| PAPAIN: | Papain cysteine protease (C1) family signature |
| Seed alignment containing 21 sequences: |
1 11 21 31 41 51 61 71 81 91 101 111 121 131 141 151 161 171 181 191 201 211 221 231 241 251 261 271 281 291 301 311 321 331 341 351 361 371 381 391 401 411 421 431 441 451 461 471 481 491 501 511 521 531 541 551 561 571 581 591 601 611 621 631 641 651 661 671 681 691 701 711 721 731 741 751 761 771 781 791 801 811 821 831 841 851 861 871 881 891 901 911 921 931 941 951 961 971 981 991 1001 1011 1021 1031 1041
|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|---------|-----
ACP2_ENTHI -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAGIRIASAIDFNTWASKNNKHFTAIEKLRRRAIFNMNAKFVDSFNKIGSFKLSVDGPFAAMTNEEYRTLLKSKRTTEENGQVKYLNIQAPESVDWRKEGK-VTP-LRDQAQCGSCYTFGSLAALEGRLLIEKGGDANTLDLSEEHM-QCTRDNGNNGCNGGLGSNVYDYIIEH--GVAKESDYPYTGSDSTCKTNVKSFRKITGYTKVPRNNEAELK-----AALSQGLLDVSIDVSSAK------------------------------FQLYKSGAYTDTKCKNNYFALN-------HEVCAVGYGVVDGKE------------------CWIVRNSWGTSWGDKGYINMVIEG----NTCGVATDPLYPTGVQYL
PGU33424 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGVGNIESMYAYKNKK-MISLSEQEVIDCSKKCFGCDGCHPFYAFLYALEN------------------------------------------------KICFEEQYEYKIMENIFCLNYRCTNKVSLTSIGSVKENE-----LIEALNKVGPLSVCVGASDD-------------------------------FVFYHEGIFDGICTKEVN-----------HAVLLVGYGQVEKNKNLQKYKGSFSDEDDNFIYYWIIKNSWGSNWGENGFMRIIRNKNGDNLF
CATH_HUMAN -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MWATLPLLCAGAWLLGVPVCGAAELSVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFASNWRKINAHNNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSVDWRKKGNFVSP-VKNQGACGSCWTFSTTGALESAIAIATGKM---LSLAEQQLVDCAQDFNNYGCQGGLPSQAFEYILYN-KGIMGEDTYPYQGKDGY-CKFQPGKAIGFVKDVANITIYDEEAMVE--AVALYNPVSFAFEVTQD-------------------------------FMMYRTGIYSSTSCHKTPDKVN-------HAVLAVGYGEKNGIP------------------YWIVKNSWGPQWGMNGYFLIERGK----NMCGLAACASYPIPLV
UCU30877 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MHLCSALFVLATLGHVYCLSEKGGCYNRKFDEGIKPVRTQSRLWESNKLVYLPTSWDWRNMNGTNYASTTRNQHIPQYCGSCWAMGSTSALADRINIKRKAAWPSAYLSVQNVIDCGNA---GSCEGGGNLGVYNYAHEK--GIPDETCNNYQAKDQECNTFNQCGTCEPGNKCNMINNYTTWKVGDFGSLAGRDAMMKEIMENGPISCGVMADAA---------------------FDAYTGGVFKEYHEQADIN----------HIISVAGWGVENGVE------------------FWIGRNSWGQPWGENGWFRMVTSKYKNGDGNKYNLGIENECAFGDPIVQ
CATB_MOUSE --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MWWSLILLSCLLALTSAHDKPSFHPLSDDLINYINKQNTTWQAGRNFYNVDISYLKKLCGTVLGGPKLPGRVAFGEDIDLPETFDAREQWSNCPTIGQ-IRDQGSCGSCWAFGAVEAISDRTCIHTNGRVN-VEVSAEDLLTCCGIQCGDGCNGGYPSGAWSFWTKK-GLVSGGVYNSHVGCLPYTIPPCEHHVNGSRPP-CTGEGD-TPRCNKSCEAGYSPS-YKEDKHFGYTSYSVSNSVKEIMAEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDMMGG----------HAIRILGWGVENGVP------------------YWLAANSWNLDWGDNGFFKILRGE----NHCGIESEIVAGIPRTDQYWGRF
CATB_BOVIN --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MWRLLATLSCLLVLTSARSSLYFPPLSDELVNFVNKQNTTWKAGHNFYNVDLSYVKKLCGAILGGPKLPQRDAFAADVVLPESFDAREQWPNCPTIKE-IRDQGSCGSCWAFGAVEAISDRICIHSNGRVN-VEVSAEDMLTCCGGECGDGCNGGFPSGAWNFWTKK-GLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPP-CTGEGD-TPKCNKTCEPGYSPS-YKEDKHFGCSSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEIMGG----------HAIRILGWGVENGTP------------------YWLVGNSWNTDWGDNGFFKILRGQ----DHCGIESEIVAGMPCTHQY
TAU32430 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLSSKSSLHVALILVVTLTDVLPLVSSSRGLVAVPTDGALEDSLLMMERFHGWMAKHGKSYAGVEEKLRRFDIFRRNVEFIEAANRDGRLSYTLGVNQFADLTHEEFLATHTSRRVVPSEEMVITTRAGVVVEGANCQPAPNAVPRSINWVNQSKVTPVKNQGKVCGACWAFSAVATIESAYAIAKRGEPP--VLSEQELIDCDTFDR--GCTSGEMYNAYFWVLRN-GGIANSSTYPYKETDGKCERGKLQEHAATIRDYKFVKHNCEEQLM---AAVAVRPVAVGFDSNDEC------------------------------FKFYQAGLYDGMCIKHGEYFGPCSSNDRIHSLAIVGYAGKGGDRVK----------------YWIAKNSWGEKWGKKGYVWLKKDVDEPEGLCGLAIQPVYPIV
PVU51723 MNPRVCFAWAMCALIGAEVGAKVAEEGLRTGLAPPQNAGSNHTGAKRLPLDRGSDRCVSPQFSSHIEADAPPRSADDAAGRGQPPQQVEHPPNRVTNVMAPPMSKQSAVEVRSALLKNHDGVKITGTCNAKVQLFLVPHISISVEAESNTIQLGRKLEDVTITKEFYRGVGGKSSPLLQFEEDADSLLNQCAEGKTFKFVVVIRGEELILKWKVYEKVPSPSDNNKVDVRKYLLKNLGRPITAIQVHSGKEESDVFLLESKAYLLRQDIPRTCERIASSCFLSGNVDIEGCYKCTLLSEDTKLGSPCFSYLPPEVKHNYEKVKMKAQDEGDLGEAQLEELIRRILHAVQRKGKSNPPRKGATEEDYPNDNLRELLLRYCQVMKKVDRSGTLEEHEVGNEMDVLANLEGLLRKHPKEEIPALREKLKNPAICMKDAAKWVEQKRGLALPLFEYKHLQRRVTTAVDSQESNSADKENIIKGEHIAAYRAVIDLSQRDQMNHSNLSGEMFCNEDYCDRWKDKSSCFSSIETEEQGNCNLSWLFTSKTHLETIRCMKGYDH---LGSSALYVASCSKRGKKSRCVSGSNPYEFLTIVEESGFLPPAVWLPYSYGDVGNGCPKREDHWHNLWEGVKLLEPADEPNSVSTKGYTSYESDDFRGDIQTFVNMVKSQVRSKGSVMAYIKVLDIL------SYDFNGKEVHTLCGDKRPD----------HAVNIIGYGNYVTPEGVKKS-------------YWLMRNSWGKYWGDGGNFKVDTHGPPGCQHNFIHTAAVFNLSMPMAEGPSKGEAHLYDYYLKSSPDFLGNIYHKISGRRSGAVEKGRTTGNQSLTVQGQEGWSDLLEGTTPSTTANPNPVGELKGAQDVPKRGNTGKRISEDPQEEVLNEELIPQLPLAPISQAAATLGEGQVEATPLPPLTVAASLPLRGDVLLERDGTNEGSKEAATVEVMHILKYIKNGKVKLGIATYRDDSDIAGDHSCSRSLAQNSEQLAECIQFCHDEWPNCRGEASPGYCLAQRRRTGDCFFCYV
PAPA_CARPA -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAMIPSISKLLFVAICLFVYMGLSFGDFSIVGYSQNDLTSTERLIQLFESWMLKHNKIYKNIDEKIYRFEIFKDNLKYIDETNKKNNSYWLGLNVFADMSNDEFKEKYTGSIAGNYTTTELSYEEVLNDGDVNIPEYVDWRQKGA-VTP-VKNQGSCGSCWAFSAVVTIEGIIKIRTGNL---NEYSEQELLDCDRRSY--GCNGGYPWSALQLVAQY--GIHYRNTYPYEGVQRYCRSREKGPYAAKTDGVRQVQPYNEGALL---YSIANQPVSVVLEAAGKD------------------------------FQLYRGGIFVGPCGNKVD-----------HAVAAVGYGPN----------------------YILIKNSWGTGWGENGYIRIKRGTGNSYGVCGLYTSSFYPVKN
ORYA_ORYSA ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRISMALAAAALLLLLSLAAADMSIVSYGERSEEEARRLYAEWKAEHGKSYNAVGEEERRYAAFRDNLRYIDEHNAAADAGVHSFRLGLNRFADLTNEEYRDTYLGLRNKPRRERKVSDRYLAADNEALPESVDWRTKGA-VAE-IKDQGGCGSCWAFSAIAAVEDINQIVTGDL---ISLSEQELVDCDTSYNE-GCNGGLMDYAFDFIINN-GGIDTEDDYPYKGKDERCDVNRKNAKVVTIDSYEDVTPNSETSLQ---KAVRNQPVSVAIEAGGRA------------------------------FQLYSSGIFTGKCGTALD-----------HGVAAVGYGTENGKD------------------YWIVRNSWGKSWGESGYVRMERNIKASSGKCGIAVEPSYPLKKGENPPNPGPTPPSPTPPPTVCDNYYTCPDSTTCCCIYEYGKYCYAWGCCPLEGATCCDDHYSCCPHEYPICNVQQGTCLMAKDSPLAVKALKRTLAKPNLSFLFGNGKKSSA
CYS1_HAECO -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKYLVLALCTYLCSQTGADENAAQGIPLEAQRLTGEPLVAYLRRSQNLFEVNSAPTPNFEQKIMDIKYKHQKLNLMVKEDPDPEVDIPPSYDPRDVWKNCTTFY--IRDQANCGSCWAVSTAAAISDRICIASKAEKQ-VNISATDIMTCCRPQCGDGCEGGWPIEAWKYFIYD-GVVSGGEYLTKDVCRPYPIHPCGHHGNDTYYGECRGTA-PTPPCKRKCRPGVRKM-YRIDKRYGKDAYIVKQSVKAIQSEILRNGPVVASFAVYEDFRHYKSGIYKHTAGELRGY----------HAVKMIGWGNENNTD------------------FWLIANSWHNDWGEKGYFRIIRGT----NDCGIEGTIAAGIVDTESL
LCPA_LEIME ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MARRNPLLFAIVVTILFVVCYGSALIAQTPPPVDNFVASAHYGSFKKRHGKAFGGDAEEGHRFNAFKQNMQTAYFLNTQNPHAHYDVSGKFADLTPQEFAKLYLNPDYYARHLKNHKEDVHVDDSAPSGVMSVDWRDKGA-VTP-VKNQGLCGSCWAFSAIGNIEGQWAASGHSL---VSLSEQMLVSCDNIDE--GCNGGLMDQAMNWIMQS-HNGSVFTEASYPYTSGGGTRPPCHDEGEVGAKITGFLSLPHDEERIAE--WVEKRGPVAVAVDATT------------------------------WQLYFGGVVSLCLAWSLN-----------HGVLIVGFNKNAKPP------------------YWIVKNSWGSSWGEKGYIRLAMGS----NQCMLKNYPVSATVESPHTPHVPTTTA
CYS2_HORVU >@1;FROM_PDBFrom XVISTAS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPEYVDWRQKGA-VTP-VKNQGSCGSCWAFSAVVTIEGIIKIRTGNL---NQYSEQELLDCDRRSY--GCNGGYPWSALQLVAQY--GIHYRNTYPYEGVQRYCRSREKGPYAAKTDGVRQVQPYNQGALL---YSIANQPVSVVLQAAGKD------------------------------FQLYRGGIFVGPCGNKVD-----------HAVAAVGYGPN----------------------YILIKNSWGTGWGENGYIRIKRGTGNSYGVCGLYTSSFYPVKN
PTCATHEL1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMLLGASLYLNNTQEVSDEIDTANLYANWKMKYNRRYTNQRDEMYRYKVFTDNLNYIRAFYESPEEATFTLELNQFADMSQQEFAQTYLSLKVPRTAKLNAANSNFQYKGAEVDWTDNKKVKYPAVKNQGSCGSCWAFSAVGALEINTDIELNRK---YELSEQDLVDCSGPYDNDGCNGGWMDSAFEYVADN--GLAEAKDYPYTAKDGTCKTSVKRPYTHVQGFKDIDSCDELAQ------TIQERTVAVAVDANP--------------------------------WQFYRSGVLSKCTKNLN------------HGVVLVGVQADG---------------------AWKIRNSWGSSWGEAGHIRLAGG-----DTCGICAAPSFPILG
PAP3_CARPA ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPENVDWRKKGA-VTP-VRHQGSCGSCWAFSAVATVEGINKIRTGKL---VELSEQELVDCERRSH--GCKGGYPPYALEYVAKN--GIHLRSKYPYKAKQGTCRAKQVGGPIVKTSGVGRVQPNNEGNLL---NAIAKQPVSVVVESKGRP------------------------------FQLYKGGIFEGPCGTKVD-----------HAVTAVGYGKSGGKG------------------YILIKNSWGTAWGEKGYIRIKRAPGNSPGVCGLYKSSYYPTKN
MMAL_DERFA ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKFVLAIASLLVLSTVYARPASIKTFEEFKKAFNKNYATVEEEEVARKNFLESLKYVEANKGAINHLSDLSLDEFKNRYLMSAEAFEQLKTQFDLNAETSACRINSVNVPSELDLRSLRT-VTP-IRMQGGCGSCWAFSGVAATESAYLAYRNTS---LDLSEQELVDCASQH---GCHGDTIPRGIEYIQQN--GVVEERSYPYVAREQRCRRPNSQHYGISNYCQIYPPDVKQIREALTQTHTAIAVIIGIKDLRA--------------------------------FQHYDGRTIIQHDNGYQPNY---------HAVNIVGYGSTQGDD------------------YWIVRNSWDTTWGDSGYGYFQA-------GNNLMMIEQYPYVVIM
CATL_CHICK ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APRSVDWREKGY-VTP-VKDQGQCGSCWAFSTTGALEGQHFRTKGKL---VSLSEQNLVDCSRPEGNQGCNGGLMDQAFQYVQDN-GGIDSEESYPYTAKDDEDCRYKAEYNAAND-TGFVDIPQGHERALMK-AVASVGPVSVAIDAGHSS------------------------------FQFYQSGIYYEPDCSS--EDLD-------HGVLVVGYGFEGGKK------------------YWIVKNSWGEKWGDKGYIYMAKDRK---NHCGIATAASYPLV
CPR6_CAEEL -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKTLLFLSCIVVAAYCACNDNLESVLDKYRNREIDSEAAELDGDDLIDYVNENQNLWTAKKQRRFSSVYGENDKAKWGLMGVNHVRLSVKGKQHLSKTKDLDLDIPESFDSRDNWPKCDSIKV-IRDQSSCGSCWAFGAVEAMSDRICIASHGELQ-VTLSADDLLSCCKS-CGFGCNGGDPLAAWRYWVKD-GIVTGSNYTANNGCKPYPFPPCEHHSKKTHFDPCPHDLYPTPKCEKKCVSDYTDKTYSEDKFFGASAYGVKDDVEAIQKELMTHGPLEIAFEVYEDFLNYDGGVYVHTGGKLGGG----------HAVKLIGWGIDDGIP------------------YWTVANSWNTDWGEDGFFRILRGV----DECGIESGVVGGIPKLNSLTSRLHRHHRRHVYDDNY
A57480 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MWTGYKFFIFFYLAKEIWTEKQFQKQVDLASYSSRNHSILEGTRFKRSIFQGQYCRSLGCCEGRNDNCVTQFYEANALCYCDKFCERENSDCCPDYKSFCQEEKEWLPHTQSWYPEGCIRDGLHYEEGSVIKENCNSCTCSGQHWKCSQHVCLVLPELIEHINKGDYGWTAQNYSQFWGMTLEEGFRFRLGTLPPSPVLLSMNEMRATLPETTDLPEFFIAFLQMAWMDSWAIGSKNCAASWAFSTASVAADRIAIQSNGRYTANLSPQNLISCCAKNRH--GCNSGSIDRAWWYLRKR--GLVSHACYPLFKDQNISNNTCAMTSKADGRGKRHATRPCPNNIEKSNRIYQCSPPYRVSSNETEIMKEIMQNGPVQAIMQVHED-----------FFHYKTGIYRHVISTNEESEKYRKLQT--HAVKLTGWGTLKGARGQKEK-------------FWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP
CPP1_ENTHI ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFTFILMFYIGYGIDFNTWVANNNKHFTAVESLRRRAIFNMNARIVAENNRKETFKLSVDGPFAAMTNEEYNSLLKLKRSGEEKGEVRYLNIQAPKAVDWRKKGK-VTP-IRDQGNCGSCYTFGSIAALEGRLLIEKGGDSETLDLSEEHMVQCTREDGNNGCNGGLGSNVYNYIMEN--GIAKESDYPYTGSDSTCRSDVKAFAKIKSYNRVARNNEVELK-----AAISQGLVDVSIDASSVQ------------------------------FQLYKSGAYTDTQCKNNYFALN-------HEVCAVGYGVVDGKE------------------CWIVRNSWGTGWGEKGYINMVIEG----NTCGVATDPLYPTGVEYL
CATV_NPVAC ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNKILFYLFVYGVVNSAAYDLLKAPNYFEEFVHRFNKDYGSEVEKLRRFKIFQHNLNEIINKNQNDSAKYEINKFSDLSKDETIAKYTGLSLPIQTQNFCKVIVLDQPPGKGPLEFDWRRLNK-VTS-VKNQGMCGACWAFATLASLESQFAIKHNQL---INLSEQQMIDCDFVDA--GCNGGLLHTAFEAIIKM-GGVQLESDYPYEADNNNCRMNSNKFLVQVKDCYRYITVYEEKLKD---LLRLVGPIPMAIDAAD--------------------------------IVNYKQGIIKYCFNSGLN-----------HAVLLVGYGVENNIP------------------YWTFKNTWGTDWGEDGFFRVQQNI----NACGMRNELASTAVIY