WORKLIST ENTRIES (1):
FACTINCAPB View alignment View Structure F-actin capping protein beta subunit signature
Type of fingerprint: COMPOUND with 5 elements
Links:
PRINTS; PR00191 FACTINCAPA; PR00597 GELSOLIN
INTERPRO; IPR001698
PROSITE; PS00231 F_ACTIN_CAPPING_BETA
PFAM; PF01115 F_actin_cap_B
Creation date 14-JUL-1994; UPDATE 07-JUN-1999
1. MARUYAMA, K., KUROKAWA, H., OOSAWA, M., SHIMAOKA, S. YAMAMOTO, H.,
ITO, M. AND MARUYAMA, K.
Beta-actinin is equivalent to CapZ protein.
J.BIOL.CHEM. 265 8712-8715 (1990).
2. HARTMANN, H., NOEGEL, A.A., ECKERSKORN, C., RAPP, S. AND SCHLEICHER, M.
Ca2+-independent F-actin capping proteins. Cap 32/34, a capping protein
from Dictyolstelium discoideum, does not share sequence homologies with
known actin-binding proteins.
J.BIOL.CHEM. 264 12639-12647 (1989).
The actin filament system, a prominent part of the cytoskeleton in
eukaryotic cells, is both a static structure and a dynamic network that
can undergo rearrangements: it is thought to be involved in processes
such as cell movement and phagocytosis [1], as well as muscle contraction.
Capping proteins bind to the ends of actin filaments, blocking the addition
of actin monomers at this end. The capping protein is a heterodimer of alpha
and beta subunits [2]: it binds to the barbed end of actin filaments, but
unlike gelsolin and severin does not sever the filament [1]. Neither of the
subunits shows sequence similarity to other filament-capping proteins [1].
FACTINCAPB is a 5-element fingerprint that provides a signature for the
F-actin capping protein beta subunit. The fingerprint was derived from
an initial alignment of 3 sequences: the motifs were drawn from conserved
regions spanning virtually the full alignment length, motif 3 including
the region encoded by PROSITE pattern F_ACTIN_CAPPING_BETA (PS00231).
Two iterations on OWL23.2 were required to reach convergence, at which
point a true set comprising 5 sequences was identified.
An update on SPTR37_9f identified a true set of 8 sequences.
SUMMARY INFORMATION
8 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
5| 8 8 8 8 8
4| 0 0 0 0 0
3| 0 0 0 0 0
2| 0 0 0 0 0
--+--------------------------
| 1 2 3 4 5
True positives..
CAPB_CHICK P79136 CAPB_MOUSE CAPB_HUMAN
CAPB_DROME CAPB_CAEEL CAPB_DICDI CAPB_YEAST
PROTEIN TITLES
CAPB_CHICK F-ACTIN CAPPING PROTEIN BETA SUBUNIT ISOFORMS 1 AND 2 (CAPZ
P79136 F-ACTIN CAPPING PROTEIN BETA SUBUNIT ISOFORM 3 (CAPZ) (CP BE
CAPB_MOUSE F-ACTIN CAPPING PROTEIN BETA SUBUNIT ISOFORMS 1 AND 2 (CAPZ)
CAPB_HUMAN F-ACTIN CAPPING PROTEIN BETA SUBUNIT (CAPZ) - HOMO SAPIENS (
CAPB_DROME F-ACTIN CAPPING PROTEIN BETA SUBUNIT - DROSOPHILA MELANOGAST
CAPB_CAEEL F-ACTIN CAPPING PROTEIN BETA SUBUNIT - CAENORHABDITIS ELEGAN
CAPB_DICDI F-ACTIN CAPPING PROTEIN BETA SUBUNIT (CAP32) - DICTYOSTELIUM
CAPB_YEAST F-ACTIN CAPPING PROTEIN BETA SUBUNIT - SACCHAROMYCES CEREVIS
SCAN HISTORY
OWL23_2 2 100 NSINGLE
OWL28_0 1 80 NSINGLE
SPTR37_9f 2 9 NSINGLE
INITIAL MOTIF SETS
FACTINCAPB1 Length of motif = 21 Motif number = 1
F-Actin capping protein beta subunit motif I - 1
PCODE ST INT
QLDCALDLMRRLPPQQIEKNL CAPB_CHICK 5 5
QLSCCLDLMRRLPPSQIEDNL CAPB_DICDI 5 5
QFDAALDLLRRLNPTTLQENL CAPB_YEAST 5 5
FACTINCAPB2 Length of motif = 22 Motif number = 2
F-Actin capping protein beta subunit motif II - 1
PCODE ST INT
SDLIDLVPSLCEDLLSSVDQPL CAPB_CHICK 26 0
AGLLDLVPDLTEDLLSSIDQPL CAPB_DICDI 26 0
NNLIELQPNLAQDLLSSVDVPL CAPB_YEAST 26 0
FACTINCAPB3 Length of motif = 27 Motif number = 3
F-Actin capping protein beta subunit motif III - 1
PCODE ST INT
KDYLLCDYNRDGDSYRSPWSNKYDPPL CAPB_CHICK 57 9
KDYLLCDYNRDADSYRSPWSNKYDPPL CAPB_DICDI 57 9
REYLCCDYNRDIDSFRSPWSNTYYPEL CAPB_YEAST 58 10
FACTINCAPB4 Length of motif = 28 Motif number = 4
F-Actin capping protein beta subunit motif IV - 1
PCODE ST INT
EVEANNAFDQYRDLYFEGGVSSVYLWDL CAPB_CHICK 97 13
EVQANEIFEIYLNLYFEGGVSSVYCWDL CAPB_DICDI 97 13
EILANDSFDVYRDLYYEGGISSVYLWDL CAPB_YEAST 103 18
FACTINCAPB5 Length of motif = 27 Motif number = 5
F-Actin capping protein beta subunit motif V - 1
PCODE ST INT
NIGRLVEDMENKIRSTLNEIYFGKTKD CAPB_CHICK 212 87
NIGKMVEDMESKLRQTLETIYFGKTKE CAPB_DICDI 214 89
NLGSLIEDIESQMRNLLETVYFEKTRD CAPB_YEAST 229 98
FINAL MOTIF SETS
FACTINCAPB1 Length of motif = 21 Motif number = 1
F-Actin capping protein beta subunit motif I - 2
PCODE ST INT
QLDCALDLMRRLPPQQIEKNL CAPB_CHICK 5 5
QLDCALDLMRRLPPQQIEKNL P79136 34 34
QLDCALDLMRRLPPQQIEKNL CAPB_MOUSE 5 5
QLDCALDLMRRLPPQQIEKNL CAPB_HUMAN 5 5
QMDCALDLMRRLPPQQIEKNL CAPB_DROME 5 5
QLDCALDLMRRLPPQHCDKNL CAPB_CAEEL 5 5
QLSCCLDLMRRLPPSQIEDNL CAPB_DICDI 5 5
QFDAALDLLRRLNPTTLQENL CAPB_YEAST 5 5
FACTINCAPB2 Length of motif = 22 Motif number = 2
F-Actin capping protein beta subunit motif II - 2
PCODE ST INT
SDLIDLVPSLCEDLLSSVDQPL CAPB_CHICK 26 0
SDLIDLVPSLCEDLLSSVDQPL P79136 55 0
SDLIDLVPSLCEDLLSSVDQPL CAPB_MOUSE 26 0
SDLIDLVPSLCEDLLSSVDQPL CAPB_HUMAN 26 0
IDLIDLAPDLCEDLLSSVDQPL CAPB_DROME 26 0
TDLIDLCPHLVDDLLSTIDQPL CAPB_CAEEL 26 0
AGLLDLVPDLTEDLLSSIDQPL CAPB_DICDI 26 0
NNLIELQPNLAQDLLSSVDVPL CAPB_YEAST 26 0
FACTINCAPB3 Length of motif = 27 Motif number = 3
F-Actin capping protein beta subunit motif III - 2
PCODE ST INT
KDYLLCDYNRDGDSYRSPWSNKYDPPL CAPB_CHICK 57 9
KDYLLCDYNRDGDSYRSPWSNKYDPPL P79136 86 9
KDYLLCDYNRDGDSYRSPWSNKYDPPL CAPB_MOUSE 57 9
KDYLLCDYNRDGDSYRSPWSNKYDPPL CAPB_HUMAN 57 9
KDYLLCDYNRDGDSYRSPWSNSYYPPL CAPB_DROME 57 9
KQYLLCDYNRDGDSYRSPWSNTYDPPL CAPB_CAEEL 57 9
KDYLLCDYNRDADSYRSPWSNKYDPPL CAPB_DICDI 57 9
REYLCCDYNRDIDSFRSPWSNTYYPEL CAPB_YEAST 58 10
FACTINCAPB4 Length of motif = 28 Motif number = 4
F-Actin capping protein beta subunit motif IV - 2
PCODE ST INT
EVEANNAFDQYRDLYFEGGVSSVYLWDL CAPB_CHICK 97 13
EVEANNAFDQYRDLYFEGGVSSVYLWDL P79136 126 13
EVEANNAFDQYRDLYFEGGVSSVYLWDL CAPB_MOUSE 97 13
EVEANNAFDQYRDLYFEGGVSSVYLWDL CAPB_HUMAN 97 13
EIEANYAFDQYREMYYEGGVSSVYLWDL CAPB_DROME 97 13
EIEANAAFESYRDLYFEGGVSSVYFWDL CAPB_CAEEL 97 13
EVQANEIFEIYLNLYFEGGVSSVYCWDL CAPB_DICDI 97 13
EILANDSFDVYRDLYYEGGISSVYLWDL CAPB_YEAST 103 18
FACTINCAPB5 Length of motif = 27 Motif number = 5
F-Actin capping protein beta subunit motif V - 2
PCODE ST INT
NIGRLVEDMENKIRSTLNEIYFGKTKD CAPB_CHICK 212 87
NIGRLVEDMENKIRSTLNEIYFGKTKD P79136 241 87
NIGRLVEDMENKIRSTLNEIYFGKTKD CAPB_MOUSE 212 87
NIGRLVEDMENKIRSTLNEIYFGKTKD CAPB_HUMAN 212 87
NIGKMVEEMENKIRNTLNEIYFGKTKD CAPB_DROME 212 87
NMGRMIEDQESKMRLTINEIYFGKTKK CAPB_CAEEL 211 86
NIGKMVEDMESKLRQTLETIYFGKTKE CAPB_DICDI 214 89
NLGSLIEDIESQMRNLLETVYFEKTRD CAPB_YEAST 229 98
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