WORKLIST ENTRIES (1):
FACTINCAPA View alignment View Structure F-actin capping protein alpha subunit signature
Type of fingerprint: COMPOUND with 3 elements
Links:
PRINTS; PR00192 FACTINCAPB; PR00597 GELSOLIN
INTERPRO; IPR002189
PROSITE; PS00748 F_ACTIN_CAPPING_A_1; PS00749 F_ACTIN_CAPPING_A_2
PFAM; PF01267 F-actin_cap_A
Creation date 14-JUL-1994; UPDATE 07-JUN-1999
1. MARUYAMA, K., KUROKAWA, H., OOSAWA, M., SHIMAOKA, S. YAMAMOTO, H.,
ITO, M. AND MARUYAMA, K.
Beta-actinin is equivalent to CapZ protein.
J.BIOL.CHEM. 265 8712-8715 (1990).
2. HARTMANN, H., NOEGEL, A.A., ECKERSKORN, C., RAPP, S. AND SCHLEICHER, M.
Ca2+-independent F-actin capping proteins. Cap 32/34, a capping protein
from Dictyolstelium discoideum, does not share sequence homologies with
known actin-binding proteins.
J.BIOL.CHEM. 264 12639-12647 (1989).
The actin filament system, a prominent part of the cytoskeleton in
eukaryotic cells, is both a static structure and a dynamic network that
can undergo rearrangements: it is thought to be involved in processes
such as cell movement and phagocytosis [1], as well as muscle contraction.
Capping proteins bind to the ends of actin filaments, blocking the addition
of actin monomers at this end. The capping protein is a heterodimer of alpha
and beta subunits [2]: it binds to the barbed end of actin filaments, but
unlike gelsolin and severin does not sever the filament [1]. Neither of the
subunits shows sequence similarity to other filament-capping proteins [1].
FACTINCAPA is a 3-element fingerprint that provides a signature for the
F-actin capping protein alpha subunit. The fingerprint was derived from
an initial alignment of 5 sequences: the motifs span conserved regions
located in the C-terminal half of the alignment, motifs 2 and 3 including
the regions encoded by PROSITE patterns F_ACTIN_CAPPING_A_1 (PS00748) and
F_ACTIN_CAPPING_A_2 (PS00749). Two iterations on OWL23.2 were required to
reach convergence, at which point a true set comprising 7 sequences was
identified.
An update on SPTR37_9f identified a true set of 10 sequences.
SUMMARY INFORMATION
10 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
3| 10 10 10
2| 0 0 0
--+----------------
| 1 2 3
True positives..
CAZ1_CHICK CAZ1_HUMAN CAZ2_CHICK CAZ2_HUMAN
CAZ2_MOUSE CAPA_CAEEL CAPA_YEAST CAPA_DICDI
CAPA_SCHPO O82631
PROTEIN TITLES
CAZ1_CHICK F-ACTIN CAPPING PROTEIN ALPHA-1 SUBUNIT (CAPZ 36/32) (BETA-A
CAZ1_HUMAN F-ACTIN CAPPING PROTEIN ALPHA-1 SUBUNIT (CAPZ) - HOMO SAPIEN
CAZ2_CHICK F-ACTIN CAPPING PROTEIN ALPHA-2 SUBUNIT (CAPZ 36/32) (BETA-A
CAZ2_HUMAN F-ACTIN CAPPING PROTEIN ALPHA-2 SUBUNIT (CAPZ) - HOMO SAPIEN
CAZ2_MOUSE F-ACTIN CAPPING PROTEIN ALPHA-2 SUBUNIT (CAPZ) - MUS MUSCULU
CAPA_CAEEL F-ACTIN CAPPING PROTEIN ALPHA SUBUNIT - CAENORHABDITIS ELEGA
CAPA_YEAST F-ACTIN CAPPING PROTEIN ALPHA SUBUNIT - SACCHAROMYCES CEREVI
CAPA_DICDI F-ACTIN CAPPING PROTEIN ALPHA SUBUNIT (CAP34) - DICTYOSTELIU
CAPA_SCHPO PROBABLE F-ACTIN CAPPING PROTEIN ALPHA SUBUNIT - SCHIZOSACCH
O82631 F-ACTIN CAPPING PROTEIN ALPHA SUBUNIT - ARABIDOPSIS THALIANA
SCAN HISTORY
OWL23_2 2 100 NSINGLE
OWL28_0 1 100 NSINGLE
SPTR37_9f 2 12 NSINGLE
INITIAL MOTIF SETS
FACTINCAPA1 Length of motif = 15 Motif number = 1
F-Actin capping protein alpha subunit motif I - 1
PCODE ST INT
FQPKNFWNGRWRSEW CAPA_CHICK 163 163
FQPKNFWNGRWRSEW CAPA_XENLA 133 133
FQAKNFWNGRWRSEW CAP2_CHICK 163 163
YNPNNFWNGHWRSSY CAPA_YEAST 153 153
YKPNAFYSGRWRSVW CAPA_DICDI 157 157
FACTINCAPA2 Length of motif = 14 Motif number = 2
F-Actin capping protein alpha subunit motif II - 1
PCODE ST INT
QVHYYEDGNVQLVS CAPA_CHICK 195 17
QVHYYEDGNVQLVS CAPA_XENLA 165 17
QVHYYEDGNVQLVS CAP2_CHICK 195 17
QVHYYEDGNVSFQS CAPA_YEAST 183 15
NVHYFEDGNVQLNT CAPA_DICDI 191 19
FACTINCAPA3 Length of motif = 20 Motif number = 3
F-Actin capping protein alpha subunit motif III - 1
PCODE ST INT
DTTFKALRRQLPVTRTKIDW CAPA_CHICK 252 43
DTTFKALRRQLPVTRTKIDW CAPA_XENLA 222 43
DTTFKALRRQLPVTRTKIDW CAP2_CHICK 252 43
EKQFKALRRRLPVTRSKINW CAPA_YEAST 232 35
DTTFKALRRALPINRTKINW CAPA_DICDI 248 43
FINAL MOTIF SETS
FACTINCAPA1 Length of motif = 15 Motif number = 1
F-Actin capping protein alpha subunit motif I - 2
PCODE ST INT
FQPKNFWNGRWRSEW CAZ1_CHICK 163 163
FQPKNFWNGRWRSEW CAZ1_HUMAN 163 163
FQAKNFWNGRWRSEW CAZ2_CHICK 163 163
FQAKNFWNGRWRSEW CAZ2_HUMAN 163 163
FQAKNFWNGRWRSEW CAZ2_MOUSE 163 163
FQPKNFCNGRWRSEW CAPA_CAEEL 157 157
YNPNNFWNGHWRSSY CAPA_YEAST 153 153
YKPNAFYSGRWRSVW CAPA_DICDI 157 157
YNPKNYWNGSWRCIC CAPA_SCHPO 145 145
LSPQNFCNGSWRSVW O82631 178 178
FACTINCAPA2 Length of motif = 14 Motif number = 2
F-Actin capping protein alpha subunit motif II - 2
PCODE ST INT
QVHYYEDGNVQLVS CAZ1_CHICK 195 17
QVHYYEDGNVQLVS CAZ1_HUMAN 195 17
QVHYYEDGNVQLVS CAZ2_CHICK 195 17
QVHYYEDGNVQLVS CAZ2_HUMAN 195 17
QVHYYEDGNVQLVS CAZ2_MOUSE 195 17
QVHYYEDGNVQLFS CAPA_CAEEL 192 20
QVHYYEDGNVSFQS CAPA_YEAST 183 15
NVHYFEDGNVQLNT CAPA_DICDI 191 19
RVHYYEDGNVWLDA CAPA_SCHPO 175 15
GAHYFEEGNVELDA O82631 212 19
FACTINCAPA3 Length of motif = 20 Motif number = 3
F-Actin capping protein alpha subunit motif III - 2
PCODE ST INT
DTTFKALRRQLPVTRTKIDW CAZ1_CHICK 252 43
DTTFKALRRQLPVTRTKIDW CAZ1_HUMAN 252 43
DTTFKALRRQLPVTRTKIDW CAZ2_CHICK 252 43
DTTFKALRRQLPVTRTKIDW CAZ2_HUMAN 252 43
DTTFKALRRQLPVTRTKIDW CAZ2_MOUSE 252 43
DTTFKALRRQLPVTRAKMDW CAPA_CAEEL 250 44
EKQFKALRRRLPVTRSKINW CAPA_YEAST 232 35
DTTFKALRRALPINRTKINW CAPA_DICDI 248 43
DKKFKELRRQLPVTRQKINW CAPA_SCHPO 226 37
DNTFKDLRRKLPVTRTLFPW O82631 269 43
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