PAPAIN: Papain cysteine protease (C1) family signature
Seed alignment containing 21 sequences:

                       1         11        21        31        41        51        61        71        81        91        101       111       121       131       141       151       161       171       181       191       201       211       221       231       241       251       261       271       281       291       301       311       321       331       341       351       361       371       381       391       401       411       421       431       441       451       461       471       481       491       501       511       521       531       541       551       561       571       581       591       601       611       621       631       641       651       661       671       681       691       701       711       721       731       741       751       761       771       781       791       801       811       821       831       841       851       861       871       881       891       901       911       921       931       941       951       961       971       981       991       1001      1011      1021      1031      1041  
                       |---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|-----
 ACP2_ENTHI            -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAGIRIASAIDFNTWASKNNKHFTAIEKLRRRAIFNMNAKFVDSFNKIGSFKLSVDGPFAAMTNEEYRTLLKSKRTTEENGQVKYLNIQAPESVDWRKEGK-VTP-LRDQAQCGSCYTFGSLAALEGRLLIEKGGDANTLDLSEEHM-QCTRDNGNNGCNGGLGSNVYDYIIEH--GVAKESDYPYTGSDSTCKTNVKSFRKITGYTKVPRNNEAELK-----AALSQGLLDVSIDVSSAK------------------------------FQLYKSGAYTDTKCKNNYFALN-------HEVCAVGYGVVDGKE------------------CWIVRNSWGTSWGDKGYINMVIEG----NTCGVATDPLYPTGVQYL  
PGU33424 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGVGNIESMYAYKNKK-MISLSEQEVIDCSKKCFGCDGCHPFYAFLYALEN------------------------------------------------KICFEEQYEYKIMENIFCLNYRCTNKVSLTSIGSVKENE-----LIEALNKVGPLSVCVGASDD-------------------------------FVFYHEGIFDGICTKEVN-----------HAVLLVGYGQVEKNKNLQKYKGSFSDEDDNFIYYWIIKNSWGSNWGENGFMRIIRNKNGDNLF
CATH_HUMAN -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MWATLPLLCAGAWLLGVPVCGAAELSVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFASNWRKINAHNNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSVDWRKKGNFVSP-VKNQGACGSCWTFSTTGALESAIAIATGKM---LSLAEQQLVDCAQDFNNYGCQGGLPSQAFEYILYN-KGIMGEDTYPYQGKDGY-CKFQPGKAIGFVKDVANITIYDEEAMVE--AVALYNPVSFAFEVTQD-------------------------------FMMYRTGIYSSTSCHKTPDKVN-------HAVLAVGYGEKNGIP------------------YWIVKNSWGPQWGMNGYFLIERGK----NMCGLAACASYPIPLV
UCU30877 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MHLCSALFVLATLGHVYCLSEKGGCYNRKFDEGIKPVRTQSRLWESNKLVYLPTSWDWRNMNGTNYASTTRNQHIPQYCGSCWAMGSTSALADRINIKRKAAWPSAYLSVQNVIDCGNA---GSCEGGGNLGVYNYAHEK--GIPDETCNNYQAKDQECNTFNQCGTCEPGNKCNMINNYTTWKVGDFGSLAGRDAMMKEIMENGPISCGVMADAA---------------------FDAYTGGVFKEYHEQADIN----------HIISVAGWGVENGVE------------------FWIGRNSWGQPWGENGWFRMVTSKYKNGDGNKYNLGIENECAFGDPIVQ
CATB_MOUSE --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MWWSLILLSCLLALTSAHDKPSFHPLSDDLINYINKQNTTWQAGRNFYNVDISYLKKLCGTVLGGPKLPGRVAFGEDIDLPETFDAREQWSNCPTIGQ-IRDQGSCGSCWAFGAVEAISDRTCIHTNGRVN-VEVSAEDLLTCCGIQCGDGCNGGYPSGAWSFWTKK-GLVSGGVYNSHVGCLPYTIPPCEHHVNGSRPP-CTGEGD-TPRCNKSCEAGYSPS-YKEDKHFGYTSYSVSNSVKEIMAEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDMMGG----------HAIRILGWGVENGVP------------------YWLAANSWNLDWGDNGFFKILRGE----NHCGIESEIVAGIPRTDQYWGRF
CATB_BOVIN --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MWRLLATLSCLLVLTSARSSLYFPPLSDELVNFVNKQNTTWKAGHNFYNVDLSYVKKLCGAILGGPKLPQRDAFAADVVLPESFDAREQWPNCPTIKE-IRDQGSCGSCWAFGAVEAISDRICIHSNGRVN-VEVSAEDMLTCCGGECGDGCNGGFPSGAWNFWTKK-GLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPP-CTGEGD-TPKCNKTCEPGYSPS-YKEDKHFGCSSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEIMGG----------HAIRILGWGVENGTP------------------YWLVGNSWNTDWGDNGFFKILRGQ----DHCGIESEIVAGMPCTHQY
TAU32430 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLSSKSSLHVALILVVTLTDVLPLVSSSRGLVAVPTDGALEDSLLMMERFHGWMAKHGKSYAGVEEKLRRFDIFRRNVEFIEAANRDGRLSYTLGVNQFADLTHEEFLATHTSRRVVPSEEMVITTRAGVVVEGANCQPAPNAVPRSINWVNQSKVTPVKNQGKVCGACWAFSAVATIESAYAIAKRGEPP--VLSEQELIDCDTFDR--GCTSGEMYNAYFWVLRN-GGIANSSTYPYKETDGKCERGKLQEHAATIRDYKFVKHNCEEQLM---AAVAVRPVAVGFDSNDEC------------------------------FKFYQAGLYDGMCIKHGEYFGPCSSNDRIHSLAIVGYAGKGGDRVK----------------YWIAKNSWGEKWGKKGYVWLKKDVDEPEGLCGLAIQPVYPIV
PVU51723 MNPRVCFAWAMCALIGAEVGAKVAEEGLRTGLAPPQNAGSNHTGAKRLPLDRGSDRCVSPQFSSHIEADAPPRSADDAAGRGQPPQQVEHPPNRVTNVMAPPMSKQSAVEVRSALLKNHDGVKITGTCNAKVQLFLVPHISISVEAESNTIQLGRKLEDVTITKEFYRGVGGKSSPLLQFEEDADSLLNQCAEGKTFKFVVVIRGEELILKWKVYEKVPSPSDNNKVDVRKYLLKNLGRPITAIQVHSGKEESDVFLLESKAYLLRQDIPRTCERIASSCFLSGNVDIEGCYKCTLLSEDTKLGSPCFSYLPPEVKHNYEKVKMKAQDEGDLGEAQLEELIRRILHAVQRKGKSNPPRKGATEEDYPNDNLRELLLRYCQVMKKVDRSGTLEEHEVGNEMDVLANLEGLLRKHPKEEIPALREKLKNPAICMKDAAKWVEQKRGLALPLFEYKHLQRRVTTAVDSQESNSADKENIIKGEHIAAYRAVIDLSQRDQMNHSNLSGEMFCNEDYCDRWKDKSSCFSSIETEEQGNCNLSWLFTSKTHLETIRCMKGYDH---LGSSALYVASCSKRGKKSRCVSGSNPYEFLTIVEESGFLPPAVWLPYSYGDVGNGCPKREDHWHNLWEGVKLLEPADEPNSVSTKGYTSYESDDFRGDIQTFVNMVKSQVRSKGSVMAYIKVLDIL------SYDFNGKEVHTLCGDKRPD----------HAVNIIGYGNYVTPEGVKKS-------------YWLMRNSWGKYWGDGGNFKVDTHGPPGCQHNFIHTAAVFNLSMPMAEGPSKGEAHLYDYYLKSSPDFLGNIYHKISGRRSGAVEKGRTTGNQSLTVQGQEGWSDLLEGTTPSTTANPNPVGELKGAQDVPKRGNTGKRISEDPQEEVLNEELIPQLPLAPISQAAATLGEGQVEATPLPPLTVAASLPLRGDVLLERDGTNEGSKEAATVEVMHILKYIKNGKVKLGIATYRDDSDIAGDHSCSRSLAQNSEQLAECIQFCHDEWPNCRGEASPGYCLAQRRRTGDCFFCYV
PAPA_CARPA -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAMIPSISKLLFVAICLFVYMGLSFGDFSIVGYSQNDLTSTERLIQLFESWMLKHNKIYKNIDEKIYRFEIFKDNLKYIDETNKKNNSYWLGLNVFADMSNDEFKEKYTGSIAGNYTTTELSYEEVLNDGDVNIPEYVDWRQKGA-VTP-VKNQGSCGSCWAFSAVVTIEGIIKIRTGNL---NEYSEQELLDCDRRSY--GCNGGYPWSALQLVAQY--GIHYRNTYPYEGVQRYCRSREKGPYAAKTDGVRQVQPYNEGALL---YSIANQPVSVVLEAAGKD------------------------------FQLYRGGIFVGPCGNKVD-----------HAVAAVGYGPN----------------------YILIKNSWGTGWGENGYIRIKRGTGNSYGVCGLYTSSFYPVKN
ORYA_ORYSA ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRISMALAAAALLLLLSLAAADMSIVSYGERSEEEARRLYAEWKAEHGKSYNAVGEEERRYAAFRDNLRYIDEHNAAADAGVHSFRLGLNRFADLTNEEYRDTYLGLRNKPRRERKVSDRYLAADNEALPESVDWRTKGA-VAE-IKDQGGCGSCWAFSAIAAVEDINQIVTGDL---ISLSEQELVDCDTSYNE-GCNGGLMDYAFDFIINN-GGIDTEDDYPYKGKDERCDVNRKNAKVVTIDSYEDVTPNSETSLQ---KAVRNQPVSVAIEAGGRA------------------------------FQLYSSGIFTGKCGTALD-----------HGVAAVGYGTENGKD------------------YWIVRNSWGKSWGESGYVRMERNIKASSGKCGIAVEPSYPLKKGENPPNPGPTPPSPTPPPTVCDNYYTCPDSTTCCCIYEYGKYCYAWGCCPLEGATCCDDHYSCCPHEYPICNVQQGTCLMAKDSPLAVKALKRTLAKPNLSFLFGNGKKSSA
CYS1_HAECO -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKYLVLALCTYLCSQTGADENAAQGIPLEAQRLTGEPLVAYLRRSQNLFEVNSAPTPNFEQKIMDIKYKHQKLNLMVKEDPDPEVDIPPSYDPRDVWKNCTTFY--IRDQANCGSCWAVSTAAAISDRICIASKAEKQ-VNISATDIMTCCRPQCGDGCEGGWPIEAWKYFIYD-GVVSGGEYLTKDVCRPYPIHPCGHHGNDTYYGECRGTA-PTPPCKRKCRPGVRKM-YRIDKRYGKDAYIVKQSVKAIQSEILRNGPVVASFAVYEDFRHYKSGIYKHTAGELRGY----------HAVKMIGWGNENNTD------------------FWLIANSWHNDWGEKGYFRIIRGT----NDCGIEGTIAAGIVDTESL
LCPA_LEIME ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MARRNPLLFAIVVTILFVVCYGSALIAQTPPPVDNFVASAHYGSFKKRHGKAFGGDAEEGHRFNAFKQNMQTAYFLNTQNPHAHYDVSGKFADLTPQEFAKLYLNPDYYARHLKNHKEDVHVDDSAPSGVMSVDWRDKGA-VTP-VKNQGLCGSCWAFSAIGNIEGQWAASGHSL---VSLSEQMLVSCDNIDE--GCNGGLMDQAMNWIMQS-HNGSVFTEASYPYTSGGGTRPPCHDEGEVGAKITGFLSLPHDEERIAE--WVEKRGPVAVAVDATT------------------------------WQLYFGGVVSLCLAWSLN-----------HGVLIVGFNKNAKPP------------------YWIVKNSWGSSWGEKGYIRLAMGS----NQCMLKNYPVSATVESPHTPHVPTTTA
CYS2_HORVU >@1;FROM_PDBFrom XVISTAS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPEYVDWRQKGA-VTP-VKNQGSCGSCWAFSAVVTIEGIIKIRTGNL---NQYSEQELLDCDRRSY--GCNGGYPWSALQLVAQY--GIHYRNTYPYEGVQRYCRSREKGPYAAKTDGVRQVQPYNQGALL---YSIANQPVSVVLQAAGKD------------------------------FQLYRGGIFVGPCGNKVD-----------HAVAAVGYGPN----------------------YILIKNSWGTGWGENGYIRIKRGTGNSYGVCGLYTSSFYPVKN
PTCATHEL1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMLLGASLYLNNTQEVSDEIDTANLYANWKMKYNRRYTNQRDEMYRYKVFTDNLNYIRAFYESPEEATFTLELNQFADMSQQEFAQTYLSLKVPRTAKLNAANSNFQYKGAEVDWTDNKKVKYPAVKNQGSCGSCWAFSAVGALEINTDIELNRK---YELSEQDLVDCSGPYDNDGCNGGWMDSAFEYVADN--GLAEAKDYPYTAKDGTCKTSVKRPYTHVQGFKDIDSCDELAQ------TIQERTVAVAVDANP--------------------------------WQFYRSGVLSKCTKNLN------------HGVVLVGVQADG---------------------AWKIRNSWGSSWGEAGHIRLAGG-----DTCGICAAPSFPILG
PAP3_CARPA ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPENVDWRKKGA-VTP-VRHQGSCGSCWAFSAVATVEGINKIRTGKL---VELSEQELVDCERRSH--GCKGGYPPYALEYVAKN--GIHLRSKYPYKAKQGTCRAKQVGGPIVKTSGVGRVQPNNEGNLL---NAIAKQPVSVVVESKGRP------------------------------FQLYKGGIFEGPCGTKVD-----------HAVTAVGYGKSGGKG------------------YILIKNSWGTAWGEKGYIRIKRAPGNSPGVCGLYKSSYYPTKN
MMAL_DERFA ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKFVLAIASLLVLSTVYARPASIKTFEEFKKAFNKNYATVEEEEVARKNFLESLKYVEANKGAINHLSDLSLDEFKNRYLMSAEAFEQLKTQFDLNAETSACRINSVNVPSELDLRSLRT-VTP-IRMQGGCGSCWAFSGVAATESAYLAYRNTS---LDLSEQELVDCASQH---GCHGDTIPRGIEYIQQN--GVVEERSYPYVAREQRCRRPNSQHYGISNYCQIYPPDVKQIREALTQTHTAIAVIIGIKDLRA--------------------------------FQHYDGRTIIQHDNGYQPNY---------HAVNIVGYGSTQGDD------------------YWIVRNSWDTTWGDSGYGYFQA-------GNNLMMIEQYPYVVIM
CATL_CHICK ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APRSVDWREKGY-VTP-VKDQGQCGSCWAFSTTGALEGQHFRTKGKL---VSLSEQNLVDCSRPEGNQGCNGGLMDQAFQYVQDN-GGIDSEESYPYTAKDDEDCRYKAEYNAAND-TGFVDIPQGHERALMK-AVASVGPVSVAIDAGHSS------------------------------FQFYQSGIYYEPDCSS--EDLD-------HGVLVVGYGFEGGKK------------------YWIVKNSWGEKWGDKGYIYMAKDRK---NHCGIATAASYPLV
CPR6_CAEEL -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKTLLFLSCIVVAAYCACNDNLESVLDKYRNREIDSEAAELDGDDLIDYVNENQNLWTAKKQRRFSSVYGENDKAKWGLMGVNHVRLSVKGKQHLSKTKDLDLDIPESFDSRDNWPKCDSIKV-IRDQSSCGSCWAFGAVEAMSDRICIASHGELQ-VTLSADDLLSCCKS-CGFGCNGGDPLAAWRYWVKD-GIVTGSNYTANNGCKPYPFPPCEHHSKKTHFDPCPHDLYPTPKCEKKCVSDYTDKTYSEDKFFGASAYGVKDDVEAIQKELMTHGPLEIAFEVYEDFLNYDGGVYVHTGGKLGGG----------HAVKLIGWGIDDGIP------------------YWTVANSWNTDWGEDGFFRILRGV----DECGIESGVVGGIPKLNSLTSRLHRHHRRHVYDDNY
A57480 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MWTGYKFFIFFYLAKEIWTEKQFQKQVDLASYSSRNHSILEGTRFKRSIFQGQYCRSLGCCEGRNDNCVTQFYEANALCYCDKFCERENSDCCPDYKSFCQEEKEWLPHTQSWYPEGCIRDGLHYEEGSVIKENCNSCTCSGQHWKCSQHVCLVLPELIEHINKGDYGWTAQNYSQFWGMTLEEGFRFRLGTLPPSPVLLSMNEMRATLPETTDLPEFFIAFLQMAWMDSWAIGSKNCAASWAFSTASVAADRIAIQSNGRYTANLSPQNLISCCAKNRH--GCNSGSIDRAWWYLRKR--GLVSHACYPLFKDQNISNNTCAMTSKADGRGKRHATRPCPNNIEKSNRIYQCSPPYRVSSNETEIMKEIMQNGPVQAIMQVHED-----------FFHYKTGIYRHVISTNEESEKYRKLQT--HAVKLTGWGTLKGARGQKEK-------------FWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP
CPP1_ENTHI ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFTFILMFYIGYGIDFNTWVANNNKHFTAVESLRRRAIFNMNARIVAENNRKETFKLSVDGPFAAMTNEEYNSLLKLKRSGEEKGEVRYLNIQAPKAVDWRKKGK-VTP-IRDQGNCGSCYTFGSIAALEGRLLIEKGGDSETLDLSEEHMVQCTREDGNNGCNGGLGSNVYNYIMEN--GIAKESDYPYTGSDSTCRSDVKAFAKIKSYNRVARNNEVELK-----AAISQGLVDVSIDASSVQ------------------------------FQLYKSGAYTDTQCKNNYFALN-------HEVCAVGYGVVDGKE------------------CWIVRNSWGTGWGEKGYINMVIEG----NTCGVATDPLYPTGVEYL
CATV_NPVAC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNKILFYLFVYGVVNSAAYDLLKAPNYFEEFVHRFNKDYGSEVEKLRRFKIFQHNLNEIINKNQNDSAKYEINKFSDLSKDETIAKYTGLSLPIQTQNFCKVIVLDQPPGKGPLEFDWRRLNK-VTS-VKNQGMCGACWAFATLASLESQFAIKHNQL---INLSEQQMIDCDFVDA--GCNGGLLHTAFEAIIKM-GGVQLESDYPYEADNNNCRMNSNKFLVQVKDCYRYITVYEEKLKD---LLRLVGPIPMAIDAAD--------------------------------IVNYKQGIIKYCFNSGLN-----------HAVLLVGYGVENNIP------------------YWTFKNTWGTDWGEDGFFRVQQNI----NACGMRNELASTAVIY