WORKLIST ENTRIES (1):
ANNEXINIV View alignment View Structure Annexin type IV signature
Type of fingerprint: COMPOUND with 4 elements
Links:
PRINTS; PR00196 ANNEXIN
PRINTS; PR00197 ANNEXINI; PR00198 ANNEXINII; PR00199 ANNEXINIII
PRINTS; PR00201 ANNEXINV; PR00202 ANNEXINVI; PR01871 ANNEXINVII
PRINTS; PR01808 ANNEXINVIII; PR01809 ANNEXINX; PR01810 ANNEXINXI
PRINTS; PR01811 ANNEXINXIII; PR01812 ANNEXINXXXI; PR01813 ANNEXINFUNGI
PRINTS; PR01814 ANNEXINPLANT
INTERPRO; IPR002391
MIM; 106491
Creation date 28-OCT-1993; UPDATE 06-OCT-2003
1. BARTON, G.J., NEWMAN, R.H., FREEMONT, P.S. AND CRUMPTON, M.J.
Amino acid sequence analysis of the annexin super-gene family of proteins.
EUR.J.BIOCHEM. 198 749-760 (1991).
2. BRAUN, E.L., KANG, S., NELSON, M.A. AND NATVIG, D.O.
Identification of the first fungal annexin: analysis of annexin gene
duplications and implications for eukaryotic evolution.
J.MOL.EVOL. 47 531-543 (1998).
3. BENZ, J. AND HOFMANN, A.
Annexins: from structure to function.
BIOL.CHEM. 378 177-183 (1997).
4. GEISOW, M.J.
Annexins-forms without function but not without fun.
TRENDS BIOTECHNOL. 9 180-181 (1991).
The annexins (or lipocortins) are a family of proteins that bind to
phospholipids in a calcium-dependent manner [1]. They are distributed
ubiquitously in different tissues and cell types of higher and lower
eukaryotes, including mammals, fish, birds, Drosophila melanogaster,
Xenopus laevis, Caenorhabtidis elegans, Dictyostelium discoideum and
Neurospora crassa [2,3]. The plant annexins are somewhat distinct from
those found in other taxa [3].
Several distinct annexin subtypes exist, each of which has an amino-acid
sequence consisting of an N-terminal 'arm' followed by 4 or 8 copies of a
conserved domain of 61 residues (only one of these residues, an arginine,
is conserved between all copies). The calcium-binding sites are found in
the repeated domains [4]. Individual repeats (sometimes referred to as
endonexin folds) consist of 5 alpha-helices wound into a right-handed
superhelix. The biological roles of some annexin subtypes is unclear; the
family has been linked with inhibition of phospholipase activity, exo-
cytosis and endoctyosis, signal transduction, organisation of the extra-
cellular matrix, resistance to reactive oxygen species and DNA replication
[2]. The type IV class has not been identified in all species known to
possess annexins, but are thought to be required for the budding of
clathrin-coated pits.
ANNEXINIV is a 4-element fingerprint that provides a signature for type
IV annexins. The fingerprint was derived from an initial alignment of 6
sequences: the motifs were drawn from conserved regions spanning the N-
terminal half of the alignment, focusing on those areas that characterise
type IV annexins but distinguish them from related annexin subtypes -
motifs 1-3 lie in the first annexin repeat; and motif 4 resides in the
second repeat. Two iterations on SPTR41_24f were required to reach
convergence, at which point a true set comprising 8 sequences was
identified. A single partial match was also found, Q90X16, a type IV
annexin from Xenopus laevis that failed to match motif 1.
SUMMARY INFORMATION
8 codes involving 4 elements
1 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
4| 8 8 8 8
3| 0 1 1 1
2| 0 0 0 0
--+---------------------
| 1 2 3 4
True positives..
ANX4_MOUSE Q9R0V2 Q8BSL2 ANX4_RAT
ANX4_PIG ANX4_HUMAN ANX4_BOVIN ANX4_CANFA
Subfamily: Codes involving 3 elements
Subfamily True positives..
Q90X16
PROTEIN TITLES
ANX4_MOUSE Annexin A4 (Annexin IV) - Mus musculus (Mouse).
Q9R0V2 Truncated annexin IV - Mus musculus (Mouse).
Q8BSL2 Annexin A4 - Mus musculus (Mouse).
ANX4_RAT Annexin A4 (Annexin IV) (Lipocortin IV) (36 kDa zymogen gran
ANX4_PIG Annexin A4 (Annexin IV) (Lipocortin IV) (Endonexin I) (Chrom
ANX4_HUMAN Annexin A4 (Annexin IV) (Lipocortin IV) (Endonexin I) (Chrom
ANX4_BOVIN Annexin A4 (Annexin IV) (Lipocortin IV) (Endonexin I) (Chrom
ANX4_CANFA Annexin A4 (Annexin IV) (Lipocortin IV) (36 kDa zymogen gran
Q90X16 Annexin 4 - Xenopus laevis (African clawed frog).
SCAN HISTORY
SPTR41_24f 2 150 NSINGLE
INITIAL MOTIF SETS
ANNEXINIV1 Length of motif = 10 Motif number = 1
Annexin type IV motif I - 1
PCODE ST INT
GVLACRNTAQ ANX4_RAT 38 38
SVLAPRNTSQ ANX4_CANFA 38 38
GILAYRNTAQ ANX4_MOUSE 38 38
SVLAYRSTAQ ANX4_PIG 38 38
SVLAYRNTAQ ANX4_HUMAN 38 38
NVLAYRSTAQ ANX4_BOVIN 38 38
ANNEXINIV2 Length of motif = 11 Motif number = 2
Annexin type IV motif II - 1
PCODE ST INT
QEIRTAYKSTI ANX4_RAT 49 1
QEIRTAYKSTI ANX4_CANFA 49 1
QEIRSAYKSTI ANX4_MOUSE 49 1
QEIRTAYKSTI ANX4_PIG 49 1
QEIRTAYKSTI ANX4_HUMAN 49 1
QEIRTAYKTTI ANX4_BOVIN 49 1
ANNEXINIV3 Length of motif = 16 Motif number = 3
Annexin type IV motif III - 1
PCODE ST INT
QVILGMMTPTVLYDVQ ANX4_RAT 77 17
RVIVGMITPTVLYDVQ ANX4_CANFA 77 17
QVILGLMTPTVLYDVQ ANX4_MOUSE 77 17
QVILGMMTPTVLYDVQ ANX4_PIG 77 17
QVIVGMMTPTVLYDVQ ANX4_HUMAN 77 17
QVILGMMTPTVLYDVQ ANX4_BOVIN 77 17
ANNEXINIV4 Length of motif = 15 Motif number = 4
Annexin type IV motif IV - 1
PCODE ST INT
EIRRINQTYQQQYGR ANX4_RAT 119 26
ELRCINQTYQLQYGR ANX4_CANFA 119 26
EIRRINQTYQQQYGR ANX4_MOUSE 119 26
EIRRINQTYQLQYGR ANX4_PIG 119 26
EIRRISQTYQQQYGR ANX4_HUMAN 119 26
EIRRINQTYQLQYGR ANX4_BOVIN 119 26
FINAL MOTIF SETS
ANNEXINIV1 Length of motif = 10 Motif number = 1
Annexin type IV motif I - 2
PCODE ST INT
GILAYRNTAQ ANX4_MOUSE 38 38
GILAYRNTAQ Q9R0V2 39 39
GILAYRNTAQ Q8BSL2 39 39
GVLACRNTAQ ANX4_RAT 38 38
SVLAYRSTAQ ANX4_PIG 38 38
SVLAYRNTAQ ANX4_HUMAN 38 38
NVLAYRSTAQ ANX4_BOVIN 38 38
SVLAPRNTSQ ANX4_CANFA 38 38
ANNEXINIV2 Length of motif = 11 Motif number = 2
Annexin type IV motif II - 2
PCODE ST INT
QEIRSAYKSTI ANX4_MOUSE 49 1
QEIRSAYKSTI Q9R0V2 50 1
QEIRSAYKSTI Q8BSL2 50 1
QEIRTAYKSTI ANX4_RAT 49 1
QEIRTAYKSTI ANX4_PIG 49 1
QEIRTAYKSTI ANX4_HUMAN 49 1
QEIRTAYKTTI ANX4_BOVIN 49 1
QEIRTAYKSTI ANX4_CANFA 49 1
ANNEXINIV3 Length of motif = 16 Motif number = 3
Annexin type IV motif III - 2
PCODE ST INT
QVILGLMTPTVLYDVQ ANX4_MOUSE 77 17
QVILGLMTPTVLYDVQ Q9R0V2 78 17
QVILGLMTPTVLYDVQ Q8BSL2 78 17
QVILGMMTPTVLYDVQ ANX4_RAT 77 17
QVILGMMTPTVLYDVQ ANX4_PIG 77 17
QVIVGMMTPTVLYDVQ ANX4_HUMAN 77 17
QVILGMMTPTVLYDVQ ANX4_BOVIN 77 17
RVIVGMITPTVLYDVQ ANX4_CANFA 77 17
ANNEXINIV4 Length of motif = 15 Motif number = 4
Annexin type IV motif IV - 2
PCODE ST INT
EIRRINQTYQQQYGR ANX4_MOUSE 119 26
EIRRINQTYQQQYGR Q9R0V2 120 26
EIRRINQTYQQQYGR Q8BSL2 120 26
EIRRINQTYQQQYGR ANX4_RAT 119 26
EIRRINQTYQLQYGR ANX4_PIG 119 26
EIRRISQTYQQQYGR ANX4_HUMAN 119 26
EIRRINQTYQLQYGR ANX4_BOVIN 119 26
ELRCINQTYQLQYGR ANX4_CANFA 119 26
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