WORKLIST ENTRIES (1):
ANATPEPTIDE View alignment Atrial natriuretic peptide signature
Type of fingerprint: COMPOUND with 7 elements
Links:
PRINTS; PR00710 NATPEPTIDES; PR00712 BNATPEPTIDE; PR00713 CNATPEPTIDE
INTERPRO; IPR002407
PFAM; PF00212 ANP
Creation date 01-JUN-1996; UPDATE 13-JUN-1999
1. INAGAMI, T.
Atrial natriuretic factor.
J.BIOL.CHEM. 264 3043-3046 (1989).
2. SAGNELLA, G.A. AND MCGREGOR, G.A.
Structural and functional features of atrial natriuretic peptides.
TRENDS BIOCHEM.SCI. 11 299-302 (1986).
3. ROSENZWEIG, A. AND SEIDMAN, C.E.
Atrial natriuretic factor and related peptide hormones.
ANNU.REV.BIOCHEM. 60 229-255 (1991).
4. TAKEI, Y., TAKAHASHI, A., WATANABE, T.X., NAKAJIMA, K.
AND SAKAKIBARA, S.
A novel natriuretic peptide isolated from eel cardiac ventricles.
FEBS LETT. 282 317-320 (1991).
5. SCHWEITZ, H., WIGNE, P., MOINIER, D., FRELIN, C. AND LAZDUNSKI, M.
A new member of the natriuretic peptide family is present in the venom of
the green mamba (Dendroaspis angusticeps.
J.BIOL.CHEM. 267 13928-13932 (1992).
Atrial natriuretic peptides (ANPs) are vertebrate hormones that play an
important role in the control of cardiovascular homeostatis, and sodium
and water balance in general [1-3]. There are different NPs that vary in
length but share a common core. All are processed from a single precursor.
A disulphide bond resident in the C-terminal section is required for full
activity of atriopeptins.
The family of NPs includes structurally-related peptides that elicit
similar pharmacological spectra: amongst these are brain natriuretic
peptide (BNP); C-type natriuretic peptide (CNP); ventricular natriuretic
peptide (VNP) [4]; and green mamba natriuretic peptide (DNP) [5].
ANATPEPTIDE is a 7-element fingerprint that provides a signature for atrial
natriuretic peptides. The fingerprint was derived from an initial alignment
of 8 sequences: the motifs were drawn from conserved regions spanning the
full alignment length - motif 7 spans the C-terminal region encoded by
PROSITE pattern NATRIURETIC_PEPTIDE (PS00263), which includes the two
functionally important cysteines and two conserved glycines, which may be
important for the conformation of the peptides. Two iterations on OWL29.3
were required to reach convergence, at which point a true set comprising
10 sequences was identified. Several partial matches were also found, all
of which are natriuretic peptide fragments.
An update on SPTR37_9f identified a true set of 10 sequences, and 3
partial matches.
SUMMARY INFORMATION
10 codes involving 7 elements
1 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
1 codes involving 3 elements
1 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
7| 10 10 10 10 10 10 10
6| 1 1 1 1 0 1 1
5| 0 0 0 0 0 0 0
4| 0 0 0 0 0 0 0
3| 0 1 0 0 0 1 1
2| 1 0 0 0 0 0 1
--+------------------------------------
| 1 2 3 4 5 6 7
True positives..
ANF_HUMAN Q13766 ANF_HORSE ANF_PIG
ANF_CANFA ANF_RAT ANF_BOVIN ANF_MOUSE
ANF_RABIT Q29130
Subfamily: Codes involving 6 elements
Subfamily True positives..
O46540
Subfamily: Codes involving 3 elements
Subfamily True positives..
ANF_RANCA
Subfamily: Codes involving 2 elements
Subfamily True positives..
ANF_CHICK
PROTEIN TITLES
ANF_HUMAN ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETI
Q13766 ATRIAL NATRIURETIC FACTOR PRECURSOR - HOMO SAPIENS (HUMAN).
ANF_HORSE ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETI
ANF_PIG ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETI
ANF_CANFA ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETI
ANF_RAT ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETI
ANF_BOVIN ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETI
ANF_MOUSE ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETI
ANF_RABIT ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETI
Q29130 CARDIODILATIN, ATRIAL NATRIURETIC PEPTIDE - TUPAIA BELANGERI
O46540 ATRIAL NATRIURETIC PEPTIDE - OVIS ARIES (SHEEP).
ANF_RANCA ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETI
ANF_CHICK ATRIAL NATRIURETIC FACTOR PRECURSOR (ANF) (ATRIAL NATRIURETI
SCAN HISTORY
OWL29_3 2 50 NSINGLE
SPTR37_9f 2 30 NSINGLE
INITIAL MOTIF SETS
ANATPEPTIDE1 Length of motif = 19 Motif number = 1
Atrial natriuretic peptide motif I - 1
PCODE ST INT
FLLFLAFQLPGQTGANPVY ANF_BOVIN 10 10
FFLFLAFWLPGHIGANPVY ANF_RAT 10 10
FLLFLAFQLQGQTRANPVY ANF_HORSE 11 11
FLLFLAVQLLGQTGANPVY ANF_CANFA 9 9
FFLVLAFWLPGHIGANPVY ANF_MOUSE 10 10
FLLLLAFQLLGQTRANPMY ANF_HUMAN 11 11
FLLVLVFQFPGQTRANPVY ANF_PIG 10 10
FLFCLAFWHPDQIGANPVY ANF_RABIT 11 11
ANATPEPTIDE2 Length of motif = 19 Motif number = 2
Atrial natriuretic peptide motif II - 1
PCODE ST INT
VSNADLMDFKNLLDRLEDK ANF_BOVIN 31 2
VSNTDLMDFKNLLDHLEEK ANF_RAT 31 2
VSNGDLMDFKNLLDRLEDK ANF_HORSE 32 2
VSNADLLDFKNLLDRLEDK ANF_CANFA 30 2
VSNTDLMDFKNLLDHLEEK ANF_MOUSE 31 2
VSNADLMDFKNLLDHLEEK ANF_HUMAN 32 2
VSNADLMDFKNLLDHLEDK ANF_PIG 31 2
MSNADLMDFKNLLDHLEDR ANF_RABIT 32 2
ANATPEPTIDE3 Length of motif = 19 Motif number = 3
Atrial natriuretic peptide motif III - 1
PCODE ST INT
MPLEDEAVPSQVLSEQNEE ANF_BOVIN 50 0
MPVEDEVMPPQALSEQTDE ANF_RAT 50 0
MPLEDEVMPPQVLSDQSEE ANF_HORSE 51 0
MPLEDEAESPQALSEQNAE ANF_CANFA 49 0
MPVEDEVMPPQALSEQTEE ANF_MOUSE 50 0
MPLEDEVVPPQVLSEPNEE ANF_HUMAN 51 0
MPLEDEAMPPQVLSEQNEE ANF_PIG 50 0
MPFEDEAVPPQALSEQSDE ANF_RABIT 51 0
ANATPEPTIDE4 Length of motif = 18 Motif number = 4
Atrial natriuretic peptide motif IV - 1
PCODE ST INT
APLSPLSEMPPWMGEVNP ANF_BOVIN 71 2
AALSSLSEVPPWTGEVNP ANF_RAT 71 2
AALSPLPEVPPWTGEVNP ANF_HORSE 72 2
AALSPLPEVPPWTGEVSP ANF_CANFA 70 2
AALSSLPEVPPWTGEVNP ANF_MOUSE 71 2
AALSPLPEVPPWTGEVSP ANF_HUMAN 72 2
APLSPLLEVPPWTGEVNP ANF_PIG 71 2
AALSPLPEVPPWTGEVSP ANF_RABIT 72 2
ANATPEPTIDE5 Length of motif = 17 Motif number = 5
Atrial natriuretic peptide motif V - 1
PCODE ST INT
REGGVLGRGPWESSDRS ANF_BOVIN 91 2
RDGGALGRGPWDPSDRS ANF_RAT 91 2
RDGGALGRGSWDSSDRS ANF_HORSE 92 2
RDGGALGRSPWDSSDRS ANF_CANFA 90 2
RDGSASRRSPWDPSDRS ANF_MOUSE 91 2
RDGGALGRGPWDSSDRS ANF_HUMAN 92 2
RDGGALGRGPWDASDRS ANF_PIG 91 2
RDGEALGRSTWEASERS ANF_RABIT 92 2
ANATPEPTIDE6 Length of motif = 19 Motif number = 6
Atrial natriuretic peptide motif VI - 1
PCODE ST INT
ALLKSKLRALLTAPRSLRR ANF_BOVIN 108 0
ALLKSKLRALLAGPRSLRR ANF_RAT 108 0
ALLKSKLRALLAAPRSLRR ANF_HORSE 109 0
ALLKSKLRALLAAPRSLRR ANF_CANFA 107 0
ALLKSKLRALLAGPRSLRR ANF_MOUSE 108 0
ALLKSKLRALLTAPRSLRR ANF_HUMAN 109 0
ALLKSKLRALLAAPRSLRR ANF_PIG 108 0
ALLKSKLRALLTAPRSLRR ANF_RABIT 109 0
ANATPEPTIDE7 Length of motif = 23 Motif number = 7
Atrial natriuretic peptide motif VII - 1
PCODE ST INT
SSCFGGRMDRIGAQSGLGCNSFR ANF_BOVIN 127 0
SSCFGGRIDRIGAQSGLGCNSFR ANF_RAT 127 0
SSCFGGRMDRIGAQSGLGCNSFR ANF_HORSE 128 0
SSCFGGRMDRIGAQSGLGCNSFR ANF_CANFA 126 0
SSCFGGRIDRIGAQSGLGCNSFR ANF_MOUSE 127 0
SSCFGGRMDRIGAQSGLGCNSFR ANF_HUMAN 128 0
SSCFGGRMDRIGAQSGLGCNSFR ANF_PIG 127 0
SSCFGGRIDRIGAQSGLGCNSFR ANF_RABIT 128 0
FINAL MOTIF SETS
ANATPEPTIDE1 Length of motif = 19 Motif number = 1
Atrial natriuretic peptide motif I - 2
PCODE ST INT
FLLLLAFQLLGQTRANPMY ANF_HUMAN 11 11
FLLLLAFQLLGQTRANPMY Q13766 11 11
FLLFLAFQLQGQTRANPVY ANF_HORSE 11 11
FLLVLVFQFPGQTRANPVY ANF_PIG 10 10
FLLFLAVQLLGQTGANPVY ANF_CANFA 9 9
FFLFLAFWLPGHIGANPVY ANF_RAT 10 10
FLLFLAFQLPGQTGANPVY ANF_BOVIN 10 10
FFLVLAFWLPGHIGANPVY ANF_MOUSE 10 10
FLFCLAFWHPDQIGANPVY ANF_RABIT 11 11
FLVFLLPGQMGHIGASPVY Q29130 13 13
ANATPEPTIDE2 Length of motif = 19 Motif number = 2
Atrial natriuretic peptide motif II - 2
PCODE ST INT
VSNADLMDFKNLLDHLEEK ANF_HUMAN 32 2
VSNADLMDFKNLLDHLEEK Q13766 32 2
VSNGDLMDFKNLLDRLEDK ANF_HORSE 32 2
VSNADLMDFKNLLDHLEDK ANF_PIG 31 2
VSNADLLDFKNLLDRLEDK ANF_CANFA 30 2
VSNTDLMDFKNLLDHLEEK ANF_RAT 31 2
VSNADLMDFKNLLDRLEDK ANF_BOVIN 31 2
VSNTDLMDFKNLLDHLEEK ANF_MOUSE 31 2
MSNADLMDFKNLLDHLEDR ANF_RABIT 32 2
MSSADLMDFKDLLDRLEDK Q29130 34 2
ANATPEPTIDE3 Length of motif = 19 Motif number = 3
Atrial natriuretic peptide motif III - 2
PCODE ST INT
MPLEDEVVPPQVLSEPNEE ANF_HUMAN 51 0
MPLEDEVVPPQVLSDPNEE Q13766 51 0
MPLEDEVMPPQVLSDQSEE ANF_HORSE 51 0
MPLEDEAMPPQVLSEQNEE ANF_PIG 50 0
MPLEDEAESPQALSEQNAE ANF_CANFA 49 0
MPVEDEVMPPQALSEQTDE ANF_RAT 50 0
MPLEDEAVPSQVLSEQNEE ANF_BOVIN 50 0
MPVEDEVMPPQALSEQTEE ANF_MOUSE 50 0
MPFEDEAVPPQALSEQSDE ANF_RABIT 51 0
MPLEDEVAPPQILSEQTDE Q29130 53 0
ANATPEPTIDE4 Length of motif = 18 Motif number = 4
Atrial natriuretic peptide motif IV - 2
PCODE ST INT
AALSPLPEVPPWTGEVSP ANF_HUMAN 72 2
AALSPLPEVPPWTGEVSP Q13766 72 2
AALSPLPEVPPWTGEVNP ANF_HORSE 72 2
APLSPLLEVPPWTGEVNP ANF_PIG 71 2
AALSPLPEVPPWTGEVSP ANF_CANFA 70 2
AALSSLSEVPPWTGEVNP ANF_RAT 71 2
APLSPLSEMPPWMGEVNP ANF_BOVIN 71 2
AALSSLPEVPPWTGEVNP ANF_MOUSE 71 2
AALSPLPEVPPWTGEVSP ANF_RABIT 72 2
AALSPLPEVPPWTGEVSP Q29130 74 2
ANATPEPTIDE5 Length of motif = 17 Motif number = 5
Atrial natriuretic peptide motif V - 2
PCODE ST INT
RDGGALGRGPWDSSDRS ANF_HUMAN 92 2
RDGGALGRGPWDSSDRS Q13766 92 2
RDGGALGRGSWDSSDRS ANF_HORSE 92 2
RDGGALGRGPWDASDRS ANF_PIG 91 2
RDGGALGRSPWDSSDRS ANF_CANFA 90 2
RDGGALGRGPWDPSDRS ANF_RAT 91 2
REGGVLGRGPWESSDRS ANF_BOVIN 91 2
RDGSASRRSPWDPSDRS ANF_MOUSE 91 2
RDGEALGRSTWEASERS ANF_RABIT 92 2
RDGGALGRSPWDSSERS Q29130 94 2
ANATPEPTIDE6 Length of motif = 19 Motif number = 6
Atrial natriuretic peptide motif VI - 2
PCODE ST INT
ALLKSKLRALLTAPRSLRR ANF_HUMAN 109 0
ALLKSKLRALLTAPRSLRR Q13766 109 0
ALLKSKLRALLAAPRSLRR ANF_HORSE 109 0
ALLKSKLRALLAAPRSLRR ANF_PIG 108 0
ALLKSKLRALLAAPRSLRR ANF_CANFA 107 0
ALLKSKLRALLAGPRSLRR ANF_RAT 108 0
ALLKSKLRALLTAPRSLRR ANF_BOVIN 108 0
ALLKSKLRALLAGPRSLRR ANF_MOUSE 108 0
ALLKSKLRALLTAPRSLRR ANF_RABIT 109 0
ALLKSKLRAMLAAPRSLRR Q29130 111 0
ANATPEPTIDE7 Length of motif = 23 Motif number = 7
Atrial natriuretic peptide motif VII - 2
PCODE ST INT
SSCFGGRMDRIGAQSGLGCNSFR ANF_HUMAN 128 0
SSCFGGRMDRIGAQSGLGCNSFR Q13766 128 0
SSCFGGRMDRIGAQSGLGCNSFR ANF_HORSE 128 0
SSCFGGRMDRIGAQSGLGCNSFR ANF_PIG 127 0
SSCFGGRMDRIGAQSGLGCNSFR ANF_CANFA 126 0
SSCFGGRIDRIGAQSGLGCNSFR ANF_RAT 127 0
SSCFGGRMDRIGAQSGLGCNSFR ANF_BOVIN 127 0
SSCFGGRIDRIGAQSGLGCNSFR ANF_MOUSE 127 0
SSCFGGRIDRIGAQSGLGCNSFR ANF_RABIT 128 0
SSCFGGRMDRIGAQSGLGCNSFR Q29130 130 0
User query: Display/Full Code "ANATPEPTIDE"