WORKLIST ENTRIES (1):

AMINACHANNEL View alignment     Amiloride-sensitive sodium channel alpha-subunit signature
 Type of fingerprint: COMPOUND with 13 elements
Links:
   INTERPRO; IPR001873
   PROSITE; PS01206 ASC
   PFAM; PF00858 ASC

 Creation date 03-FEB-1999; UPDATE 12-JUN-1999

   1. GARTY, H.
   Molecular properties of epithelial, amiloride-blockable Na+ channels.
   FASEB J. 8 522-528 (1994).

   2. JENTSCH, T.J.
   Trinity of cation channels. 
   NATURE 367 412-413 (1994).

   3, LE, T. AND SAIER, M.H.
   Phylogenetic characterization of the epithelial Na+ channel
   (ENaC) family.
   MOL.MEMBR.BIOL. 13 149-157 (1996).

   4. WALDMANN, R., CHAMPIGNY, G., BASSILANA, F., VOILLEY, N. AND LAZDUNSKI, M.
   Molecular cloning and functional expression of a novel amiloride-sensitive
   Na+ channel.
   J.BIOL.CHEM. 270(46) 27411-27414 (1995).

   5. SNYDER, P.M., MCDONALD, F.J., STOKES, J.B. AND WELSH, M.J.
   Membrane topology of the amiloride-sensitive epithelial sodium channel.
   J.BIOL.CHEM. 269(39) 24379-24383 (1994).

   The apical membrane of many tight epithelia contains sodium channels that
   are primarily characterised by their high affinity to the diuretic blocker
   amiloride [1-4]. These channels mediate the first step of active sodium
   reabsorption essential for the maintenance of body salt and water
   homeostasis [1]. In vertebrates, the channels control reabsorption of
   sodium in kidney, colon, lung and sweat glands; they also play a role in
   taste perception. 
  
   Members of the epithelial Na+ channel (ENaC) family fall into four 
   subfamilies, termed alpha, beta, gamma and delta [3]. The proteins exhibit
   the same apparent topology, each with two transmembrane (TM) spanning
   segments, separated by a large extracellular loop. In most ENaC proteins
   studied to date, the extracellular domains are highly conserved and contain
   numerous cysteine residues, with flanking C-terminal amphipathic TM regions,
   postulated to contribute to the formation of the hydrophilic pores of the 
   oligomeric channel protein complexes. It is thought that the well-conserved
   extracellular domains serve as receptors to control the activities of the 
   channels [3]. 
  
   Vertebrate ENaC proteins are similar to degenerins of Caenorhabditis elegans
   [5]: deg-1, del-1, mec-4, mec-10 and unc-8. These proteins can be mutated to
   cause neuronal degradation, and are also thought to form sodium channels.
  
   AMINACHANNEL is a 13-element fingerprint that provides a signature for
   amiloride-sensitive sodium channels. The fingerprint was derived from an
   initial alignment of 18 sequences: the motifs were drawn from conserved
   regions spanning virtually the full alignment length - motif 1 spans
   putative TM domain 1; motifs 2-12 reside in the central extracellular
   domain; and motif 13 encodes the N-terminus of putative TM domain 2. Two
   iterations on OWL31.1 were required to reach convergence, at which point a
   true set comprising 30 sequences was identified. Numerous partial matches
   were also found, all of which are homologues and fragments that fail to
   match six or more motifs.
  
   An update on SPTR37_9f identified a true set of 25 sequences, and 32
   partial matches.

  SUMMARY INFORMATION
     25 codes involving 13 elements
      0 codes involving 12 elements
      0 codes involving 11 elements
      0 codes involving 10 elements
      4 codes involving  9 elements
      3 codes involving  8 elements
      3 codes involving  7 elements
      1 codes involving  6 elements
      0 codes involving  5 elements
      7 codes involving  4 elements
      3 codes involving  3 elements
     11 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
   13|  25   25   25   25   25   25   25   25   25   25   25   25   25  
   12|   0    0    0    0    0    0    0    0    0    0    0    0    0  
   11|   0    0    0    0    0    0    0    0    0    0    0    0    0  
   10|   0    0    0    0    0    0    0    0    0    0    0    0    0  
    9|   4    4    3    4    4    4    1    0    0    4    4    0    4  
    8|   1    3    2    1    3    3    2    0    0    3    3    0    3  
    7|   2    2    0    1    3    3    1    0    1    3    2    0    3  
    6|   0    1    0    0    1    1    0    0    0    1    1    0    1  
    5|   0    0    0    0    0    0    0    0    0    0    0    0    0  
    4|   3    5    1    0    3    3    0    1    2    0    3    0    7  
    3|   2    1    2    0    2    0    0    0    0    0    0    0    2  
    2|   3    5    0    0    2    1    1    0    3    1    0    0    6  
   --+------------------------------------------------------------------
     |   1    2    3    4    5    6    7    8    9   10   11   12   13  

True positives..
 SCAA_HUMAN     SCAA_RAT       SCG2_XENLA     SCAG_XENLA     
 SCAA_BOVIN     SCAA_CHICK     SCAG_RAT       SCB2_XENLA     
 SCAA_XENLA     MEC4_CAEEL     SCAB_XENLA     SCAB_HUMAN     
 MEC4_CAEBR     SCAG_HUMAN     SCAB_RAT       ME10_CAEEL     
 DEGX_CAEEL     DEGY_CAEEL     DEG1_CAEEL     UNC8_CAEEL     
 DEL1_CAEEL     SCAD_HUMAN     O46547         P91835         
 DEGW_CAEEL     
Subfamily:  Codes involving 9 elements
 Subfamily True positives..
 ASC1_RAT       P78349         P78348         O35240         
Subfamily:  Codes involving 8 elements
 Subfamily True positives..
 O75906         O88762         O60263         
Subfamily:  Codes involving 7 elements
 Subfamily True positives..
 FANA_HELAS     BNA1_HUMAN     BNA1_RAT       
Subfamily:  Codes involving 6 elements
 Subfamily True positives..
 O55163         
Subfamily:  Codes involving 4 elements
 Subfamily True positives..
 Q20851         P91100         Q22970         O77036         
 Q19115         YSX7_CAEEL     O61365         
Subfamily:  Codes involving 3 elements
 Subfamily True positives..
 Q94181         O45402         O61370         
Subfamily:  Codes involving 2 elements
 Subfamily True positives..
 P91102         O46342         Q19777         O44940         
 O46104         Q08265         PSG1_HUMAN     Q18077         
 P91103         P97820         O92933         


  PROTEIN TITLES
   SCAA_HUMAN       AMILORIDE-SENSITIVE SODIUM CHANNEL ALPHA-SUBUNIT (LUNG NA+ C
   SCAA_RAT         AMILORIDE-SENSITIVE SODIUM CHANNEL ALPHA-SUBUNIT (EPITHELIAL
   SCG2_XENLA       AMILORIDE-SENSITIVE SODIUM CHANNEL GAMMA-2-SUBUNIT (EPITHELI
   SCAG_XENLA       AMILORIDE-SENSITIVE SODIUM CHANNEL GAMMA-SUBUNIT (EPITHELIAL
   SCAA_BOVIN       AMILORIDE-SENSITIVE SODIUM CHANNEL ALPHA-SUBUNIT (EPITHELIAL
   SCAA_CHICK       AMILORIDE-SENSITIVE SODIUM CHANNEL ALPHA-SUBUNIT (EPITHELIAL
   SCAG_RAT         AMILORIDE-SENSITIVE SODIUM CHANNEL GAMMA-SUBUNIT (EPITHELIAL
   SCB2_XENLA       AMILORIDE-SENSITIVE SODIUM CHANNEL BETA-2-SUBUNIT (EPITHELIA
   SCAA_XENLA       AMILORIDE-SENSITIVE SODIUM CHANNEL ALPHA-SUBUNIT (LUNG NA+ C
   MEC4_CAEEL       MECHANOSENSORY PROTEIN 4 (DEGENERIN MEC-4) - CAENORHABDITIS 
   SCAB_XENLA       AMILORIDE-SENSITIVE SODIUM CHANNEL BETA-SUBUNIT (EPITHELIAL 
   SCAB_HUMAN       AMILORIDE-SENSITIVE SODIUM CHANNEL BETA-SUBUNIT (EPITHELIAL 
   MEC4_CAEBR       MECHANOSENSORY PROTEIN 4 (DEGENERIN MEC-4) - CAENORHABDITIS 
   SCAG_HUMAN       AMILORIDE-SENSITIVE SODIUM CHANNEL GAMMA-SUBUNIT (EPITHELIAL
   SCAB_RAT         AMILORIDE-SENSITIVE SODIUM CHANNEL BETA-SUBUNIT (EPITHELIAL 
   ME10_CAEEL       MECHANOSENSORY PROTEIN 10 (DEGENERIN MEC-10) - CAENORHABDITI
   DEGX_CAEEL       DEGENERIN-LIKE PROTEIN C41C4.5 IN CHROMOSOME II - CAENORHABD
   DEGY_CAEEL       DEGENERIN-LIKE PROTEIN ZK770.1 IN CHROMOSOME I - CAENORHABDI
   DEG1_CAEEL       DEGENERIN DEG-1 - CAENORHABDITIS ELEGANS.
   UNC8_CAEEL       DEGENERIN UNC-8 - CAENORHABDITIS ELEGANS.
   DEL1_CAEEL       DEGENERIN DEL-1 - CAENORHABDITIS ELEGANS.
   SCAD_HUMAN       AMILORIDE-SENSITIVE SODIUM CHANNEL DELTA-SUBUNIT (EPITHELIAL
   O46547           EPITHELIAL SODIUM CHANNEL DELTA SUBUNIT - PAN TROGLODYTES (C
   P91835           T28B8.5 PROTEIN - CAENORHABDITIS ELEGANS.
   DEGW_CAEEL       DEGENERIN-LIKE PROTEIN T28F4.2 IN CHROMOSOME I - CAENORHABDI
 
   ASC1_RAT         PROTON GATED CATION CHANNEL ASIC1 - RATTUS NORVEGICUS (RAT).
   P78349           SODIUM CHANNEL 2 - HOMO SAPIENS (HUMAN).
   P78348           SODIUM CHANNEL 2 - HOMO SAPIENS (HUMAN).
   O35240           PROTON GATED CATION CHANNEL DRASIC - RATTUS NORVEGICUS (RAT)
 
   O75906           PROTON-GATED CATION CHANNEL SUBUNIT - HOMO SAPIENS (HUMAN).
   O88762           ASIC-BETA - RATTUS NORVEGICUS (RAT).
   O60263           SODIUM CHANNEL - HOMO SAPIENS (HUMAN).
 
   FANA_HELAS       FMRFAMIDE-ACTIVATED AMILORIDE-SENSITIVE SODIUM CHANNEL (FANA
   BNA1_HUMAN       AMILORIDE-SENSITIVE BRAIN SODIUM CHANNEL BNAC1 (BNC1) (DEGEN
   BNA1_RAT         AMILORIDE-SENSITIVE BRAIN SODIUM CHANNEL BNAC1 (BNC1) (DEGEN
 
   O55163           PROTON-GATED CATION CHANNELS MODULATORY SUBUNIT MDEG2 - RATT
 
   Q20851           COSMID F55G1 - CAENORHABDITIS ELEGANS.
   P91100           SIMILAR TO DEGENERINS - CAENORHABDITIS ELEGANS.
   Q22970           SIMILAR TO AMILORIDE-SENITIVE SODIIUM CHANNEL SUBUNIT - CAEN
   O77036           FLR-1 - CAENORHABDITIS ELEGANS.
   Q19115           F02D10.5 PROTEIN - CAENORHABDITIS ELEGANS.
   YSX7_CAEEL       HYPOTHETICAL 113.1 KD PROTEIN T28D9.7 IN CHROMOSOME II - CAE
   O61365           PUTATIVE SODIUM CHANNEL - DROSOPHILA MELANOGASTER (FRUIT FLY
 
   Q94181           SIMILAR TO SODIUM CHANNEL SUBUNIT - CAENORHABDITIS ELEGANS.
   O45402           F23B2.3 PROTEIN - CAENORHABDITIS ELEGANS.
   O61370           PUTATIVE SODIUM CHANNEL - DROSOPHILA ANANASSAE (FRUIT FLY).
 
   P91102           SIMILAR TO DEGENERINS - CAENORHABDITIS ELEGANS.
   O46342           AMILORIDE-SENSITIVE NA+ CHANNEL - DROSOPHILA MELANOGASTER (F
   Q19777           F25D1.4 PROTEIN - CAENORHABDITIS ELEGANS.
   O44940           AMILORIDE-SENSITIVE NA+ CHANNEL - DROSOPHILA MELANOGASTER (F
   O46104           DROSOPHILA MULTIDENDRITIC NEURONS SODIUM CHANNEL 1 - DROSOPH
   Q08265           PREGNANCY-SPECIFIC BETA-1 GLYCOPROTEIN PRECURSOR - HOMO SAPI
   PSG1_HUMAN       PREGNANCY-SPECIFIC BETA-1-GLYCOPROTEIN 1 PRECURSOR (PSBG-1) 
   Q18077           SIMILAR TO AMILORIDE-SENSITIVE SODIUM CHANNEL BETA-SUBUNIT -
   P91103           SIMILAR TO DEGENERINS - CAENORHABDITIS ELEGANS.
   P97820           NIK - MUS MUSCULUS (MOUSE).
   O92933           POLYPROTEIN - HEPATITIS C VIRUS.

SCAN HISTORY OWL31_1 2 100 NSINGLE SPTR37_9f 2 100 NSINGLE INITIAL MOTIF SETS AMINACHANNEL1 Length of motif = 18 Motif number = 1 Amiloride-sensitive sodium channel motif I - 1 PCODE ST INT TAFWAVLWLCTFGMMYWQ SCAA_HUMAN 84 84 TAFWAVLWLCTFGMMYWQ SCAA_RAT 110 110 TAFWLVLFLVTFGLMYWQ SCAA_XENLA 48 48 TAFWSVLFILTFGLMYWQ SCAA_CHICK 76 76 TVFWAVLWLCTFGMMYWQ SCAA_BOVIN 64 64 RLLWIGFTLTAVALILWQ SCAG_HUMAN 53 53 RLLWIAFTLTAVALIIWQ SCAG_RAT 53 53 KAMWFLLTLLFAALVCWQ SCAB_HUMAN 49 49 KAMWFLLTLLFACLVCWQ SCAB_RAT 49 49 TTSWGLLSLGALVALCWQ SCAD_HUMAN 85 85 RFLWVVVSLVCICLCMYS DEL1_CAEEL 67 67 KLMWGLIIFSFLLMFAYQ DEG1_CAEEL 80 80 RAAWVFLLLICAIQFINQ ME10_CAEEL 121 121 RAVWVMLFLGCMIMLYLN MEC4_CAEBR 108 108 RAVWVVLFLGCMIMLYLN MEC4_CAEEL 108 108 RYVWAALFMCMLMAFLLQ UNC8_CAEEL 127 127 RYMWLLCFLFCLSCFGHQ DEGY_CAEEL 57 57 RWFWYTAFTICLLALLIQ DEGX_CAEEL 92 92 AMINACHANNEL2 Length of motif = 17 Motif number = 2 Amiloride-sensitive sodium channel motif II - 1 PCODE ST INT DKLVFPAVTICTLNPYR SCAA_HUMAN 123 21 DKLVFPAVTVCTLNPYR SCAA_RAT 149 21 DKLPFPAVTVCTLNPYR SCAA_XENLA 87 21 DRLTFPAVTLCTLNPYR SCAA_CHICK 115 21 DKLVFPAVSICTLNPYR SCAA_BOVIN 103 21 RKLDFPAVTICNINPYK SCAG_HUMAN 90 19 QKLDFPAVTICNINPYK SCAG_RAT 90 19 KTMDFPAVTICNASPFK SCAB_HUMAN 88 21 KTMNFPAVTVCNSSPFQ SCAB_RAT 88 21 ERKLLPLVTLCDGNPRR SCAD_HUMAN 124 21 ESAPFPAITVCNLNPFK DEL1_CAEEL 106 21 DDVEFPAITFCNLNPYK DEG1_CAEEL 119 21 DTAPFPAITLCNLNPYK ME10_CAEEL 160 21 DTAPFPAITLCNLNPYK MEC4_CAEBR 147 21 DTAPFPAITLCNLNPYK MEC4_CAEEL 147 21 EAAAFPAATVCNLNAFK UNC8_CAEEL 166 21 EEIKFPAVTICNMNPYK DEGY_CAEEL 96 21 ENAPFPSITICNLNPYK DEGX_CAEEL 131 21 AMINACHANNEL3 Length of motif = 12 Motif number = 3 Amiloride-sensitive sodium channel motif III - 1 PCODE ST INT IFACRFNQVSCN SCAA_HUMAN 279 139 IFTCRFNQAPCN SCAA_RAT 307 141 IFACRFNEESCT SCAA_XENLA 238 134 IYACRFNEATCD SCAA_CHICK 266 134 IFTCRFNQDSCN SCAA_BOVIN 260 140 LVTCFFDGVSCD SCAG_HUMAN 257 150 LVTCFFDGMSCD SCAG_RAT 258 151 ILACLFGAEPCN SCAB_HUMAN 246 141 ILACLFGTEPCS SCAB_RAT 244 139 VLSCSYDGLDCQ SCAD_HUMAN 260 119 IKMCSFNGQQCN DEL1_CAEEL 338 215 IEMCSFNGKECD DEG1_CAEEL 436 300 IHKCSFNGKPCD ME10_CAEEL 407 230 VHKCSFNGKACD MEC4_CAEBR 448 284 VHKCSFNGKACD MEC4_CAEEL 447 283 VLRCSFNSKDCS UNC8_CAEEL 420 237 IMKCSFNGRECN DEGY_CAEEL 463 350 VLKCSFNQKDCQ DEGX_CAEEL 417 269 AMINACHANNEL4 Length of motif = 17 Motif number = 4 Amiloride-sensitive sodium channel motif IV - 1 PCODE ST INT NYSHFHHPMYGNCYTFN SCAA_HUMAN 293 2 NYSKFHHPMYGNCYTFN SCAA_RAT 321 2 NYSSFHHAIYGNCYTFN SCAA_XENLA 252 2 NYTHFHHPLYGNCYTFN SCAA_CHICK 280 2 NYSHFHHPMYGNCYTFN SCAA_BOVIN 274 2 NFTLFHHPMHGNCYTFN SCAG_HUMAN 271 2 NFTLFHHPMYGNCYTFN SCAG_RAT 272 2 NFTSIFYPHYGNCYIFN SCAB_HUMAN 260 2 NFTPIFYPDYGNCYIFN SCAB_RAT 258 2 QFRTFHHPTYGSCYTVD SCAD_HUMAN 274 2 EFKLHIDPSFGNCYTFN DEL1_CAEEL 353 3 DFRLHVDPEFGNCFTFN DEG1_CAEEL 451 3 DFELVADPTFGNCFVFN ME10_CAEEL 422 3 DFLTHIDPVFGSCFTFN MEC4_CAEBR 463 3 DFLTHIDPAFGSCFTFN MEC4_CAEEL 462 3 DFKLHVDPEYGNCYTFN UNC8_CAEEL 435 3 DFVEYLDPTYGACFTYG DEGY_CAEEL 478 3 DFTLHYDNTFGNCYTFN DEGX_CAEEL 432 3 AMINACHANNEL5 Length of motif = 19 Motif number = 5 Amiloride-sensitive sodium channel motif V - 1 PCODE ST INT GINNGLSLMLRAEQNDFIP SCAA_HUMAN 323 13 GVNNGLSLTLRTEQNDFIP SCAA_RAT 351 13 GIKNGLTLVLRTEQHDYIP SCAA_XENLA 284 15 GINNGLSLVVRTEQNDFIP SCAA_CHICK 309 12 GVNNGLSLTLRTEQNDFIP SCAA_BOVIN 304 13 GSEYGLQVILYINEEEYNP SCAG_HUMAN 301 13 GSEYGLQVILYINEDEYNP SCAG_RAT 302 13 GTEFGLKLILDIGQEDYVP SCAB_HUMAN 290 13 GTEFGLKLILDIGQEDYVP SCAB_RAT 288 13 GITHGVGLVLRVEQQPHLP SCAD_HUMAN 299 8 GPSYGLRLMMFVNSSDYLP DEL1_CAEEL 382 12 GPMYGIRVLLFVNTSDYMS DEG1_CAEEL 480 12 GPQYGLRVMLFVNASDYLP ME10_CAEEL 451 12 GPMYGLRMLVYVNASDYMP MEC4_CAEBR 492 12 GPMYGLRMLVYVNASDYMP MEC4_CAEEL 491 12 GPMYGLRLLLNVHQSDYMP UNC8_CAEEL 464 12 GPAYGLRLEVFVNVTEYLP DEGY_CAEEL 506 11 GANYGLRVLLYANVSEYLP DEGX_CAEEL 461 12 AMINACHANNEL6 Length of motif = 19 Motif number = 6 Amiloride-sensitive sodium channel motif VI - 1 PCODE ST INT GARVMVHGQDEPAFMDDGG SCAA_HUMAN 348 6 GARVMVHGQDEPAFMDDGG SCAA_RAT 376 6 GARVLVHGHKEPAFMDDNG SCAA_XENLA 309 6 GARVMVHDQNEPAFMDDGG SCAA_CHICK 334 6 GARVMVHERDEPAFMDDAG SCAA_BOVIN 329 6 GAKVIIHRQDEYPSVEDVG SCAG_HUMAN 326 6 GAKVLIHQQNEYPFIEDVG SCAG_RAT 327 6 GVRLMLHEQRSYPFIRDEG SCAB_HUMAN 315 6 GARLMLHEQRTYPFIREEG SCAB_RAT 313 6 GIRVMVHGRNHTPFLGHHS SCAD_HUMAN 324 6 GVRIAIHGKEECPFPDTFG DEL1_CAEEL 406 5 GVRLAIHPPTEYPFPDTFG DEG1_CAEEL 504 5 GIRLTIHDKDDFPFPDTFG ME10_CAEEL 475 5 GVRLTIHDKEDFPFPDTFG MEC4_CAEBR 516 5 GVRLTIHDKEDFPFPDTFG MEC4_CAEEL 515 5 GVRLVVHEQDQEPFPDTFG UNC8_CAEEL 488 5 GVRLTVHATDEQPFPDTLG DEGY_CAEEL 530 5 GFRITVHDKHIVPFPDAFG DEGX_CAEEL 485 5 AMINACHANNEL7 Length of motif = 17 Motif number = 7 Amiloride-sensitive sodium channel motif VII - 1 PCODE ST INT SMRKETLDRLGGDYGDC SCAA_HUMAN 378 11 SMRKEALDSLGGNYGDC SCAA_RAT 406 11 GMKKETINRLGGKYSDC SCAA_XENLA 339 11 SMRKEMTERLGGSYSDC SCAA_CHICK 364 11 SMSKEAVDRLGGDYGDC SCAA_BOVIN 359 11 GMHLTESFKLSEPSSQC SCAG_HUMAN 356 11 GMHLTESFKLSEPYSQC SCAG_RAT 357 11 GVLVDKLQRMGEPYSPC SCAB_HUMAN 345 11 GVLLDKLQGKGEPYSPC SCAB_RAT 343 11 SIREDEVHRLGSPYGHC SCAD_HUMAN 354 11 GISLRNINRLPQPYGNC DEL1_CAEEL 436 11 GIKKKVMQRLPAPYGEC DEG1_CAEEL 534 11 GMRMKKMSRLPAPYGDC ME10_CAEEL 505 11 GLRLRKMSRLPAPYGDC MEC4_CAEBR 546 11 GLRLRKMSRLPAPYGDC MEC4_CAEEL 545 11 GLKTKELHRLSAPWGNC UNC8_CAEEL 518 11 GIKLKSMVRLPAPYGDC DEGY_CAEEL 560 11 GVRMKQFIRLEPPYGHC DEGX_CAEEL 515 11 AMINACHANNEL8 Length of motif = 12 Motif number = 8 Amiloride-sensitive sodium channel motif VIII - 1 PCODE ST INT YTQQVCIHSCFQ SCAA_HUMAN 411 16 YTQQVCIHSCFQ SCAA_RAT 439 16 YTEQVCVRSCFQ SCAA_XENLA 372 16 YTEQVCIRSCFQ SCAA_CHICK 397 16 YTQQVCIHSCFQ SCAA_BOVIN 392 16 YSLQICLHSCFQ SCAG_HUMAN 389 16 YSLQICLYSCFQ SCAG_RAT 390 16 YSIQACLRSCFQ SCAB_HUMAN 381 19 YSIQACLHSCFQ SCAB_RAT 379 19 YTRQACLVSCFQ SCAD_HUMAN 387 16 YEPEGCFRSCYQ DEL1_CAEEL 469 16 YHPEGCHRSCFQ DEG1_CAEEL 568 17 YSTEGCYRTCFQ ME10_CAEEL 537 15 YSVEGCYRSCFQ MEC4_CAEBR 578 15 YSVEGCYRSCFQ MEC4_CAEEL 577 15 YSPEGCHRNCFQ UNC8_CAEEL 549 14 YNTEGCQRSCIQ DEGY_CAEEL 592 15 YSVEACHRSCAQ DEGX_CAEEL 548 16 AMINACHANNEL9 Length of motif = 18 Motif number = 9 Amiloride-sensitive sodium channel motif IX - 1 PCODE ST INT QESMIKECGCAYIFYPRP SCAA_HUMAN 422 -1 QENMIKKCGCAYIFYPKP SCAA_RAT 450 -1 QAAMVARCGCGYAFYPLS SCAA_XENLA 383 -1 QLNMVKRCSCAYYFYPLP SCAA_CHICK 408 -1 QESMIKECGCAYIFYPRP SCAA_BOVIN 403 -1 QTKMVEKCGCAQYSQPLP SCAG_HUMAN 400 -1 QTKMVEKCGCAQYSQPLP SCAG_RAT 401 -1 QDHMIRNCNCGHYLYPLP SCAB_HUMAN 392 -1 QDHMIHNCSCGHYLYPLP SCAB_RAT 390 -1 QQLMVETCSCGYYLHPLP SCAD_HUMAN 398 -1 QYRIIAKCGCADPRYPKP DEL1_CAEEL 480 -1 QNGLIDDCSCGDPRFPVP DEG1_CAEEL 579 -1 QELIIDRCGCSDPRFPSI ME10_CAEEL 548 -1 QQLVLKECRCGDPRFPVP MEC4_CAEBR 589 -1 QQLVLKECRCGDPRFPVP MEC4_CAEEL 588 -1 QLKVLEICGCGDPRFPLP UNC8_CAEEL 560 -1 QKHLSKTCGCGDPRFPPY DEGY_CAEEL 603 -1 QKVIVEACGCADPMYPVA DEGX_CAEEL 559 -1 AMINACHANNEL10 Length of motif = 21 Motif number = 10 Amiloride-sensitive sodium channel motif X - 1 PCODE ST INT CRKPCSVTSYQLSAGYSRWPS SCAA_HUMAN 475 35 CRKPCSVINYKLSAGYSRWPS SCAA_RAT 503 35 CRKPCLVSEYQLTAGYSKWPN SCAA_XENLA 436 35 CRKPCKMTEYQLSAGYSRWPS SCAA_CHICK 461 35 CRKPCSVTIYKLSASYSQWPS SCAA_BOVIN 456 35 CKEACRFKEWTLTTSLAQWPS SCAG_HUMAN 453 35 CKQSCSFKEWTLTTSLAQWPS SCAG_RAT 454 35 CKESCNDTQYKMTISMADWPS SCAB_HUMAN 444 34 CKESCNDTQYKMTISMADWPS SCAB_RAT 442 34 CPRPCRESAFKLSTGTSRWPS SCAD_HUMAN 451 35 CIQPCQQDQYTTTYSAAKWPS DEL1_CAEEL 533 35 CKQSCEEIIHEVTFSCSKWPS DEG1_CAEEL 635 38 CQQPCNQTIYTTSYSEAIWPS ME10_CAEEL 600 34 CQQPCGQSIYSVTYSPAKWPS MEC4_CAEBR 641 34 CQQPCRQSIYSVTYSPAKWPS MEC4_CAEEL 640 34 CRQPCHEKVFETAYSASAWPS UNC8_CAEEL 614 36 CKQPCNQDVYSVSYSASRWPA DEGY_CAEEL 655 34 CHQPCQETNYEVTYSSARWPS DEGX_CAEEL 621 44 AMINACHANNEL11 Length of motif = 21 Motif number = 11 Amiloride-sensitive sodium channel motif XI - 1 PCODE ST INT RNGVAKVNIFFKELNYKTNSE SCAA_HUMAN 518 22 RNGVAKLNIFFKELNYKTNSE SCAA_RAT 546 22 RNGIAKLNIYFEELNYKTILE SCAA_XENLA 476 19 RNGVAKVNIFFEEWNYKTNGE SCAA_CHICK 504 22 RDGVAKLNIFFKELNYKSNSE SCAA_BOVIN 499 22 KTDLAKLLIFYKDLNQRSIME SCAG_HUMAN 498 24 KTDLAKLLIFYKDLNQRSIME SCAG_RAT 499 24 RKGIVKLNIYFQEFNYRTIEE SCAB_HUMAN 489 24 RKGIVKLNIYFQEFNYRTIEE SCAB_RAT 487 24 RSSLAKINIVYQELNYRSVEE SCAD_HUMAN 495 23 REHAAMIEIYYEQMSYEILRE DEL1_CAEEL 572 18 RLNAAMIEVFYEQLNYELLQE DEG1_CAEEL 676 20 KENAAMLEVFYEALNFEVLSE ME10_CAEEL 642 21 KENGAMVEVFYEQLNFEMLTE MEC4_CAEBR 683 21 KENGAMVEVFYEQLNFEMLTE MEC4_CAEEL 682 21 RQNTAYIEIYYEQLNFESLKE UNC8_CAEEL 661 26 REQGSMIEVYFEQLNYESLLE DEGY_CAEEL 697 21 RKNAAMVQIFYEELNYETMQE DEGX_CAEEL 661 19 AMINACHANNEL12 Length of motif = 15 Motif number = 12 Amiloride-sensitive sodium channel motif XII - 1 PCODE ST INT ESPSVTMVTLLSNLG SCAA_HUMAN 538 -1 ESPSVTMVSLLSNLG SCAA_RAT 566 -1 ESPTINMAMLLSLLG SCAA_XENLA 496 -1 ESPAFTVVTLLSQLG SCAA_CHICK 524 -1 ESPSVTMVTLLSNLG SCAA_BOVIN 519 -1 ESPANSIEMLLSNFG SCAG_HUMAN 518 -1 ESPANSIEMLLSNFG SCAG_RAT 519 -1 ESAANNIVWLLSNLG SCAB_HUMAN 509 -1 ESPANNIVWLLSNLG SCAB_RAT 507 -1 EAPVYSVPQLLSAMG SCAD_HUMAN 515 -1 ESESYSWFNLMADMG DEL1_CAEEL 592 -1 ESEAYGLVNLIADFG DEG1_CAEEL 696 -1 ESEAYGIVKMMADFG ME10_CAEEL 662 -1 ESEAYGFVNLLADFG MEC4_CAEBR 703 -1 ESEAYGFVNLLADFG MEC4_CAEEL 702 -1 ETAGYTLVNLFSDFG UNC8_CAEEL 681 -1 ESEAYGWSNLLSDFG DEGY_CAEEL 717 -1 ESPAYTLTSVLADLG DEGX_CAEEL 681 -1 AMINACHANNEL13 Length of motif = 17 Motif number = 13 Amiloride-sensitive sodium channel motif XIII - 1 PCODE ST INT GSQWSLWFGSSVLSVVE SCAA_HUMAN 552 -1 GSQWSLWFGSSVLSVVE SCAA_RAT 580 -1 GSQWSLWFGSSVLSVVE SCAA_XENLA 510 -1 GNQWSLWFGSSVLSVME SCAA_CHICK 538 -1 GSQWSLWFGSSVLSVVE SCAA_BOVIN 533 -1 GGQLGLWMSCSVVCVIE SCAG_HUMAN 532 -1 GGQLGLWMSCSVVCVIE SCAG_RAT 533 -1 GGQFGFWMGGSVLCLIE SCAB_HUMAN 523 -1 GGQFGFWMGGSVLCLIE SCAB_RAT 521 -1 GSLYSLWFGASVLSLLE SCAD_HUMAN 529 -1 GGQAGLFLGASIMSVIE DEL1_CAEEL 606 -1 GGHLGLWLGFSVITVME DEG1_CAEEL 710 -1 GGHLGLWSGVSVMTCCE ME10_CAEEL 676 -1 GGQLGLWCGISFLTCCE MEC4_CAEBR 717 -1 GGQLGLWCGISFLTCCE MEC4_CAEEL 716 -1 GGNIGLWIGFSVITFAE UNC8_CAEEL 695 -1 GGQLGLWMGVSVITIGE DEGY_CAEEL 731 -1 GGLTGLWIGASVVSLLE DEGX_CAEEL 695 -1 FINAL MOTIF SETS AMINACHANNEL1 Length of motif = 18 Motif number = 1 Amiloride-sensitive sodium channel motif I - 2 PCODE ST INT TAFWAVLWLCTFGMMYWQ SCAA_HUMAN 84 84 TAFWAVLWLCTFGMMYWQ SCAA_RAT 110 110 RWIWIVLTLIAVALIFWQ SCG2_XENLA 54 54 RWIWISLTLCAVAVIFWQ SCAG_XENLA 54 54 TVFWAVLWLCTFGMMYWQ SCAA_BOVIN 64 64 TAFWSVLFILTFGLMYWQ SCAA_CHICK 76 76 RLLWIAFTLTAVALIIWQ SCAG_RAT 53 53 RVMWFILTLVFAGLVFWQ SCB2_XENLA 55 55 TAFWLVLFLVTFGLMYWQ SCAA_XENLA 48 48 RAVWVVLFLGCMIMLYLN MEC4_CAEEL 108 108 RVMWFILTLVFAGLVFWQ SCAB_XENLA 55 55 KAMWFLLTLLFAALVCWQ SCAB_HUMAN 49 49 RAVWVMLFLGCMIMLYLN MEC4_CAEBR 108 108 RLLWIGFTLTAVALILWQ SCAG_HUMAN 53 53 KAMWFLLTLLFACLVCWQ SCAB_RAT 49 49 RAAWVFLLLICAIQFINQ ME10_CAEEL 121 121 RWFWYTAFTICLLALLIQ DEGX_CAEEL 92 92 RYMWLLCFLFCLSCFGHQ DEGY_CAEEL 57 57 KLMWGLIIFSFLLMFAYQ DEG1_CAEEL 80 80 RYVWAALFMCMLMAFLLQ UNC8_CAEEL 127 127 RFLWVVVSLVCICLCMYS DEL1_CAEEL 67 67 TTSWGLLSLGALVALCWQ O46547 85 85 TTSWGLLSLGALVALCWQ SCAD_HUMAN 85 85 RAFWILVVVVSIALFIWQ P91835 36 36 RIFWIAIFLFVLGMFAYE DEGW_CAEEL 34 34 AMINACHANNEL2 Length of motif = 17 Motif number = 2 Amiloride-sensitive sodium channel motif II - 2 PCODE ST INT DKLVFPAVTICTLNPYR SCAA_HUMAN 123 21 DKLVFPAVTVCTLNPYR SCAA_RAT 149 21 QKLVYPAVTICNLNPYS SCG2_XENLA 91 19 QKLVYPAVTICNLNPYS SCAG_XENLA 91 19 DKLVFPAVSICTLNPYR SCAA_BOVIN 103 21 DRLTFPAVTLCTLNPYR SCAA_CHICK 115 21 QKLDFPAVTICNINPYK SCAG_RAT 90 19 KTMEFPAVTVCNTNPYK SCB2_XENLA 94 21 DKLPFPAVTVCTLNPYR SCAA_XENLA 87 21 DTAPFPAITLCNLNPYK MEC4_CAEEL 147 21 KTMEFPAVTLCNANPFK SCAB_XENLA 94 21 KTMDFPAVTICNASPFK SCAB_HUMAN 88 21 DTAPFPAITLCNLNPYK MEC4_CAEBR 147 21 RKLDFPAVTICNINPYK SCAG_HUMAN 90 19 KTMNFPAVTVCNSSPFQ SCAB_RAT 88 21 DTAPFPAITLCNLNPYK ME10_CAEEL 160 21 ENAPFPSITICNLNPYK DEGX_CAEEL 131 21 EEIKFPAVTICNMNPYK DEGY_CAEEL 96 21 DDVEFPAITFCNLNPYK DEG1_CAEEL 119 21 EAAAFPAATVCNLNAFK UNC8_CAEEL 166 21 ESAPFPAITVCNLNPFK DEL1_CAEEL 106 21 ERKLLPLVTLCDGNPRR O46547 124 21 ERKLLPLVTLCDGNPRR SCAD_HUMAN 124 21 AERTFPTVTICHLNPWK P91835 75 21 EKQIFPVVTVCNMNPYK DEGW_CAEEL 73 21 AMINACHANNEL3 Length of motif = 12 Motif number = 3 Amiloride-sensitive sodium channel motif III - 2 PCODE ST INT IFACRFNQVSCN SCAA_HUMAN 279 139 IFTCRFNQAPCN SCAA_RAT 307 141 IVTCLFDGLSCD SCG2_XENLA 260 152 IVTCFFDGLSCD SCAG_XENLA 260 152 IFTCRFNQDSCN SCAA_BOVIN 260 140 IYACRFNEATCD SCAA_CHICK 266 134 LVTCFFDGMSCD SCAG_RAT 258 151 ILTCLFGGQPCS SCB2_XENLA 264 153 IFACRFNEESCT SCAA_XENLA 238 134 VHKCSFNGKACD MEC4_CAEEL 447 283 ILTCLFGGQPCS SCAB_XENLA 265 154 ILACLFGAEPCN SCAB_HUMAN 246 141 VHKCSFNGKACD MEC4_CAEBR 448 284 LVTCFFDGVSCD SCAG_HUMAN 257 150 ILACLFGTEPCS SCAB_RAT 244 139 IHKCSFNGKPCD ME10_CAEEL 407 230 VLKCSFNQKDCQ DEGX_CAEEL 417 269 IMKCSFNGRECN DEGY_CAEEL 463 350 IEMCSFNGKECD DEG1_CAEEL 436 300 VLRCSFNSKDCS UNC8_CAEEL 420 237 IKMCSFNGQQCN DEL1_CAEEL 338 215 VLSCSYDGLDCQ O46547 260 119 VLSCSYDGLDCQ SCAD_HUMAN 260 119 VVSCTYNAKTCN P91835 183 91 IQDCSFAGIPCS DEGW_CAEEL 165 75 AMINACHANNEL4 Length of motif = 17 Motif number = 4 Amiloride-sensitive sodium channel motif IV - 2 PCODE ST INT NYSHFHHPMYGNCYTFN SCAA_HUMAN 293 2 NYSKFHHPMYGNCYTFN SCAA_RAT 321 2 NFTLFHHPLYGNCYTFN SCG2_XENLA 274 2 NFTLFHHPLYGNCYTFN SCAG_XENLA 274 2 NYSHFHHPMYGNCYTFN SCAA_BOVIN 274 2 NYTHFHHPLYGNCYTFN SCAA_CHICK 280 2 NFTLFHHPMYGNCYTFN SCAG_RAT 272 2 NFTHIYDADYGNCYIFN SCB2_XENLA 278 2 NYSSFHHAIYGNCYTFN SCAA_XENLA 252 2 DFLTHIDPAFGSCFTFN MEC4_CAEEL 462 3 NFTHIYDADYGNCYIFN SCAB_XENLA 279 2 NFTSIFYPHYGNCYIFN SCAB_HUMAN 260 2 DFLTHIDPVFGSCFTFN MEC4_CAEBR 463 3 NFTLFHHPMHGNCYTFN SCAG_HUMAN 271 2 NFTPIFYPDYGNCYIFN SCAB_RAT 258 2 DFELVADPTFGNCFVFN ME10_CAEEL 422 3 DFTLHYDNTFGNCYTFN DEGX_CAEEL 432 3 DFVEYLDPTYGACFTYG DEGY_CAEEL 478 3 DFRLHVDPEFGNCFTFN DEG1_CAEEL 451 3 DFKLHVDPEYGNCYTFN UNC8_CAEEL 435 3 EFKLHIDPSFGNCYTFN DEL1_CAEEL 353 3 QFRTFHHPTYGSCYTVD O46547 274 2 QFRTFHHPTYGSCYTVD SCAD_HUMAN 274 2 DFNDFYNPSYGNCLQFN P91835 197 2 DFTKFIDPVYGACYSFN DEGW_CAEEL 179 2 AMINACHANNEL5 Length of motif = 19 Motif number = 5 Amiloride-sensitive sodium channel motif V - 2 PCODE ST INT GINNGLSLMLRAEQNDFIP SCAA_HUMAN 323 13 GVNNGLSLTLRTEQNDFIP SCAA_RAT 351 13 GAEYGLKVVLYIDEDEYNP SCG2_XENLA 304 13 GAEYGLKVVLYIDEDEYNP SCAG_XENLA 304 13 GVNNGLSLTLRTEQNDFIP SCAA_BOVIN 304 13 GINNGLSLVVRTEQNDFIP SCAA_CHICK 309 12 GSEYGLQVILYINEDEYNP SCAG_RAT 302 13 GADFGLKLVLDIEQDEYLP SCB2_XENLA 309 14 GIKNGLTLVLRTEQHDYIP SCAA_XENLA 284 15 GPMYGLRMLVYVNASDYMP MEC4_CAEEL 491 12 GADFGLKLVLDIEQGEYLP SCAB_XENLA 310 14 GTEFGLKLILDIGQEDYVP SCAB_HUMAN 290 13 GPMYGLRMLVYVNASDYMP MEC4_CAEBR 492 12 GSEYGLQVILYINEEEYNP SCAG_HUMAN 301 13 GTEFGLKLILDIGQEDYVP SCAB_RAT 288 13 GPQYGLRVMLFVNASDYLP ME10_CAEEL 451 12 GANYGLRVLLYANVSEYLP DEGX_CAEEL 461 12 GPAYGLRLEVFVNVTEYLP DEGY_CAEEL 506 11 GPMYGIRVLLFVNTSDYMS DEG1_CAEEL 480 12 GPMYGLRLLLNVHQSDYMP UNC8_CAEEL 464 12 GPSYGLRLMMFVNSSDYLP DEL1_CAEEL 382 12 GITHGVGLVLRVEQQPHLP O46547 299 8 GITHGVGLVLRVEQQPHLP SCAD_HUMAN 299 8 GPLYGLRMVMRTDQDTYLP P91835 224 10 GIQFGLKLMLTVTQTKTNG DEGW_CAEEL 208 12 AMINACHANNEL6 Length of motif = 19 Motif number = 6 Amiloride-sensitive sodium channel motif VI - 2 PCODE ST INT GARVMVHGQDEPAFMDDGG SCAA_HUMAN 348 6 GARVMVHGQDEPAFMDDGG SCAA_RAT 376 6 GAKILVHDQDEYPFIEDLG SCG2_XENLA 329 6 GAKILVHDQDEYPFIEYLG SCAG_XENLA 329 6 GARVMVHERDEPAFMDDAG SCAA_BOVIN 329 6 GARVMVHDQNEPAFMDDGG SCAA_CHICK 334 6 GAKVLIHQQNEYPFIEDVG SCAG_RAT 327 6 AARLILHQQRSFPFVKDLG SCB2_XENLA 334 6 GARVLVHGHKEPAFMDDNG SCAA_XENLA 309 6 GVRLTIHDKEDFPFPDTFG MEC4_CAEEL 515 5 AARLILHQQRSFPFVKDLG SCAB_XENLA 335 6 GVRLMLHEQRSYPFIRDEG SCAB_HUMAN 315 6 GVRLTIHDKEDFPFPDTFG MEC4_CAEBR 516 5 GAKVIIHRQDEYPSVEDVG SCAG_HUMAN 326 6 GARLMLHEQRTYPFIREEG SCAB_RAT 313 6 GIRLTIHDKDDFPFPDTFG ME10_CAEEL 475 5 GFRITVHDKHIVPFPDAFG DEGX_CAEEL 485 5 GVRLTVHATDEQPFPDTLG DEGY_CAEEL 530 5 GVRLAIHPPTEYPFPDTFG DEG1_CAEEL 504 5 GVRLVVHEQDQEPFPDTFG UNC8_CAEEL 488 5 GVRIAIHGKEECPFPDTFG DEL1_CAEEL 406 5 GIRVMVHGRNHTPFLGHHS O46547 324 6 GIRVMVHGRNHTPFLGHHS SCAD_HUMAN 324 6 GVIIDIHMQDEIPYPDVFG P91835 248 5 GARIGVNSRGSSPGLDSNG DEGW_CAEEL 238 11 AMINACHANNEL7 Length of motif = 17 Motif number = 7 Amiloride-sensitive sodium channel motif VII - 2 PCODE ST INT SMRKETLDRLGGDYGDC SCAA_HUMAN 378 11 SMRKEALDSLGGNYGDC SCAA_RAT 406 11 GMQLTESTKLSDPYSDC SCG2_XENLA 359 11 GMQLTESAKLSDPYSDC SCAG_XENLA 359 11 SMSKEAVDRLGGDYGDC SCAA_BOVIN 359 11 SMRKEMTERLGGSYSDC SCAA_CHICK 364 11 GMHLTESFKLSEPYSQC SCAG_RAT 357 11 AVLVDQLQQMEAPYSSC SCB2_XENLA 364 11 GMKKETINRLGGKYSDC SCAA_XENLA 339 11 GLRLRKMSRLPAPYGDC MEC4_CAEEL 545 11 SVLVDQLEHMEAPYSSC SCAB_XENLA 365 11 GVLVDKLQRMGEPYSPC SCAB_HUMAN 345 11 GLRLRKMSRLPAPYGDC MEC4_CAEBR 546 11 GMHLTESFKLSEPSSQC SCAG_HUMAN 356 11 GVLLDKLQGKGEPYSPC SCAB_RAT 343 11 GMRMKKMSRLPAPYGDC ME10_CAEEL 505 11 GVRMKQFIRLEPPYGHC DEGX_CAEEL 515 11 GIKLKSMVRLPAPYGDC DEGY_CAEEL 560 11 GIKKKVMQRLPAPYGEC DEG1_CAEEL 534 11 GLKTKELHRLSAPWGNC UNC8_CAEEL 518 11 GISLRNINRLPQPYGNC DEL1_CAEEL 436 11 SIREDEVHRLGSPYGHC O46547 354 11 SIREDEVHRLGSPYGHC SCAD_HUMAN 354 11 GVSYVQTTRLSKPYGSC P91835 278 11 SVSLTQNVRAKKPYGTC DEGW_CAEEL 268 11 AMINACHANNEL8 Length of motif = 12 Motif number = 8 Amiloride-sensitive sodium channel motif VIII - 2 PCODE ST INT YTQQVCIHSCFQ SCAA_HUMAN 411 16 YTQQVCIHSCFQ SCAA_RAT 439 16 YTLQICLNSCFQ SCG2_XENLA 392 16 YTLQICLNSCFQ SCAG_XENLA 392 16 YTQQVCIHSCFQ SCAA_BOVIN 392 16 YTEQVCIRSCFQ SCAA_CHICK 397 16 YSLQICLYSCFQ SCAG_RAT 390 16 YSIQSCLRSCYQ SCB2_XENLA 400 19 YTEQVCVRSCFQ SCAA_XENLA 372 16 YSVEGCYRSCFQ MEC4_CAEEL 577 15 YSIQSCLRSCYQ SCAB_XENLA 401 19 YSIQACLRSCFQ SCAB_HUMAN 381 19 YSVEGCYRSCFQ MEC4_CAEBR 578 15 YSLQICLHSCFQ SCAG_HUMAN 389 16 YSIQACLHSCFQ SCAB_RAT 379 19 YSTEGCYRTCFQ ME10_CAEEL 537 15 YSVEACHRSCAQ DEGX_CAEEL 548 16 YNTEGCQRSCIQ DEGY_CAEEL 592 15 YHPEGCHRSCFQ DEG1_CAEEL 568 17 YSPEGCHRNCFQ UNC8_CAEEL 549 14 YEPEGCFRSCYQ DEL1_CAEEL 469 16 YTRQACLVSCFQ O46547 387 16 YTRQACLVSCFQ SCAD_HUMAN 387 16 YTVEACFRSCMQ P91835 309 14 YTLETCFNGCKQ DEGW_CAEEL 300 15 AMINACHANNEL9 Length of motif = 18 Motif number = 9 Amiloride-sensitive sodium channel motif IX - 2 PCODE ST INT QESMIKECGCAYIFYPRP SCAA_HUMAN 422 -1 QENMIKKCGCAYIFYPKP SCAA_RAT 450 -1 QREMVRSCGCAHYDQPLP SCG2_XENLA 403 -1 QREMVRSCGCAHYDQPLP SCAG_XENLA 403 -1 QESMIKECGCAYIFYPRP SCAA_BOVIN 403 -1 QLNMVKRCSCAYYFYPLP SCAA_CHICK 408 -1 QTKMVEKCGCAQYSQPLP SCAG_RAT 401 -1 QEEMVKTCKCAHYQYPLP SCB2_XENLA 411 -1 QAAMVARCGCGYAFYPLS SCAA_XENLA 383 -1 QQLVLKECRCGDPRFPVP MEC4_CAEEL 588 -1 QEEMVKTCKCAHYQYPLP SCAB_XENLA 412 -1 QDHMIRNCNCGHYLYPLP SCAB_HUMAN 392 -1 QQLVLKECRCGDPRFPVP MEC4_CAEBR 589 -1 QTKMVEKCGCAQYSQPLP SCAG_HUMAN 400 -1 QDHMIHNCSCGHYLYPLP SCAB_RAT 390 -1 QELIIDRCGCSDPRFPSI ME10_CAEEL 548 -1 QKVIVEACGCADPMYPVA DEGX_CAEEL 559 -1 QKHLSKTCGCGDPRFPPY DEGY_CAEEL 603 -1 QNGLIDDCSCGDPRFPVP DEG1_CAEEL 579 -1 QLKVLEICGCGDPRFPLP UNC8_CAEEL 560 -1 QYRIIAKCGCADPRYPKP DEL1_CAEEL 480 -1 QQLMVETCSCGYYLHPLP O46547 398 -1 QQLMVETCSCGYYLHPLP SCAD_HUMAN 398 -1 QEKIIASCGCYYPAYSHA P91835 320 -1 QRDTIAKCQCANPRLALG DEGW_CAEEL 311 -1 AMINACHANNEL10 Length of motif = 21 Motif number = 10 Amiloride-sensitive sodium channel motif X - 2 PCODE ST INT CRKPCSVTSYQLSAGYSRWPS SCAA_HUMAN 475 35 CRKPCSVINYKLSAGYSRWPS SCAA_RAT 503 35 CRESCSFKEWTLTRSLAKWPS SCG2_XENLA 456 35 CRESCSFKEWTLTRSLAKWPS SCAG_XENLA 456 35 CRKPCSVTIYKLSASYSQWPS SCAA_BOVIN 456 35 CRKPCKMTEYQLSAGYSRWPS SCAA_CHICK 461 35 CKQSCSFKEWTLTTSLAQWPS SCAG_RAT 454 35 CQQPCNDTHYKMVISMADWPS SCB2_XENLA 463 34 CRKPCLVSEYQLTAGYSKWPN SCAA_XENLA 436 35 CQQPCRQSIYSVTYSPAKWPS MEC4_CAEEL 640 34 CQQPCNDTHYKMVISMADWPS SCAB_XENLA 464 34 CKESCNDTQYKMTISMADWPS SCAB_HUMAN 444 34 CQQPCGQSIYSVTYSPAKWPS MEC4_CAEBR 641 34 CKEACRFKEWTLTTSLAQWPS SCAG_HUMAN 453 35 CKESCNDTQYKMTISMADWPS SCAB_RAT 442 34 CQQPCNQTIYTTSYSEAIWPS ME10_CAEEL 600 34 CHQPCQETNYEVTYSSARWPS DEGX_CAEEL 621 44 CKQPCNQDVYSVSYSASRWPA DEGY_CAEEL 655 34 CKQSCEEIIHEVTFSCSKWPS DEG1_CAEEL 635 38 CRQPCHEKVFETAYSASAWPS UNC8_CAEEL 614 36 CIQPCQQDQYTTTYSAAKWPS DEL1_CAEEL 533 35 CPRPCRESAFKLSTGTSRWPS O46547 451 35 CPRPCRESAFKLSTGTSRWPS SCAD_HUMAN 451 35 CPQPCEIDSYGVTVSTAQWPS P91835 378 40 CNPPCDESTYTPTVSLAQFPS DEGW_CAEEL 366 37 AMINACHANNEL11 Length of motif = 21 Motif number = 11 Amiloride-sensitive sodium channel motif XI - 2 PCODE ST INT RNGVAKVNIFFKELNYKTNSE SCAA_HUMAN 518 22 RNGVAKLNIFFKELNYKTNSE SCAA_RAT 546 22 KNDLGNLNIFYQDLNSRSISE SCG2_XENLA 501 24 KNDLANLNIFYQDLNSRSISE SCAG_XENLA 501 24 RDGVAKLNIFFKELNYKSNSE SCAA_BOVIN 499 22 RNGVAKVNIFFEEWNYKTNGE SCAA_CHICK 504 22 KTDLAKLLIFYKDLNQRSIME SCAG_RAT 499 24 RNGIIRLNIYFQEFNYRSISE SCB2_XENLA 508 24 RNGIAKLNIYFEELNYKTILE SCAA_XENLA 476 19 KENGAMVEVFYEQLNFEMLTE MEC4_CAEEL 682 21 RNGIVRLNIYFQEFNYRSISE SCAB_XENLA 509 24 RKGIVKLNIYFQEFNYRTIEE SCAB_HUMAN 489 24 KENGAMVEVFYEQLNFEMLTE MEC4_CAEBR 683 21 KTDLAKLLIFYKDLNQRSIME SCAG_HUMAN 498 24 RKGIVKLNIYFQEFNYRTIEE SCAB_RAT 487 24 KENAAMLEVFYEALNFEVLSE ME10_CAEEL 642 21 RKNAAMVQIFYEELNYETMQE DEGX_CAEEL 661 19 REQGSMIEVYFEQLNYESLLE DEGY_CAEEL 697 21 RLNAAMIEVFYEQLNYELLQE DEG1_CAEEL 676 20 RQNTAYIEIYYEQLNFESLKE UNC8_CAEEL 661 26 REHAAMIEIYYEQMSYEILRE DEL1_CAEEL 572 18 RSSLAKINIVYQELNYRSVEE O46547 495 23 RSSLAKINIVYQELNYRSVEE SCAD_HUMAN 495 23 KANTILIEIYYERMNFQVLTE P91835 427 28 NNNGMIIQVFLETLSYELYTE DEGW_CAEEL 420 33 AMINACHANNEL12 Length of motif = 15 Motif number = 12 Amiloride-sensitive sodium channel motif XII - 2 PCODE ST INT ESPSVTMVTLLSNLG SCAA_HUMAN 538 -1 ESPSVTMVSLLSNLG SCAA_RAT 566 -1 ESPTYNIVTLLSNFG SCG2_XENLA 521 -1 ESPTYNIVTLLSNFG SCAG_XENLA 521 -1 ESPSVTMVTLLSNLG SCAA_BOVIN 519 -1 ESPAFTVVTLLSQLG SCAA_CHICK 524 -1 ESPANSIEMLLSNFG SCAG_RAT 519 -1 ESEATNVVWLLSNLG SCB2_XENLA 528 -1 ESPTINMAMLLSLLG SCAA_XENLA 496 -1 ESEAYGFVNLLADFG MEC4_CAEEL 702 -1 ESEATNVVWLLSNLG SCAB_XENLA 529 -1 ESAANNIVWLLSNLG SCAB_HUMAN 509 -1 ESEAYGFVNLLADFG MEC4_CAEBR 703 -1 ESPANSIEMLLSNFG SCAG_HUMAN 518 -1 ESPANNIVWLLSNLG SCAB_RAT 507 -1 ESEAYGIVKMMADFG ME10_CAEEL 662 -1 ESPAYTLTSVLADLG DEGX_CAEEL 681 -1 ESEAYGWSNLLSDFG DEGY_CAEEL 717 -1 ESEAYGLVNLIADFG DEG1_CAEEL 696 -1 ETAGYTLVNLFSDFG UNC8_CAEEL 681 -1 ESESYSWFNLMADMG DEL1_CAEEL 592 -1 EAPVYSVPQLLSAMG O46547 515 -1 EAPVYSVPQLLSAMG SCAD_HUMAN 515 -1 ESPAYTFVNFISDVG P91835 447 -1 ETAGYTVSNVINDLG DEGW_CAEEL 440 -1 AMINACHANNEL13 Length of motif = 17 Motif number = 13 Amiloride-sensitive sodium channel motif XIII - 2 PCODE ST INT GSQWSLWFGSSVLSVVE SCAA_HUMAN 552 -1 GSQWSLWFGSSVLSVVE SCAA_RAT 580 -1 GGQLGLWMSCSMVCGLE SCG2_XENLA 535 -1 GGQLGLWMSCSMICVLE SCAG_XENLA 535 -1 GSQWSLWFGSSVLSVVE SCAA_BOVIN 533 -1 GNQWSLWFGSSVLSVME SCAA_CHICK 538 -1 GGQLGLWMSCSVVCVIE SCAG_RAT 533 -1 GGQFGFWMGGSVLCIIE SCB2_XENLA 542 -1 GSQWSLWFGSSVLSVVE SCAA_XENLA 510 -1 GGQLGLWCGISFLTCCE MEC4_CAEEL 716 -1 GGQFGFWMGGSVLCIIE SCAB_XENLA 543 -1 GGQFGFWMGGSVLCLIE SCAB_HUMAN 523 -1 GGQLGLWCGISFLTCCE MEC4_CAEBR 717 -1 GGQLGLWMSCSVVCVIE SCAG_HUMAN 532 -1 GGQFGFWMGGSVLCLIE SCAB_RAT 521 -1 GGHLGLWSGVSVMTCCE ME10_CAEEL 676 -1 GGLTGLWIGASVVSLLE DEGX_CAEEL 695 -1 GGQLGLWMGVSVITIGE DEGY_CAEEL 731 -1 GGHLGLWLGFSVITVME DEG1_CAEEL 710 -1 GGNIGLWIGFSVITFAE UNC8_CAEEL 695 -1 GGQAGLFLGASIMSVIE DEL1_CAEEL 606 -1 GSLCSLWFGASVLSLLE O46547 529 -1 GSLYSLWFGASVLSLLE SCAD_HUMAN 529 -1 GGQVGLFLGMSIISAIE P91835 461 -1 GGQAGLWLGLSVISVVE DEGW_CAEEL 454 -1

User query: Display/Full Code "AMINACHANNEL"