WORKLIST ENTRIES (1):
5HTRECEPTOR View alignment View Structure 5-hydroxytryptamine receptor signature
Type of fingerprint: COMPOUND with 4 elements
Links:
PRINTS; PR00237 GPCRRHODOPSN; PR00247 GPCRCAMP; PR00248 GPCRMGR
PRINTS; PR00249 GPCRSECRETIN; PR00250 GPCRSTE2; PR00899 GPCRSTE3
PRINTS; PR00251 BACTRLOPSIN
PRINTS; PR00512 5HT1ARECEPTR; PR00513 5HT1BRECEPTR; PR00514 5HT1DRECEPTR
PRINTS; PR00515 5HT1FRECEPTR; PR00516 5HT2ARECEPTR; PR00651 5HT2BRECEPTR
PRINTS; PR00517 5HT2CRECEPTR; PR01059 5HT4RECEPTR; PR00518 5HT5ARECEPTR
PRINTS; PR00519 5HT5BRECEPTR; PR01102 5HT6RECEPTR; PR00652 5HT7RECEPTR
INTERPRO; IPR002231
Creation date 03-APR-1999
1. ATTWOOD, T.K. AND FINDLAY, J.B.C.
Fingerprinting G protein-coupled receptors.
PROTEIN ENG. 7(2) 195-203 (1994).
2. ATTWOOD, T.K. AND FINDLAY, J.B.C.
G protein-coupled receptor fingerprints.
7TM, VOLUME 2, EDS. G.VRIEND AND B.BYWATER (1993).
3. BIRNBAUMER, L.
G proteins in signal transduction.
ANNU.REV.PHARMACOL.TOXICOL. 30 675-705 (1990).
4. CASEY, P.J. AND GILMAN, A.G.
G protein involvement in receptor-effector coupling.
J.BIOL.CHEM. 263(6) 2577-2580 (1988).
5. ATTWOOD, T.K. AND FINDLAY, J.B.C.
Design of a discriminating fingerprint for G protein-coupled receptors.
PROTEIN ENG. 6(2) 167-176 (1993).
6. WATSON, S. AND ARKINSTALL, S.
5-Hydroxytryptamine.
IN THE G PROTEIN-LINKED RECEPTOR FACTSBOOK, ACADEMIC PRESS, 1994, PP.159-180.
G protein-coupled receptors (GPCRs) constitute a vast protein family that
encompasses a wide range of functions (including various autocrine, para-
crine and endocrine processes). They show considerable diversity at the
sequence level, on the basis of which they can be separated into distinct
groups. We use the term clan to describe the GPCRs, as they embrace a group
of families for which there are indications of evolutionary relationship,
but between which there is no statistically significant similarity in
sequence [1,2]. The currently known clan members include the rhodopsin-like
GPCRs, the secretin-like GPCRs, the cAMP receptors, the fungal mating
pheromone receptors, and the metabotropic glutamate receptor family.
The rhodopsin-like GPCRs themselves represent a widespread protein family
that includes hormone, neurotransmitter and light receptors, all of
which transduce extracellular signals through interaction with guanine
nucleotide-binding (G) proteins. Although their activating ligands vary
widely in structure and character, the amino acid sequences of the
receptors are very similar and are believed to adopt a common structural
framework comprising 7 transmembrane (TM) helices [3-5].
5-Hydroxytryptamine (or serotonin) is ubiquitous in plants and animals.
It is an important neurotransmitter and local hormone in the CNS and
instestine, and is implicated in a vast array of physiological and patho-
physiological pathways [6]. In the periphery, 5HT contracts a number of
smooth muscles, and induces endothelium-dependent vasodilation through
the formation of NO [6]. It is a mediator of peristalsis, and may be
involved in platelet aggregation and homeostasis. In the CNS, 5HT is
believed to be involved in a wide range of functions, including the
control of appetite, mood, anxiety, hallucinations, sleep, vomiting and
pain perception [6]. 5HT receptor ligands are of clinical use in the
treatment of depression, migraine and post-operative vomiting.
Numerous receptor subtypes have been classified according to their
antagonist susceptibilities and their affinities for 5HT. Five 5HT1
subtypes and at least three 5HT2 subtypes have now been identified, in
addition to subtypes 5HT3-7 [6]. All share a high degree of sequence
similarity, and have overlapping pharmacological specificities.
5HTRECEPTOR is a 4-element fingerprint that provides a signature for the
5HT receptors. The fingerprint was derived from an initial alignment of
31 sequences: the motifs were drawn from conserved sections within either
TM or C-terminal regions, focusing on those areas of the alignment that
characterise the 5HT receptors but distinguish them from the rest of the
rhodopsin-like superfamily - motif 1 lies in the C-terminal portion of TM
domain 1; motif 2 spans the N-terminal portion of TM domain 5; motif 3 lies
in the C-terminal portion of TM domain 6; and motif 4 resides at the
C-terminus. Three iterations on SPTR37_9f were required to reach convergence,
at which point a true set comprising 48 sequences was identified. Numerous
partial matches were also found, all of which are 5HT receptors and closely-
related members of the superfamily that fail to match one or more motifs.
SUMMARY INFORMATION
48 codes involving 4 elements
6 codes involving 3 elements
51 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
4| 48 48 48 48
3| 5 6 6 1
2| 37 27 21 17
--+---------------------
| 1 2 3 4
True positives..
Q98998 5H1D_CAVPO 5H1D_MOUSE 5H1D_RAT
5H1D_RABIT 5H1A_HUMAN 5H1A_RAT 5H1A_MOUSE
O42385 O42384 5H1F_RAT 5H1F_CAVPO
5H1F_MOUSE 5H1D_HUMAN 5H1F_HUMAN 5H1B_HUMAN
5H1B_RAT 5H1B_MOUSE 5H1B_CAVPO 5H1B_CRIGR
5H1D_CANFA 5H1B_RABIT 5H1D_FUGRU 5H2A_CRIGR
5H2A_RAT 5H2A_MOUSE 5H1E_HUMAN 5H5A_RAT
5H5A_HUMAN 5H5A_MOUSE 5H5B_RAT 5H2A_HUMAN
5H2A_PIG 5H2A_MACMU 5H5B_MOUSE 5H2C_MOUSE
5H2C_RAT 5H2C_HUMAN 5H2B_MOUSE 5H2B_HUMAN
5H2B_RAT 5H7_XENLA 5H7_CAVPO P97842
P78336 5H7_RAT 5H7_HUMAN 5H7_MOUSE
Subfamily: Codes involving 3 elements
Subfamily True positives..
5H1B_SPAEH 5H1B_DIDMA 5HT_LYMST Q62842
O76267 O18512
Subfamily: Codes involving 2 elements
Subfamily True positives..
5HT_HELVI 5HTA_DROME A2AR_CARAU
5HTB_DROME DOP2_DROME A2AR_LABOS
5HT_BOMMO OAR2_LYMST O15969
YDBM_CAEEL A2AB_RAT D3DR_MOUSE D3DR_RAT
A2AC_HUMAN A2AD_HUMAN A2AC_RAT A2AC_MOUSE
D3DR_CERAE D3DR_HUMAN
O73810
D2D1_XENLA O77254
D2DR_BOVIN D2DR_MOUSE D2DR_HUMAN D2DR_FUGRU
D2DR_CERAE O77408 OAR_DROME
B1AR_MELGA OAR_HELVI A2AA_CAVPO A2AA_PIG
A2AA_HUMAN B3AR_BOVIN OAR_BOMMO
Q93126 Q93128
PROTEIN TITLES
Q98998 5-HT1A RECEPTOR - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
5H1D_CAVPO 5-HYDROXYTRYPTAMINE 1D RECEPTOR (5-HT-1D) (SEROTONIN RECEPTO
5H1D_MOUSE 5-HYDROXYTRYPTAMINE 1D RECEPTOR (5-HT-1D) (SEROTONIN RECEPTO
5H1D_RAT 5-HYDROXYTRYPTAMINE 1D RECEPTOR (5-HT-1D) (SEROTONIN RECEPTO
5H1D_RABIT 5-HYDROXYTRYPTAMINE 1D RECEPTOR (5-HT-1D) (SEROTONIN RECEPTO
5H1A_HUMAN 5-HYDROXYTRYPTAMINE 1A RECEPTOR (5-HT-1A) (SEROTONIN RECEPTO
5H1A_RAT 5-HYDROXYTRYPTAMINE 1A RECEPTOR (5-HT-1A) (SEROTONIN RECEPTO
5H1A_MOUSE 5-HYDROXYTRYPTAMINE 1A RECEPTOR (5-HT-1A) (SEROTONIN RECEPTO
O42385 SEROTONIN RECEPTOR - FUGU RUBRIPES (JAPANESE PUFFERFISH) (TA
O42384 SEROTONIN RECEPTOR - FUGU RUBRIPES (JAPANESE PUFFERFISH) (TA
5H1F_RAT 5-HYDROXYTRYPTAMINE 1F RECEPTOR (5-HT-1F) (SEROTONIN RECEPTO
5H1F_CAVPO 5-HYDROXYTRYPTAMINE 1F RECEPTOR (5-HT-1F) (SEROTONIN RECEPTO
5H1F_MOUSE 5-HYDROXYTRYPTAMINE 1F RECEPTOR (5-HT-1F) (SEROTONIN RECEPTO
5H1D_HUMAN 5-HYDROXYTRYPTAMINE 1D RECEPTOR (5-HT-1D) (SEROTONIN RECEPTO
5H1F_HUMAN 5-HYDROXYTRYPTAMINE 1F RECEPTOR (5-HT-1F) (SEROTONIN RECEPTO
5H1B_HUMAN 5-HYDROXYTRYPTAMINE 1B RECEPTOR (5-HT-1B) (SEROTONIN RECEPTO
5H1B_RAT 5-HYDROXYTRYPTAMINE 1B RECEPTOR (5-HT-1B) (SEROTONIN RECEPTO
5H1B_MOUSE 5-HYDROXYTRYPTAMINE 1B RECEPTOR (5-HT-1B) (SEROTONIN RECEPTO
5H1B_CAVPO 5-HYDROXYTRYPTAMINE 1B RECEPTOR (5-HT-1B) (SEROTONIN RECEPTO
5H1B_CRIGR 5-HYDROXYTRYPTAMINE 1B RECEPTOR (5-HT-1B) (SEROTONIN RECEPTO
5H1D_CANFA 5-HYDROXYTRYPTAMINE 1D RECEPTOR (5-HT-1D) (SEROTONIN RECEPTO
5H1B_RABIT 5-HYDROXYTRYPTAMINE 1B RECEPTOR (5-HT-1B) (SEROTONIN RECEPTO
5H1D_FUGRU 5-HYDROXYTRYPTAMINE 1D RECEPTOR (5-HT-1D) (SEROTONIN RECEPTO
5H2A_CRIGR 5-HYDROXYTRYPTAMINE 2A RECEPTOR (5-HT-2A) (SEROTONIN RECEPTO
5H2A_RAT 5-HYDROXYTRYPTAMINE 2A RECEPTOR (5-HT-2A) (SEROTONIN RECEPTO
5H2A_MOUSE 5-HYDROXYTRYPTAMINE 2A RECEPTOR (5-HT-2A) (SEROTONIN RECEPTO
5H1E_HUMAN 5-HYDROXYTRYPTAMINE 1E RECEPTOR (5-HT-1E) (SEROTONIN RECEPTO
5H5A_RAT 5-HYDROXYTRYPTAMINE 5A RECEPTOR (5-HT-5A) (SEROTONIN RECEPTO
5H5A_HUMAN 5-HYDROXYTRYPTAMINE 5A RECEPTOR (5-HT-5A) (SEROTONIN RECEPTO
5H5A_MOUSE 5-HYDROXYTRYPTAMINE 5A RECEPTOR (5-HT-5A) (SEROTONIN RECEPTO
5H5B_RAT 5-HYDROXYTRYPTAMINE 5B RECEPTOR (5-HT-5B) (SEROTONIN RECEPTO
5H2A_HUMAN 5-HYDROXYTRYPTAMINE 2A RECEPTOR (5-HT-2A) (SEROTONIN RECEPTO
5H2A_PIG 5-HYDROXYTRYPTAMINE 2A RECEPTOR (5-HT-2A) (SEROTONIN RECEPTO
5H2A_MACMU 5-HYDROXYTRYPTAMINE 2A RECEPTOR (5-HT-2A) (SEROTONIN RECEPTO
5H5B_MOUSE 5-HYDROXYTRYPTAMINE 5B RECEPTOR (5-HT-5B) (SEROTONIN RECEPTO
5H2C_MOUSE 5-HYDROXYTRYPTAMINE 2C RECEPTOR (5-HT-2C) (SEROTONIN RECEPTO
5H2C_RAT 5-HYDROXYTRYPTAMINE 2C RECEPTOR (5-HT-2C) (SEROTONIN RECEPTO
5H2C_HUMAN 5-HYDROXYTRYPTAMINE 2C RECEPTOR (5-HT-2C) (SEROTONIN RECEPTO
5H2B_MOUSE 5-HYDROXYTRYPTAMINE 2B RECEPTOR (5-HT-2B) (SEROTONIN RECEPTO
5H2B_HUMAN 5-HYDROXYTRYPTAMINE 2B RECEPTOR (5-HT-2B) (SEROTONIN RECEPTO
5H2B_RAT 5-HYDROXYTRYPTAMINE 2B RECEPTOR (5-HT-2B) (SEROTONIN RECEPTO
5H7_XENLA 5-HYDROXYTRYPTAMINE 7 RECEPTOR (5-HT-7) (SEROTONIN RECEPTOR)
5H7_CAVPO 5-HYDROXYTRYPTAMINE 7 RECEPTOR (5-HT-7) (5-HT-X) (SEROTONIN
P97842 5-HYDROXYTRYPTAMINE7 RECEPTOR ISOFORM C - RATTUS NORVEGICUS
P78336 5-HYDROXYTRYPTAMINE7 RECEPTOR ISOFORM D - HOMO SAPIENS (HUMA
5H7_RAT 5-HYDROXYTRYPTAMINE 7 RECEPTOR (5-HT-7) (5-HT-X) (SEROTONIN
5H7_HUMAN 5-HYDROXYTRYPTAMINE 7 RECEPTOR (5-HT-7) (5-HT-X) (SEROTONIN
5H7_MOUSE 5-HYDROXYTRYPTAMINE 7 RECEPTOR (5-HT-7) (5-HT-X) (SEROTONIN
5H1B_SPAEH 5-HYDROXYTRYPTAMINE 1B RECEPTOR (5-HT-1B) (SEROTONIN RECEPTO
5H1B_DIDMA 5-HYDROXYTRYPTAMINE 1B RECEPTOR (5-HT-1B) (SEROTONIN RECEPTO
5HT_LYMST 5-HYDROXYTRYPTAMINE RECEPTOR (5-HT RECEPTOR) (SEROTONIN RECE
Q62842 SEROTONIN 5-HT2C - RATTUS NORVEGICUS (RAT).
O76267 G protein-coupled 5-HYDROXYTRYPTAMINE RECEPTOR - APLYSIA CAL
O18512 SEROTONIN RECEPTOR PRECURSOR - CAENORHABDITIS ELEGANS.
5HT_HELVI 5-HYDROXYTRYPTAMINE RECEPTOR (5-HT RECEPTOR) (SEROTONIN RECE
5HTA_DROME 5-HYDROXYTRYPTAMINE RECEPTOR 2A (5-HT RECEPTOR) (SEROTONIN R
A2AR_CARAU ALPHA-2 ADRENERGIC RECEPTOR (ALPHA-2 ADRENOCEPTOR) - CARASSI
5HTB_DROME 5-HYDROXYTRYPTAMINE RECEPTOR 2B (5-HT RECEPTOR) (SEROTONIN R
DOP2_DROME DOPAMINE RECEPTOR 2 - DROSOPHILA MELANOGASTER (FRUIT FLY).
A2AR_LABOS ALPHA-2 ADRENERGIC RECEPTOR (ALPHA-2 ADRENOCEPTOR) - LABRUS
5HT_BOMMO 5-HYDROXYTRYPTAMINE RECEPTOR (5-HT RECEPTOR) (SEROTONIN RECE
OAR2_LYMST OCTOPAMINE RECEPTOR 2 (OA2) - LYMNAEA STAGNALIS (GREAT POND
O15969 SEROTONIN RECEPTOR-LIKE PLANARIAN RECEPTOR 4 - DUGESIA JAPON
YDBM_CAEEL PROBABLE G PROTEIN-COUPLED RECEPTOR F01E11.5 - CAENORHABDITI
A2AB_RAT ALPHA-2B ADRENERGIC RECEPTOR (ALPHA-2B ADRENOCEPTOR) - RATTU
D3DR_MOUSE D(3) DOPAMINE RECEPTOR - MUS MUSCULUS (MOUSE).
D3DR_RAT D(3) DOPAMINE RECEPTOR - RATTUS NORVEGICUS (RAT).
A2AC_HUMAN ALPHA-2C-1 ADRENERGIC RECEPTOR (ALPHA-2C-1 ADRENOCEPTOR) (SU
A2AD_HUMAN ALPHA-2C-2 ADRENERGIC RECEPTOR (ALPHA-2C-2 ADRENOCEPTOR) - H
A2AC_RAT ALPHA-2C ADRENERGIC RECEPTOR (ALPHA-2C ADRENOCEPTOR) (SUBTYP
A2AC_MOUSE ALPHA-2C ADRENERGIC RECEPTOR (ALPHA-2C ADRENOCEPTOR) (SUBTYP
D3DR_CERAE D(3) DOPAMINE RECEPTOR - CERCOPITHECUS AETHIOPS (GREEN MONKE
D3DR_HUMAN D(3) DOPAMINE RECEPTOR - HOMO SAPIENS (HUMAN).
O73810 D2 DOPAMINE RECEPTOR - MELEAGRIS GALLOPAVO (COMMON TURKEY).
D2D1_XENLA D(2) DOPAMINE RECEPTOR 1 - XENOPUS LAEVIS (AFRICAN CLAWED FR
O77254 G protein COUPLED RECEPTOR - BOOPHILUS MICROPLUS (CATTLE TIC
D2DR_BOVIN D(2) DOPAMINE RECEPTOR - BOS TAURUS (BOVINE).
D2DR_MOUSE D(2) DOPAMINE RECEPTOR - MUS MUSCULUS (MOUSE), AND RATTUS NO
D2DR_HUMAN D(2) DOPAMINE RECEPTOR - HOMO SAPIENS (HUMAN).
D2DR_FUGRU D(2)-LIKE DOPAMINE RECEPTOR - FUGU RUBRIPES (JAPANESE PUFFER
D2DR_CERAE D(2) DOPAMINE RECEPTOR - CERCOPITHECUS AETHIOPS (GREEN MONKE
O77408 OCTOPAMINE RECEPTOR 1 (OA1) - LYMNAEA STAGNALIS (GREAT POND
OAR_DROME OCTOPAMINE RECEPTOR PRECURSOR (TYRAMINE RECEPTOR) - DROSOPHI
B1AR_MELGA BETA-1 ADRENERGIC RECEPTOR (BETA-T) - MELEAGRIS GALLOPAVO (C
OAR_HELVI OCTOPAMINE RECEPTOR - HELIOTHIS VIRESCENS (NOCTUID MOTH) (OW
A2AA_CAVPO ALPHA-2A ADRENERGIC RECEPTOR (ALPHA-2A ADRENOCEPTOR) (ALPHA-
A2AA_PIG ALPHA-2A ADRENERGIC RECEPTOR (ALPHA-2A ADRENOCEPTOR) (ALPHA-
A2AA_HUMAN ALPHA-2A ADRENERGIC RECEPTOR (ALPHA-2A ADRENOCEPTOR) (ALPHA-
B3AR_BOVIN BETA-3 ADRENERGIC RECEPTOR - BOS TAURUS (BOVINE).
OAR_BOMMO OCTOPAMINE RECEPTOR - BOMBYX MORI (SILK MOTH).
Q93126 G PROTEIN-COUPLED RECEPTOR - BALANUS AMPHITRITE.
Q93128 G PROTEIN-COUPLED RECEPTOR - BALANUS AMPHITRITE.
SCAN HISTORY
SPTR37_9f 3 607 NSINGLE
INITIAL MOTIF SETS
5HTRECEPTOR1 Length of motif = 9 Motif number = 1
5HT receptor motif I - 1
PCODE ST INT
VVAAIALER 5H1A_HUMAN 57 57
VVAAIALER 5H1A_RAT 57 57
VIATVYRTR 5H1B_CRIGR 66 66
VIATVYRTR 5H1B_HUMAN 70 70
VIATVYRTR 5H1B_MOUSE 66 66
VLTTIFLTR 5H1D_CANFA 59 59
VLTTILLTR 5H1D_HUMAN 59 59
VLTTILLTK 5H1D_RAT 56 56
VLTTILLTR 5H1D_RABIT 59 59
VIAAIIVTR 5H1F_HUMAN 44 44
VIAAIIVTR 5H1F_MOUSE 44 44
VITAIIVTR 5H1F_RAT 44 44
VIMAVSLEK 5H2A_CRIGR 95 95
VIMAVSLEK 5H2A_HUMAN 95 95
VIMAVSLEK 5H2A_RAT 95 95
VIMAVSLEK 5H2A_MOUSE 95 95
VILAVSLEK 5H2B_HUMAN 75 75
VILAVALEK 5H2B_MOUSE 74 74
VILAVSLEK 5H2B_RAT 74 74
VIMAVSMEK 5H2C_HUMAN 74 74
VIMAVSMEK 5H2C_MOUSE 75 75
VIMAVSMEK 5H2C_RAT 75 75
VLATILKVR 5H5A_MOUSE 61 61
VLATILRVR 5H5A_HUMAN 61 61
VLATILRVR 5H5A_RAT 61 61
VLVTILRVR 5H5B_MOUSE 73 73
VLVTILRVR 5H5B_RAT 73 73
VVISVCFVK 5H7_HUMAN 102 102
VVISVCFVK 5H7_CAVPO 103 103
VVISVCFVK 5H7_RAT 105 105
VVISVCFVK 5H7_MOUSE 105 105
5HTRECEPTOR2 Length of motif = 9 Motif number = 2
5HT receptor motif II - 1
PCODE ST INT
TIYSTFGAF 5H1A_HUMAN 196 130
TIYSTFGAF 5H1A_RAT 196 130
TVYSTGGAF 5H1B_CRIGR 205 130
TVYSTVGAF 5H1B_HUMAN 209 130
TVYSTVGAF 5H1B_MOUSE 205 130
TIYSTCGAF 5H1D_CANFA 198 130
TIYSTCGAF 5H1D_HUMAN 198 130
TIYSTCGAF 5H1D_RAT 195 130
TIYSTCGAF 5H1D_RABIT 198 130
TIYSTFGAF 5H1F_HUMAN 182 129
TIYSTFGAF 5H1F_MOUSE 182 129
TIYSTFGAF 5H1F_RAT 182 129
VLIGSFVAF 5H2A_CRIGR 235 131
VLIGSFVSF 5H2A_HUMAN 235 131
VLIGSFVAF 5H2A_RAT 235 131
VLIGSFVAF 5H2A_MOUSE 235 131
MLFGSLAAF 5H2B_HUMAN 218 134
MVFGSLAAF 5H2B_MOUSE 217 134
MLFGSLAAF 5H2B_RAT 217 134
VLIGSFVAF 5H2C_HUMAN 215 132
VLIGSFVAF 5H2C_MOUSE 216 132
VLIGSFVAF 5H2C_RAT 216 132
TVFSTVGAF 5H5A_MOUSE 201 131
AVFSTVGAF 5H5A_HUMAN 201 131
TVFSTVGAF 5H5A_RAT 201 131
AVFSTCGAF 5H5B_MOUSE 214 132
AVFSTCGAF 5H5B_RAT 214 132
TIYSTAVAF 5H7_HUMAN 240 129
TIYSTAVAF 5H7_CAVPO 241 129
TIYSTAVAF 5H7_RAT 243 129
TIYSTAVAF 5H7_MOUSE 243 129
5HTRECEPTOR3 Length of motif = 12 Motif number = 3
5HT receptor motif III - 1
PCODE ST INT
FFIVALVLPFCE 5H1A_HUMAN 361 156
FFIVALVLPFCE 5H1A_RAT 361 156
FFIISLVMPICK 5H1B_CRIGR 326 112
FFIISLVMPICK 5H1B_HUMAN 330 112
FFIISLVMPICK 5H1B_MOUSE 326 112
FFVASLVLPICR 5H1D_CANFA 317 110
FFVVSLVLPICR 5H1D_HUMAN 317 110
FFVVSLVLPICR 5H1D_RAT 314 110
FFVASLVLPICR 5H1D_RABIT 317 110
FFVKELVVNVCD 5H1F_HUMAN 309 118
FFVKELVVNVCE 5H1F_MOUSE 309 118
FFVKELVVNICE 5H1F_RAT 309 118
FFITNIMAVICK 5H2A_CRIGR 339 95
FFITNIMAVICK 5H2A_HUMAN 339 95
FFITNIMAVICK 5H2A_RAT 339 95
FFITNIMAVICK 5H2A_MOUSE 339 95
FFITNITLVLCD 5H2B_HUMAN 340 113
FFITNLTLALCD 5H2B_MOUSE 339 113
FFITNVTLALCD 5H2B_RAT 339 113
FFITNILSVLCE 5H2C_HUMAN 327 103
FFITNILSVLCG 5H2C_MOUSE 328 103
FFITNILSVLCG 5H2C_RAT 329 104
FFVTELISPLCS 5H5A_MOUSE 301 91
FFLTELISPLCS 5H5A_HUMAN 301 91
FFVTELISPLCS 5H5A_RAT 301 91
FFLTELISPLCA 5H5B_MOUSE 314 91
FFLTELVSPLCA 5H5B_RAT 314 91
FLLSTARPFICG 5H7_HUMAN 344 95
FLLSTARPFICG 5H7_CAVPO 345 95
FLLSTARPFICG 5H7_RAT 347 95
FLLSTARPFICG 5H7_MOUSE 347 95
5HTRECEPTOR4 Length of motif = 6 Motif number = 4
5HT receptor motif IV - 1
PCODE ST INT
AYFNKD 5H1A_HUMAN 401 28
AYFNKD 5H1A_RAT 401 28
TMSNED 5H1B_CRIGR 366 28
TMSNED 5H1B_HUMAN 370 28
TMSNED 5H1B_MOUSE 366 28
TVFNEE 5H1D_CANFA 357 28
TVFNEE 5H1D_HUMAN 357 28
TVFNED 5H1D_RAT 354 28
TVFNED 5H1D_RABIT 357 28
TIFNED 5H1F_HUMAN 348 27
TIFNED 5H1F_MOUSE 348 27
TIFNED 5H1F_RAT 348 27
TLFNKT 5H2A_CRIGR 381 30
TLFNKT 5H2A_HUMAN 381 30
TLFNKT 5H2A_RAT 381 30
TLFNKT 5H2A_MOUSE 381 30
TLFNKT 5H2B_HUMAN 381 29
TLFNKT 5H2B_MOUSE 380 29
TLFNKT 5H2B_RAT 380 29
TLFNKI 5H2C_HUMAN 369 30
TLFNKI 5H2C_MOUSE 370 30
TLFNKI 5H2C_RAT 371 30
TAFNRS 5H5A_MOUSE 339 26
TAFNKN 5H5A_HUMAN 339 26
TAFNRS 5H5A_RAT 339 26
TAFNKN 5H5B_MOUSE 352 26
TAFNKN 5H5B_RAT 352 26
AFFNRD 5H7_HUMAN 385 29
AFFNRD 5H7_CAVPO 386 29
AFFNRD 5H7_RAT 388 29
SFFNRD 5H7_MOUSE 388 29
FINAL MOTIF SETS
5HTRECEPTOR1 Length of motif = 9 Motif number = 1
5HT receptor motif I - 3
PCODE ST INT
VIAAIALER Q98998 51 51
VLTTILLTR 5H1D_CAVPO 59 59
VLTTILLTK 5H1D_MOUSE 56 56
VLTTILLTK 5H1D_RAT 56 56
VLTTILLTR 5H1D_RABIT 59 59
VVAAIALER 5H1A_HUMAN 57 57
VVAAIALER 5H1A_RAT 57 57
VVAAIALER 5H1A_MOUSE 57 57
VVAAIALER O42385 66 66
VVAAIALER O42384 54 54
VITAIIVTR 5H1F_RAT 44 44
VIAAIIVTR 5H1F_CAVPO 44 44
VIAAIIVTR 5H1F_MOUSE 44 44
VLTTILLTR 5H1D_HUMAN 59 59
VIAAIIVTR 5H1F_HUMAN 44 44
VIATVYRTR 5H1B_HUMAN 70 70
VIATVYRTR 5H1B_RAT 66 66
VIATVYRTR 5H1B_MOUSE 66 66
VIATVYRTR 5H1B_CAVPO 69 69
VIATVYRTR 5H1B_CRIGR 66 66
VLTTIFLTR 5H1D_CANFA 59 59
VVATVYRTR 5H1B_RABIT 70 70
VIATIFLTR 5H1D_FUGRU 57 57
VIMAVSLEK 5H2A_CRIGR 95 95
VIMAVSLEK 5H2A_RAT 95 95
VIMAVSLEK 5H2A_MOUSE 95 95
VIMAIGTTK 5H1E_HUMAN 43 43
VLATILRVR 5H5A_RAT 61 61
VLATILRVR 5H5A_HUMAN 61 61
VLATILKVR 5H5A_MOUSE 61 61
VLVTILRVR 5H5B_RAT 73 73
VIMAVSLEK 5H2A_HUMAN 95 95
VIMAVSLEK 5H2A_PIG 95 95
VIMAVSLEK 5H2A_MACMU 95 95
VLVTILRVR 5H5B_MOUSE 73 73
VIMAVSMEK 5H2C_MOUSE 75 75
VIMAVSMEK 5H2C_RAT 75 75
VIMAVSMEK 5H2C_HUMAN 74 74
VILAVALEK 5H2B_MOUSE 74 74
VILAVSLEK 5H2B_HUMAN 75 75
VILAVSLEK 5H2B_RAT 74 74
VIISVCIVK 5H7_XENLA 91 91
VVISVCFVK 5H7_CAVPO 103 103
VVISVCFVK P97842 105 105
VVISVCFVK P78336 102 102
VVISVCFVK 5H7_RAT 105 105
VVISVCFVK 5H7_HUMAN 102 102
VVISVCFVK 5H7_MOUSE 105 105
5HTRECEPTOR2 Length of motif = 9 Motif number = 2
5HT receptor motif II - 3
PCODE ST INT
TIYSTFGAF Q98998 190 130
TIYSTCGAF 5H1D_CAVPO 198 130
TIYSTCGAF 5H1D_MOUSE 195 130
TIYSTCGAF 5H1D_RAT 195 130
TIYSTCGAF 5H1D_RABIT 198 130
TIYSTFGAF 5H1A_HUMAN 196 130
TIYSTFGAF 5H1A_RAT 196 130
TIYSTFGAF 5H1A_MOUSE 196 130
TIYSTFGAF O42385 205 130
TIYSTFGAF O42384 198 135
TIYSTFGAF 5H1F_RAT 182 129
TIYSTFGAF 5H1F_CAVPO 182 129
TIYSTFGAF 5H1F_MOUSE 182 129
TIYSTCGAF 5H1D_HUMAN 198 130
TIYSTFGAF 5H1F_HUMAN 182 129
TVYSTVGAF 5H1B_HUMAN 209 130
TVYSTVGAF 5H1B_RAT 205 130
TVYSTVGAF 5H1B_MOUSE 205 130
TVYSTGGAF 5H1B_CAVPO 208 130
TVYSTGGAF 5H1B_CRIGR 205 130
TIYSTCGAF 5H1D_CANFA 198 130
TVYSTVGAF 5H1B_RABIT 209 130
TLYSTFGAF 5H1D_FUGRU 196 130
VLIGSFVAF 5H2A_CRIGR 235 131
VLIGSFVAF 5H2A_RAT 235 131
VLIGSFVAF 5H2A_MOUSE 235 131
TIYSTLGAF 5H1E_HUMAN 183 131
TVFSTVGAF 5H5A_RAT 201 131
AVFSTVGAF 5H5A_HUMAN 201 131
TVFSTVGAF 5H5A_MOUSE 201 131
AVFSTCGAF 5H5B_RAT 214 132
VLIGSFVSF 5H2A_HUMAN 235 131
VLIGSFVSF 5H2A_PIG 235 131
VLIGSFVSF 5H2A_MACMU 235 131
AVFSTCGAF 5H5B_MOUSE 214 132
VLIGSFVAF 5H2C_MOUSE 216 132
VLIGSFVAF 5H2C_RAT 216 132
VLIGSFVAF 5H2C_HUMAN 215 132
MVFGSLAAF 5H2B_MOUSE 217 134
MLFGSLAAF 5H2B_HUMAN 218 134
MLFGSLAAF 5H2B_RAT 217 134
TVYSTAVAF 5H7_XENLA 229 129
TIYSTAVAF 5H7_CAVPO 241 129
TIYSTAVAF P97842 243 129
TIYSTAVAF P78336 240 129
TIYSTAVAF 5H7_RAT 243 129
TIYSTAVAF 5H7_HUMAN 240 129
TIYSTAVAF 5H7_MOUSE 243 129
5HTRECEPTOR3 Length of motif = 12 Motif number = 3
5HT receptor motif III - 3
PCODE ST INT
FFIVALVLPFCE Q98998 348 149
FFVVSLVLPICR 5H1D_CAVPO 316 109
FFVVSLVLPICR 5H1D_MOUSE 314 110
FFVVSLVLPICR 5H1D_RAT 314 110
FFVASLVLPICR 5H1D_RABIT 317 110
FFIVALVLPFCE 5H1A_HUMAN 361 156
FFIVALVLPFCE 5H1A_RAT 361 156
FFIVALVLPFCE 5H1A_MOUSE 361 156
FFIVALVLPFCA O42385 362 148
FFIVALVMPFCQ O42384 355 148
FFVKELVVNICE 5H1F_RAT 309 118
FFVKELVVNVCE 5H1F_CAVPO 309 118
FFVKELVVNVCE 5H1F_MOUSE 309 118
FFVVSLVLPICR 5H1D_HUMAN 317 110
FFVKELVVNVCD 5H1F_HUMAN 309 118
FFIISLVMPICK 5H1B_HUMAN 330 112
FFIISLVMPICK 5H1B_RAT 326 112
FFIISLVMPICK 5H1B_MOUSE 326 112
FFIISLVMPICK 5H1B_CAVPO 329 112
FFIISLVMPICK 5H1B_CRIGR 326 112
FFVASLVLPICR 5H1D_CANFA 317 110
FFIISLVMPICK 5H1B_RABIT 330 112
FFVVTLVWAICK 5H1D_FUGRU 322 117
FFITNIMAVICK 5H2A_CRIGR 339 95
FFITNIMAVICK 5H2A_RAT 339 95
FFITNIMAVICK 5H2A_MOUSE 339 95
FFIKELIVGLSI 5H1E_HUMAN 307 115
FFVTELISPLCS 5H5A_RAT 301 91
FFLTELISPLCS 5H5A_HUMAN 301 91
FFVTELISPLCS 5H5A_MOUSE 301 91
FFLTELVSPLCA 5H5B_RAT 314 91
FFITNIMAVICK 5H2A_HUMAN 339 95
FFITNIMAVICK 5H2A_PIG 338 94
FFITNIMAVICK 5H2A_MACMU 339 95
FFLTELISPLCA 5H5B_MOUSE 314 91
FFITNILSVLCG 5H2C_MOUSE 328 103
FFITNILSVLCG 5H2C_RAT 329 104
FFITNILSVLCE 5H2C_HUMAN 327 103
FFITNLTLALCD 5H2B_MOUSE 339 113
FFITNITLVLCD 5H2B_HUMAN 340 113
FFITNVTLALCD 5H2B_RAT 339 113
FLLSTARPFICG 5H7_XENLA 340 102
FLLSTARPFICG 5H7_CAVPO 345 95
FLLSTARPFICG P97842 347 95
FLLSTARPFICG P78336 344 95
FLLSTARPFICG 5H7_RAT 347 95
FLLSTARPFICG 5H7_HUMAN 344 95
FLLSTARPFICG 5H7_MOUSE 347 95
5HTRECEPTOR4 Length of motif = 6 Motif number = 4
5HT receptor motif IV - 3
PCODE ST INT
AYFNKD Q98998 387 27
TVFNED 5H1D_CAVPO 356 28
TVFNED 5H1D_MOUSE 354 28
TVFNED 5H1D_RAT 354 28
TVFNED 5H1D_RABIT 357 28
AYFNKD 5H1A_HUMAN 401 28
AYFNKD 5H1A_RAT 401 28
AYFNKD 5H1A_MOUSE 401 28
AYFNKD O42385 402 28
AYFNKD O42384 395 28
TIFNED 5H1F_RAT 348 27
TIFNED 5H1F_CAVPO 348 27
TIFNED 5H1F_MOUSE 348 27
TVFNEE 5H1D_HUMAN 357 28
TIFNED 5H1F_HUMAN 348 27
TMSNED 5H1B_HUMAN 370 28
TMSNED 5H1B_RAT 366 28
TMSNED 5H1B_MOUSE 366 28
TMSNED 5H1B_CAVPO 369 28
TMSNED 5H1B_CRIGR 366 28
TVFNEE 5H1D_CANFA 357 28
TMSNED 5H1B_RABIT 370 28
TVFNDE 5H1D_FUGRU 361 27
TLFNKT 5H2A_CRIGR 381 30
TLFNKT 5H2A_RAT 381 30
TLFNKT 5H2A_MOUSE 381 30
TSFNED 5H1E_HUMAN 345 26
TAFNRS 5H5A_RAT 339 26
TAFNKN 5H5A_HUMAN 339 26
TAFNRS 5H5A_MOUSE 339 26
TAFNKN 5H5B_RAT 352 26
TLFNKT 5H2A_HUMAN 381 30
TLFNKT 5H2A_PIG 380 30
TLFNKT 5H2A_MACMU 381 30
TAFNKN 5H5B_MOUSE 352 26
TLFNKI 5H2C_MOUSE 370 30
TLFNKI 5H2C_RAT 371 30
TLFNKI 5H2C_HUMAN 369 30
TLFNKT 5H2B_MOUSE 380 29
TLFNKT 5H2B_HUMAN 381 29
TLFNKT 5H2B_RAT 380 29
AFFNRD 5H7_XENLA 381 29
AFFNRD 5H7_CAVPO 386 29
AFFNRD P97842 388 29
AFFNRD P78336 385 29
AFFNRD 5H7_RAT 388 29
AFFNRD 5H7_HUMAN 385 29
SFFNRD 5H7_MOUSE 388 29
User query: Display/Full Code "5HTRECEPTOR"