WORKLIST ENTRIES (1): ANNEXINXXXI View alignment Annexin type XXXI signature Type of fingerprint: COMPOUND with 4 elements Links: PRINTS; PR00196 ANNEXIN PRINTS; PR00197 ANNEXINI; PR00198 ANNEXINII; PR00199 ANNEXINIII PRINTS; PR00200 ANNEXINIV; PR00201 ANNEXINV; PR00202 ANNEXINVI PRINTS; PR01871 ANNEXINVII; PR01808 ANNEXINVIII; PR01809 ANNEXINX PRINTS; PR01810 ANNEXINXI; PR01811 ANNEXINXIII; PR01813 ANNEXINFUNGI PRINTS; PR01814 ANNEXINPLANT MIM; 603319 Creation date 13-JAN-2003 1. BARTON, G.J., NEWMAN, R.H., FREEMONT, P.S. AND CRUMPTON, M.J. Amino acid sequence analysis of the annexin super-gene family of proteins. EUR.J.BIOCHEM. 198 749-760 (1991). 2. BRAUN, E.L., KANG, S., NELSON, M.A. AND NATVIG, D.O. Identification of the first fungal annexin: analysis of annexin gene duplications and implications for eukaryotic evolution. J.MOL.EVOL. 47 531-543 (1998). 3. BENZ, J. AND HOFMANN, A. Annexins: from structure to function. BIOL.CHEM. 378 177-183 (1997). 4. GEISOW, M.J. Annexins-forms without function but not without fun. TRENDS BIOTECHNOL. 9 180-181 (1991). 5. MORGAN, R.O. AND FERNANDEZ, M.P. Expression profile and structural divergence of novel human annexin 31. FEBS LETT. 434 300-304 (1998). The annexins (or lipocortins) are a family of proteins that bind to phospholipids in a calcium-dependent manner . They are distributed ubiquitously in different tissues and cell types of higher and lower eukaryotes, including mammals, fish, birds, Drosophila melanogaster, Xenopus laevis, Caenorhabtidis elegans, Dictyostelium discoideum and Neurospora crassa [2,3]. The plant annexins are somewhat distinct from those found in other taxa . Several distinct annexin subtypes exist, each of which has an amino acid sequence consisting of an N-terminal 'arm' followed by 4 or 8 copies of a conserved domain of 61 residues (only one of these residues, an arginine, is conserved between all copies). The calcium binding sites are found within the repeated domains . Individual repeats (sometimes referred to as endonexin folds) consist of 5 alpha-helices wound into a right-handed superhelix. The biological roles of some annexin subtypes is unclear; the family has been linked with inhibition of phospholipase activity, exocytosis and endoctyosis, signal transduction, organisation of the extracellular matrix, resistance to reactive oxygen species and DNA replication . Human annexin XXXI was first identified in silico by searches of dbEST with a number of divergent annexins . The full-length cDNA encoded a protein of 338 residues, with less than 40% sequence identity to other annexins. The most striking distinction of the type XXXI subtype is the complete ablation of all four type II calcium-binding sites in the conserved tetrad core. The protein is well represented in actively differentiating tissues. ANNEXINXXXI is a 4-element fingerprint that provides a signature for the type XXXI annexins. The fingerprint was derived from an initial alignment of 2 sequences: the motifs were drawn from conserved regions spanning virtually the full alignment length, focusing on those sections that characterise type XXXI annexins but distinguish them from other closely related annexin subtypes - motifs 1 and 2 lie in the N-terminal section preceeding the first core repeat; motif 3 resides within the first repeat; and motif 4 is located within the fourth endonexin fold. Two iterations on SPTR40_20f were required to reach convergence, at which point a true set comprising 4 sequences was identified. SUMMARY INFORMATION 4 codes involving 4 elements 0 codes involving 3 elements 0 codes involving 2 elements COMPOSITE FINGERPRINT INDEX 4| 4 4 4 4 3| 0 0 0 0 2| 0 0 0 0 --+--------------------- | 1 2 3 4 True positives.. ANX9_HUMAN Q9HBJ6 ANX9_MOUSE Q9CQS1 PROTEIN TITLES ANX9_HUMAN Annexin A9 (Annexin 31) (Annexin XXXI) - Homo sapiens (Human Q9HBJ6 KERATINOCYTE ANNEXIN-LIKE PROTEIN PEMPHAXIN - Homo sapiens ( ANX9_MOUSE Annexin A9 (Annexin 31) (Annexin XXXI) - Mus musculus (Mouse Q9CQS1 2310069F17RIK PROTEIN (1110003P15RIK PROTEIN) - Mus musculus
SCAN HISTORY SPTR40_20f 2 300 NSINGLE INITIAL MOTIF SETS ANNEXINXXXI1 Length of motif = 15 Motif number = 1 Annexin type XXXI motif I - 1 PCODE ST INT MAPSLTQEILSHLGL ANX9_HUMAN 1 1 MGTSLTQEILSSLGL ANX9_MOUSE 1 1 ANNEXINXXXI2 Length of motif = 15 Motif number = 2 Annexin type XXXI motif II - 1 PCODE ST INT KTAAWGTLGTLRTFL ANX9_HUMAN 18 2 KTAAWGTLGTLRTFL ANX9_MOUSE 18 2 ANNEXINXXXI3 Length of motif = 11 Motif number = 3 Annexin type XXXI motif III - 1 PCODE ST INT DAQRLLRAITG ANX9_HUMAN 39 6 DVQRLLKAIAG ANX9_MOUSE 39 6 ANNEXINXXXI4 Length of motif = 10 Motif number = 4 Annexin type XXXI motif IV - 1 PCODE ST INT LQDAVKGDCQ ANX9_HUMAN 317 267 LQDVVRGDCR ANX9_MOUSE 317 267 FINAL MOTIF SETS ANNEXINXXXI1 Length of motif = 15 Motif number = 1 Annexin type XXXI motif I - 2 PCODE ST INT MAPSLTQEILSHLGL ANX9_HUMAN 1 1 MAPSLTQEILSHLGL Q9HBJ6 8 8 MGTSLTQEILSSLGL ANX9_MOUSE 1 1 LGTSLTQEILSSLGL Q9CQS1 8 8 ANNEXINXXXI2 Length of motif = 15 Motif number = 2 Annexin type XXXI motif II - 2 PCODE ST INT KTAAWGTLGTLRTFL ANX9_HUMAN 18 2 KTAAWGTLGTLRTFL Q9HBJ6 25 2 KTAAWGTLGTLRTFL ANX9_MOUSE 18 2 KTAAWGTLGTLRTFL Q9CQS1 25 2 ANNEXINXXXI3 Length of motif = 11 Motif number = 3 Annexin type XXXI motif III - 2 PCODE ST INT DAQRLLRAITG ANX9_HUMAN 39 6 DAQRLLRAITG Q9HBJ6 46 6 DVQRLLKAIAG ANX9_MOUSE 39 6 DVQRLLKAIAG Q9CQS1 46 6 ANNEXINXXXI4 Length of motif = 10 Motif number = 4 Annexin type XXXI motif IV - 2 PCODE ST INT LQDAVKGDCQ ANX9_HUMAN 317 267 LQDAVKGDCQ Q9HBJ6 324 267 LQDVVRGDCR ANX9_MOUSE 317 267 LQDVVRGDCR Q9CQS1 324 267
User query: Display/Full Code "ANNEXINXXXI"