WORKLIST ENTRIES (1):
AFLATOXINBRP View alignment View Structure Aflatoxin biosynthesis regulatory protein signature
Type of fingerprint: COMPOUND with 6 elements
Links:
PRINTS; PR00054 FUNGALZNCYS
INTERPRO; IPR002409
Creation date 25-AUG-1997; UPDATE 06-JUN-1999
1. WOLOSHUK, C.P., FOUTZ, K.R., BREWER, J.F., BHATNAGAR, D.,
CLEVELAND, T.E. AND PAYNE, G.A.
Molecular characterization of aflR, a regulatory locus for
aflatoxin biosynthesis.
APPL.ENVIRON.MICROBIOL. 60(7) 2408-2414 (1994).
2. PAN, T. AND COLEMAN, J.E.
GAL4 transcription factor is not a "zinc finger" but forms a Zn(II)2Cys6
binuclear cluster.
PROC.NATL.ACAD.SCI.U.S.A. 87 2077-2081 (1990).
3. MARMORSTEIN, R., CAREY, M., PTASHNE, M. AND HARRISON, S.C.
DNA recognition by GAL4: structure of a protein-DNA complex.
NATURE 356 408-414 (1992).
Aflatoxins belong to a family of decaketides that are produced as secondary
metabolites by Aspergillus flavus and A.parasiticus [1]. The aflatoxin
biosynthetic pathway involves several enzymatic steps that appear to be
regulated by the afl2 gene in A.flavus and the apa2 gene in A.parasiticus
[1]. These genes are homologues and have been designated aflR [1].
AflR encodes a protein that contains a cysteine-rich motif. Several fungal
transcriptional activator proteins contain this motif, which binds DNA in
a zinc-dependent fashion. The motif forms a binuclear zinc cluster in which
six conserved cysteines bind two zinc cations [2,3].
AFLATOXINBRP is a 6-element fingerprint that provides a signature for
aflatoxin biosynthesis regulatory proteins. The fingerprint was derived
from an initial alignment of 3 sequences: the motifs were drawn from
conserved regions spanning virtually the full alignment length - motifs
1 and 2 span the region encoded by PROSITE pattern ZN2_CY6_FUNGAL (PS00463),
which contains the binuclear cluster motif. A single iteration on OWL29.4
was required to reach convergence, no further sequences being identified
beyond the starting set.
An update on SPTR37_9f identified a true set of 3 sequences.
SUMMARY INFORMATION
3 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
6| 3 3 3 3 3 3
5| 0 0 0 0 0 0
4| 0 0 0 0 0 0
3| 0 0 0 0 0 0
2| 0 0 0 0 0 0
--+-------------------------------
| 1 2 3 4 5 6
True positives..
AFLR_ASPFL AFLR_ASPPA AFLR_EMENI
PROTEIN TITLES
AFLR_ASPFL AFLATOXIN BIOSYNTHESIS REGULATORY PROTEIN - ASPERGILLUS FLAV
AFLR_ASPPA AFLATOXIN BIOSYNTHESIS REGULATORY PROTEIN - ASPERGILLUS PARA
AFLR_EMENI STERIGMATOCYSTIN BIOSYNTHESIS REGULATORY PROTEIN - EMERICELL
SCAN HISTORY
OWL29_4 1 50 NSINGLE
SPTR37_9f 2 4 NSINGLE
INITIAL MOTIF SETS
AFLATOXINBRP1 Length of motif = 20 Motif number = 1
Aflatoxin motif I - 1
PCODE ST INT
RRARKLRDSCTSCASSKVRC AFLR_ASPFL 20 20
RRARKLRDSCTSCASSKVRC AFLR_ASPPA 20 20
QGTRKLRESCISCSRSKVKC AFLR_EMENI 19 19
AFLATOXINBRP2 Length of motif = 23 Motif number = 2
Aflatoxin motif II - 1
PCODE ST INT
KEKPACARCIERGLACQYMVSKR AFLR_ASPFL 41 1
KEKPACARCIERGLACQYMVSKR AFLR_ASPPA 41 1
KEKPTCSRCVRRGLPCEYMVSRR AFLR_EMENI 40 1
AFLATOXINBRP3 Length of motif = 20 Motif number = 3
Aflatoxin motif III - 1
PCODE ST INT
RYCCFSLALQTLTHLFPHAP AFLR_ASPFL 231 167
RYCCFSLALQTLTCLFPHAP AFLR_ASPPA 231 167
HSYCLSICLDTLMRLFPNAG AFLR_EMENI 214 151
AFLATOXINBRP4 Length of motif = 22 Motif number = 4
Aflatoxin motif IV - 1
PCODE ST INT
YLLSMVVLIVLKVLAWYAAAAG AFLR_ASPFL 297 46
YLLSMVVLIVLKVLGWYAAAAG AFLR_ASPPA 297 46
YVVTLVSLIVFKVLGWYVAAAR AFLR_EMENI 278 44
AFLATOXINBRP5 Length of motif = 23 Motif number = 5
Aflatoxin motif V - 1
PCODE ST INT
CLTEERVLHLPSMMGEDCVDEED AFLR_ASPFL 346 27
CLTEERVLHHPSMVGEDCVDEED AFLR_ASPPA 346 27
SSFEEQVLHLPTVVGTYCIDGHH AFLR_EMENI 325 25
AFLATOXINBRP6 Length of motif = 22 Motif number = 6
Aflatoxin motif VI - 1
PCODE ST INT
ELHRVQSLVNLLAKRLQEGGDD AFLR_ASPFL 380 11
ELHRVQSLANLLAKRLQEGGDD AFLR_ASPPA 380 11
ELYRVQRLVTQVSRRLESIRRR AFLR_EMENI 359 11
FINAL MOTIF SETS
AFLATOXINBRP1 Length of motif = 20 Motif number = 1
Aflatoxin motif I - 2
PCODE ST INT
RRARKLRDSCTSCASSKVRC AFLR_ASPFL 20 20
RRARKLRDSCTSCASSKVRC AFLR_ASPPA 20 20
QGTRKLRESCISCSRSKVKC AFLR_EMENI 19 19
AFLATOXINBRP2 Length of motif = 23 Motif number = 2
Aflatoxin motif II - 2
PCODE ST INT
KEKPACARCIERGLACQYMVSKR AFLR_ASPFL 41 1
KEKPACARCIERGLACQYMVSKR AFLR_ASPPA 41 1
KEKPTCSRCVRRGLPCEYMVSRR AFLR_EMENI 40 1
AFLATOXINBRP3 Length of motif = 20 Motif number = 3
Aflatoxin motif III - 2
PCODE ST INT
RYCCFSLALQTLTHLFPHAP AFLR_ASPFL 231 167
RYCCFSLALQTLTCLFPHAP AFLR_ASPPA 231 167
HSYCLSICLDTLMRLFPNAG AFLR_EMENI 214 151
AFLATOXINBRP4 Length of motif = 22 Motif number = 4
Aflatoxin motif IV - 2
PCODE ST INT
YLLSMVVLIVLKVLAWYAAAAG AFLR_ASPFL 297 46
YLLSMVVLIVLKVLGWYAAAAG AFLR_ASPPA 297 46
YVVTLVSLIVFKVLGWYVAAAR AFLR_EMENI 278 44
AFLATOXINBRP5 Length of motif = 23 Motif number = 5
Aflatoxin motif V - 2
PCODE ST INT
CLTEERVLHLPSMMGEDCVDEED AFLR_ASPFL 346 27
CLTEERVLHHPSMVGEDCVDEED AFLR_ASPPA 346 27
SSFEEQVLHLPTVVGTYCIDGHH AFLR_EMENI 325 25
AFLATOXINBRP6 Length of motif = 22 Motif number = 6
Aflatoxin motif VI - 2
PCODE ST INT
ELHRVQSLVNLLAKRLQEGGDD AFLR_ASPFL 380 11
ELHRVQSLANLLAKRLQEGGDD AFLR_ASPPA 380 11
ELYRVQRLVTQVSRRLESIRRR AFLR_EMENI 359 11
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