WORKLIST ENTRIES (1):
EAGCHANNEL View alignment EAG potassium channel signature
Type of fingerprint: COMPOUND with 12 elements
Links:
PRINTS; PR00169 KCHANNEL; PR01463 EAGCHANLFMLY; PR01465 ELKCHANNEL
PRINTS; PR01470 ERGCHANNEL
Creation date 01-DEC-2000
1. MILLER, C.
An overview of the potassium channel family.
GENOME BIOL. 1(4) 1-5 (2000).
2. ASHCROFT, F.M.
Voltage-gated K+ channels.
IN ION CHANNELS AND DISEASE, ACADEMIC PRESS, 2000, PP.97-123.
3. LITTLETON, J.T. AND GANETZKY, B.
Ion Channels and synaptic organisation: analysis of the Drosophila genome
NEURON 26 35-43 (2000).
4. FRINGS, S., BRULL, N., DZEJA, C. ANGELE, A., HAGEN, V. AND KAUPP U.B.
Characterisation of a ether-a-go-go channels present in photoreceptors
reveals similarity to IK a K+ current in rod inner segments.
J.GEN.PHYSIOL. 111 583-599 (1998).
Potassium ion (K+) channels are a structurally diverse group of proteins
that facilitate the flow of K+ ions across cell membranes. They are
ubiquitous, being present in virtually all cell types. Activation of K+
channels tends to hyperpolarise cells, reducing the membrane's electrical
resistance, dampening nervous activity. In eukaryotic cells, K+ channels
are involved in neural signalling and generation of the cardiac rhythm, and
act as effectors in signal transduction pathways involving G protein-
coupled receptors (GPCRs). In prokaryotic cells, they play a role in the
maintenance of ionic homeostasis [1].
Structurally, EAG channels belong to the subfamily of K+ channels whose
subunits contain 6 transmembrane (TM) domains: these are the voltage-gated
K+ channels, the KCNQ channels, the EAG-like K+ channels and 3 kinds of
Ca2+-activated K+ channel (BK, IK and SK) [2]. All K+ channels share a
characteristic sequence feature: a TMxTVGYG motif that resides between the
2 C-terminal membrane-spanning helices, and forms the K+-selective pore
domain [1]. However, unlike other families within this structural class,
EAG channels possess a cyclic nucleotide binding domain within their
putative intracellular C-termini.
The first EAG K+ channel was identified in Drosophila, following a screen
for mutations giving rise to behavioural abnormalities. Disruption of the
Eag gene caused an ether-induced, leg-shaking behaviour. Subsequent studies
have revealed a conserved multi-gene family of EAG-like K+ channels, which
are present in Homo sapiens and many other species. Based on the varying
functional properties of the channels, the family has been divided into
3 subfamilies: EAG, ELK and ERG. Interestingly, C.elegans appears to lack
the ELK type [3].
The EAG subfamily has been expressed in heterologous systems to reveal their
biophysical and pharmacological functions and to determine their currents in
native tissues. All mammalian EAG subfamily K+ channels that have been
identified have properties typical of delayed rectifiers, with no measurable
inactivation [5]. Only the Drosophila Eag channel exhibits partial
inactivation.
EAGCHANNEL is a 12-element fingerprint that provides a signature for the
EAG potassium channels. The fingerprint was derived from an initial
alignment of 7 sequences: the motifs were drawn from conserved regions
spanning virtually the full alignment length, focusing on those sections
that characterise the EAG channels but distinguish them from other members
of the K+ channel superfamily - motifs 1-4 reside within the N-terminal
domain; motif 5 encodes putative TM domain 1; motif 6 encompasses TM domain
3; motif 7 spans part of the loop between TM domains 3 and 4; motif 8 spans
the loop between TM domains 5 and 6; and motifs 9-12 reside within the
C-terminal region. Four iterations on SPTR39_14f were required to reach
convergence, at which point a true set comprising 9 sequences was
identified. A single partial match was found, Q9XYX7, the C.elegans EAG K+
channel EGL-2, which fails to make significant matches with motifs 1, 2, 4,
8 and 12.
SUMMARY INFORMATION
9 codes involving 12 elements
0 codes involving 11 elements
0 codes involving 10 elements
0 codes involving 9 elements
0 codes involving 8 elements
1 codes involving 7 elements
0 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
12| 9 9 9 9 9 9 9 9 9 9 9 9
11| 0 0 0 0 0 0 0 0 0 0 0 0
10| 0 0 0 0 0 0 0 0 0 0 0 0
9| 0 0 0 0 0 0 0 0 0 0 0 0
8| 0 0 0 0 0 0 0 0 0 0 0 0
7| 0 0 1 0 1 1 1 0 1 1 1 0
6| 0 0 0 0 0 0 0 0 0 0 0 0
5| 0 0 0 0 0 0 0 0 0 0 0 0
4| 0 0 0 0 0 0 0 0 0 0 0 0
3| 0 0 0 0 0 0 0 0 0 0 0 0
2| 0 0 0 0 0 0 0 0 0 0 0 0
--+-------------------------------------------------------------
| 1 2 3 4 5 6 7 8 9 10 11 12
True positives..
O18965 Q63472 Q60603 O95259
O76035 O18966 Q9QXT2 Q9VXZ6
CIKE_DROME
Subfamily: Codes involving 7 elements
Subfamily True positives..
Q9XYX7
PROTEIN TITLES
O18965 EAG CHANNEL - Bos taurus (Bovine).
Q63472 POTASSIUM CHANNEL SUBUNIT - Rattus norvegicus (Rat).
Q60603 LONG (ELECTOCARDIOGRAPHIC) QT SYNDROME 2 (POTASSIUM CHANNEL
O95259 VOLTAGE-GATED POTASSIUM CHANNEL EAGB - Homo sapiens (Human).
O76035 POTASSIUM CHANNEL H-EAG - Homo sapiens (Human).
O18966 EAG CHANNEL - Bos taurus (Bovine).
Q9QXT2 POTASIUM CHANNEL EAG2 - Rattus norvegicus (Rat).
Q9VXZ6 EAG PROTEIN - Drosophila melanogaster (Fruit fly).
CIKE_DROME POTASSIUM CHANNEL PROTEIN EAG - Drosophila melanogaster (Fru
Q9XYX7 EAG K+ CHANNEL EGL-2 - Caenorhabditis elegans.
SCAN HISTORY
SPTR39_14f 4 10 NSINGLE
INITIAL MOTIF SETS
EAGCHANNEL1 Length of motif = 8 Motif number = 1
EAG potassium channel motif I - 1
PCODE ST INT
ENIIRRSN CIKE_DROME 17 17
ENIVRRSN O18966 19 19
ENIVRRSN O18965 19 19
ENIVRRSN O95259 19 19
ENIVRRSN Q60603 19 19
ENIVRRSN O76035 19 19
ENIVRRSN Q63472 19 19
EAGCHANNEL2 Length of motif = 14 Motif number = 2
EAG potassium channel motif II - 1
PCODE ST INT
APIRNERDLVVLFL CIKE_DROME 134 109
APIRNEQDKVVLFL O18966 114 87
APIRNEQDKVVLFL O18965 114 87
APIRNEQDKVVLFL O95259 114 87
APIRNEQDKVVLFL Q60603 114 87
APIRNEQDKVVLFL O76035 114 87
APIRNEQDKVVLFL Q63472 114 87
EAGCHANNEL3 Length of motif = 12 Motif number = 3
EAG potassium channel motif III - 1
PCODE ST INT
TFRDITALKQPI CIKE_DROME 149 1
TFSDITAFKQPI O18966 129 1
TFSDITAFKQPI O18965 129 1
TFSDITAFKQPI O95259 129 1
TFSDITAFKQPI Q60603 129 1
TFSDITAFKQPI O76035 129 1
TFSDITAFKQPI Q63472 129 1
EAGCHANNEL4 Length of motif = 13 Motif number = 4
EAG potassium channel motif IV - 1
PCODE ST INT
KFAKLARSVTRSR CIKE_DROME 173 12
KFARLTRALTSSR O18966 150 9
KFARLTRALTSSR O18965 150 9
KFARLTRALTSSR O95259 150 9
KFARLTRALTSSR Q60603 150 9
KFARLTRALTSSR O76035 150 9
KFARLTRALTSSR Q63472 150 9
EAGCHANNEL5 Length of motif = 18 Motif number = 5
EAG potassium channel motif V - 1
PCODE ST INT
SLSADIMPQYRQEAPKTP CIKE_DROME 208 22
QLGSDILPQYKQEAPKTP O18966 189 26
QLGSDILPQYKQEAPKTP O18965 189 26
QLGSDILPQYKQEAPKTP O95259 189 26
QLGSDILPQYKQEAPKTP Q60603 189 26
QLGSDILPQYKQEAPKTP O76035 189 26
QLGSDILPQYKQEAPKTP Q63472 189 26
EAGCHANNEL6 Length of motif = 9 Motif number = 6
EAG potassium channel motif VI - 1
PCODE ST INT
IIDLLSCLP CIKE_DROME 317 91
VIDLLSCLP O18966 297 90
VIDLLSCLP O18965 297 90
VIDLLSCLP O95259 297 90
VIDLLSCLP Q60603 297 90
VIDLLSCLP O76035 297 90
VIDLLSCLP Q63472 297 90
EAGCHANNEL7 Length of motif = 10 Motif number = 7
EAG potassium channel motif VII - 1
PCODE ST INT
GIGSLFSALK CIKE_DROME 338 12
GISSLFSSLK O18966 345 39
GISSLFSSLK O18965 318 12
GISSLFSSLK O95259 345 39
GISSLFSSLK Q60603 345 39
GISSLFSSLK O76035 318 12
GISSLFSSLK Q63472 318 12
EAGCHANNEL8 Length of motif = 7 Motif number = 8
EAG potassium channel motif VIII - 1
PCODE ST INT
SWLWKLA CIKE_DROME 405 57
SWLYQLA O18966 417 62
SWLYQLA O18965 390 62
SWLYQLA O95259 417 62
SWLYQLA Q60603 417 62
SWLYQLA O76035 390 62
SWLYQLA Q63472 390 62
EAGCHANNEL9 Length of motif = 13 Motif number = 9
EAG potassium channel motif IX - 1
PCODE ST INT
TEKVLNCCPKDMK CIKE_DROME 542 130
TEKVLQICPKDMR O18966 552 128
TEKVLQICPKDMR O18965 525 128
TEKVLQICPKDMR O95259 552 128
TEKVLQICPKDMR Q60603 552 128
TEKVLQICPKDMR O76035 525 128
TEKVLQICPKDMR Q63472 525 128
EAGCHANNEL10 Length of motif = 16 Motif number = 10
EAG potassium channel motif X - 1
PCODE ST INT
DFYSAFANSFARNLVL CIKE_DROME 672 117
EFYTAFSHSFSRNLIL O18966 682 117
EFYTAFSHSFSRNLIL O18965 655 117
EFYTAFSHSFSRNLIL O95259 682 117
EFYTAFSHSFSRNLIL Q60603 682 117
EFYTAFSHSFSRNLIL O76035 655 117
EFYTAFSHSFSRNLIL Q63472 655 117
EAGCHANNEL11 Length of motif = 15 Motif number = 11
EAG potassium channel motif XI - 1
PCODE ST INT
RHRLIFRRVADVKRE CIKE_DROME 692 4
RKRIVFRKISDVKRE O18966 702 4
RKRIVFRKISDVKRE O18965 675 4
RKRIVFRKISDVKRE O95259 702 4
RKRIVFRKISDVKRE Q60603 702 4
RKRIVFRKISDVKRE O76035 675 4
RKRIVFRKISDVKRE Q63472 675 4
EAGCHANNEL12 Length of motif = 12 Motif number = 12
EAG potassium channel motif XII - 1
PCODE ST INT
DHLVRKIFSKFR CIKE_DROME 724 17
DHPVRRLFQRFR O18966 734 17
DHPVRRLFQRFR O18965 707 17
DHPVRRLFQRFR O95259 734 17
DHPVRRLFQRFR Q60603 734 17
DHPVRRLFQRFR O76035 707 17
DHPVRRLFQRFR Q63472 707 17
FINAL MOTIF SETS
EAGCHANNEL1 Length of motif = 8 Motif number = 1
EAG potassium channel motif I - 4
PCODE ST INT
ENIVRRSN O18965 19 19
ENIVRRSN Q63472 19 19
ENIVRRSN Q60603 19 19
ENIVRRSN O95259 19 19
ENIVRRSN O76035 19 19
ENIVRRSN O18966 19 19
ENIVRRSS Q9QXT2 17 17
ENIIRRSN Q9VXZ6 17 17
ENIIRRSN CIKE_DROME 17 17
EAGCHANNEL2 Length of motif = 14 Motif number = 2
EAG potassium channel motif II - 4
PCODE ST INT
APIRNEQDKVVLFL O18965 114 87
APIRNEQDKVVLFL Q63472 114 87
APIRNEQDKVVLFL Q60603 114 87
APIRNEQDKVVLFL O95259 114 87
APIRNEQDKVVLFL O76035 114 87
APIRNEQDKVVLFL O18966 114 87
APIRNEHEKVVLFL Q9QXT2 112 87
APIRNERDLVVLFL Q9VXZ6 134 109
APIRNERDLVVLFL CIKE_DROME 134 109
EAGCHANNEL3 Length of motif = 12 Motif number = 3
EAG potassium channel motif III - 4
PCODE ST INT
TFSDITAFKQPI O18965 129 1
TFSDITAFKQPI Q63472 129 1
TFSDITAFKQPI Q60603 129 1
TFSDITAFKQPI O95259 129 1
TFSDITAFKQPI O76035 129 1
TFSDITAFKQPI O18966 129 1
TFKDITLFKQPI Q9QXT2 127 1
TFRDITALKQPI Q9VXZ6 149 1
TFRDITALKQPI CIKE_DROME 149 1
EAGCHANNEL4 Length of motif = 13 Motif number = 4
EAG potassium channel motif IV - 4
PCODE ST INT
KFARLTRALTSSR O18965 150 9
KFARLTRALTSSR Q63472 150 9
KFARLTRALTSSR Q60603 150 9
KFARLTRALTSSR O95259 150 9
KFARLTRALTSSR O76035 150 9
KFARLTRALTSSR O18966 150 9
KFARLTRALTNSR Q9QXT2 148 9
KFAKLARSVTRSR Q9VXZ6 173 12
KFAKLARSVTRSR CIKE_DROME 173 12
EAGCHANNEL5 Length of motif = 18 Motif number = 5
EAG potassium channel motif V - 4
PCODE ST INT
QLGSDILPQYKQEAPKTP O18965 189 26
QLGSDILPQYKQEAPKTP Q63472 189 26
QLGSDILPQYKQEAPKTP Q60603 189 26
QLGSDILPQYKQEAPKTP O95259 189 26
QLGSDILPQYKQEAPKTP O76035 189 26
QLGSDILPQYKQEAPKTP O18966 189 26
QLGSDILPQYKQEAPKTP Q9QXT2 186 25
SLSADIMPQYRQEAPKTP Q9VXZ6 208 22
SLSADIMPQYRQEAPKTP CIKE_DROME 208 22
EAGCHANNEL6 Length of motif = 9 Motif number = 6
EAG potassium channel motif VI - 4
PCODE ST INT
VIDLLSCLP O18965 297 90
VIDLLSCLP Q63472 297 90
VIDLLSCLP Q60603 297 90
VIDLLSCLP O95259 297 90
VIDLLSCLP O76035 297 90
VIDLLSCLP O18966 297 90
VIDLLSCLP Q9QXT2 294 90
IIDLLSCLP Q9VXZ6 317 91
IIDLLSCLP CIKE_DROME 317 91
EAGCHANNEL7 Length of motif = 10 Motif number = 7
EAG potassium channel motif VII - 4
PCODE ST INT
GISSLFSSLK O18965 318 12
GISSLFSSLK Q63472 318 12
GISSLFSSLK Q60603 345 39
GISSLFSSLK O95259 345 39
GISSLFSSLK O76035 318 12
GISSLFSSLK O18966 345 39
GISSLFSSLK Q9QXT2 315 12
GIGSLFSALK Q9VXZ6 338 12
GIGSLFSALK CIKE_DROME 338 12
EAGCHANNEL8 Length of motif = 7 Motif number = 8
EAG potassium channel motif VIII - 4
PCODE ST INT
SWLYQLA O18965 390 62
SWLYQLA Q63472 390 62
SWLYQLA Q60603 417 62
SWLYQLA O95259 417 62
SWLYQLA O76035 390 62
SWLYQLA O18966 417 62
SWLYQLA Q9QXT2 387 62
SWLWKLA Q9VXZ6 405 57
SWLWKLA CIKE_DROME 405 57
EAGCHANNEL9 Length of motif = 13 Motif number = 9
EAG potassium channel motif IX - 4
PCODE ST INT
TEKVLQICPKDMR O18965 525 128
TEKVLQICPKDMR Q63472 525 128
TEKVLQICPKDMR Q60603 552 128
TEKVLQICPKDMR O95259 552 128
TEKVLQICPKDMR O76035 525 128
TEKVLQICPKDMR O18966 552 128
TEKVLSICPKDMR Q9QXT2 521 127
TEKVLNYCPKDMK Q9VXZ6 542 130
TEKVLNCCPKDMK CIKE_DROME 542 130
EAGCHANNEL10 Length of motif = 16 Motif number = 10
EAG potassium channel motif X - 4
PCODE ST INT
EFYTAFSHSFSRNLIL O18965 655 117
EFYTAFSHSFSRNLIL Q63472 655 117
EFYTAFSHSFSRNLIL Q60603 682 117
EFYTAFSHSFSRNLIL O95259 682 117
EFYTAFSHSFSRNLIL O76035 655 117
EFYTAFSHSFSRNLIL O18966 682 117
DFYTAFANSFSRNLTL Q9QXT2 651 117
DFYSAFANSFARNLVL Q9VXZ6 672 117
DFYSAFANSFARNLVL CIKE_DROME 672 117
EAGCHANNEL11 Length of motif = 15 Motif number = 11
EAG potassium channel motif XI - 4
PCODE ST INT
RKRIVFRKISDVKRE O18965 675 4
RKRIVFRKISDVKRE Q63472 675 4
RKRIVFRKISDVKRE Q60603 702 4
RKRIVFRKISDVKRE O95259 702 4
RKRIVFRKISDVKRE O76035 675 4
RKRIVFRKISDVKRE O18966 702 4
RKRIIFRKISDVKKE Q9QXT2 671 4
RHRLIFRKVADVKRE Q9VXZ6 692 4
RHRLIFRRVADVKRE CIKE_DROME 692 4
EAGCHANNEL12 Length of motif = 12 Motif number = 12
EAG potassium channel motif XII - 4
PCODE ST INT
DHPVRRLFQRFR O18965 707 17
DHPVRRLFQRFR Q63472 707 17
DHPVRRLFQRFR Q60603 734 17
DHPVRRLFQRFR O95259 734 17
DHPVRRLFQRFR O76035 707 17
DHPVRRLFQRFR O18966 734 17
DHPVRKLFQKFK Q9QXT2 703 17
DHLVRKIFSKFR Q9VXZ6 724 17
DHLVRKIFSKFR CIKE_DROME 724 17
User query: Display/Full Code "EAGCHANNEL"