEKSAKANNDRSRFEGSRVDTHGNILLTSLEIHNE----VASNEVTTSVTDARNSTISFDNSGIQYRKQSSHRESLGRRSSDRTGSHSKRGHLRRRSSQLKIK------------------------------------------------------IPDLTDVNAIDRWSRMVFPFTFSLFNLIYWLYYVN
GAC3_MOUSE -------------------MAAKLLLLLCLFSGLHARSRRVEEDENEDSPSNQKWVLAPKPQDT----------DATLILNKLLREYDKKLRPDIGIKP-TVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTMKTLT--LNS-NMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDAHACPLTFSSYGYPKEEMIYRW---RKNSVEAADQKSWRLY---------QFDFMGLRNTTEIVTT-SA--GDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIK----KDATPARTTLGITTVLTMTTLSTIARK---SLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTIRKKKTSLLHPDSTRWIPDRISLQAPSNYSLLDMRPPPPVMITLNNSMYWQEFEDTCVYECLDGKDCQSFFCCYEECKSG------------------------------------------------------------------------------SWRRGRIHIDVSELDSYSRVFFPTSFLLFNLVYWVGYLYL
ACH3_HUMAN --------------------------------------------MALAVSLPLACRARLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSGYGG--AEFMRVPAQKIWKPDIVLYNNAVGDFQVTTKTKALLKY--TGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVL----------IGSSMNLKD----YWESGEWAIIKAPGYKHDIKYNCCE-EIYPDITYSLYSRRLPLFYTINLIIPCLLISFLTVLVFYLPSDC-GEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSW-VKTVFLNLLPRVMFMTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVD-------------------------------------AVVSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA
GAD_MOUSE -----------------MDVLGWLLLPLLLLCTQPHHGARAMNDIGDYVGSNLEISWLP-------------------NLDGLMEGYARNFRPGIGGAP-VNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHTNETLG--LDS-RFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPLDEQECMLDLESYGYSSEDIVYYW---SENQEQIHGLDRLQLA---------QFTITSYRFTTELMNFKSA--GQFPRLSLHFQLRRNRGVYIIQSYMPSVLLVAMSWVSFWIS----QAAVPARVSLGITTVLTMTTLMVSARS---SLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKRKAKVKVT-------KPRAEMDVRNAIVLFSLSAAGVSQELAISRRQGRVPGNLMGSYRSVEVEAKKEGGSRPGGPGGI----------------------------------------------------------------------------------RSRLKPIDADTIDIYARAVFPAAFAAVNIIYWAAYTM
GAR2_HUMAN ---------------YFTRLILFLFCLMVLVESRKPKRKRWTGQVEMPKPSHLYKKNLDVTKIRKGKP--------QQLLRVDEHDFSMRPAFGGPAIP---VGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSSASNKSMTF--DGRLVKKIWVPDVFFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFSHFPLDSQTCSLELESYAYTDEDLMLHW---KNGDESLKTDEKISLS---------QFLIQKFHTTSRLAFYSST--GWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWID----RRAVPARVSLGITTVLTMTTIITGVNA---SMPRVSYVKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKERKLREK---FPCMCGMLHSKTMMLDGSYSESEANSLAGYPRSHILTEEERQDKIVVHLGLSGEANAARKKGLLKGQT-----------------------------------------------------------------------------------GFRIFQNTHAIDKYSRLIFPASYIFFNLIYWSVFS
GAB2_RAT ---------MWRVRKRGYFGIWSFPLIIAAVCA-QSVNDPSNMS------------------------------LVKETVDRLLKGYDIRLRPDFGGPP-VAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLT--LDN-RVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIE---LP---------QFSIVDYKLITKKVVF-ST--GSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWIN----YDASAARVALGITTVLTMTTINTHLRE---TLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAANANNEKMRLDVNKMDPHENILLSTLEIKNE----MATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFG-RNALERHVAQKKSRLRRRASQLKIT------------------------------------------------------IPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN
GAA5_RAT ---------MDNGMLSRFIMTKTLLVFCISMTLSSHFGFSQMPTSSVQ------------------DETNDNITIFTRILDGLLDGYDNRLRPGLGERI-TQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLP--LNN-LLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGS-RLN---------QYHLMGQTVGTENIST-ST--GEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLN----RESVPARTVFGVTTVLTMTTLSISARN---SLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAAKIKKKERELILN-KSTNAFTTGKLTHPPNIPKEQLPGGTGNAVGTASIRASEEKTSESK-----------------------------------------------------------------------------------------------KTYNSISKIDKMSRIVFPILFGTFNLVYWATYLNREPVIKGATSPK
ACHD_CHICK ----------------------------------------------------MAVLLALFGALVLSGGLCVNQEERLIHHLFEERGYNKEVRPVASADEVVDVYLALTLSNLISLKEVDETLTTNVWVEQSWTDYRLQWNTSEFGG--VDVLRLLPEMLWLPEIVLENNNDGLFEVAYYCNVLVYN--TGYVYWLPPAIFRSACPINVNFFPFDWQNCTLKFSSLAYNAQEINMHLKEESDPETEKNYRVEWIIIDPEGFTENGEWEIIHRPARKNIHPSYPTESSEHQDITFYLIIKRKPLFYVINIVTPCVLIAFMAILVFYLPADS-GEKMTLVISVLLAQSVFLLLVSQRLPATSHAIPLIGKYLLFIMLLVTAVVVICVVVLNFHFRTPSTHVMSDW-VRGVFLEILPRLLHMSHPAESPAGAPCIRRCSSAGYIAKAEEYYSVKSRSELMFEKQSERHGLASRVTPA---------------------------------------------------RFAPAATSEEQLYDHLKPTLDEANFIVKHMREKNSYNEEKDNWNRVARTLDRLCLFLITPMLVVGTLWIFLMGIYNHPPPLPFSGDPFDYREENKRYI
GRB_RAT --------------------MKFSLAVSFFILMSLLFEDACSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPPNSTSNILNRLLVSYDPRIRPNFKGIP-VDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQL-EKIA----LP---------QFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWIN----PDASAARVPLGIFSVLSLASECTTLAA---ELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNAAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKPQAKN------------------------------------------------------------KKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL
GAB4_CHICK ---------MWTFQADRLSGIVSALAALCVACCAQS-PSTGNIS------------------------------VVKEIVDKLLKGYDVRLRPDFGGNP-VTVGMSIHISSIDQISEVNMDYTITMYFQQSWRDKRLAYNDLPLNLT--LDN-RVADQLWLPDTYFLNDKKSFLHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDQQNCTLEIESYGYTVDDIVFFW---QGNDSAVTGMEVLELP---------QFTIIEQRLVSREVVF-TT--GSYLRLSLSFRIKRNIGYFILQTYMPSILITILSWVSFWIN----YDASAARVALGVTTVLTMTTINTHLRE---TLPKIPYVKAIDVYLMGCFVFVFLALLEYAFVNYIFFGRGPRQQKKQSERISKANNERHRYEEKRVREQVDPYGNILLSTLDMNNELLATDMMSSVGDSRNSVMSFEGSGIQFRKPLASRDGFGHHPTLDRHVPLTHHAAARNRANCRLR---------------------------------------------RRSSKLKLKIPDLTDVSTIDKWSRIIFPITFGFFNLVYWLYYVN
GAA6_MOUSE -----------MVLLLPWLFIILWLENAQAQLEDEGNFYSENVS---------------------------------RILDNLLEGYDNRLRPGFGGAV-TEVKTDIYVTSFGPVSDVEM----------TWTDERLKFKGPAEILS--LNN-LMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRLMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKTEIIYTWKKGPLYSVEVPEESS-SLL---------QYDLIGQTVSSETIKS-NT--GEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWIN----KESVPARTVFGITTVLTMTTLSISARH---SLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNL---QSQKAERQAQTAATP-----PVAKSKASESLEAEIVVHSDSKYHLKKRISSLTLPIVPSSEASKALSRTPILKSTP---------------------------------------------------------------------------------VSPPLLLPATGGTSKIDQYSRILFPVAFAGFNLVYWIVYLSKDTMEVSSTVE