WORKLIST ENTRIES (1):
ANNEXINII View alignment View Structure Annexin type II signature
Type of fingerprint: COMPOUND with 6 elements
Links:
PRINTS; PR00196 ANNEXIN
PRINTS; PR00197 ANNEXINI; PR00199 ANNEXINIII; PR00200 ANNEXINIV
PRINTS; PR00201 ANNEXINV; PR00202 ANNEXINVI; PR01871 ANNEXINVII
PRINTS; PR01808 ANNEXINVIII; PR01809 ANNEXINX; PR01810 ANNEXINXI
PRINTS; PR01811 ANNEXINXIII; PR01812 ANNEXINXXXI; PR01813 ANNEXINFUNGI
PRINTS; PR01814 ANNEXINPLANT
INTERPRO; IPR002389
MIM; 151740
Creation date 27-OCT-1993; UPDATE 06-OCT-2003
1. BARTON, G.J., NEWMAN, R.H., FREEMONT, P.S. AND CRUMPTON, M.J.
Amino acid sequence analysis of the annexin super-gene family of proteins.
EUR.J.BIOCHEM. 198 749-760 (1991).
2. BRAUN, E.L., KANG, S., NELSON, M.A. AND NATVIG, D.O.
Identification of the first fungal annexin: analysis of annexin gene
duplications and implications for eukaryotic evolution.
J.MOL.EVOL. 47 531-543 (1998).
3. BENZ, J. AND HOFMANN, A.
Annexins: from structure to function.
BIOL.CHEM. 378 177-183 (1997).
4. GEISOW, M.J.
Annexins-forms without function but not without fun.
TRENDS BIOTECHNOL. 9 180-181 (1991).
The annexins (or lipocortins) are a family of proteins that bind to
phospholipids in a calcium-dependent manner [1]. They are distributed
ubiquitously in different tissues and cell types of higher and lower
eukaryotes, including mammals, fish, birds, Drosophila melanogaster,
Xenopus laevis, Caenorhabtidis elegans, Dictyostelium discoideum and
Neurospora crassa [2,3]. The plant annexins are somewhat distinct from
those found in other taxa [3].
Several distinct annexin subtypes exist, each of which has an amino-acid
sequence consisting of an N-terminal 'arm' followed by 4 or 8 copies of a
conserved domain of 61 residues (only one of these residues, an arginine,
is conserved between all copies). The calcium-binding sites are found in
the repeated domains [4]. Individual repeats (sometimes referred to as
endonexin folds) consist of 5 alpha-helices wound into a right-handed
superhelix. The biological roles of some annexin subtypes is unclear; the
family has been linked with inhibition of phospholipase activity, exo-
cytosis and endoctyosis, signal transduction, organisation of the extra-
cellular matrix, resistance to reactive oxygen species and DNA replication
[2]. Type II annexins bind 2 calcium ions, and inhibit phospholipase A2,
following dephosphorylation by protein kinases involved in the signal
transduction pathway. They may also cross-link plasma membrane phospholipids
with actin and the cytoskeleton, and possibly play a part in exocytosis,
as they are also involved in granule aggregation and membrane fusion.
ANNEXINII is a 6-element fingerprint that provides a signature for type
II annexins. The fingerprint was derived from an initial alignment of 6
sequences: the motifs were drawn from conserved regions spanning virtually
the full alignment length, focusing on those areas that characterise type
II annexins but distinguish them from related annexin subtypes - motifs 1
and 2 reside in the putative P10 binding site at the N-terminus; motif 3
lies in the second annexin repeat; motif 4 is located between the second
and third annexin repeats; motif 5 lies in repeat 3; and motif 6 resides
between repeats 3 and 4. Two iterations on SPTR41_24f were required to
reach convergence, at which point a true set comprising 10 sequences was
identified. Two partial matches were also found, Q99KH3 and Q804G8, which
are type II annexin isoforms from mouse and zebrafish respectively.
SUMMARY INFORMATION
10 codes involving 6 elements
0 codes involving 5 elements
1 codes involving 4 elements
1 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
6| 10 10 10 10 10 10
5| 0 0 0 0 0 0
4| 0 0 1 1 1 1
3| 0 0 1 1 1 0
2| 0 0 0 0 0 0
--+-------------------------------
| 1 2 3 4 5 6
True positives..
ANX2_BOVIN ANX2_MOUSE Q8TBV2 ANX2_HUMAN
Q9CZI7 ANX2_RAT ANX2_CHICK ANXB_XENLA
Q7ZXM2 ANX2_XENLA
Subfamily: Codes involving 4 elements
Subfamily True positives..
Q99KH3
Subfamily: Codes involving 3 elements
Subfamily True positives..
Q804G8
PROTEIN TITLES
ANX2_BOVIN Annexin A2 (Annexin II) (Lipocortin II) (Calpactin I heavy c
ANX2_MOUSE Annexin A2 (Annexin II) (Lipocortin II) (Calpactin I heavy c
Q8TBV2 Annexin A2 - Homo sapiens (Human).
ANX2_HUMAN Annexin A2 (Annexin II) (Lipocortin II) (Calpactin I heavy c
Q9CZI7 11 days embryo cDNA, RIKEN full-length enriched library, clo
ANX2_RAT Annexin A2 (Annexin II) (Lipocortin II) (Calpactin I heavy c
ANX2_CHICK Annexin A2 (Annexin II) (Lipocortin II) (Calpactin I heavy c
ANXB_XENLA Annexin II type I (Lipocortin II) (Calpactin I heavy chain)
Q7ZXM2 Hypothetical protein - Xenopus laevis (African clawed frog).
ANX2_XENLA Annexin II type II (Lipocortin II) (Calpactin I heavy chain)
Q99KH3 Similar to annexin A2 - Mus musculus (Mouse).
Q804G8 Annexin 2b - Brachydanio rerio (Zebrafish) (Danio rerio).
SCAN HISTORY
SPTR41_24f 2 150 NSINGLE
INITIAL MOTIF SETS
ANNEXINII1 Length of motif = 19 Motif number = 1
Annexin type II motif I - 1
PCODE ST INT
STVHEILCKLSLEGDHSTP ANX2_BOVIN 1 1
STVHEILCKLSLEGDHSTP ANX2_RAT 1 1
STVHEILSKLSLEGDHSLP ANX2_CHICK 1 1
ALIHEILGKLSLEGNQSCA ANXB_XENLA 1 1
STVHEILCKLSLEGDHSTP ANX2_HUMAN 1 1
STVHEILCKLSLEGDHSTP ANX2_MOUSE 1 1
ANNEXINII2 Length of motif = 12 Motif number = 2
Annexin type II motif II - 1
PCODE ST INT
PSAYGSVKAYTN ANX2_BOVIN 20 0
PSAYGSVKPYTN ANX2_RAT 20 0
PSAYATVKAYSN ANX2_CHICK 20 0
QSALGTVKASTN ANXB_XENLA 21 1
PSAYGSVKAYTN ANX2_HUMAN 20 0
PSAYGSVKPYTN ANX2_MOUSE 20 0
ANNEXINII3 Length of motif = 12 Motif number = 3
Annexin type II motif III - 1
PCODE ST INT
KLMVALAKGRRA ANX2_BOVIN 168 136
KLLVALAKGKRA ANX2_RAT 168 136
KLMVALAKGKRC ANX2_CHICK 168 136
KLMVALAKGKRQ ANXB_XENLA 169 136
KLMVALAKGRRA ANX2_HUMAN 168 136
KLMVALAKGRRA ANX2_MOUSE 168 136
ANNEXINII4 Length of motif = 12 Motif number = 4
Annexin type II motif IV - 1
PCODE ST INT
EDGSVIDYELID ANX2_BOVIN 180 0
EDGSVIDYELID ANX2_RAT 180 0
EDTSVIDYELID ANX2_CHICK 180 0
EEGSVVDYEKID ANXB_XENLA 181 0
EDGSVIDYELID ANX2_HUMAN 180 0
EDGSVIDYELID ANX2_MOUSE 180 0
ANNEXINII5 Length of motif = 10 Motif number = 5
Annexin type II motif V - 1
PCODE ST INT
PYDMLESIKK ANX2_BOVIN 236 44
PYDMLESIRK ANX2_RAT 236 44
PYDMLESIKK ANX2_CHICK 236 44
PYDMEESIKK ANXB_XENLA 237 44
PYDMLESIRK ANX2_HUMAN 236 44
PYDMLESIKK ANX2_MOUSE 236 44
ANNEXINII6 Length of motif = 11 Motif number = 6
Annexin type II motif VI - 1
PCODE ST INT
NAFLNLVQCIQ ANX2_BOVIN 253 7
NAFLNLVQCIQ ANX2_RAT 253 7
NAFLNLVQCIQ ANX2_CHICK 253 7
NAFLNLVQCIQ ANXB_XENLA 254 7
NAFLNLVQCIQ ANX2_HUMAN 253 7
NAFLNLVQCIQ ANX2_MOUSE 253 7
FINAL MOTIF SETS
ANNEXINII1 Length of motif = 19 Motif number = 1
Annexin type II motif I - 2
PCODE ST INT
STVHEILCKLSLEGDHSTP ANX2_BOVIN 1 1
STVHEILCKLSLEGDHSTP ANX2_MOUSE 1 1
STVHEILCKLSLEGDHSTP ANX2_HUMAN 1 1
STVHEILCKLSLEGDHSTP Q8TBV2 2 2
STVHEILCKLSLEGDHSTP Q9CZI7 2 2
STVHEILCKLSLEGDHSTP ANX2_RAT 1 1
STVHEILSKLSLEGDHSLP ANX2_CHICK 1 1
ALIHEILGKLSLEGNQSCA ANXB_XENLA 1 1
ALIHEILGKLSLEGNQSSS ANX2_XENLA 1 1
ALIHEILGKLSLEGNQSSS Q7ZXM2 2 2
ANNEXINII2 Length of motif = 12 Motif number = 2
Annexin type II motif II - 2
PCODE ST INT
PSAYGSVKAYTN ANX2_BOVIN 20 0
PSAYGSVKPYTN ANX2_MOUSE 20 0
PSAYGSVKAYTN ANX2_HUMAN 20 0
PSAYGSVKAYTN Q8TBV2 21 0
PSAYGSVKPYTN Q9CZI7 21 0
PSAYGSVKPYTN ANX2_RAT 20 0
PSAYATVKAYSN ANX2_CHICK 20 0
QSALGTVKASTN ANXB_XENLA 21 1
QSKLGSVKAATH ANX2_XENLA 21 1
QSKLGSVKAATH Q7ZXM2 22 1
ANNEXINII3 Length of motif = 12 Motif number = 3
Annexin type II motif III - 2
PCODE ST INT
KLMVALAKGRRA ANX2_BOVIN 168 136
KLMVALAKGRRA ANX2_MOUSE 168 136
KLMVALAKGRRA ANX2_HUMAN 168 136
KLMVALAKGRRA Q8TBV2 169 136
KLMVALAKSRRA Q9CZI7 169 136
KLLVALAKGKRA ANX2_RAT 168 136
KLMVALAKGKRC ANX2_CHICK 168 136
KLMVALAKGKRQ ANXB_XENLA 169 136
KLMVALAKGRRQ ANX2_XENLA 169 136
KLMVALAKGRRQ Q7ZXM2 170 136
ANNEXINII4 Length of motif = 12 Motif number = 4
Annexin type II motif IV - 2
PCODE ST INT
EDGSVIDYELID ANX2_BOVIN 180 0
EDGSVIDYELID ANX2_MOUSE 180 0
EDGSVIDYELID ANX2_HUMAN 180 0
EDGSVIDYELID Q8TBV2 181 0
EDGSVIDYELID Q9CZI7 181 0
EDGSVIDYELID ANX2_RAT 180 0
EDTSVIDYELID ANX2_CHICK 180 0
EEGSVVDYEKID ANXB_XENLA 181 0
EDGNMVDYEKID ANX2_XENLA 181 0
EDGNMVDYEKID Q7ZXM2 182 0
ANNEXINII5 Length of motif = 10 Motif number = 5
Annexin type II motif V - 2
PCODE ST INT
PYDMLESIKK ANX2_BOVIN 236 44
PYDMLESIKK ANX2_MOUSE 236 44
PYDMLESIRK ANX2_HUMAN 236 44
PYDMLESIRK Q8TBV2 237 44
PYDMLESIKK Q9CZI7 237 44
PYDMLESIRK ANX2_RAT 236 44
PYDMLESIKK ANX2_CHICK 236 44
PYDMEESIKK ANXB_XENLA 237 44
PYDIEESIKK ANX2_XENLA 237 44
PYDIEESIKK Q7ZXM2 238 44
ANNEXINII6 Length of motif = 11 Motif number = 6
Annexin type II motif VI - 2
PCODE ST INT
NAFLNLVQCIQ ANX2_BOVIN 253 7
NAFLNLVQCIQ ANX2_MOUSE 253 7
NAFLNLVQCIQ ANX2_HUMAN 253 7
NAFLNLVQCIQ Q8TBV2 254 7
NAFLNLVQCIQ Q9CZI7 254 7
NAFLNLVQCIQ ANX2_RAT 253 7
NAFLNLVQCIQ ANX2_CHICK 253 7
NAFLNLVQCIQ ANXB_XENLA 254 7
NAFLNLVQCIQ ANX2_XENLA 254 7
NAFLNLVQCIQ Q7ZXM2 255 7
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