WORKLIST ENTRIES (1):
EP450II View alignment View Structure Group II E-class P450 signature
Type of fingerprint: COMPOUND with 3 elements
Links:
PRINTS; PR00385 P450; PR01239 EP450IICYP52; PR01689 EP450IICYP3A
INTERPRO; IPR002402
PDB; 2HPD 3Dinfo
SCOP; 2HPD
CATH; 2HPD
Creation date 20-MAR-1996; UPDATE 01-DEC-1999
1. NOMENCLATURE COMMITTEE OF THE INTERNATIONAL UNION OF BIOCHEMISTRY (NC-IUB).
Nomenclature of electron-transfer proteins. Recommendations 1989.
EUR.J.BIOCHEM. 200 599-611 (1991).
2. NEBERT, D.W. AND GONZALEZ, F.J.
P450 genes: structure, evolution, and regulation.
ANNU.REV.BIOCHEM. 56 945-993 (1987).
3. NELSON, D.R., KAMATAKI, T., WAXMAN, D.J., GUENGERICH, F.P.,
ESTABROOK, R.W., FEYEREISEN, R., GONZALEZ, F.J., COON, M.J.,
GUNSALUS, I.C., GOTOH, O., OKUDA, K. AND NEBERT, D.W.
The P450 superfamily: update on new sequences, gene mapping, accession
numbers, early trivial names of enzymes, and nomenclature.
DNA CELL BIOL. 12 1-51 (1993).
4. GOTOH, O.
Evolution and differentiation of P-450 genes.
IN CYTOCHROME P-450, 2ND ED., OMURA, T., ISHIMURA, Y. AND FUJII-KURIYAMA, Y.,
EDS., KODANSHA, TOKYO, 1993, PP.255-272.
5. NELSON, D.R.
Metazoan Cytochrome P450 evolution.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY PART C 121 15-22 (1998).
6. RAVICHANDRAN, K.G., BODDUPALLI, S.S., HASEMANN, C.A., PETERSON, J.A.
AND DEISENHOFER, J.
Crystal structure of hemoprotein domain of P450BM-3, a prototype for
microsomal P450s.
SCIENCE 261 731-736 (1993).
P450 enzymes constitute a superfamily of haem-thiolate proteins [1],
widely distributed in bacteria, fungi, plants and animals. The enzymes
are involved in metabolism of a plethora of both exogenous and endogenous
compounds [2]. Usually, they act as terminal oxidases in multi-component
electron transfer chains, called P450-containing monooxygenase systems.
Current P450 nomenclature, based on divergent evolution of the P450
superfamily, was proposed and developed by Nebert et al. [3]. On the basis
of sequence similarity, all P450s can be categorised into 2 main classes,
the so-called B- and E-classes: P450 proteins of prokaryotic 3-component
systems and fungal P450nor (CYP55) belong to the B-class; all other known
P450s from distinct systems are of the E-class [4]. E-class P450S may be
further divided into 5 subclasses (groups) according to protein sequence
similarities.
On the basis of sequence similarity, Nelson introduced the concept of a
higher order classification of P450 families into clans [6], which is
similar to the previous grouping into B- and E-classes; both classifications
are still used. According to Nelson's system, clans 3 and 4 correspond to
the E-class group II proteins [5].
Group II P450s are distributed widely in life, i.e., in eubacteria (family
CYP102), cyanobacteria (CYP110), fungi (CYP52, CYP53 and CYP56), insects
(CYP4 and CYP6) and mammals (CYP3, CYP4 and CYP5). Many group II P450s
catalyse hydroxylation of linear chains such as alkanes (CYP52), alcohols
and fatty acids (CYP4, CYP5, CYP102); Aspergillus niger CYP53 carries out
para-hydroxylation of benzoate; yeast CYP56 is possibly involved in
oxidation of tyrosine residues; insect CYP6 metabolises a wide range of
toxic compounds; and members of the CYP3 family are omnivorous [4]. The
existence of two prokaryotic P450s in group II strongly suggests that the
divergence of the P450 superfamily into B- and E-classes, and further
divergence into stable P450 groups within the E-class, must be very ancient
and had occured before the appearance of eukaryotes [4].
The 3D structure of the P450 domain of P450BM-3 (CYP102) has been determined
[6] and is used as a model for microsomal P450s. The P450 molecule is an
alpha/beta protein, shaped like a triangular prism: the overall structure
can be roughly divided into alpha-rich ('right side') and beta-rich ('left
side') domains. However, this division appears to be artificial since the
alpha- and beta-rich domains comprise discontinuous assemblies of secondary
structure elements, and do not constitute independent folding units.
EP450II is a 3-element fingerprint that provides a signature for group II
E-class P450s. The fingerprint was derived from an initial alignment of 21
sequences: the motifs were drawn from conserved regions spanning the
C-terminal half of the alignment, focusing on those sections that
characterise the group II E class proteins but distinguish them from the
rest of the P450 superfamily - motifs 1 and 2 denote helices C and E; motif
3 spans the beta-strand 8 and helix K' (according to the structure of the
P450BM-3 hemoprotein domain [5]). Four iterations on SPTR37_10f were
required to reach convergence, at which point a true set comprising 139
sequences was identified. Numerous partial matches were also found, most of
which are group II E-class P450s (those belonging to CYP4 and CYP52 were
missing motif 3), while others are group I E-class P450s.
SUMMARY INFORMATION
139 codes involving 3 elements
46 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
3| 139 139 139
2| 42 36 14
--+----------------
| 1 2 3
True positives..
CP34_HUMAN Q16757 CP33_HUMAN CP38_MACFA
CP3P_MOUSE CP31_RAT Q06884 CP3B_MOUSE
CP3T_PIG CP3V_MESAU CP3I_RAT CP32_RAT
CP35_HUMAN CP37_HUMAN CP3A_MESAU CP36_RABIT
CP39_RAT CP3L_CALJA CP3O_SHEEP CP3D_MOUSE
CP3E_CAVPO CP3G_MOUSE CP3F_CAVPO CP3C_CANFA
CP3S_BOVIN O97689 O76107 CP3H_CAVPO
C6A1_MUSDO Q27703 CP46_RABIT Q27694
C6A9_DROME Q27691 CP4Y_HUMAN Q16802
CP45_RABIT O76800 C6A2_DROME C6A8_DROME
CP48_RAT CP5K_CANMA CP41_RAT O74131
O88833 O74133 O76801 P90730
CP42_RAT O74626 CP5J_CANMA CP3R_ONCMY
CP44_RABIT Q27692 CP5D_CANMA Q12582
O35728 Q25176 CP43_RAT Q12581
C6B7_HELAM CP5B_CANTR CP47_RABIT CPF5_RAT
O16156 YRV5_CAEEL O94080 CP5I_CANMA
Q27693 YRV1_CAEEL C6B4_PAPGL CP5C_CANMA
YRV2_CAEEL C6B2_HELAM Q40411 CP5F_CANTR
CP5E_CANMA C6B6_HELAM Q27697 Q27700
Q27699 Q27698 CP5H_CANTR CP5T_CANMA
YRVA_CAEEL CP72_CATRO Q42700 CPF1_RAT
THAS_MOUSE O80729 THAS_PIG O48786
CPF3_HUMAN O60634 CPF6_RAT O80728
O76799 CP5A_CANTR CPF2_HUMAN Q21424
YRV8_CAEEL O01997 YRV7_CAEEL O74132
YS24_CAEEL CP4B_MOUSE CP4B_RABIT CP4B_RAT
CPF4_RAT O74130 THAS_HUMAN O17807
O74127 Q27480 THAS_RAT O45605
Q27477 C6B3_PAPPO O76345 O17806
Q16843 O46054 C6B1_PAPPO Q27476
C972_SOYBN YRV3_CAEEL C4D2_DROME O46053
O46051 C973_ARATH O08336 O74129
CPXB_BACME P96813 O81117 C862_ARATH
C861_ARATH Q59990 O13490
Subfamily: Codes involving 2 elements
Subfamily True positives..
CP5G_CANTR Q9YI34 O45219 CP4B_HUMAN
C4DA_DROMT P77900 O74128 CP5V_CANAP
C971_PEA CP5Q_CANMA O17851 C4D1_DROME
C4D1_DROSI O17624 O17625 CP5W_CANAP
O74134 Q21262 Q27478 CP5P_CANTR
Q27472 C4E2_DROME Q27479 TRI4_FUSSP
Q9ZW95 CP4C_BLADI C4E5_DROMT O44485
Q27466 O14987 CP53_ASPNG O22162
STCS_EMENI O64631 O08447 O08394
CPT7_HUMAN Q12668 O52823 O87674
CP5N_CANTR O80823 CPT7_BOVIN STCF_EMENI
CPT7_PIG O69653
PROTEIN TITLES
CP34_HUMAN CYTOCHROME P450 3A4 (EC 1.14.14.1) (CYPIIIA4) (NIFEDIPINE O
Q16757 CYTOCHROME P450 (NIFEDIPINE OXIDASE) (EC 1.14.14.1) - HOMO t
CP33_HUMAN CYTOCHROME P450 3A3 (EC 1.14.14.1) (CYPIIIA3) (HLP) - HOMO t
CP38_MACFA CYTOCHROME P450 3A8 (EC 1.14.14.1) (CYPIIIA8) (P450-MKNF2) t
CP3P_MOUSE CYTOCHROME P450 3A25 (EC 1.14.14.1) (CYPIIIA25) - MUS t
CP31_RAT CYTOCHROME P450 3A1 (EC 1.14.14.1) (CYPIIIA1) (P450-PCN1) -
Q06884 CYTOCHROME P450 IIIA (EC 1.14.14.1) (STEROID INDUCIBLE) - t
CP3B_MOUSE CYTOCHROME P450 3A11 (EC 1.14.14.1) (CYPIIIA11) (P-450IIIAM1
CP3T_PIG CYTOCHROME P450 3A29 (EC 1.14.14.1) (CYPIIIA29) - SUS SCROFA
CP3V_MESAU CYTOCHROME P450 3A31 (EC 1.14.14.1) (CYPIIIA31) (P450 SH3A-1
CP3I_RAT CYTOCHROME P450 3A18 (EC 1.14.14.1) (CYPIIIA18) (P450(6)BETA
CP32_RAT CYTOCHROME P450 3A2 (EC 1.14.14.1) (CYPIIIA2) (P450-PCN2) (P
CP35_HUMAN CYTOCHROME P450 3A5 (EC 1.14.14.1) (CYPIIIA5) (P450-PCN3) -
CP37_HUMAN CYTOCHROME P450 3A7 (EC 1.14.14.1) (CYPIIIA7) (P450-HFLA) -
CP3A_MESAU CYTOCHROME P450 3A10 (EC 1.14.14.1) (CYPIIIA10) (6 BETA-HYDR
CP36_RABIT CYTOCHROME P450 3A6 (EC 1.14.14.1) (CYPIIIA6) (P450-3C) - OR
CP39_RAT CYTOCHROME P450 3A9 (EC 1.14.14.1) (CYPIIIA9) (P450-OLF3) OL
CP3L_CALJA CYTOCHROME P450 3A21 (EC 1.14.14.1) (CYPIIIA21) (P450 CM3A-1
CP3O_SHEEP CYTOCHROME P450 3A24 (EC 1.14.14.1) (CYPIIIA24) - OVIS ARIES
CP3D_MOUSE CYTOCHROME P450 3A13 (EC 1.14.14.1) (CYPIIIA13) - MUS MUSCUL
CP3E_CAVPO CYTOCHROME P450 3A14 (EC 1.14.14.1) (CYPIIIA14) - CAVIA PORC
CP3G_MOUSE CYTOCHROME P450 3A16 (EC 1.14.14.1) (CYPIIIA16) - MUS MUSCUL
CP3F_CAVPO CYTOCHROME P450 3A15 (EC 1.14.14.1) (CYPIIIA15) - CAVIA PORC
CP3C_CANFA CYTOCHROME P450 3A12 (EC 1.14.14.1) (CYPIIIA12) (P450-PBD-1)
CP3S_BOVIN CYTOCHROME P450 3A28 (EC 1.14.14.1) (CYPIIIA28) - BOS TAURUS
O97689 CYTOCHROME P450 - SUS SCROFA (PIG).
O76107 CYTOCHROME P450 - CULEX QUINQUEFASCIATUS (SOUTHERN HOUSE MOS
CP3H_CAVPO CYTOCHROME P450 3A17 (EC 1.14.14.1) (CYPIIIA17) - CAVIA PORC
C6A1_MUSDO CYTOCHROME P450 6A1 (EC 1.14.14.1) (CYPVIA1) - MUSCA DOMESTI
Q27703 CYTOCHROME P450 (EC 1.14.14.1) - MUSCA DOMESTICA (HOUSE FLY)
CP46_RABIT CYTOCHROME P450 4A6 PRECURSOR (EC 1.14.15.3) (CYPIVA6) (LAUR
Q27694 CYTOCHROME P450 (EC 1.14.14.1) - MUSCA DOMESTICA (HOUSE FLY)
C6A9_DROME CYTOCHROME P450 6A9 (EC 1.14.14.1) (CYPVIA9) - DROSOPHILA ME
Q27691 CYTOCHROME P450 (EC 1.14.14.1) - MUSCA DOMESTICA (HOUSE FLY)
CP4Y_HUMAN CYTOCHROME P450 4A11 PRECURSOR (EC 1.14.15.3) (CYPIVA11) (FA
Q16802 FATTY ACID OMEGA-HYDROXYLASE (CYTOCHROME P450) (EC 1.14.14.1
CP45_RABIT CYTOCHROME P450 4A5 PRECURSOR (EC 1.14.15.3) (CYPIVA5) (LAUR
O76800 CYP6-LIKE MICROSOMAL CYTOCHROME P450 - DROSOPHILA tt; MELANO
C6A2_DROME CYTOCHROME P450 6A2 (EC 1.14.14.1) (CYPVIA2) (P450-B1) - DRO
C6A8_DROME CYTOCHROME P450 6A8 (EC 1.14.14.1) (CYPVIA8) - DROSOPHILA ME
CP48_RAT CYTOCHROME P450 4A8 (EC 1.14.14.1) (CYPIVA8) (P450-KP1) (P45
CP5K_CANMA CYTOCHROME P450 52A11 (EC 1.14.14.1) (CYPLIIA11) (ALKANE-IND
CP41_RAT CYTOCHROME P450 4A1 (EC 1.14.15.3) (CYPIVA1) (LAURIC ACID OM
O74131 ALK5 - YARROWIA LIPOLYTICA (CANDIDA LIPOLYTICA).
O88833 CYTOCHROME P-450 - MUS MUSCULUS (MOUSE).
O74133 ALK7 - YARROWIA LIPOLYTICA (CANDIDA LIPOLYTICA).
O76801 CYP9 CYTOCHROME P450 - DROSOPHILA METTLERI (FRUIT FLY).
P90730 CYTOCHROME P450 (EC 1.14.14.1) - CERATITIS CAPITATA (MEDITER
CP42_RAT CYTOCHROME P450 4A2 PRECURSOR (EC 1.14.15.3) (CYPIVA2) (LAUR
O74626 ALK8 PROTEIN - CANDIDA ALBICANS (YEAST).
CP5J_CANMA CYTOCHROME P450 52A10 (EC 1.14.14.1) (CYPLIIA10) (ALKANE-IND
CP3R_ONCMY CYTOCHROME P450 3A27 (EC 1.14.14.1) (CYPIIIA27) - ONCORHYNCH
CP44_RABIT CYTOCHROME P450 4A4 (EC 1.14.14.1) (CYPIVA4) (PROSTAGLANDIN
Q27692 CYTOCHROME P450 (EC 1.14.14.1) - MUSCA DOMESTICA (HOUSE FLY)
CP5D_CANMA CYTOCHROME P450 52A4 (EC 1.14.14.1) (CYPLIIA4) (ALKANE-INDUC
Q12582 N-ALKANE INDUCIBLE CYTOCHROME P-450 (EC 1.14.14.1) - CANDIDA
O35728 CYTOCHROME P450 - MUS MUSCULUS (MOUSE).
Q25176 CYTOCHROME P-450 - HELIOTHIS VIRESCENS (NOCTUID MOTH) (OWLET
CP43_RAT CYTOCHROME P450 4A3 (EC 1.14.15.3) (CYPIVA3) (LAURIC ACID OM
Q12581 N-ALKANE INDUCIBLE CYTOCHROME P-450 (EC 1.14.14.1) - CANDIDA
C6B7_HELAM CYTOCHROME P450 6B7 (EC 1.14.14.1) (CYPVIB7) - HELICOVERPA A
CP5B_CANTR CYTOCHROME P450 52A2 (EC 1.14.14.1) (CYPLIIA2) (ALKANE-INDUC
CP47_RABIT CYTOCHROME P450 4A7 PRECURSOR (EC 1.14.15.3) (CYPIVA7) (LAUR
CPF5_RAT CYTOCHROME P450 4F5 (EC 1.14.14.1) (CYPIVF5) - RATTUS NORVEG
O16156 CYTOCHROME P450 30 - MERCENARIA MERCENARIA (NORTHERN QUAHOG)
YRV5_CAEEL PUTATIVE CYTOCHROME P450 T10B9.5 IN CHROMOSOME II (EC 1.14.-
O94080 ALKANE HYDROXYLATING CYTOCHROME P-450 - CANDIDA MALTOSA (YEA
CP5I_CANMA CYTOCHROME P450 52A9 (EC 1.14.14.1) (CYPLIIA9) (ALKANE-INDUC
Q27693 CYTOCHROME P450 (EC 1.14.14.1) - MUSCA DOMESTICA (HOUSE FLY)
YRV1_CAEEL PUTATIVE CYTOCHROME P450 T10B9.1 IN CHROMOSOME II (EC 1.14.-
C6B4_PAPGL CYTOCHROME P450 6B4 (EC 1.14.14.1) (CYPVIB4) (CYP6B4V1/CYP6B
CP5C_CANMA CYTOCHROME P450 52A3 (EC 1.14.14.1) (CYPLIIA3) (ALKANE-INDU
YRV2_CAEEL PUTATIVE CYTOCHROME P450 T10B9.2 IN CHROMOSOME II (EC 1.14.-
C6B2_HELAM CYTOCHROME P450 6B2 (EC 1.14.14.1) (CYPVIB2) - HELICOVERPA A
Q40411 PUTATIVE CYTOCHROME P-450 - NICOTIANA PLUMBAGINIFOLIA (LEAD
CP5F_CANTR CYTOCHROME P450 52A6 (EC 1.14.14.1) (CYPLIIA6) (ALKANE-INDU
CP5E_CANMA CYTOCHROME P450 52A5 (EC 1.14.14.1) (CYPLIIA5) (ALKANE-INDUC
C6B6_HELAM CYTOCHROME P450 6B6 (EC 1.14.14.1) (CYPVIB6) - HELICOVERPA A
Q27697 CYTOCHROME P450 (EC 1.14.14.1) - MUSCA DOMESTICA (HOUSE FLY)
Q27700 PYRETHROID RESISTANCE CYTOCHROME P450 (EC 1.14.14.1) - MUSCA
Q27699 PYRETHROID RESISTANCE CYTOCHROME P450 (EC 1.14.14.1) - MUSCA
Q27698 CYTOCHROME P450 (EC 1.14.14.1) - MUSCA DOMESTICA (HOUSE FLY)
CP5H_CANTR CYTOCHROME P450 52A8 (EC 1.14.14.1) (CYPLIIA8)(ALKANE-INDUCI
CP5T_CANMA CYTOCHROME P450 52D1 (EC 1.14.14.-) (CYPLIID1)(ALKANE-INDUCI
YRVA_CAEEL PUTATIVE CYTOCHROME P450 T10B9.10 IN CHROMOSOME II (EC 1.14.
CP72_CATRO CYTOCHROME P450 72A1 (EC 1.14.14.1) (CYPLXXII) (PROBABLE GE
Q42700 CYTOCHROME P450 (EC 1.14.14.1) - CATHARANTHUS ROSEUS (ROSY
CPF1_RAT CYTOCHROME P450 4F1 (EC 1.14.14.1) (CYPIVF1) (P450-A3) - RAT
THAS_MOUSE THROMBOXANE-A SYNTHASE (EC 5.3.99.5) (TXA SYNTHASE) (TXS) (T
O80729 PUTATIVE CYTOCHROME P450 - ARABIDOPSIS THALIANA (MOUSE-EAR C
THAS_PIG THROMBOXANE-A SYNTHASE (EC 5.3.99.5) (TXA SYNTHASE) (TXS) -
O48786 PUTATIVE CYTOCHROME P450 - ARABIDOPSIS THALIANA (MOUSE-EAR C
CPF3_HUMAN CYTOCHROME P450 4F3 (EC 1.14.13.30) (CYPIVF3) (LEUKOTRIENE-B
O60634 CYTOCHROME P-450 - HOMO SAPIENS (HUMAN).
CPF6_RAT CYTOCHROME P450 4F6 (EC 1.14.14.1) (CYPIVF6) - RATTUS NORVE
O80728 PUTATIVE CYTOCHROME P450 - ARABIDOPSIS THALIANA (MOUSE-EAR
O76799 MICROSOMAL CYTOCHROME P450 - DROSOPHILA METTLERI (FRUIT FLY)
CP5A_CANTR CYTOCHROME P450 52A1 (EC 1.14.14.1) (CYPLIIA1) (ALKANE-INDUC
CPF2_HUMAN CYTOCHROME P450 4F2 (EC 1.14.13.30) (CYPIVF2) (LEUKOTRIENE-B
Q21424 T19B10.1 PROTEIN - CAENORHABDITIS ELEGANS.
YRV8_CAEEL PUTATIVE CYTOCHROME P450 T10B9.8 IN CHROMOSOME II (EC 1.14.-
O01997 T10B9.4 PROTEIN - CAENORHABDITIS ELEGANS.
YRV7_CAEEL PUTATIVE CYTOCHROME P450 T10B9.7 IN CHROMOSOME II (EC 1.14.-
O74132 ALK6 - YARROWIA LIPOLYTICA (CANDIDA LIPOLYTICA).
YS24_CAEEL PUTATIVE CYTOCHROME P450 ZK1320.4 IN CHROMOSOME II (EC 1.14
CP4B_MOUSE CYTOCHROME P450 4B1 (EC 1.14.14.1) (CYPIVB1) - MUS MUSCULUS
CP4B_RABIT CYTOCHROME P450 4B1 (EC 1.14.14.1) (CYPIVB1) (P450-ISOZYME 5
CP4B_RAT CYTOCHROME P450 4B1 (EC 1.14.14.1) (CYPIVB1) (P450-ISOZYME 5
CPF4_RAT CYTOCHROME P450 4F4 (EC 1.14.14.1) (CYPIVF4) - RATTUS NORVE
O74130 ALK4 - YARROWIA LIPOLYTICA (CANDIDA LIPOLYTICA).
THAS_HUMAN THROMBOXANE-A SYNTHASE (EC 5.3.99.5) (TXA SYNTHASE) (TXS) -
O17807 F14F7.3 PROTEIN - CAENORHABDITIS ELEGANS.
O74127 ALK1 - YARROWIA LIPOLYTICA (CANDIDA LIPOLYTICA).
Q27480 C44C10.2 PROTEIN - CAENORHABDITIS ELEGANS.
THAS_RAT THROMBOXANE-A SYNTHASE (EC 5.3.99.5) (TXA SYNTHASE) (TXS) -
O45605 H02I12.8 PROTEIN - CAENORHABDITIS ELEGANS.
Q27477 C36A4.1 PROTEIN - CAENORHABDITIS ELEGANS.
C6B3_PAPPO CYTOCHROME P450 6B3 (EC 1.14.14.1) (CYPVIB4) (CYP6B3V1/CYP6B
O76345 CYTOCHROME P450 - HOMARUS AMERICANUS (AMERICAN LOBSTER).
O17806 F14F7.2 PROTEIN - CAENORHABDITIS ELEGANS.
Q16843 THROMBOXANE SYNTHASE (EC 5.3.99.5) (THROMBOXANE-A SYNTHASE)
O46054 COSMID 152A3 - DROSOPHILA MELANOGASTER (FRUIT FLY).
C6B1_PAPPO CYTOCHROME P450 6B1 (EC 1.14.14.1) (CYPVIB1) (CYP6B1V1/CYP6B
Q27476 C36A4.2 PROTEIN - CAENORHABDITIS ELEGANS.
C972_SOYBN CYTOCHROME P450 97B2 (EC 1.14.-.-) - GLYCINE MAX (SOYBEAN).
YRV3_CAEEL PUTATIVE CYTOCHROME P450 T10B9.3 IN CHROMOSOME II (EC 1.14.
C4D2_DROME CYTOCHROME P450 4D2 (EC 1.14.14.1) (CYPIVD2) - DROSOPHILA M
O46053 COSMID 152A3 - DROSOPHILA MELANOGASTER (FRUIT FLY).
O46051 EG:152A3.2 PROTEIN - DROSOPHILA MELANOGASTER (FRUIT FLY).
C973_ARATH CYTOCHROME P450 97B3 (EC 1.14.-.-) - ARABIDOPSIS THALIANA (
O08336 CYTOCHROME P450 102 (EC 1.14.14.1) - BACILLUS SUBTILIS.
O74129 ALK3 - YARROWIA LIPOLYTICA (CANDIDA LIPOLYTICA).
CPXB_BACME CYTOCHROME P450(BM-3) (P450BM-3) [INCLUDES: CYTOCHROME P450
P96813 HYPOTHETICAL 49.3 KD PROTEIN (EC 1.14.14.1) - MYCOBACTERIUM
O81117 CYP94A1 - VICIA SATIVA (SPRING VETCH) (TARE).
C862_ARATH CYTOCHROME P450 86A2 (EC 1.14.-.-) - ARABIDOPSIS THALIANA (
C861_ARATH CYTOCHROME P450 86A1 (EC 1.14.-.-) (CYPLXXXVI) - ARABIDOPSIS
Q59990 CYTOCHROME P450 (EC 1.14.14.1) - SYNECHOCYSTIS SP. (STRAIN P
O13490 CYTOCHROME P450 - MYROTHECIUM RORIDUM.
CP5G_CANTR CYTOCHROME P450 52A7 (EC 1.14.14.1) (CYPLIIA7) (ALKANE-INDUC
Q9YI34 CYTOCHROME P450 - DICENTRARCHUS LABRAX (EUROPEAN SEA BASS).
O45219 B0331.1 PROTEIN - CAENORHABDITIS ELEGANS.
CP4B_HUMAN CYTOCHROME P450 4B1 (EC 1.14.14.1) (CYPIVB1) (P450-HP) - HOM
C4DA_DROMT CYTOCHROME P450 4D10 (EC 1.14.14.1) (CYPIVD10) - DROSOPHILA
P77900 HYPOTHETICAL 52.2 KD PROTEIN CY21B4.11C (EC 1.14.14.1) - MYC
O74128 ALK2 - YARROWIA LIPOLYTICA (CANDIDA LIPOLYTICA).
CP5V_CANAP CYTOCHROME P450 52E1 (EC 1.14.14.1) (CYPLIIE1) - CANDIDA API
C971_PEA CYTOCHROME P450 97B1 (EC 1.14.-.-) (P450 97A2) - PISUM SATIV
CP5Q_CANMA CYTOCHROME P450 52C2 (EC 1.14.14.-) (CYPLIIC2) (ALKANE-INDUC
O17851 F28G4.1 PROTEIN - CAENORHABDITIS ELEGANS.
C4D1_DROME CYTOCHROME P450 4D1 (EC 1.14.14.1) (CYPIVD1) - DROSOPHILA ME
C4D1_DROSI CYTOCHROME P450 4D1 (EC 1.14.14.1) (CYPIVD1) - DROSOPHILA SI
O17624 F02C12.5A PROTEIN - CAENORHABDITIS ELEGANS.
O17625 F02C12.5B PROTEIN - CAENORHABDITIS ELEGANS.
CP5W_CANAP CYTOCHROME P450 52E2 (EC 1.14.14.1) (CYPLIIE2) - CANDIDA API
O74134 ALK8 - YARROWIA LIPOLYTICA (CANDIDA LIPOLYTICA).
Q21262 SIMILAR TO CYTOCHROME P450. NCBI GI: 1208882 - CAENORHABDITI
Q27478 C36A4.3 PROTEIN - CAENORHABDITIS ELEGANS.
CP5P_CANTR CYTOCHROME P450 52C1 (EC 1.14.14.-) (CYPLIIC1) (ALKANE-INDUC
Q27472 SIMILAR TO CYTOCHROME P450. NCBI GI: 1255383 (EC 1.14.14.1)
C4E2_DROME CYTOCHROME P450 4E2 (EC 1.14.14.1) (CYPIVE2) - DROSOPHILA M
Q27479 C36A4.6 PROTEIN - CAENORHABDITIS ELEGANS.
TRI4_FUSSP TRICHODIENE OXYGENASE (EC 1.14.-.-) (CYTOCHROME P450 58) - F
Q9ZW95 F5A8.3 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
CP4C_BLADI CYTOCHROME P450 4C1 (EC 1.14.14.1) (CYPIVC1) - BLABERUS DIS
C4E5_DROMT CYTOCHROME P450 4E5 PRECURSOR (EC 1.14.-.-) (CYPIVE5) - DRO
O44485 F42A6.4 PROTEIN - CAENORHABDITIS ELEGANS.
Q27466 C01F6.3 PROTEIN - CAENORHABDITIS ELEGANS.
O14987 THROMBOXANE A2 SYNTHASE - HOMO SAPIENS (HUMAN).
CP53_ASPNG BENZOATE 4-MONOOXYGENASE (EC 1.14.13.12) (BENZOATE-PARA-HYD
O22162 CYTOCHROME P450 ISOLOG - ARABIDOPSIS THALIANA (MOUSE-EAR CR
STCS_EMENI PROBABLE STERIGMATOCYSTIN BIOSYNTHESIS P450 MONOOXYGENASE ST
O64631 PUTATIVE CYTOCHROME P-450 - ARABIDOPSIS THALIANA (MOUSE-EAR
O08447 PUTATIVE CYTOCHROME P450 MONOXYGENASE (EC 1.14.14.1) - MYCO
O08394 PROBABLE CYTOCHROME P450 (YFNJ) (EC 1.14.14.1) - BACILLUS S
CPT7_HUMAN CYTOCHROME P450 17 (EC 1.14.99.9) (CYPXVII) (P450-C17) (STE
Q12668 CYTOCHROME P450 (BENZOATE 4-HYDROXYLASE) (EC 1.14.14.1) - R
O52823 PCZA363.7 - AMYCOLATOPSIS ORIENTALIS.
O87674 OXYGENASE B - AMYCOLATOPSIS MEDITERRANEI.
CP5N_CANTR CYTOCHROME P450 52B1 (EC 1.14.14.1) (CYPLIIB1) (ALKANE-INDU
O80823 PUTATIVE CYTOCHROME P450 (PUTATIVE CYTOCHROME P450, 3' PART
CPT7_BOVIN CYTOCHROME P450 17 (EC 1.14.99.9) (CYPXVII) (P450-C17) (STE
STCF_EMENI PROBABLE STERIGMATOCYSTIN BIOSYNTHESIS P450 MONOOXYGENASE S
CPT7_PIG CYTOCHROME P450 17 (EC 1.14.99.9) (CYPXVII) (P450-C17) (STE
O69653 PUTATIVE CYTOCHROME P-450 - MYCOBACTERIUM TUBERCULOSIS.
SCAN HISTORY
OWL27_0 3 1000 NSINGLE
SPTR37_9f 3 1000 NSINGLE
SPTR37_10f 4 300 NSINGLE
INITIAL MOTIF SETS
EP450II1 Length of motif = 21 Motif number = 1
E-class P450 group II motif I - 1
PCODE ST INT
GEGWKHSRAMLRPQFAREQIA CP5E_CANMA 142 142
GENWKATRSVLRNMFDRKSID CP5I_CANTR 144 144
GQSWKHSRIMLRPVFAKEHVK CP5J_CANTR 132 132
GDGWKHSRALLRPQFSREQVS CP5L_CANAP 135 135
GDGWKNSRALLRPQFSREQVS CACYTP450 135 135
GEPWKHSRIMLRPQFIKSQVS JS0722 130 130
DEEWKRYRALLSPTFTSGRLK CP32_RAT 123 123
DRRWEEVRGALMSSFSPEKLD THAS_MOUSE 129 129
GDKWSRHRRMLTPAFHFNILK CP4F_RAT 141 141
GQTWFQHRRMLTPAFHYDILK CP44_RABIT 132 132
GPKWLQHRKLLTPGFHYDVLK CP4B_HUMAN 131 131
GAKWHSHRKMITPTFHFKILD CP4C_BLADI 124 124
GRKWHKRRKIITPAFHFKILD CP4D_DROME 124 124
GDRWRSLRNRFTPLFTSGKLK CP61_PAPPO 120 120
GEKWRSLRTKLSPTFTAGKMK CP61_MUSDO 125 125
GQSWRTLRMKLAPSFSSGKLK MDU22362 119 119
GEMWRKIRTKITPTFTAAPMR MDU09233 120 120
EKNWKKAHNILLPSFSQQAMK CPXB_BACME 93 93
RAEHTRKRKTVSHTFSMKSIG CP53_ASPNG 119 119
GAVWRNYRNAVTNGLQHFDDA CP56_YEAST 124 124
GDRHRRERKLLMPPFHGERLQ APU385376 91 91
EP450II2 Length of motif = 19 Motif number = 2
E-class P450 group II motif II - 1
PCODE ST INT
RFTVDTATEFLFGESVHSL CP5E_CANMA 194 31
KLGLELSIEFIFGQVVSED CP5I_CANTR 195 30
LFTIDYSTDFLLGESCDSL CP5J_CANTR 184 31
NLTIDTATEFLFGESTNTL CP5L_CANAP 186 30
NLTIDTATEFLFGESTNTL CACYTP450 186 30
RFTLDTATEFLFGQSVHSL JS0722 182 31
AYSMDVITSTSFGVNVDSL CP32_RAT 178 34
CYTIDVVASVAFGTQVDSQ THAS_MOUSE 184 34
LMTLDSLQKCVFSFDSNCQ CP4F_RAT 197 35
LMTLDTIMKCAFSYQGSVQ CP44_RABIT 187 34
HMALNTLMKCTFGRGDTGL CP4B_HUMAN 186 34
HCALDIICETAMGIQMNAQ CP4C_BLADI 178 33
LCTMDTICETAMGVSINAQ CP4D_DROME 181 36
KFTMTNIAACVFGLNLDEG CP61_PAPPO 175 34
RFNTDVIGSVAFGIECNSL CP61_MUSDO 180 34
TYAVDIIGSVIFGLEIDSF MDU22362 176 36
RFTTDVIGNVAFGLDCNSL MDU09233 176 35
RLTLDTIGLCGFNYRFNSF CPXB_BACME 147 33
YLAFDIIGDLAFGAPFGML CP53_ASPNG 181 41
RMALDNISQVALGFDFGAL CP56_YEAST 176 31
KLSLEVIIQIVFGLADGER APU385376 142 30
EP450II3 Length of motif = 16 Motif number = 3
E-class P450 group II motif III - 1
PCODE ST INT
GSSVVYTVYKTHRLEE CP5E_CANMA 420 207
GQSVGFISIATHLDPV CP5I_CANTR 399 185
GEQVLFSFYSVNREEK CP5J_CANTR 405 202
GQNVFYSTYSMQRRTD CP5L_CANAP 409 204
GQKVFYATYVMQRNAG CACYTP450 409 204
GQPVAYFICATHVDEK JS0722 393 192
GSVVTIPTYALHHDPQ CP32_RAT 392 196
GTVLEIAVGALHHDPE THAS_MOUSE 428 225
GIICLISIFGIHHNPS CP4F_RAT 417 201
GVILFLSIYGLHYNPK CP44_RABIT 404 198
GSLISMHIYALHRNSA CP4B_HUMAN 402 197
GCMMNLQIYHVHRNQD CP4C_BLADI 401 204
GTNIGISPLYLGRREE CP4D_DROME 404 204
GQTIIVSTWGIQNDPK CP61_PAPPO 392 198
GTLVFIPVLGIHYDPE CP61_MUSDO 398 199
ETGIIISLLGIHRDPQ MDU22362 411 216
YVHIIIPIYAIHHDPE MDU09233 388 193
GDELMVLIPQLHRDKT CPXB_BACME 350 184
GDVVSVPSYTIHRSKE CP53_ASPNG 409 209
GVYVGYNNFGTSHDPK CP56_YEAST 376 181
DTTLMASIYLIHYRED APU385376 345 184
FINAL MOTIF SETS
EP450II1 Length of motif = 21 Motif number = 1
E-class P450 group II motif I - 4
PCODE ST INT
DEEWKRLRSLLSPTFTSGKLK CP34_HUMAN 122 122
DEEWKRLRSLLSPTFTSGKLK Q16757 123 123
DEEWKRLRSLLSPTFTSGKLK CP33_HUMAN 122 122
DEEWKRIRSLLSPTFTSGKLK CP38_MACFA 123 123
DEEWKRLRTLLSPTFTSGKLK CP3P_MOUSE 123 123
DEEWKRYRALLSPTFTSGRLK CP31_RAT 123 123
DEEWKRYRALLSPTFTSGRLK Q06884 123 123
DDEWKRYRALLSPTFTSGKLK CP3B_MOUSE 123 123
DEEWKRIRTLLSPTFTSGKLK CP3T_PIG 123 123
DEEWKRIRALLSPTFTSGKLK CP3V_MESAU 123 123
DEEWKRLRTILSPTFTSGKLK CP3I_RAT 123 123
DEEWKRYRALLSPTFTSGRLK CP32_RAT 123 123
DEEWKRIRSLLSPTFTSGKLK CP35_HUMAN 123 123
DEEWKRIRSLLSPTFTSGKLK CP37_HUMAN 123 123
DEEWKRLRTLLSPAFTSGKLK CP3A_MESAU 123 123
DEDWKRVRTLLSPTFTSGKLK CP36_RABIT 121 121
DEEWKRIRALLSPTFTSGKLK CP39_RAT 123 123
DDEWKRIRSLLSPTFTSGKLK CP3L_CALJA 123 123
DEQWKRIRTLLSPTFTSGKLK CP3O_SHEEP 123 123
NEEWKRIRALLSPTFTSGRLK CP3D_MOUSE 123 123
DEEWKRIRTQLSPNFTSGKLK CP3E_CAVPO 123 123
DEEWKRYRALLSPTFTSGNLK CP3G_MOUSE 123 123
DEEWKRIRTQLSPNFTSGKLK CP3F_CAVPO 123 123
DEEWKRMRTLLSPTFTTGKLK CP3C_CANFA 123 123
DEQWKRIRTLLSPAFTSGKLK CP3S_BOVIN 123 123
DEEWKRIRTLLSPTFTSGKLK O97689 123 123
GDKWKSLRTKLTPTFTSGKMK O76107 120 120
DEEWKRIRTQLSQNFTSGKLK CP3H_CAVPO 123 123
GEKWRSLRTKLSPTFTAGKMK C6A1_MUSDO 125 125
GEKWRSLRTKLSPTFTAGKMK Q27703 125 125
GQTWFQHRRMLTPAFHYDILK CP46_RABIT 136 136
GEQWRAMRTKLSPVFTSARMK Q27694 123 123
GQKWKSMRSKLSSTFTSGKMK C6A9_DROME 125 125
GEQWRALRAKLTPVFTSARMK Q27691 124 124
GQTWFQHRRMLTPAFHYDILK CP4Y_HUMAN 136 136
GQTWFQHRRMLTPAFHYDILK Q16802 136 136
GQPWFQHRRMLTPAFHYDILK CP45_RABIT 136 136
DAIGREFRTKLTPVFTSGKVK O76800 139 139
GKKWKDMRQRLTPTFTSGKMK C6A2_DROME 123 123
GAQWRLLRNKLSSTFTSGKMK C6A8_DROME 126 126
GQTWFQHRRMLTPAFHYDTLK CP48_RAT 134 134
GEGWKHSRAMLRPQFSRDQVG CP5K_CANMA 138 138
GQPWFQHRRMLTPAFHYDILK CP41_RAT 135 135
GHGWTHSRALLRPQFAREQVS O74131 130 130
GQPWFQHRRMLTPAFHYDILK O88833 135 135
GHGWTHSRALLRPQFAREQVS O74133 130 130
DARWKDMRRPLSPAFTGSKMR O76801 129 129
PHRWRVMRNKLSPTFTSGKMK P90730 125 125
GKKWFQHRRMLTPAFHYDILK CP42_RAT 130 130
GEGWKHSRSMLRPQFAREQIA O74626 138 138
GNGWKHSRAMLRPQFSRDQIG CP5J_CANMA 138 138
DDTWRRIRSVLSPSFTSGRLK CP3R_ONCMY 124 124
GQTWFQHRRMLTPAFHYDILK CP44_RABIT 132 132
GEQWRAMRTKLTPVFTSARMK Q27692 120 120
GAGWKHSRAMLRPQFAREQVA CP5D_CANMA 157 157
GAGWKHSRAMLRPQFAREQVA Q12582 157 157
GKKWFQHRRMLTPAFHYDILK O35728 133 133
GDEWKAMRSTMSPAFTSSKMR Q25176 122 122
GKKWFQHRRMLTPAFHYGILK CP43_RAT 133 133
GAGWKHSRAMLRPQFAREQVG Q12581 145 145
GETWRALRNRFTPIFTSGKLK C6B7_HELAM 122 122
GAGWKHSRSMLRPQFAREQVS CP5B_CANTR 141 141
GQTWFQHRRMLTPAFHYDILK CP47_RABIT 136 136
GDKWSRHRRLLTPAFHFDILK CPF5_RAT 141 141
GEHWRFLRTTLSPTFTTGKIR O16156 125 125
GHRWKRLRTLASPTFSNKSLR YRV5_CAEEL 122 122
GEGWKHSRAMLRPQFAREQIA O94080 142 142
GEGWKHSRAMLRPQFAREQVG CP5I_CANMA 140 140
GEMWRKIRTKITPTFTAAPMR Q27693 120 120
GHRWKRLRTLASPTFSNKSLR YRV1_CAEEL 122 122
GDRWRVLRQCFTPLFTSGKLK C6B4_PAPGL 120 120
GEGWKLSRAMLRPQFAREQIA CP5C_CANMA 142 142
GHRWKRLRTLSSPTFSNKNLR YRV2_CAEEL 122 122
GDTWRTLRNRFTPIFTSGKLK C6B2_HELAM 122 122
GEKWDTHRKLLNPAFHVEKLK Q40411 142 142
GEGWKHSRAMLRPQFARDQIG CP5F_CANTR 143 143
GEGWKHSRAMLRPQFAREQIA CP5E_CANMA 142 142
GETWRALRNRFTPIFTSGKPK C6B6_HELAM 122 122
GQSWRTLRMKLAPSFSSGKLK Q27697 119 119
GQSWRTLRMKLAPSFSSGKLK Q27700 119 119
GQSWRTLRMKLAPSFSSGKLK Q27699 118 118
GQSWRTLRMKLAPSFSSGKLK Q27698 119 119
GQGWKHSRAMLRPQFAREQVA CP5H_CANTR 136 136
GEPWKHSRIMLRPQFIKSQVS CP5T_CANMA 130 130
GHRWKRLRTLASPTFSNKSLR YRVA_CAEEL 122 122
GAKWSKHRRIISPAFTLEKLK CP72_CATRO 150 150
GAKWSKHRRIISPAFTLEKLK Q42700 150 150
GDKWSRHRRMLTPAFHFNILK CPF1_RAT 141 141
DRRWEEVRGALMSSFSPEKLD THAS_MOUSE 129 129
GLDWVRHRRILNPAFSMDKLK O80729 149 149
DKRWEEVRSVLTSAFSPKKLN THAS_PIG 129 129
GEKWAHHRKIISPTFHMENLK O48786 149 149
GEKWSRHRRMLTPAFHFNILK CPF3_HUMAN 141 141
GEKWSRHRRMLTPAFHFNILK O60634 141 141
GEKWNHHRRLLTPAFHFDILK CPF6_RAT 141 141
GADWVRHRRILNPAFSIDRLK O80728 148 148
DQRWKHMRNTLTPVFTSAKMR O76799 123 123
GAGWKHSRTMLRPQFAREQVS CP5A_CANTR 159 159
GDKWSRHRRMLTPAFHFNILK CPF2_HUMAN 141 141
GERWKSHRKMLTPAFHFAKLG Q21424 129 129
GFRWKRLRAISSPTFSNSSLR YRV8_CAEEL 123 123
GFRWKRLRTITAPAFSNGSIK O01997 117 117
GYRWKRLRTISSQSFSNASLK YRV7_CAEEL 124 124
GEGWTHSRALLRPQFARDQVS O74132 130 130
GFRWKRLRAISSPTFSNNSLR YS24_CAEEL 132 132
GPKWFQHRKLLTPGFHYDVLK CP4B_MOUSE 131 131
GPKWFQHRKLLTPGFHYDVLK CP4B_RABIT 126 126
GPKWFQHRKLLTPGFHYDVLK CP4B_RAT 131 131
GDKWSCHRRMLTPAFHFNILK CPF4_RAT 141 141
GEGWTHSRALLRPQFSRQQIS O74130 130 130
DKRWEEVRGALMSAFSPEKLN THAS_HUMAN 129 129
GHRWKRLRTISSPTFSNNSLR O17807 122 122
GQGWQHSRAMLRPQFARDQVS O74127 136 136
GERWRTHRKLLTPTFHFAKLE Q27480 459 459
DRRWEEVRGALMSAFSPEKLN THAS_RAT 129 129
KEQWRPKRKLLTPTFHYDILK O45605 122 122
SSGWKHTRSAIAPIFSTGKMK Q27477 131 131
GDRWRSLRNRFTPLFTSGKLK C6B3_PAPPO 120 120
DQQWKDVRRIMTPVFSSAKMK O76345 119 119
GHRWKRLRTIANPTFSSNNLR O17806 121 121
DKRWEEVRGALMSAFSPEKLN Q16843 130 130
GKEWHTMRKIITPTFHFSILE O46054 122 122
GDRWRSLRNRFTPLFTSGKLK C6B1_PAPPO 120 120
ATGWKHTRSAIAPIFSTGKMK Q27476 131 131
LDTWKQRRRVIAPAFHNSYLE C972_SOYBN 160 160
GKRWKRLRTLSSPSFSNNSLR YRV3_CAEEL 120 120
GRKWHGRRKIITPTFHFKILE C4D2_DROME 119 119
GRKWHGRRKIITPTFHFKILE O46053 95 95
GKKWFRRRKIITPAFHFKILE O46051 121 121
LDTWKLRRRAITPAFHKLYLE C973_ARATH 161 161
EPNWQKAHRILLPSFSQKAMK O08336 95 95
GSSWSHSRALLRPQFSREQIS O74129 128 128
EKNWKKAHNILLPSFSQQAMK CPXB_BACME 93 93
GDDHRRRRRLLAPPFHGKSMK P96813 101 101
GPNWKFQRQVASHEFNTKSIR O81117 136 136
GDTWLFQRKTAALEFTTRTLR C862_ARATH 124 124
GDTWLMQRKTAALEFTTRTLR C861_ARATH 127 127
GEIHRSRRKILYQAFLPRTLD Q59990 98 98
HDTHRARRGYLNPYFSKRSLA O13490 133 133
EP450II2 Length of motif = 19 Motif number = 2
E class P450 group II motif II - 4
PCODE ST INT
AYSMDVITSTSFGVNIDSL CP34_HUMAN 177 34
AYSMDVITSTSFGVNIDSL Q16757 178 34
AYSMDVITSSSFGVNVDSL CP33_HUMAN 177 34
AYSMDVITSTSFGVNIDSL CP38_MACFA 178 34
AYSMDVITGTSFGVNVDSL CP3P_MOUSE 178 34
AYSMDVITSTSFGVNVDSL CP31_RAT 178 34
AYSMDVITSTSFGVNVDSL Q06884 176 32
AYSMDVITSTSFGVNVDSL CP3B_MOUSE 178 34
AYSMDVITSTAFGVNIDSL CP3T_PIG 178 34
AYSMDVITSTAFGVSVDSL CP3V_MESAU 178 34
AYSMDVITGTSFGVNVDSL CP3I_RAT 178 34
AYSMDVITSTSFGVNVDSL CP32_RAT 178 34
AYSMDVITGTSFGVNIDSL CP35_HUMAN 178 34
AYSMDVITSTSFGVSIDSL CP37_HUMAN 178 34
AYSMDVITGTSFGVNVDSL CP3A_MESAU 178 34
AYSMDVITGTSFGVNIDSL CP36_RABIT 176 34
AYSMDVITATSFGVNVDSL CP39_RAT 178 34
AYSMDVITGTSFGVNIDSL CP3L_CALJA 178 34
AYSMDVITSTSFGVNIDSL CP3O_SHEEP 178 34
AYSMDVITATSFGVNIDSL CP3D_MOUSE 178 34
AYSMDIIVATAFGVNVDSL CP3E_CAVPO 178 34
AYSMDVIISTTFGVNIDSL CP3G_MOUSE 178 34
AYGMDIIIATAFGVNVDSL CP3F_CAVPO 178 34
AYSMDVITSTSFGVNIDSL CP3C_CANFA 178 34
AYSMDVITGTAFGVNIDSL CP3S_BOVIN 178 34
AYSMDVITSTAFGVNTDFL O97689 178 34
RFAMDVIGSCAFGLDCNSL O76107 175 34
AYSMDIIIATAFGVNVDSL CP3H_CAVPO 178 34
RFNTDVIGSVAFGIECNSL C6A1_MUSDO 180 34
RFNTDVIGSVAFGIECNSL Q27703 180 34
LMTLDTIMKCAFSHQGSVQ CP46_RABIT 191 34
RFTTDVIGTCAFGIECNSL Q27694 180 36
RFTTDVIGTCAFGIECSSL C6A9_DROME 180 34
RYTTDVIANCAFGIECSSL Q27691 183 38
LMTLDTIMKCAFSHQGSIQ CP4Y_HUMAN 191 34
LMTLDTIMKCAFSHQGSIQ Q16802 191 34
LMTLDTIMKCAFSYQGSVQ CP45_RABIT 191 34
QFSTDSIATIAFGIRANSL O76800 197 37
RFTTDVIGTCRFGIECNTL C6A2_DROME 181 37
RFTVDVIGTCAFAIQCNSL C6A8_DROME 181 34
LMTLDTIMKCAFSQEGSVQ CP48_RAT 189 34
RFTVDSATEFLFGESVSSL CP5K_CANMA 190 31
LMTLDTVMKCAFSHNGSVQ CP41_RAT 190 34
LFTLDSATEFLFGSSVDSL O74131 188 37
LMTLDTVMKCAFSHKGSVQ O88833 190 34
LMTLDTATEFLFGSSVDSL O74133 188 37
RFTNDVIASTAFGLQVNSF O76801 186 36
RFTTDVIAPCAFGIDVNSL P90730 180 34
LMTLDTVMKCAFSHQGSVQ CP42_RAT 185 34
RFTVDSATEFLFGESVSSL O74626 190 31
RFTVDSATEFLFGESVSSL CP5J_CANMA 190 31
PYSMDVVTSTAFSVDIDSL CP3R_ONCMY 179 34
LMTLDTIMKCAFSYQGSVQ CP44_RABIT 187 34
RFTTDVIGNCAFGIECNSL Q27692 178 37
RLTVDSSTEFLFGGSVESL CP5D_CANMA 209 31
RLTVDSSTEFLFGGSVESL Q12582 209 31
LMTLDTVMKCAFSYQGSVQ O35728 188 34
RYANDVIASCAFGLKVNSQ Q25176 181 38
LMTLDTVMKCAFSHQGSVQ CP43_RAT 188 34
RFTVDSATEFLFGESVESL Q12581 197 31
TYTMSTISSCAFGVSYNSI C6B7_HELAM 177 34
RLTVDSATEFLFGESVESL CP5B_CANTR 193 31
LMTLETIMKCAFSHQGSVQ CP47_RABIT 191 34
LMTLDSLQKCLFGFDSNCQ CPF5_RAT 197 35
GYTLDVICSTGFGLDVDAQ O16156 181 35
EFTMDIIGKIAMGQSGSMM YRV5_CAEEL 177 34
RFTVDTATEFLFGESVHSL O94080 194 31
RFTVDSATEFLFGESVESL CP5I_CANMA 192 31
RFTTDVIGNVAFGLDCNSL Q27693 176 35
EFTLDIIGRIAMGQTESLM YRV1_CAEEL 177 34
KFTMASITTCAFGMELDEE C6B4_PAPGL 175 34
RFTVDTATEFLFGESVHSL CP5C_CANMA 194 31
EFTLDIIGRIAMGQTESLM YRV2_CAEEL 177 34
TYTMSTISSCAFGVSYDTI C6B2_HELAM 177 34
NLGGDVISRAAFGSNIAEG Q40411 199 36
RFTVDTATEFLFGESVHSL CP5F_CANTR 195 31
RFTVDTATEFLFGESVHSL CP5E_CANMA 194 31
TYTMSTIAACAFGISYDSI C6B6_HELAM 177 34
TYAVDIIGSVIFGLEIDSF Q27697 176 36
TYAVDIIGSVIFGLEIDSF Q27700 176 36
TYAVDIIGSVIFGLEIDSF Q27699 175 36
TYAVDIIGSVIFGLEIDSF Q27698 176 36
RFTVDSATEFLFGESVHSL CP5H_CANTR 188 31
RFTLDTATEFLFGQSVHSL CP5T_CANMA 182 31
EFTMDIIGKMAMGQEKSLM YRVA_CAEEL 177 34
VLTSDVISKVAFGSTYEEG CP72_CATRO 207 36
VLTSDVISKVAFGSTYEEG Q42700 207 36
LMTLDSLQKCVFSFDSNCQ CPF1_RAT 197 35
CYTIDVVASVAFGTQVDSQ THAS_MOUSE 184 34
RLTADIIATAAFGSSYAEG O80729 207 37
CYTTDVVASVAFGTQVNSS THAS_PIG 184 34
ILTEDVISRTAFGSSYEDG O48786 206 36
LMTLDSLQKCVFSFDSHCQ CPF3_HUMAN 197 35
LMTLDSLQKCVFSFDSHCQ O60634 197 35
LMTLDSLQKCIFSFDSNCQ CPF6_RAT 197 35
RLTADIIATSAFGSSYVEG O80728 209 40
RLSNDLIATTAFGLKVSSY O76799 184 40
RLTVDSATEFLLGESAESL CP5A_CANTR 211 31
LMTLDSLQKCVFSFDSHCQ CPF2_HUMAN 197 35
RCALDIISETAMGIKIDAQ Q21424 184 34
EFTLDVIGRIAMGQTDSQM YRV8_CAEEL 178 34
EYTFDVISRVAMGQPDSQM O01997 172 34
EYTMDVIGRFAMGQTDSMM YRV7_CAEEL 179 34
MLTLDTATEFLCGDSVDSL O74132 187 36
EFTMDTIGRIAMGQTDSQM YS24_CAEEL 187 34
HMALDTLMKCTFGKGDSGL CP4B_MOUSE 186 34
HMALDTLMKCTFGKGDSGL CP4B_RABIT 181 34
HMALDTLMKCTFGKGDSGL CP4B_RAT 186 34
LMTLDSLQKCVFSFDSNCQ CPF4_RAT 197 35
MFTLDSATEFLYGASVDTL O74130 182 31
NYTTDVVASVAFGTPVDSW THAS_HUMAN 184 34
EFTLDVIGRIAMGQTDSQM O17807 177 34
NLTLDTATEFLFGQSVGSQ O74127 187 30
RCALDIICGAAIGTKINAQ Q27480 514 34
CFTTNVVASVAFGIEVNSQ THAS_RAT 184 34
LCTLDIICETSMGKAIGAQ O45605 176 33
GLTLDVIGKCAFAIDSNCQ Q27477 186 34
IFTITNIAACAFGLNLDEN C6B3_PAPPO 175 34
CLTMDVINRCAITLDINCI O76345 174 34
EFTMDVIGRIAMGQPDSLM O17806 176 34
NYTTDVVASVPFGTPVDSW Q16843 185 34
LAALDIITETAMGVNVDAQ O46054 177 34
KFTMTNIAACVFGLNLDEG C6B1_PAPPO 175 34
GLTLDVIGKCAFAIDSNCQ Q27476 186 34
SLALDIIGLGVFNYDFGSV C972_SOYBN 222 41
EYTLGVISRIALGQSESNM YRV3_CAEEL 175 34
LTALDIIAETAMGTKINAQ C4D2_DROME 174 34
LTALDIIAETAMGTKINAQ O46053 150 34
LCAMDIIAETAMGVKINAQ O46051 176 34
SLALDIIGLSVFNYDFGSV C973_ARATH 224 42
RLTLDTIGLCGFNYRFNSF O08336 149 33
SLAMDTATDFLLGEAVGNL O74129 180 31
RLTLDTIGLCGFNYRFNSF CPXB_BACME 147 33
HITLNAILRAIFGAGGSEL P96813 152 30
RFTFDNICNIAFGYDPEYL O81117 193 36
RLTFDNICGLAFGKDTRTC C862_ARATH 181 36
RLTFDNICGLTFGKDPETL C861_ARATH 184 36
RMTFDVAATLFMGEKVSQN Q59990 149 30
ALTADIICSRFYGKNFDYL O13490 188 34
EP450II3 Length of motif = 16 Motif number = 3
E class P450 group II motif III - 4
PCODE ST INT
GWVVMIPSYALHRDPK CP34_HUMAN 390 194
GWVVMIPSYALHRDPK Q16757 390 193
GWVVMIPSYALHRDPK CP33_HUMAN 391 195
GVVVMIPSYALHHDPK CP38_MACFA 391 194
GTVVMIPIYPLHRNPE CP3P_MOUSE 391 194
GSVVMIPSYALHRDPQ CP31_RAT 392 195
GSVVMIPSYALHRDPQ Q06884 390 195
GSTVMIPSYALHHDPQ CP3B_MOUSE 392 195
GTVVVVPVFVLHRDPD CP3T_PIG 391 194
GSIVMVPVFALHYDPQ CP3V_MESAU 389 192
GTVVTIPIYPLHRNPE CP3I_RAT 391 194
GSVVTIPTYALHHDPQ CP32_RAT 392 195
GSMVVIPTYALHHDPK CP35_HUMAN 391 194
GVVVMIPSYVLHHDPK CP37_HUMAN 391 194
GITVMVPTYPLHRDPE CP3A_MESAU 391 194
GTIVMMPTYALHRDPQ CP36_RABIT 389 194
GTVVMIPTFALHKDPH CP39_RAT 391 194
GVVVMIPSYALHYDPK CP3L_CALJA 391 194
GTAVTVPIFVLHRDPQ CP3O_SHEEP 391 194
GTVVMIPTFALHKDPK CP3D_MOUSE 391 194
GTGVMIPSFALHRDSK CP3E_CAVPO 391 194
GSTVIIPSYVLHHDPQ CP3G_MOUSE 392 195
GTLVMIPSFALHRDSK CP3F_CAVPO 391 194
GTVVMVPTFTLHRDQS CP3C_CANFA 391 194
GTTVLVPLFVLHNNPE CP3S_BOVIN 391 194
GTVMMVPVFSIHRDPE O97689 391 194
GYRVVIPVYGIHHDPD O76107 379 185
GTGVMIPSFALHRDSK CP3H_CAVPO 391 194
GTLVFIPVLGIHYDPE C6A1_MUSDO 398 199
GTLVFIPVLGIHYDPE Q27703 396 197
GVIVTLSIYALHHNPK CP46_RABIT 408 198
GIMTVIPVHAIHHDPE Q27694 401 202
GMPVLIPCGAMHRDEK C6A9_DROME 398 199
DIQVVIPVHAIHHDPE Q27691 393 191
GIMVLLSIYGLHHNPK CP4Y_HUMAN 408 198
GIMVLLSIYGLHHNPK Q16802 409 199
GFTVTLSIYGLHHNPN CP45_RABIT 409 199
GTPVFIPIYALHHDPK O76800 419 203
GTQVIIPACAYHRDED C6A2_DROME 401 201
GQSVIIPSSAIHHDPS C6A8_DROME 388 188
GITVMLSFYGLHHNPT CP48_RAT 406 198
GQTVMYSVYALQRDEK CP5K_CANMA 415 206
GIQVTLSIYGLHHNPK CP41_RAT 407 198
GQTVSYSVYWTHRDPR O74131 421 214
GVQVTLSIYGLHHNPK O88833 407 198
GQTVSYSVWWTHRDPE O74133 421 214
GEAVWLPTCGFHRDPK O76801 407 202
GMQVIIPAAPFHRDAD P90730 398 199
GIRVTILIYGLHHNPS CP42_RAT 402 198
GQAVMYSIYSTQRDPK O74626 411 202
GQTVMYSVYALQRDEK CP5J_CANMA 415 206
DCIVLVPTWTLHRDPE CP3R_ONCMY 396 198
GVILFLSIYGLHYNPK CP44_RABIT 404 198
DIMTIIPIHAIHHDPQ Q27692 399 202
GQNVMYTISATHRDPS CP5D_CANMA 434 206
GQNVMYTILATHRDPN Q12582 434 206
GITATISIYGLHHNPR O35728 405 198
GQAVAISPWLFHRNPK Q25176 422 222
GITTTILIYGLHHNPS CP43_RAT 405 198
GQTVMYSVYATHRMES Q12581 422 206
DTMVLISPRGIHYDPK C6B7_HELAM 394 198
GQTVMYSVYAAHRNKQ CP5B_CANTR 418 206
GIIITLSIYGLHHNPK CP47_RABIT 409 199
GNICVISIFGIHHNPS CPF5_RAT 419 203
GMDCTFSILALHYMPE O16156 407 207
GTNVQADTWTLHYDPK YRV5_CAEEL 412 216
GSSVVYSVYKTHRLKQ O94080 418 205
GAVVSYGINSTHLDPM CP5I_CANMA 417 206
YVHIIIPIYAIHHDPE Q27693 388 193
GTNVQVDTWTLHYDPK YRV1_CAEEL 412 216
GQTVVVSGFGIHYDPK C6B4_PAPGL 392 198
GSSVVYSVYKTHRLKQ CP5C_CANMA 420 207
GTNVQVDTWTLHYDPK YRV2_CAEEL 412 216
DTVVLISPRGIHYDPK C6B2_HELAM 394 198
GVQVCVPTHLVHRDPE Q40411 404 186
GSTVAYIVYKTHRLEE CP5F_CANTR 421 207
GSSVVYTVYKTHRLEE CP5E_CANMA 420 207
DTIVLISPRGIHYDPK C6B6_HELAM 394 198
ETGIIISLLGIHRDPQ Q27697 411 216
ETGIIISLLGIHRDPQ Q27700 411 216
ETGIIISLLGIHRDPQ Q27699 410 216
ETGIIISLLGIHRDPQ Q27698 411 216
GEAVSYGINSTHLDPV CP5H_CANTR 413 206
GQPVAYFICATHVDEK CP5T_CANMA 393 192
GTNINVDTWSLHHDPK YRVA_CAEEL 412 216
GTQVMLPTVMLHREKS CP72_CATRO 417 191
GTQVMLPTVMLHREKS Q42700 417 191
GIICLISIFGIHHNPS CPF1_RAT 417 201
GTVLEIAVGALHHDPE THAS_MOUSE 428 225
GTTIILPIAKMHRDKA O80729 410 184
GTVLEVAVGALHHDPK THAS_PIG 429 226
GTELLIPIIAVHHDQA O48786 410 185
GIICLISVFGTHHNPA CPF3_HUMAN 417 201
GIICLISVFGTHHNPA O60634 417 201
GNICVISIFGVHHNPS CPF6_RAT 417 201
GTTVVIPLLKMHSDKT O80728 418 190
GDRINIPIVGLHLDDK O76799 399 196
GQVVMYTILATHRDKD CP5A_CANTR 436 206
GIICLISVFGTHHNPA CPF2_HUMAN 417 201
GGNVTISPMVLHSNHH Q21424 398 195
GTMIQVDTWTLHTDPN YRV8_CAEEL 412 215
GVDVMIDTWTLHHDKN O01997 406 215
GVYVQMDTWSLHYDPE YRV7_CAEEL 409 211
GGIVVYSVYHTHRAEE O74132 420 214
GTMVQVDTWSLHTDTK YS24_CAEEL 437 231
GSLISLHIYALHRNSA CP4B_MOUSE 402 197
GSLISLHIYALHRNSD CP4B_RABIT 397 197
GSLISLHIYALHRNST CP4B_RAT 402 197
GVICIINIFATHHNPT CPF4_RAT 417 201
GQMVAYCVYWMHRDKK O74130 413 212
GAVLEMAVGALHHDPE THAS_HUMAN 428 225
GTNILCDTWTLHSDKS O17807 410 214
GNLVSYHVFTTHRLKE O74127 410 204
GANVSIAPLALHSNAQ Q27480 626 93
GSVLEIAVGALHHDPE THAS_RAT 428 225
GVTFLLNLYLVHRDPA O45605 377 182
GAIVVCLPHTVHRNPE Q27477 405 200
GQTIIVSTWGIQNDPK C6B3_PAPPO 392 198
GTEVEVPVWSIHHNPE O76345 386 193
GVDILCDTWTLHYDKS O17806 409 214
GAVLEMAVGALHHDPE Q16843 429 225
GTNVVVLLWQLLRDEA O46054 392 196
GQTIIVSTWGIQNDPK C6B1_PAPPO 392 198
GSVVTCLPHTVHLNPE Q27476 417 212
GTDVFISVYNLHRSPY C972_SOYBN 446 205
GMNIQVDTWTLHHNPR YRV3_CAEEL 410 216
GTNFTMGIFVLLRDPE C4D2_DROME 399 206
GTNFTMGIFVLLRDPE O46053 375 206
DSNVIILIYHAQRDPD O46051 403 208
GTDIFISVYNLHRSPY C973_ARATH 448 205
GQPVTVLIPKLHRDQN O08336 353 185
GQKINYAIFWTHRDKE O74129 403 204
GDELMVLIPQLHRDKT CPXB_BACME 350 184
GYSIIINIAQIHGDPD P96813 340 169
GTIVTYHVYAMGRMKS O81117 399 187
GSSVTYSIYAAGRMKS C862_ARATH 404 204
GSTVTYSIYSIGRMKT C861_ARATH 400 197
GWLVSYQISQTHADPD Q59990 339 171
GTPLSMSTYFVHTDEE O13490 403 196
User query: Display/Full Code "EP450II"