WORKLIST ENTRIES (1):
CYTOCHROMEC1 View alignment View Structure Cytochrome C1 signature
Type of fingerprint: COMPOUND with 8 elements
Links:
PRINTS; PR00604 CYTCHRMECIAB; PR00605 CYTCHROMECIC; PR00606 CYTCHROMECID
PRINTS; PR00607 CYTCHROMECIE; PR00608 CYTCHROMECII; PR00609 CYTOCHROMEC3
PRINTS; PR00610 CYTOCHROMEF
INTERPRO; IPR002326
PROSITE; PS00190 CYTOCHROME_C
Creation date 06-AUG-1996; UPDATE 28-JUL-1999
1. BECHMANN, G., SCHULTE, U. AND WEISS, H.
Mitochondrial ubiquinol-cytochrome c oxidoreductase.
IN MOLECULAR MECHANISMS IN BIOENERGETICS, ERNSTER, L. ED., ELSEVIER,
AMSTERDAM, 1992, PP.199-216.
2. PRINCE, R.C. AND GEORGE, G.N.
Cytochrome f revealed.
TRENDS BIOCHEM.SCI. 20 217-218 (1995).
3. MOORE, G.R. AND PETTIGREW, G.W.
Cytochromes c. Evolutionary, Structural, and Physicochemical Aspects.
SPRINGER-VERLAG, BERLIN-HEIDELBERG-NEW YORK (1990).
4. GRAY, K.A., DAVIDSON, E. AND DALDAL, F.
Mutagenesis of methionine-183 drastically affects the physicochemical
properties of cytochrome c1 of the bc1 complex of Rhodobacter capsulatus.
BIOCHEMISTRY 31 11864-11873 (1992).
Cytochrome bc1 complex (ubiquinol:ferricytochrome c oxidoreductase) is
found in mitochondria, photosynthetic bacteria and other prokaryotes [1].
It is minimally composed of three subunits: cytochrome b, carrying a low-
and a high-potential haem group; cytochrome c1 (cyt c1); and a high-
potential Rieske iron-sulphur protein. The general function of the complex
is electron transfer between two mobile redox carriers, ubiquinol and
cytochrome c; the electron transfer is coupled with proton translocation
across the membrane, thus generating proton-motive force in the form of an
electrochemical potential that can drive ATP synthesis. In its structure and
functions, the cytochrome bc1 complex bears extensive analogy to the
cytochrome b6f complex of chloroplasts and cyanobacteria; cyt c1 plays an
analogous role to cytochrome f, in spite of their different structures [2].
CYTOCHROMEC1 is an 8-element fingerprint that provides a signature for cyt
c1. The fingerprint was derived from an initial alignment of 10 sequences:
motif 2 includes two invariant Cys residues that covalently bind the haem
group, and a His residue, which provides the fifth haem iron ligand (cf.
PROSITE pattern CYTOCHROME_C); and motif 6 includes an invariant Met, which
provides the sixth haem iron ligand [3,4]. Two iterations on OWL28.1 were
required to reach convergence, at which point a true set comprising 16
sequences was identified. Three partial matches were also found: A44033 is
a Crithidia fasciculata cyt c1 fragment lacking motifs 7 and 8; and S65505
and S65506 are cyt c1 N-terminal fragments, from C. fasciculata and Bodo
caudatus respectively, which match only the first three motifs.
An update on SPTR37_9f identified a true set of 14 sequences, and 3
partial matches.
SUMMARY INFORMATION
14 codes involving 8 elements
1 codes involving 7 elements
0 codes involving 6 elements
0 codes involving 5 elements
1 codes involving 4 elements
0 codes involving 3 elements
1 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
8| 14 14 14 14 14 14 14 14
7| 1 1 1 1 1 1 1 0
6| 0 0 0 0 0 0 0 0
5| 0 0 0 0 0 0 0 0
4| 0 1 1 1 0 1 0 0
3| 0 0 0 0 0 0 0 0
2| 0 1 0 1 0 0 0 0
--+-----------------------------------------
| 1 2 3 4 5 6 7 8
True positives..
CY1_YEAST CY1_KLULA CY1_NEUCR CY1_HUMAN
CY1_BOVIN CY11_SOLTU O59680 CY1_RHORU
CYB_BRAJA CY1_EUGGR CY1_RHOCA P81379
CY1_PARDE CY1_RHOSH
Subfamily: Codes involving 7 elements
Subfamily True positives..
Q18853
Subfamily: Codes involving 4 elements
Subfamily True positives..
Q26325
Subfamily: Codes involving 2 elements
Subfamily True positives..
O66458
PROTEIN TITLES
CY1_YEAST CYTOCHROME C1, HEME PROTEIN PRECURSOR - SACCHAROMYCES CEREVI
CY1_KLULA CYTOCHROME C1, HEME PROTEIN PRECURSOR - KLUYVEROMYCES LACTIS
CY1_NEUCR CYTOCHROME C1, HEME PROTEIN PRECURSOR - NEUROSPORA CRASSA.
CY1_HUMAN CYTOCHROME C1, HEME PROTEIN PRECURSOR - HOMO SAPIENS (HUMAN)
CY1_BOVIN CYTOCHROME C1, HEME PROTEIN - BOS TAURUS (BOVINE).
CY11_SOLTU CYTOCHROME C1, HEME PROTEIN PRECURSOR (CLONE PC13III) - SOLA
O59680 PROBABLE CYTOCHROME C1, HEME PROTEIN PRECURSOR - SCHIZOSACCH
CY1_RHORU CYTOCHROME C1 PRECURSOR - RHODOSPIRILLUM RUBRUM.
CYB_BRAJA CYTOCHROME B/C1 [INCLUDES: CYTOCHROME B; CYTOCHROME C1] - BR
CY1_EUGGR CYTOCHROME C1, HEME PROTEIN - EUGLENA GRACILIS.
CY1_RHOCA CYTOCHROME C1 PRECURSOR - RHODOBACTER CAPSULATUS (RHODOPSEUD
P81379 CYTOCHROME C1 PRECURSOR - RHODOPSEUDOMONAS VIRIDIS.
CY1_PARDE CYTOCHROME C1 PRECURSOR - PARACOCCUS DENITRIFICANS.
CY1_RHOSH CYTOCHROME C1 PRECURSOR - RHODOBACTER SPHAEROIDES (RHODOPSEU
Q18853 C54G4.8 PROTEIN - CAENORHABDITIS ELEGANS.
Q26325 CYTOCHROME C1, HEME PROTEIN - CRITHIDIA FASCICULATA.
O66458 CYTOCHROME C - AQUIFEX AEOLICUS.
SCAN HISTORY
OWL28_1 2 100 NSINGLE
SPTR37_9f 3 50 NSINGLE
INITIAL MOTIF SETS
CYTOCHROMEC11 Length of motif = 20 Motif number = 1
Cytochrome c1 motif I - 1
PCODE ST INT
VPFSFEGPFGTFDQHQLQRG CY1_RHOSH 31 31
HAFSFEGIFGKYDQAQLRRG CY1_RHOCA 28 28
QDWSWKGIFGRYDQPQLQRG CY1_RHORU 34 34
ISFSFEGPFGKFDQHQLQRG CY1_PARDE 218 218
YPWPHEGILSSYDHASIRRG CY11_SOLTU 89 89
YPWSHRGLLSSLDHTSIRRG CY1_BOVIN 10 10
YPWSHRGLLSSLDHTSIRRG CY1_HUMAN 94 94
YAWSHNGPFETFDHASIRRG CY1_YEAST 74 74
YPWVHEQWLKTFDHQALRRG CY1_NEUCR 83 83
LPWPHFQWFQGLDWRSVRRG CY1_EUGGR 9 9
CYTOCHROMEC12 Length of motif = 20 Motif number = 2
Cytochrome c1 motif II - 1
PCODE ST INT
LQVYTEVCAACHGMKFVPIR CY1_RHOSH 51 0
FQVYNEVCSACHGMKFVPIR CY1_RHOCA 48 0
FQVFHEVCSTCHGMKRVAYR CY1_RHORU 54 0
LQVYTEVCSACHGLRYVPLR CY1_PARDE 238 0
HQVYQQVCASCHSMSLISYR CY11_SOLTU 109 0
FQVYKQVCSSCHSMDYVAYR CY1_BOVIN 30 0
FQVYKQVCASCHSMDFVAYR CY1_HUMAN 114 0
YQVYREVCAACHSLDRVAWR CY1_YEAST 94 0
FQVYREVCASCHSLSRVPYR CY1_NEUCR 103 0
KEVYEQVFAPCHSLSFIKYR CY1_EUGGR 29 0
CYTOCHROMEC13 Length of motif = 21 Motif number = 3
Cytochrome c1 motif III - 1
PCODE ST INT
TDEETGEDREGKPTDHFPHSA CY1_RHOSH 95 24
IDKDSGEERDRKETDMFPTRV CY1_RHOCA 93 25
DDNGDMFTRPGTPADHIPSPF CY1_RHORU 99 25
TDPETEEDRPRVPTDHFPTVS CY1_PARDE 282 24
NDEGEMFTRPGKLSDRFPQPY CY11_SOLTU 154 25
NEDGEMFMRPGKLSDYFPKPY CY1_BOVIN 75 25
NEDGEMFMRPGKLFDYFPKPY CY1_HUMAN 159 25
DEQGNPKKRPGKLSDYIPGPY CY1_YEAST 139 25
NDQGEIEKRPGKLSDYLPDPY CY1_NEUCR 148 25
DEKGEARKRPGKRFDTVVQPY CY1_EUGGR 73 24
CYTOCHROMEC14 Length of motif = 25 Motif number = 4
Cytochrome c1 motif IV - 1
PCODE ST INT
ENAADLSLMAKARAGFHGPMGTGIS CY1_RHOSH 117 1
GMGPDLSVMAKARAGFSGPAGSGMN CY1_RHOCA 116 2
AAPPDLSLLAKARPGGPNYIYSLLE CY1_RHORU 132 12
GMGPDLSLMAKARAGFHGPYGTGLS CY1_PARDE 305 2
AYPPDLSLITKARHNGQNYVFALLT CY11_SOLTU 187 12
ALPPDLSYIVRARHGGEDYVFSLLT CY1_BOVIN 108 12
ALPPDLSYIVRARHGGEDYVFSLLT CY1_HUMAN 192 12
ALPPDLSLIVKARHGGCDYIFSLLT CY1_YEAST 172 12
ALPPDLSLIVKARHGGCDYIFSLLT CY1_NEUCR 181 12
ALPPDLSVITNARHGGVDYIYALLT CY1_EUGGR 106 12
CYTOCHROMEC15 Length of motif = 12 Motif number = 5
Cytochrome c1 motif V - 1
PCODE ST INT
GFYYNRAFQNGS CY1_RHOSH 175 33
GYYYNKTFQIGG CY1_RHOCA 172 31
AKYFNDYFPGHA CY1_RHORU 186 29
VLYHNAAFAGNW CY1_PARDE 359 29
GLHYNPYFPGGA CY11_SOLTU 225 13
GLYFNPYFPGQA CY1_BOVIN 146 13
GLYFNPYFPGQA CY1_HUMAN 230 13
GSNYNPYFPGGS CY1_YEAST 211 14
GLNFNPYFPGTG CY1_NEUCR 220 14
TQWYNPYFHGGI CY1_EUGGR 145 14
CYTOCHROMEC16 Length of motif = 20 Motif number = 6
Cytochrome c1 motif VI - 1
PCODE ST INT
WIAMPPPLMDDLVEYADGHD CY1_RHOSH 204 17
WARMPPPLVDDQVTYEDGTP CY1_RHOCA 201 17
AISMPPPLMDDLITYEDGTA CY1_RHORU 197 -1
WIQMAAPLSDDQVTYEDGTP CY1_PARDE 370 -1
AIAMPKMLNDGAVEYEDGIP CY11_SOLTU 236 -1
AIGMAPPIYNEVLEFDDGTP CY1_BOVIN 157 -1
AIAMAPPIYTDVLEFDDGTP CY1_HUMAN 241 -1
SIAMARVLFDDMVEYEDGTP CY1_YEAST 222 -1
GIAMARVLYDGLVDYEDGTP CY1_NEUCR 231 -1
IIGMPPPLTDDMIEYEDGTP CY1_EUGGR 156 -1
CYTOCHROMEC17 Length of motif = 20 Motif number = 7
Cytochrome c1 motif VII - 1
PCODE ST INT
ASVHAMAEDVSAFLMWAAEP CY1_RHOSH 224 0
ATVDQMAQDVSAFLMWAAEP CY1_RHOCA 221 0
ATKDQMAQDVVAYLNWAAEP CY1_RHORU 217 0
ATVDQMATDVAAFLMWTAEP CY1_PARDE 390 0
ATEAQMGKDVVSFLSWAAEP CY11_SOLTU 256 0
ATMSQVAKDVCTFLRWAAEP CY1_BOVIN 177 0
ATMSQIAKDVCTFLRWASEP CY1_HUMAN 261 0
ATTSQMAKDVTTFLNWCAEP CY1_YEAST 242 0
ASTSQMAKDVVEFLNWAAEP CY1_NEUCR 251 0
ASVPQMAKDVTCFLEWCSNP CY1_EUGGR 176 0
CYTOCHROMEC18 Length of motif = 16 Motif number = 8
Cytochrome c1 motif VIII - 1
PCODE ST INT
PKLMARKQAGFTAVMF CY1_RHOSH 243 -1
PKLVARKQMGLVAMVM CY1_RHOCA 240 -1
PELDARKSLGLKVLLF CY1_RHORU 236 -1
PKMMDRKQVGFVSVIF CY1_PARDE 409 -1
PEMEERKLMGFKWIFV CY11_SOLTU 275 -1
PEHDHRKRMGLKMLLM CY1_BOVIN 196 -1
PEHDHRKRMGLKMLMM CY1_HUMAN 280 -1
PEHDERKRLGLKTVII CY1_YEAST 261 -1
PEMDDRKRMGMKVLVV CY1_NEUCR 270 -1
PWWDERKLLGYKTIAT CY1_EUGGR 195 -1
FINAL MOTIF SETS
CYTOCHROMEC11 Length of motif = 20 Motif number = 1
Cytochrome c1 motif I - 3
PCODE ST INT
YAWSHNGPFETFDHASIRRG CY1_YEAST 74 74
YGWSHNGPLETFDHSSIRRG CY1_KLULA 59 59
YPWVHEQWLKTFDHQALRRG CY1_NEUCR 83 83
YPWSHRGLLSSLDHTSIRRG CY1_HUMAN 94 94
YPWSHRGLLSSLDHTSIRRG CY1_BOVIN 10 10
YPWPHEGILSSYDHASIRRG CY11_SOLTU 89 89
HDWPQSKVLSGFDHASLRRG O59680 75 75
QDWSWKGIFGRYDQPQLQRG CY1_RHORU 34 34
NKWSFAGPFGKFDRGALQRG CYB_BRAJA 444 444
LPWPHFQWFQGLDWRSVRRG CY1_EUGGR 9 9
HAFSFEGIFGKYDQAQLRRG CY1_RHOCA 28 28
QSWSFAGPFGQYDKAQLRRG P81379 35 35
ISFSFEGPFGKFDQHQLQRG CY1_PARDE 218 218
VPFSFEGPFGTFDQHQLQRG CY1_RHOSH 31 31
CYTOCHROMEC12 Length of motif = 20 Motif number = 2
Cytochrome c1 motif II - 3
PCODE ST INT
YQVYREVCAACHSLDRVAWR CY1_YEAST 94 0
YQVYREVCAACHSLDRVAWR CY1_KLULA 79 0
FQVYREVCASCHSLSRVPYR CY1_NEUCR 103 0
FQVYKQVCASCHSMDFVAYR CY1_HUMAN 114 0
FQVYKQVCSSCHSMDYVAYR CY1_BOVIN 30 0
HQVYQQVCASCHSMSLISYR CY11_SOLTU 109 0
FQVYREVCSACHSLNLIAWR O59680 95 0
FQVFHEVCSTCHGMKRVAYR CY1_RHORU 54 0
LKVYKEVCASCHGLSYIAFR CYB_BRAJA 464 0
KEVYEQVFAPCHSLSFIKYR CY1_EUGGR 29 0
FQVYNEVCSACHGMKFVPIR CY1_RHOCA 48 0
FQVFQNVCVSCHTLENGGFR P81379 55 0
LQVYTEVCSACHGLRYVPLR CY1_PARDE 238 0
LQVYTEVCAACHGMKFVPIR CY1_RHOSH 51 0
CYTOCHROMEC13 Length of motif = 21 Motif number = 3
Cytochrome c1 motif III - 3
PCODE ST INT
DEQGNPKKRPGKLSDYIPGPY CY1_YEAST 139 25
DDQGNPKKRPGKLADYVPGPY CY1_KLULA 124 25
NDQGEIEKRPGKLSDYLPDPY CY1_NEUCR 148 25
NEDGEMFMRPGKLFDYFPKPY CY1_HUMAN 159 25
NEDGEMFMRPGKLSDYFPKPY CY1_BOVIN 75 25
NDEGEMFTRPGKLSDRFPQPY CY11_SOLTU 154 25
DDEGNMFKRPGKLSDFLPPPY O59680 140 25
DDNGDMFTRPGTPADHIPSPF CY1_RHORU 99 25
NDAGDMFERPGRPADYFPSPF CYB_BRAJA 512 28
DEKGEARKRPGKRFDTVVQPY CY1_EUGGR 73 24
IDKDSGEERDRKETDMFPTRV CY1_RHOCA 93 25
NDKGDPMQRAPKLPDRIPSQY P81379 104 29
TDPETEEDRPRVPTDHFPTVS CY1_PARDE 282 24
TDEETGEDREGKPTDHFPHSA CY1_RHOSH 95 24
CYTOCHROMEC14 Length of motif = 25 Motif number = 4
Cytochrome c1 motif IV - 3
PCODE ST INT
ALPPDLSLIVKARHGGCDYIFSLLT CY1_YEAST 172 12
ALPPDLSLIVKARHGGPDYIFALLT CY1_KLULA 157 12
ALPPDLSLIVKARHGGCDYIFSLLT CY1_NEUCR 181 12
ALPPDLSYIVRARHGGEDYVFSLLT CY1_HUMAN 192 12
ALPPDLSYIVRARHGGEDYVFSLLT CY1_BOVIN 108 12
AYPPDLSLITKARHNGQNYVFALLT CY11_SOLTU 187 12
AAPPDLSCVVRGRHGGQDYIYSLLT O59680 173 12
AAPPDLSLLAKARPGGPNYIYSLLE CY1_RHORU 132 12
AAPPDLSLITKARSYGRGFPWFIFD CYB_BRAJA 545 12
ALPPDLSVITNARHGGVDYIYALLT CY1_EUGGR 106 12
GMGPDLSVMAKARAGFSGPAGSGMN CY1_RHOCA 116 2
AVPPDLSVIAKARTFQRGFPWWVTD P81379 137 12
GMGPDLSLMAKARAGFHGPYGTGLS CY1_PARDE 305 2
ENAADLSLMAKARAGFHGPMGTGIS CY1_RHOSH 117 1
CYTOCHROMEC15 Length of motif = 12 Motif number = 5
Cytochrome c1 motif V - 3
PCODE ST INT
GSNYNPYFPGGS CY1_YEAST 211 14
GANYNPYFPGGS CY1_KLULA 196 14
GLNFNPYFPGTG CY1_NEUCR 220 14
GLYFNPYFPGQA CY1_HUMAN 230 13
GLYFNPYFPGQA CY1_BOVIN 146 13
GLHYNPYFPGGA CY11_SOLTU 225 13
GMNFNPFFPGTQ O59680 211 13
AKYFNDYFPGHA CY1_RHORU 186 29
GSYYNKYFPGHA CYB_BRAJA 602 32
TQWYNPYFHGGI CY1_EUGGR 145 14
GYYYNKTFQIGG CY1_RHOCA 172 31
GSFYNKYFPGHI P81379 193 31
VLYHNAAFAGNW CY1_PARDE 359 29
GFYYNRAFQNGS CY1_RHOSH 175 33
CYTOCHROMEC16 Length of motif = 20 Motif number = 6
Cytochrome c1 motif VI - 3
PCODE ST INT
SIAMARVLFDDMVEYEDGTP CY1_YEAST 222 -1
SIAMGRVLFDDLVEYEDGTP CY1_KLULA 207 -1
GIAMARVLYDGLVDYEDGTP CY1_NEUCR 231 -1
AIAMAPPIYTDVLEFDDGTP CY1_HUMAN 241 -1
AIGMAPPIYNEVLEFDDGTP CY1_BOVIN 157 -1
AIAMPKMLNDGAVEYEDGIP CY11_SOLTU 236 -1
QIAMARPLFDDAVEFEDGTP O59680 222 -1
AISMPPPLMDDLITYEDGTA CY1_RHORU 197 -1
AIKMPKPLSDGQVTYDDGSP CYB_BRAJA 613 -1
IIGMPPPLTDDMIEYEDGTP CY1_EUGGR 156 -1
WARMPPPLVDDQVTYEDGTP CY1_RHOCA 201 17
IIGMTPPIADGLVTYGDGTP P81379 204 -1
WIQMAAPLSDDQVTYEDGTP CY1_PARDE 370 -1
WIAMPPPLMDDLVEYADGHD CY1_RHOSH 204 17
CYTOCHROMEC17 Length of motif = 20 Motif number = 7
Cytochrome c1 motif VII - 3
PCODE ST INT
ATTSQMAKDVTTFLNWCAEP CY1_YEAST 242 0
ATTSQMAKDVTTFLHWCSEP CY1_KLULA 227 0
ASTSQMAKDVVEFLNWAAEP CY1_NEUCR 251 0
ATMSQIAKDVCTFLRWASEP CY1_HUMAN 261 0
ATMSQVAKDVCTFLRWAAEP CY1_BOVIN 177 0
ATEAQMGKDVVSFLSWAAEP CY11_SOLTU 256 0
ATTAQAAKDVVNFLHWASEP O59680 242 0
ATKDQMAQDVVAYLNWAAEP CY1_RHORU 217 0
ATVAQYSKDVTTFLMWTAEP CYB_BRAJA 633 0
ASVPQMAKDVTCFLEWCSNP CY1_EUGGR 176 0
ATVDQMAQDVSAFLMWAAEP CY1_RHOCA 221 0
ETQLQYSKDVAAFLMWAAEP P81379 224 0
ATVDQMATDVAAFLMWTAEP CY1_PARDE 390 0
ASVHAMAEDVSAFLMWAAEP CY1_RHOSH 224 0
CYTOCHROMEC18 Length of motif = 16 Motif number = 8
Cytochrome c1 motif VIII - 3
PCODE ST INT
PEHDERKRLGLKTVII CY1_YEAST 261 -1
PEHDERKRLGLKAMIV CY1_KLULA 246 -1
PEMDDRKRMGMKVLVV CY1_NEUCR 270 -1
PEHDHRKRMGLKMLMM CY1_HUMAN 280 -1
PEHDHRKRMGLKMLLM CY1_BOVIN 196 -1
PEMEERKLMGFKWIFV CY11_SOLTU 275 -1
PELDIRKKMGFQVITV O59680 261 -1
PELDARKSLGLKVLLF CY1_RHORU 236 -1
PHMEARKRLGFQVFVF CYB_BRAJA 652 -1
PWWDERKLLGYKTIAT CY1_EUGGR 195 -1
PKLVARKQMGLVAMVM CY1_RHOCA 240 -1
PTLDVRKRIGWWVLGF P81379 243 -1
PKMMDRKQVGFVSVIF CY1_PARDE 409 -1
PKLMARKQAGFTAVMF CY1_RHOSH 243 -1
User query: Display/Full Code "CYTOCHROMEC1"