WORKLIST ENTRIES (1):
CALPAIN View alignment View Structure Calpain cysteine protease (C2) family signature
Type of fingerprint: COMPOUND with 9 elements
Links:
PRINTS; PR00705 PAPAIN; PR00966 NIAPOTYPTASE; PR00703 ADVENDOPTASE
PRINTS; PR00797 STREPTOPAIN; PR00707 UBCTHYDRLASE; PR00776 HEMOGLOBNASE
PRINTS; PR00706 PYROGLUPTASE; PR00864 PREPILNPTASE; PR00916 2CENDOPTASE
PRINTS; PR00917 SRSVCYSPTASE
INTERPRO; IPR001300
PROSITE; PS00139 THIOL_PROTEASE_CYS; PS00639 THIOL_PROTEASE_HIS
PROSITE; PS00640 THIOL_PROTEASE_ASN
PFAM; PF00648 Cys_protease_2
Creation date 08-MAR-1997; UPDATE 10-JUN-1999
1. RAWLINGS, N.D. AND BARRETT, A.J.
Families of cysteine peptidases.
METHODS ENZYMOL. 244 461-486 (1994).
2. HATA, A., OHNO, S., AKITA, Y. AND SUZUKI, K.
Tandemly reiterated negative enhancer-like elements regulate transcription
of a human gene for the large subunit of calcium-dependent protease.
J.BIOL.CHEM. 264(11) 6404-6411 (1989).
3. SORIMACHI, H., IMAJOH-OHMI, S., EMORI, Y., KAWASAKI, H., OHNO, S.,
MINAMI, Y. AND SUZUKI, K.
Molecular cloning of a novel mammalian calcium-dependent protease distinct
from both m- and mu-types. Specific expression of the mRNA in skeletal
muscle.
J.BIOL.CHEM. 264(33) 20106-20111 (1989).
Cysteine protease activity is dependent on an active dyad of cysteine and
histidine, the order and spacing of these residues varying in the 20 or so
known families. Families C1, C2 and C10 are loosely termed papain-like, and
nearly half of all cysteine proteases are found exclusively in viruses [1].
Calpain is an intracellular protease involved in many important cellular
functions that are regulated by calcium [2]. The protein is a complex of 2
polypeptide chains (light and heavy), with three known forms in mammals
[1,3]: a highly calcium-sensitive (i.e., micro-molar range) form known as
mu-calpain, mu-CANP or calpain I; a form sensitive to calcium in the
milli-molar range, known as m-calpain, m-CANP or calpain II; and a third
form, known as p94, which is found in skeletal muscle only [3].
All three forms have identical light but different heavy chains [1,2].
The heavy chain comprises four domains: domain 2 contains the catalytic
region; domain 4 binds calcium and regulates activity [1]. Domain 2 shows
low levels of sequence similarity to papain; although the catalytic His has
not been located by biochemical means, it is likely that calpain and papain
are related [1]. Domain 4 has four EF hand calcium-binding regions and is
simmilar to sorcin and the Ca2+-binding region of calpain light chain [1].
Calpain shows preferential cleavage for Tyr-|-XAA, Met-|-XAA and Arg-|-XAA
with leucine or valine as the P2 residue. The product of the Drosophila
gene sol has also been shown to be similar to calpain [1].
CALPAIN is a 9-element fingerprint that provides a signature for the
heavy chain of the calpain cysteine protease (C2) family. The fingerprint
was derived from an initial alignment of 11 sequences: the motifs were
drawn from conserved regions spanning virtually the full alignment length -
motifs 2 and 3 span the region encoded by PROSITE pattern THIOL_PROTEASE_CYS
(PS00139), which contains the catalytic Cys. Two iterations on OWL30.0 were
required to reach convergence, at which point a true set comprising 33
sequences was identified. Several partial matches were also found: S57195,
CAN3_PIG, CAN2_RABIT, SSU23954 and CAN1_PIG are calpain fragments that lack
portions of sequence bearing one or more motifs; SOL_DROME is a Drosophila
optic lobe protein that matches motifs 1, 3, 4, 6 and 7.
An update on SPTR37_9f identified a true set of 30 sequences, and 11
partial matches.
SUMMARY INFORMATION
30 codes involving 9 elements
0 codes involving 8 elements
0 codes involving 7 elements
1 codes involving 6 elements
2 codes involving 5 elements
1 codes involving 4 elements
3 codes involving 3 elements
4 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
9| 30 30 30 30 30 30 30 30 30
8| 0 0 0 0 0 0 0 0 0
7| 0 0 0 0 0 0 0 0 0
6| 1 0 1 1 1 1 1 0 0
5| 2 0 2 2 0 2 2 0 0
4| 0 0 0 1 1 0 1 0 1
3| 0 0 2 1 2 1 2 0 1
2| 0 0 2 1 0 3 2 0 0
--+----------------------------------------------
| 1 2 3 4 5 6 7 8 9
True positives..
O08702 O70376 O70482 CAN3_MOUSE
CAN3_RAT O54843 O46596 CAN2_RAT
O88977 O35350 CAN3_HUMAN CAN2_HUMAN
CAN2_MOUSE O88666 P97571 CAN1_HUMAN
CAN3_CHICK CAN2_CHICK O42133 Q64698
CANX_CHICK O14815 CAN_DROME YKR2_CAEEL
O08688 CAN_SCHMA O15484 O35646
Q22036 O88501
Subfamily: Codes involving 6 elements
Subfamily True positives..
O75808
Subfamily: Codes involving 5 elements
Subfamily True positives..
O61346 SOL_DROME
Subfamily: Codes involving 4 elements
Subfamily True positives..
Q22143
Subfamily: Codes involving 3 elements
Subfamily True positives..
Q00204 O02259 O44903
Subfamily: Codes involving 2 elements
Subfamily True positives..
O02260 P91312 Q22386 O18165
PROTEIN TITLES
O08702 CALPAIN LP82 - RATTUS NORVEGICUS (RAT).
O70376 CALPAIN ISOFORM LP85 - RATTUS NORVEGICUS (RAT).
O70482 MUSCLE TYPE CALPAIN P94 - RATTUS NORVEGICUS (RAT).
CAN3_MOUSE CALPAIN P94, LARGE [CATALYTIC] SUBUNIT (EC 3.4.22.17) (CALCI
CAN3_RAT CALPAIN P94, LARGE [CATALYTIC] SUBUNIT (EC 3.4.22.17) (CALCI
O54843 CALPAIN 2 (80KDA M-CALPAIN SUBUNIT) - MUS MUSCULUS (MOUSE).
O46596 SKELETAL MUSCLE SPECIFIC CALPAIN - SUS SCROFA (PIG).
CAN2_RAT CALPAIN 2, LARGE [CATALYTIC] SUBUNIT (EC 3.4.22.17) (CALCIUM
O88977 CALPAIN LP82 - MUS MUSCULUS (MOUSE).
O35350 CALPAIN 1 (MICROMOLAR CALCIUM ACTIVATED NEUTRAL PROTEASE LAR
CAN3_HUMAN CALPAIN P94, LARGE [CATALYTIC] SUBUNIT (EC 3.4.22.17) (CALCI
CAN2_HUMAN CALPAIN 2, LARGE [CATALYTIC] SUBUNIT (EC 3.4.22.17) (CALCIUM
CAN2_MOUSE CALPAIN 2, LARGE [CATALYTIC] SUBUNIT (EC 3.4.22.17) (CALCIUM
O88666 CALPAIN I LARGE SUBUNIT - MUS MUSCULUS (MOUSE).
P97571 MU-CALPAIN LARGE SUBUNIT (EC 3.4.22.17) - RATTUS NORVEGICUS
CAN1_HUMAN CALPAIN 1, LARGE [CATALYTIC] SUBUNIT (EC 3.4.22.17) (CALCIUM
CAN3_CHICK CALPAIN P94, LARGE [CATALYTIC] SUBUNIT (EC 3.4.22.17) (CALCI
CAN2_CHICK CALPAIN 2, LARGE [CATALYTIC] SUBUNIT (EC 3.4.22.17) (CALCIUM
O42133 MUCL (EC 3.4.22.17) - GALLUS GALLUS (CHICKEN).
Q64698 CALPAIN, LARGE (CATALYTIC) SUBUNIT (EC 3.4.22.17) (CALCIUM-A
CANX_CHICK CALPAIN, LARGE [CATALYTIC] SUBUNIT (EC 3.4.22.17) (CALCIUM-
O14815 DIGESTIVE TRACT-SPECIFIC CALPAIN (EC 3.4.22.17) - HOMO SAPIE
CAN_DROME CALPAIN (EC 3.4.22.17) (CALCIUM-ACTIVATED NEUTRAL PROTEINASE
YKR2_CAEEL HYPOTHETICAL 70.9 KD PROTEIN C06G4.2 IN CHROMOSOME III - CAE
O08688 CALPAIN 5 (CALPAIN-LIKE PROTEASE) - MUS MUSCULUS (MOUSE).
CAN_SCHMA CALPAIN (EC 3.4.22.17) (CALCIUM-ACTIVATED NEUTRAL PROTEINASE
O15484 CALPAIN-LIKE PROTEASE - HOMO SAPIENS (HUMAN).
O35646 CALPAIN 6 (CALPAIN-LIKE PROTEASE) - MUS MUSCULUS (MOUSE).
Q22036 TRA-3 - CAENORHABDITIS ELEGANS.
O88501 CALPAIN-LIKE PROTEASE - RATTUS NORVEGICUS (RAT).
O75808 SMALL OPTIC LOBES HOMOLOG - HOMO SAPIENS (HUMAN).
O61346 SMALL OPTIC LOBES - DROSOPHILA MELANOGASTER (FRUIT FLY).
SOL_DROME SMALL OPTIC LOBES PROTEIN - DROSOPHILA MELANOGASTER (FRUIT F
Q22143 T04A8.16 PROTEIN - CAENORHABDITIS ELEGANS.
Q00204 PUTATIVE CYSTEINE PROTEASE PALB - EMERICELLA NIDULANS (ASPER
O02259 F44F1.1 PROTEIN - CAENORHABDITIS ELEGANS.
O44903 W05G11.4 PROTEIN - CAENORHABDITIS ELEGANS.
O02260 F44F1.3 PROTEIN - CAENORHABDITIS ELEGANS.
P91312 SIMILAR TO CALCIUM-ACTIVATED NEUTRAL PROTEINASES - CAENORHAB
Q22386 T11A5.6 PROTEIN - CAENORHABDITIS ELEGANS.
O18165 W04A4.4 PROTEIN - CAENORHABDITIS ELEGANS.
SCAN HISTORY
OWL30_0 2 40 NSINGLE
SPTR37_9f 2 77 NSINGLE
INITIAL MOTIF SETS
CALPAIN1 Length of motif = 24 Motif number = 1
Calpain motif I - 1
PCODE ST INT
QDYEALRNECLEAGTLFQDPSFPA CAN2_HUMAN 30 30
QDYETILNSCLASGSLFEDPLFPA CAN_DROME 73 73
QDYEQLRVRCLQSGTLFRDEAFPP CAN1_HUMAN 40 40
QNYSALRRDCRRRKVLFEDPLFPA HSNCL3PRT 11 11
QDFYELRDQCLESKRLFEDPQFLA YKR2_CAEEL 205 205
KTYEELHKKCLEENILYEDPDFPP CAN3_CHICK 53 53
KTFEQLHKKCLEKKVLYLDPEFPP CAN3_RAT 59 59
QKYQELKQECMKDGRLFCDPTFLP MMCALPAIN 11 11
QKYQELKQECIKDSRLFCDPTFLP AF029232 11 11
QKYQELKQECIKDSRLFCDPTFLP HSCANPX 11 11
KQYETLVKRLKTERTLWEDPDFPA CAN_SCHMA 84 84
CALPAIN2 Length of motif = 23 Motif number = 2
Calpain motif II - 1
PCODE ST INT
WKRPTEICADPQFIIGGATRTDI CAN2_HUMAN 75 21
WLRPHEIAENPQFFVEGYSRFDV CAN_DROME 113 16
WKRPTELLSNPQFIVDGATRTDI CAN1_HUMAN 85 21
RKRPKGICEDPRLFVDGISSHDL HSNCL3PRT 51 16
WLRPGEITREPQLITEGHSRFDV YKR2_CAEEL 245 16
WKRPREICENPRFIIGGANRTDI CAN3_CHICK 93 16
WKRPPEICENPRFIIGGANRTDI CAN3_RAT 99 16
WKRPQDISDDPHLIVGNISNHQL MMCALPAIN 51 16
WKRPQDICDDPHLIVGNISNHQL AF029232 51 16
WKRPQDICDDPHLIVGNISNHQL HSCANPX 51 16
WKRPHEINPNAKFFAGGASRFDI CAN_SCHMA 124 16
CALPAIN3 Length of motif = 17 Motif number = 3
Calpain motif III - 1
PCODE ST INT
QGALGDCWLLAAIASLT CAN2_HUMAN 99 1
QGELGDCWLLAATANLT CAN_DROME 137 1
QGALGDCWLLAAIASLT CAN1_HUMAN 109 1
QGQVGNCWFVAACSSLA HSNCL3PRT 75 1
QGELGDCWLLAAAANLT YKR2_CAEEL 269 1
QGELGDCWFLAAIACLT CAN3_CHICK 117 1
QGDLGDCWLLAAIACLT CAN3_RAT 123 1
QGRLGNKAMISAFSCLA MMCALPAIN 75 1
QGRLGHKPMVSAFSCLA AF029232 75 1
QGRLGHKPMVSAFSCLA HSCANPX 75 1
QGALGDCWLLAVVASIS CAN_SCHMA 148 1
CALPAIN4 Length of motif = 26 Motif number = 4
Calpain motif IV - 1
PCODE ST INT
YAGIFHFQFWQYGEWVEVVVDDRLPT CAN2_HUMAN 135 19
YAGIFHFRFWQYGKWVDVIIDDRLPT CAN_DROME 173 19
YAGIFHFQLWQFGEWVDVVVDDLLPI CAN1_HUMAN 145 19
YAGIFHFHFWRFGEWVDVVIDDRLPT HSNCL3PRT 117 25
YAGIFHFQFWQYGKWVDVVIDDRLPT YKR2_CAEEL 305 19
YAGIFHFQFWRYGDWVDVIIDDCLPT CAN3_CHICK 153 19
YAGIFHFQFWRYGDWVDVVIDDCLPT CAN3_RAT 159 19
YAGIFHFRFWHFGEWTEVVIDDLLPT MMCALPAIN 117 25
YAGIFHFRFWHFGEWTEVVIDDLLPT AF029232 117 25
YAGIFHFRFWHFGEWTEVVIDDLLPT HSCANPX 117 25
YVGVVRFRFWRFGHWVEVLIDDRLPV CAN_SCHMA 185 20
CALPAIN5 Length of motif = 24 Motif number = 5
Calpain motif V - 1
PCODE ST INT
LLFVHSAEGSEFWSALLEKAYAKI CAN2_HUMAN 165 4
LMYMHSTEKNEFWSALLEKAYAKL CAN_DROME 203 4
LVFVHSAEGNEFWSALLEKAYAKV CAN1_HUMAN 175 4
LIYCHSNSRNEFWCALVEKAYAKL HSNCL3PRT 147 4
LLYMHSASNNEFWSALLEKAYAKL YKR2_CAEEL 335 4
LVFTKSSQRNEFWSALLEKAYAKL CAN3_CHICK 183 4
LVFTKSNHRNEFWSALLEKAYAKL CAN3_RAT 189 4
LVFSFSTSMNEFWNALLEKAYAKL MMCALPAIN 147 4
LVFSFSTSMNEFWNALLEKAYAKL AF029232 147 4
LVFSFSTSMNEFWNALLEKAYAKL HSCANPX 147 4
LVFMHSNDPTEFWSALLEKAYAKL CAN_SCHMA 217 6
CALPAIN6 Length of motif = 28 Motif number = 6
Calpain motif VI - 1
PCODE ST INT
GCYEALSGGATTEGFEDFTGGIAEWYEL CAN2_HUMAN 190 1
GSYEALKGGSTCEAMEDFTGGVSEWYDL CAN_DROME 228 1
GSYEALSGGSTSEGFEDFTGGVTEWYEL CAN1_HUMAN 200 1
GCYQALDGGNTADALVDFTGGVSEPIDL HSNCL3PRT 172 1
GSYEALKGGTTSEALEDMTGGLTEFIDL YKR2_CAEEL 360 1
GSYEALKGGNTTEAMEDFTGGVIEFYEI CAN3_CHICK 208 1
GSYEALKGGNTTEAMEDFTGGVTEFFEI CAN3_RAT 214 1
GCYEALDGLTITDIIMDFTGTLAEIIDM MMCALPAIN 172 1
GCYEALDGLTITDIIVDFTGTLAETVDM AF029232 172 1
GCYEALDGLTITDIIVDFTGTLAETVDM HSCANPX 172 1
GCYAHLSGGSQSEAMEDLTGGICLSLEL CAN_SCHMA 242 1
CALPAIN7 Length of motif = 22 Motif number = 7
Calpain motif VII - 1
PCODE ST INT
EDGEFWMSFSDFLRHYSRLEIC CAN2_HUMAN 320 102
RDGEFWMSFQDFLNHFDRVEIC CAN_DROME 363 107
EDGEFWMSFRDFMREFTRLEIC CAN1_HUMAN 330 102
DDGEFWMTFEDVCRYFTDIIKC HSNCL3PRT 319 119
HDGEFWMSFDDFMRNFEKMEIC YKR2_CAEEL 491 103
EDGEFWISLEDFMRHFTKLEIC CAN3_CHICK 386 150
EDGEFWMSYDDFVYHFTKLEIC CAN3_RAT 393 151
DDGEFWMSLEDFCHNFHKLNVC MMCALPAIN 319 119
DDGEFWMSLEDFCRNFHKLNVC AF029232 319 119
DDGEFWMSLEDFCRNFHKLNVC HSCANPX 319 119
ADGEFWMSYEDFVTCFSRVEVC CAN_SCHMA 373 103
CALPAIN8 Length of motif = 18 Motif number = 8
Calpain motif VIII - 1
PCODE ST INT
TAGGCRNYPNTFWMNPQY CAN2_HUMAN 370 28
TAGGCRNFLDTFWHNPQY CAN_DROME 417 32
TAGGCRNYPATFWVNPQF CAN1_HUMAN 380 28
RGGGCINHKDTFFQNPQY HSNCL3PRT 373 32
TAGGCRNYINTFANNPQF YKR2_CAEEL 549 36
SAGGCRNYPDTFWTNPQY CAN3_CHICK 436 28
SAGGCRNFPDTFWTNPQY CAN3_RAT 443 28
RSGGCYNNRDTFLQNPQY MMCALPAIN 370 29
RSGGCYNNRDTFLQNPQY AF029232 370 29
RSGGCYNNRDTFLQNPQY HSCANPX 370 29
NAGGCINNRTTYWTSPQF CAN_SCHMA 427 32
CALPAIN9 Length of motif = 29 Motif number = 9
Calpain motif IX - 1
PCODE ST INT
KLPPGEYILVPSTFEPNKDGDFCIRVFSE CAN2_HUMAN 476 88
KLPPGHYLIVPSTFDPNEEGEFIIRVFSE CAN_DROME 519 84
RLPPGEYVVVPSTFEPNKEGDFVLRFFSE CAN1_HUMAN 488 90
DQPEGRYVIIPTTFEPGHTGEFLLRVFTD HSNCL3PRT 462 71
RVPPGNYVVVPSTFEPNEEAEFMLRVYTN YKR2_CAEEL 619 52
RLPPSEYVIIPSTYEPHQEGEFILRVFSE CAN3_CHICK 541 87
RLPPSEYVIVPSTYEPHQEGEFILRVFSE CAN3_RAT 548 87
YLKKGSYVLVPTMFQHGRTSEFLLRIFSE MMCALPAIN 461 73
YLKKGNYVLVPTMFQHGRTSEFLLRIFSE AF029232 461 73
YLKKGNYVLVPTMFQHGRTSEFLLRIFSE HSCANPX 461 73
RVPPGSYVVIPSTFDPNIEVNFILRVFSQ CAN_SCHMA 524 79
FINAL MOTIF SETS
CALPAIN1 Length of motif = 24 Motif number = 1
Calpain motif I - 2
PCODE ST INT
QDFVVLKQRCLAQKCLFEDRVFPA O08702 35 35
QDFVVLKQRCLAQKCLFEDRVFPA O70376 35 35
QDFVVLKQRCLAQKCLFEDRVFPA O70482 35 35
KTFEQLRKKCLEKKVLYLDPEFPP CAN3_MOUSE 59 59
KTFEQLHKKCLEKKVLYLDPEFPP CAN3_RAT 59 59
QDYETLRNECLEAGALFQDPSFPA O54843 30 30
KTFEQLHKKCLEKKVLYLDPEFPP O46596 58 58
QDYETLRNECLEAGALFQDPSFPA CAN2_RAT 30 30
QDFVVLKQRCLAQKCLFEDRVFPA O88977 35 35
QDYETLRARCLQSGVLFQDEAFPP O35350 40 40
KTFEQLHKKCLEKKVLYVDPEFPP CAN3_HUMAN 59 59
QDYEALRNECLEAGTLFQDPSFPA CAN2_HUMAN 30 30
QDYETLRNECLEAGALFQDPSFPA CAN2_MOUSE 30 30
QDYETLRARCLQSGVLFQDEAFPP O88666 40 40
QDYENLRARCLQNGVLFQDDAFPP P97571 40 40
QDYEQLRVRCLQSGTLFRDEAFPP CAN1_HUMAN 40 40
KTYEELHKKCLEENILYEDPDFPP CAN3_CHICK 53 53
QDFGALRRECLQGGRLFHDPSFPA CAN2_CHICK 30 30
QDYAALRDDCLRSGSLFRDETFPP O42133 40 40
QDFETLRKQCLNSGVLFKDPEFPA Q64698 30 30
QDYEALKQECIESGTLFRDPQFPA CANX_CHICK 32 32
QSFEQMRQECLQRGTLFEDADFPA O14815 27 27
QDYETILNSCLASGSLFEDPLFPA CAN_DROME 73 73
QDFYELRDQCLESKRLFEDPQFLA YKR2_CAEEL 205 205
QNYSALKRACLRKKVLFEDPLFPA O08688 11 11
KQYETLVKRLKTERTLWEDPDFPA CAN_SCHMA 84 84
QNYSALRQDCRRRKVLFEDPLFPA O15484 11 11
QKYQELKQECMKDGRLFCDPTFLP O35646 11 11
QNYEKLRKICIKKKQPFVDTLFPP Q22036 13 13
QKYQELKQDCMKDGRLFCDPTFLP O88501 11 11
CALPAIN2 Length of motif = 23 Motif number = 2
Calpain motif II - 2
PCODE ST INT
WKRPKEICENPRFIIGGANRTDI O08702 79 20
WKRPKEICENPRFIIGGANRTDI O70376 79 20
WKRPKEICENPRFIIGGANRTDI O70482 79 20
WKRPPEICENPRFIIGGANRTDI CAN3_MOUSE 99 16
WKRPPEICENPRFIIGGANRTDI CAN3_RAT 99 16
WKRPTEICADPQFIIGGATRTDI O54843 75 21
WKRPPEICENPRFIIGGANRTDI O46596 98 16
WKRPTEICADPQFIIGGATRTDI CAN2_RAT 75 21
WKKPKEICENPGFIIGGANRTDI O88977 79 20
WKRPTELMSNPQFIVDGATRTDI O35350 85 21
WKRPPEICENPRFIIDGANRTDI CAN3_HUMAN 99 16
WKRPTEICADPQFIIGGATRTDI CAN2_HUMAN 75 21
WKRPTEICADPQFIIGGATRTDI CAN2_MOUSE 75 21
WKRPTELMSNPQFIVDGATRTDI O88666 85 21
WKRPTELLSNPQFIVDGATRTDI P97571 85 21
WKRPTELLSNPQFIVDGATRTDI CAN1_HUMAN 85 21
WKRPREICENPRFIIGGANRTDI CAN3_CHICK 93 16
WCRPTELCSCPRFIAGGATRTDI CAN2_CHICK 75 21
WKRPTELCRHPQFIVDGATRTDI O42133 85 21
WKRPTELCPNPQFIVGGATRTDI Q64698 75 21
WKRPSELVDDPQFIVGGATRTDI CANX_CHICK 77 21
WKRPGEIVKNPEFILGGATRTDI O14815 67 16
WLRPHEIAENPQFFVEGYSRFDV CAN_DROME 113 16
WLRPGEITREPQLITEGHSRFDV YKR2_CAEEL 245 16
WKRPKDICDDPRLFVDGISSHDL O08688 51 16
WKRPHEINPNAKFFAGGASRFDI CAN_SCHMA 124 16
WKRPKGICEDPRLFVDGISSHDL O15484 51 16
WKRPQDISDDPHLIVGNISNHQL O35646 51 16
WKRPGELHPDPHLFVEGASPNDV Q22036 53 16
WKRPQDISDDPHLIVGNISNHQL O88501 51 16
CALPAIN3 Length of motif = 17 Motif number = 3
Calpain motif III - 2
PCODE ST INT
QGDLGDCWFLAAIACLT O08702 103 1
QGDLGDCWFLAAIACLT O70376 103 1
QGDLGDCWFLAAIACLT O70482 103 1
QGDLGDCWFLAAIACLT CAN3_MOUSE 123 1
QGDLGDCWLLAAIACLT CAN3_RAT 123 1
QGALGDCWLLAAIASLT O54843 99 1
QGDLGDCWFLAAIACLT O46596 122 1
QGALGDCWLLAAIASLT CAN2_RAT 99 1
QGDLGDCWFLAAIACLT O88977 103 1
QGALGDCWLLAAIASLT O35350 109 1
QGELGDCWFLAAIACLT CAN3_HUMAN 123 1
QGALGDCWLLAAIASLT CAN2_HUMAN 99 1
QGALGDCWLLAAIASLT CAN2_MOUSE 99 1
QGALGDCWLLAAIASLT O88666 109 1
QGALGDCWLLAAIASLT P97571 109 1
QGALGDCWLLAAIASLT CAN1_HUMAN 109 1
QGELGDCWFLAAIACLT CAN3_CHICK 117 1
QGALGDCWLLAAIASLT CAN2_CHICK 99 1
QGALGDCWLLAAIASLT O42133 109 1
QGGLGDCWLLAAIASLT Q64698 99 1
QGALGDCWLLAAIGSLT CANX_CHICK 101 1
QGELGDCWLLAAIASLT O14815 91 1
QGELGDCWLLAATANLT CAN_DROME 137 1
QGELGDCWLLAAAANLT YKR2_CAEEL 269 1
QGQVGNCWFVAACSSLA O08688 75 1
QGALGDCWLLAVVASIS CAN_SCHMA 148 1
QGQVGNCWFVAACSSLA O15484 75 1
QGRLGNKAMISAFSCLA O35646 75 1
QGILGNCWFVSACSALT Q22036 77 1
QGRLGNKAMISAFSCLA O88501 75 1
CALPAIN4 Length of motif = 26 Motif number = 4
Calpain motif IV - 2
PCODE ST INT
YAGIFHFQFWRYGDWVDVVIDDCLPT O08702 139 19
YAGIFHFQFWRYGDWVDVVIDDCLPT O70376 139 19
YAGIFHFQFWRYGDWVDVVIDDCLPT O70482 139 19
YAGIFHFQFWRYGDWVDVVIDDCLPT CAN3_MOUSE 159 19
YAGIFHFQFWRYGDWVDVVIDDCLPT CAN3_RAT 159 19
YAGIFHFQFWQYGEWVEVVVDDRLPT O54843 135 19
YAGIFHFQFWRYGDWVDVVIDDCLPT O46596 158 19
YAGIFHFQFWQYGEWVEVVVDDRLPT CAN2_RAT 135 19
YAGIFHFQFWRYGDWVDVVIDDCLPT O88977 139 19
YAGIFHFQLWQFGEWVDVVIDDLLPT O35350 145 19
YAGIFHFQFWRYGEWVDVVIDDCLPT CAN3_HUMAN 159 19
YAGIFHFQFWQYGEWVEVVVDDRLPT CAN2_HUMAN 135 19
YAGIFHFQFWQYGEWVEVVVDDRLPT CAN2_MOUSE 135 19
YAGIFHFQLWQFGEWVDVVIDDLLPT O88666 145 19
YAGIFHFQLWQFGEWVDVVVDDLLPT P97571 145 19
YAGIFHFQLWQFGEWVDVVVDDLLPI CAN1_HUMAN 145 19
YAGIFHFQFWRYGDWVDVIIDDCLPT CAN3_CHICK 153 19
YAGIFHFQFWQYGEWVDVVVDDRLPT CAN2_CHICK 135 19
YAGIFHFQIWQFGEWQDVVVDDYLPT O42133 145 19
YAGIFHFQFWQYGEWVEVVIDDRLPT Q64698 135 19
YAGIFHFQIWQFGEWVDVVVDDLLPT CANX_CHICK 137 19
YAGIFHFQFWQHSEWLDVVIDDRLPT O14815 127 19
YAGIFHFRFWQYGKWVDVIIDDRLPT CAN_DROME 173 19
YAGIFHFQFWQYGKWVDVVIDDRLPT YKR2_CAEEL 305 19
YAGIFHFNFWRFGEWVDVIVDDRLPT O08688 117 25
YVGVVRFRFWRFGHWVEVLIDDRLPV CAN_SCHMA 185 20
YAGIFHFHFWRLGMVDVVIDERLPTV O15484 117 25
YAGIFHFRFWHFGEWTEVVIDDLLPT O35646 117 25
YAGIFRFRFWRFGKWVEVVIDDLLPT Q22036 117 23
YAGIFRFRFWHFGEWTEVVIDDLLPT O88501 117 25
CALPAIN5 Length of motif = 24 Motif number = 5
Calpain motif V - 2
PCODE ST INT
LVFTKSNHRNEFWSALLEKAYAKL O08702 169 4
LVFTKSNHRNEFWSALLEKAYAKL O70376 169 4
LVFTKSNHRNEFWSALLEKAYAKL O70482 169 4
LVFTKSNHRNEFWSALLEKAYAKL CAN3_MOUSE 189 4
LVFTKSNHRNEFWSALLEKAYAKL CAN3_RAT 189 4
LLFVHSAEGSEFWSALLEKAYAKI O54843 165 4
LVFTKSNHRNEFWSALLEKAYAKL O46596 188 4
LLFVHSAEGSEFWSALLEKAYAKI CAN2_RAT 165 4
LVFTKSNHRNEFWSALLEKAYAKL O88977 169 4
LVFVHSAQGNEFWSALLEKAYAKV O35350 175 4
LVFTKSNHRNEFWSALLEKAYAKL CAN3_HUMAN 189 4
LLFVHSAEGSEFWSALLEKAYAKI CAN2_HUMAN 165 4
LLFVHSAEGSEFWSALLEKAYAKI CAN2_MOUSE 165 4
LVFVHSAQGNEFWSALLEKAYAKV O88666 175 4
LVFVHSAQGNEFWSALLEKAYAKV P97571 175 4
LVFVHSAEGNEFWSALLEKAYAKV CAN1_HUMAN 175 4
LVFTKSSQRNEFWSALLEKAYAKL CAN3_CHICK 183 4
LLFVHSAEGSEFWSALLEKAYAKL CAN2_CHICK 165 4
LLFVHSAEGTEFWSALLEKAYAKV O42133 175 4
LLFLHSEEGNEFWSALLEKAYAKL Q64698 165 4
LLFVHSAECTEFWSALLEKAYAKL CANX_CHICK 167 4
LVFLHSADHNEFWSALLEKAYAKL O14815 157 4
LMYMHSTEKNEFWSALLEKAYAKL CAN_DROME 203 4
LLYMHSASNNEFWSALLEKAYAKL YKR2_CAEEL 335 4
LIYCHSNSKNEFWCALVEKAYAKL O08688 147 4
LVFMHSNDPTEFWSALLEKAYAKL CAN_SCHMA 217 6
LIYCHSNSRNEFWCALVEKAYAKL O15484 146 3
LVFSFSTSMNEFWNALLEKAYAKL O35646 147 4
LLFARSKTPNEFWSALLEKAFAKL Q22036 147 4
LVFSFSTSMNEFWNALLEKAYAKL O88501 147 4
CALPAIN6 Length of motif = 28 Motif number = 6
Calpain motif VI - 2
PCODE ST INT
GSYEALKGGNTTEAMEDFTGGVTEFFEI O08702 194 1
GSYEALKGGNTTEAMEDFTGGVTEFFEI O70376 194 1
GSYEALKGGNTTEAMEDFTGGVTEFFEI O70482 194 1
GSYEALKGGNTTEAMEDFTGGVTEFFEI CAN3_MOUSE 214 1
GSYEALKGGNTTEAMEDFTGGVTEFFEI CAN3_RAT 214 1
GCYEALSGGATTEGFEDFTGGIAEWYEL O54843 190 1
GSYEALKGGNTTEAMEDFTGGVTEFFEI O46596 213 1
GCYEALSGGATTEGFEDFTGGIAEWYEL CAN2_RAT 190 1
GSYEALKGGNTTEAMEDFTGGVTEFFEI O88977 194 1
GSYEALSGGCTSEAFEDFTGGVTEWYDL O35350 200 1
GSYEALKGGNTTEAMEDFTGGVAEFFEI CAN3_HUMAN 214 1
GCYEALSGGATTEGFEDFTGGIAEWYEL CAN2_HUMAN 190 1
GCYETLSGGATTEGFEDFTGGIAEWYEL CAN2_MOUSE 190 1
GSYEALSGGCTSEAFEDFTGGVTEWYDL O88666 200 1
GSYEALSGGCTSEAFEDFTGGVTEWYDL P97571 200 1
GSYEALSGGSTSEGFEDFTGGVTEWYEL CAN1_HUMAN 200 1
GSYEALKGGNTTEAMEDFTGGVIEFYEI CAN3_CHICK 208 1
GSYEALSGGTTTEGFEDFTGGIAEWYEL CAN2_CHICK 190 1
GCYEALSGGSTSEGFEDFTGGVTEWYDL O42133 200 1
GSYEALVGGSTIEGFEDFTGGISEFYDL Q64698 190 1
GCYESLSGGSTTEGFEDFTGGVAEMYDL CANX_CHICK 192 1
GSYEALKGGSAIEAMEDFTGGVAETFQT O14815 182 1
GSYEALKGGSTCEAMEDFTGGVSEWYDL CAN_DROME 228 1
GSYEALKGGTTSEALEDMTGGLTEFIDL YKR2_CAEEL 360 1
GCYQALDGGNTADALVDFTGGVSEPIDL O08688 172 1
GCYAHLSGGSQSEAMEDLTGGICLSLEL CAN_SCHMA 242 1
GCYQALDGGNTADALVDFTGGVSEPIDL O15484 171 1
GCYEALDGLTITDIIMDFTGTLAEIIDM O35646 172 1
GCYENLVGGHLSDALQDVSGGVAETLHV Q22036 172 1
GCYEALDGLTITDIIMDFTGTLAEIIDM O88501 172 1
CALPAIN7 Length of motif = 22 Motif number = 7
Calpain motif VII - 2
PCODE ST INT
EDGEFWMSYDDFVYHFTKLEIC O08702 325 103
EDGEFWMSYDDFVYHFTKLEIC O70376 325 103
EDGEFWMSYDDFVYHFTKLEIC O70482 373 151
EDGEFWMSYDDFVYHFTKLEIC CAN3_MOUSE 393 151
EDGEFWMSYDDFVYHFTKLEIC CAN3_RAT 393 151
EDGEFWMSFSDFLRHYSRLEIC O54843 320 102
EDGEFWMSYDDFIYHFTKLEIC O46596 393 152
EDGEFWMSFSDFLRHYSRLEIC CAN2_RAT 320 102
EDGEFWMSYDDFVYHFTKLEIC O88977 325 103
EDGEFWMSFRDFIREFTKLEIC O35350 330 102
EDGEFWMSYEDFIYHFTKLEIC CAN3_HUMAN 393 151
EDGEFWMSFSDFLRHYSRLEIC CAN2_HUMAN 320 102
EDGEFWMSFSDFLRHYSRLEIC CAN2_MOUSE 320 102
EDGEFWMSFRDFIREFTKLEIC O88666 330 102
EDGEFWMSFRDFIREFTKLEIC P97571 330 102
EDGEFWMSFRDFMREFTRLEIC CAN1_HUMAN 330 102
EDGEFWISLEDFMRHFTKLEIC CAN3_CHICK 386 150
EDGEFWMAFNDFLRHYSRLEIC CAN2_CHICK 320 102
EDGEFWMSFRDFLREFTRLEIC O42133 330 102
EDGEFWMSFSDFLKQYSRLEIC Q64698 320 102
EDGEFWMSFRDFMREFSRLEIC CANX_CHICK 322 102
DDGEFWMAFKDFKAHFDKVEIC O14815 313 103
RDGEFWMSFQDFLNHFDRVEIC CAN_DROME 363 107
HDGEFWMSFDDFMRNFEKMEIC YKR2_CAEEL 491 103
DDGEFWMTFEDMCRYFTDIIKC O08688 319 119
ADGEFWMSYEDFVTCFSRVEVC CAN_SCHMA 373 103
DDGEFWMTFEDVCRYFTDIIKC O15484 318 119
DDGEFWMSLEDFCHNFHKLNVC O35646 319 119
DDGDFWMPWESFVHYFTDISLC Q22036 329 129
DDGEFWMSLEDFCHNFHKLNVC O88501 319 119
CALPAIN8 Length of motif = 18 Motif number = 8
Calpain motif VIII - 2
PCODE ST INT
SAGGCRNFPDTFWTNPQY O08702 375 28
SAGGCRNFPDTFWTNPQY O70376 375 28
SAGGCRNFPDTFWTNPQY O70482 423 28
SAGGCRNFPDTFWTNPQY CAN3_MOUSE 443 28
SAGGCRNFPDTFWTNPQY CAN3_RAT 443 28
TAGGCRNYPNTFWMNPQY O54843 370 28
SAGGCRNFPDTFWTNPQY O46596 443 28
TAGGCRNYPNTFWMNPQY CAN2_RAT 370 28
SAGGCRNFPDTFWTNPQY O88977 375 28
TAGGCRNYPATFWVNPQF O35350 380 28
SAGGCRNFPDTFWTNPQY CAN3_HUMAN 443 28
TAGGCRNYPNTFWMNPQY CAN2_HUMAN 370 28
TAGGCRNYPNTFWMNPQY CAN2_MOUSE 370 28
TAGGCRNYPATFWVNPQF O88666 380 28
TAGGCRNYPATFWVNPQF P97571 380 28
TAGGCRNYPATFWVNPQF CAN1_HUMAN 380 28
SAGGCRNYPDTFWTNPQY CAN3_CHICK 436 28
TAGGCRNYPNTFWTNPQY CAN2_CHICK 370 28
TAGGCRNYPATFWINPQF O42133 380 28
TAGGCLNYPGTYWTNPQF Q64698 370 28
TAGGCRNNPATFWINPQF CANX_CHICK 372 28
TAGGCRNFLDTFWTNPQI O14815 363 28
TAGGCRNFLDTFWHNPQY CAN_DROME 417 32
TAGGCRNYINTFANNPQF YKR2_CAEEL 549 36
RSGGCINHKDTFFQNPQY O08688 373 32
NAGGCINNRTTYWTSPQF CAN_SCHMA 427 32
RGGGCINHKDTFFQNPQY O15484 372 32
RSGGCYNNRDTFLQNPQY O35646 370 29
RAGGCHNFKATFCNNPQY Q22036 386 35
RSGGCYNNRDTFLQNPQY O88501 370 29
CALPAIN9 Length of motif = 29 Motif number = 9
Calpain motif IX - 2
PCODE ST INT
RLPPSEYVIVPSTYEPHQEGEFILRVFSE O08702 480 87
RLPPSEYVIVPSTYEPHQEGEFILRVFSE O70376 480 87
RLPPSEYVIVPSTYEPHQEGEFILRVFSE O70482 528 87
RLPPSEYVIVPSTYEPHQEGEFILRVFSE CAN3_MOUSE 548 87
RLPPSEYVIVPSTYEPHQEGEFILRVFSE CAN3_RAT 548 87
KLPPGEYVLVPSTFEPHKDGDFCIRVFSE O54843 476 88
RLPPSEYVIVPSTYEPHQEGEFILRVFSE O46596 548 87
KLPPGEYVLVPSTFEPHKNGDFCIRVFSE CAN2_RAT 476 88
RLPPSEYVIVPSTYEPHQEGEFILRVFSE O88977 480 87
RLPPGEYIVVPSTFEPNKEGDFLLRFFSE O35350 487 89
RLPPSEYVIVPSTYEPHQEGEFILRVFSE CAN3_HUMAN 548 87
KLPPGEYILVPSTFEPNKDGDFCIRVFSE CAN2_HUMAN 476 88
KLPPGEYVLVPSTFEPHKDGDFCIRVFSE CAN2_MOUSE 476 88
RPPPGEYIVVPSTFEPNKEGDFLLRFFSE O88666 487 89
RLPPGEYIVVPSTFEPNKEGDFLLRFFSE P97571 487 89
RLPPGEYVVVPSTFEPNKEGDFVLRFFSE CAN1_HUMAN 488 90
RLPPSEYVIIPSTYEPHQEGEFILRVFSE CAN3_CHICK 541 87
KLPAGEYIIVPSTFEPNLNGDFCLRVFSE CAN2_CHICK 476 88
RLPPGEYIVVPSTFEPNREGDFVLRVFSE O42133 489 91
RLPPGQYLVVPSTFEPFKDGDFCLRVFSE Q64698 478 90
RLPPGEYIVVPSTFEPHKEADFILRVFTE CANX_CHICK 478 88
KLPPGEYILIPSTFEPHQEADFCLRIFSE O14815 460 79
KLPPGHYLIVPSTFDPNEEGEFIIRVFSE CAN_DROME 519 84
RVPPGNYVVVPSTFEPNEEAEFMLRVYTN YKR2_CAEEL 619 52
ELPEGRYVIIPTTFEPGHTGEFLLRVFTD O08688 462 71
RVPPGSYVVIPSTFDPNIEVNFILRVFSQ CAN_SCHMA 524 79
DQPEGRYVIIPTTFEPGHTGEFLLRVFTD O15484 461 71
YLKKGSYVLVPTMFQHGRTSEFLLRIFSE O35646 461 73
SLPRGRYLLIPTTFAPKEQTLFMLRVYSD Q22036 475 71
YLKKGNYVLVPTMFQHGRTSEFLLRIFSE O88501 461 73
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