WORKLIST ENTRIES (1):
GABAB2RECPTR View alignment Metabotropic gamma-aminobutyric acid type B2 receptor signature
Type of fingerprint: COMPOUND with 13 elements
Links:
PRINTS; PR00237 GPCRRHODOPSN; PR00247 GPCRCAMP; PR00249 GPCRSECRETIN
PRINTS; PR00250 GPCRSTE2; PR00899 GPCRSTE3; PR00251 BACTRLOPSIN
PRINTS; PR00592 CASENSINGR; PR00593 MTABOTROPICR
PRINTS; PR01176 GABABRECEPTR; PR01177 GABAB1RECPTR
INTERPRO; IPR002457
Creation date 18-SEP-1999
1. KAUPMANN, K., HUGGEL, K., HEID, J., FLOR, P.J., BISCHOFF, S., MICKEL, S.J.,
MCMASTER, G., ANGST, C., BITTIGER, H., FROESTL, W. AND BETTLER, B.
Expression cloning of GABA(B) receptors uncovers similarity to metabotropic
glutamate receptors.
NATURE 386 239-246 (1997).
2. KAUPMANN, K., SCHULER, V., MOSBACHER., J, BISCHOFF, S., BITTIGER, H.,
HEID, J., FROESTL, W., LEONHARD, S., PFAFF, T., KARSCHIN, A. AND BETTLER, B.
Human gamma-aminobutyric acid type B receptors are differentially expressed
and regulate inwardly rectifying K+ channels.
PROC.NATL.ACAD.SCI.U.S.A. 95(25) 14991-14996 (1998),
3. WHITE, J.H., WISE, A., MAIN, M.J., GREEN, A., FRASER, N.J., DISNEY, G.H.,
BARNES, A.A., EMSON, P., FOORD, S.M. AND MARSHALL, F.H.
Heterodimerization is required for the formation of a functional GABA(B)
receptor.
NATURE 396 679-82 (1998).
GABA (gamma-amino-butyric acid) is the principal inhibitory neurotransmitter
in the brain, and signals through ionotropic (GABA(A)/GABA(C)) and
metabotropic (GABA(B)) receptor systems [1]. The GABA(B) receptors have
been cloned, and photoaffinity labelling experiments suggest that they
correspond to two highly conserved receptor forms in the vertebrate nervous
system [1].
GABA(B) receptors are involved in the fine tuning of inhibitory synaptic
transmission [2]. Presynaptic receptors inhibit neurotransmitter release by
down-regulating high-voltage activated Ca2+ channels, while postsynaptic
receptors decrease neuronal excitability by activating a prominent inwardly
rectifying K+ (Kir) conductance that underlies the late inhibitory post-
synaptic potentials [2]. GABA(B) receptors negatively couple to adenylyl
cyclase and show sequence similarity to the metabotropic receptors for the
excitatory neurotransmitter L-glutamate.
A new subtype of the GABA(B) receptor (GABA(B)R2) has been identified by
EST database mining [3]. Yeast two-hybrid screening has shown that the new
subtype forms heterodimers with GABA(B)R1 via an interaction at their
intracellular C-terminal tails [3]. On expression with GABA(B)R2 in HEK293T
cells, GABA(B)R1 is terminally glycosylated and expressed at the cell
surface. Co-expression of the receptors produces a fully functional GABA(B)
receptor at the cell surface; this receptor binds GABA with a high affinity
equivalent to that of the endogenous brain receptor [3]. Such results
indicate that, in vivo, functional brain GABA(B) receptors may be hetero-
dimers of GABA(B)R1 and GABA(B)R2.
GABAB2RECPTR is a 13-element fingerprint that provides a signature for
type 2 GABA(B) receptors. The fingerprint was derived from an initial
alignment of 2 sequences: the motifs were drawn from conserved regions
spanning virtually the full alignment length, focusing on those sections
that characterise the type 2 receptors but distinguish them from the rest
of the GABA(B) receptor family. A single iteration on SPTR37_10f was
required to reach convergence, no further sequences being identified
beyond the starting set.
SUMMARY INFORMATION
2 codes involving 13 elements
0 codes involving 12 elements
0 codes involving 11 elements
0 codes involving 10 elements
0 codes involving 9 elements
0 codes involving 8 elements
0 codes involving 7 elements
0 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
13| 2 2 2 2 2 2 2 2 2 2 2 2 2
12| 0 0 0 0 0 0 0 0 0 0 0 0 0
11| 0 0 0 0 0 0 0 0 0 0 0 0 0
10| 0 0 0 0 0 0 0 0 0 0 0 0 0
9| 0 0 0 0 0 0 0 0 0 0 0 0 0
8| 0 0 0 0 0 0 0 0 0 0 0 0 0
7| 0 0 0 0 0 0 0 0 0 0 0 0 0
6| 0 0 0 0 0 0 0 0 0 0 0 0 0
5| 0 0 0 0 0 0 0 0 0 0 0 0 0
4| 0 0 0 0 0 0 0 0 0 0 0 0 0
3| 0 0 0 0 0 0 0 0 0 0 0 0 0
2| 0 0 0 0 0 0 0 0 0 0 0 0 0
--+------------------------------------------------------------------
| 1 2 3 4 5 6 7 8 9 10 11 12 13
True positives..
O75899 O88871
PROTEIN TITLES
O75899 GABA-B RECEPTOR - HOMO SAPIENS (HUMAN).
O88871 GABA-B RECEPTOR GB2 - RATTUS NORVEGICUS (RAT).
SCAN HISTORY
SPTR37_10f 1 40 NSINGLE
INITIAL MOTIF SETS
GABAB2RECPTR1 Length of motif = 19 Motif number = 1
GABAB2 receptor motif I - 1
PCODE ST INT
LAPGAWGWARGAPRPPPSS O75899 35 35
LAPGAWGWTRGAPRPPPSS O88871 34 34
GABAB2RECPTR2 Length of motif = 17 Motif number = 2
GABAB2 receptor motif II - 1
PCODE ST INT
PLTKEVAKGSIGRGVLP O75899 63 9
PLTKEVAKGSIGRGVLP O88871 62 9
GABAB2RECPTR3 Length of motif = 18 Motif number = 3
GABAB2 receptor motif III - 1
PCODE ST INT
QIRNESLLRPYFLDLRLY O75899 87 7
QIRNESLLRPYFLDLRLY O88871 86 7
GABAB2RECPTR4 Length of motif = 21 Motif number = 4
GABAB2 receptor motif IV - 1
PCODE ST INT
WEQVHTEANSSRCLRKNLLAA O75899 290 185
WEQVHVEANSSRCLRRSLLAA O88871 289 185
GABAB2RECPTR5 Length of motif = 20 Motif number = 5
GABAB2 receptor motif V - 1
PCODE ST INT
YIGVDFEPLSSKQIKTISGK O75899 314 3
YIGVDFEPLSSKQIKTISGK O88871 313 3
GABAB2RECPTR6 Length of motif = 23 Motif number = 6
GABAB2 receptor motif VI - 1
PCODE ST INT
PQQYEREYNNKRSGVGPSKFHGY O75899 335 1
PQQFEREYNSKRSGVGPSKFHGY O88871 334 1
GABAB2RECPTR7 Length of motif = 20 Motif number = 7
GABAB2 receptor motif VII - 1
PCODE ST INT
KTLQRAMETLHASSRHQRIQ O75899 367 9
KTLQRAMETLHASSRHQRIQ O88871 366 9
GABAB2RECPTR8 Length of motif = 20 Motif number = 8
GABAB2 receptor motif VIII - 1
PCODE ST INT
FRNGERMGTIKFTQFQDSRE O75899 417 30
FRNGERMGTIKFTQFQDSRE O88871 416 30
GABAB2RECPTR9 Length of motif = 21 Motif number = 9
GABAB2 receptor motif IX - 1
PCODE ST INT
YNAVADTLEIINDTIRFQGSE O75899 442 5
YNAVADTLEIINDTIRFQGSE O88871 441 5
GABAB2RECPTR10 Length of motif = 20 Motif number = 10
GABAB2 receptor motif X - 1
PCODE ST INT
PDAATQNRRFQFTQNQKKED O75899 751 288
PDAATQNRRFQFTQNQKKED O88871 750 288
GABAB2RECPTR11 Length of motif = 25 Motif number = 11
GABAB2 receptor motif XI - 1
PCODE ST INT
RLEGLQSENHRLRMKITELDKDLEE O75899 787 16
RLEGLQSENHRLRMKITELDKDLEE O88871 786 16
GABAB2RECPTR12 Length of motif = 21 Motif number = 12
GABAB2 receptor motif XII - 1
PCODE ST INT
KAILKNHLDQNPQLQWNTTEP O75899 851 39
KAILKNHLDQNPQLQWNTTEP O88871 850 39
GABAB2RECPTR13 Length of motif = 21 Motif number = 13
GABAB2 receptor motif XIII - 1
PCODE ST INT
DASCVSPCVSPTASPRHRHVP O75899 911 39
DASCVSPCVSPTASPRHRHVP O88871 910 39
FINAL MOTIF SETS
GABAB2RECPTR1 Length of motif = 19 Motif number = 1
GABAB2 receptor motif I - 1
PCODE ST INT
LAPGAWGWARGAPRPPPSS O75899 35 35
LAPGAWGWTRGAPRPPPSS O88871 34 34
GABAB2RECPTR2 Length of motif = 17 Motif number = 2
GABAB2 receptor motif II - 1
PCODE ST INT
PLTKEVAKGSIGRGVLP O75899 63 9
PLTKEVAKGSIGRGVLP O88871 62 9
GABAB2RECPTR3 Length of motif = 18 Motif number = 3
GABAB2 receptor motif III - 1
PCODE ST INT
QIRNESLLRPYFLDLRLY O75899 87 7
QIRNESLLRPYFLDLRLY O88871 86 7
GABAB2RECPTR4 Length of motif = 21 Motif number = 4
GABAB2 receptor motif IV - 1
PCODE ST INT
WEQVHTEANSSRCLRKNLLAA O75899 290 185
WEQVHVEANSSRCLRRSLLAA O88871 289 185
GABAB2RECPTR5 Length of motif = 20 Motif number = 5
GABAB2 receptor motif V - 1
PCODE ST INT
YIGVDFEPLSSKQIKTISGK O75899 314 3
YIGVDFEPLSSKQIKTISGK O88871 313 3
GABAB2RECPTR6 Length of motif = 23 Motif number = 6
GABAB2 receptor motif VI - 1
PCODE ST INT
PQQYEREYNNKRSGVGPSKFHGY O75899 335 1
PQQFEREYNSKRSGVGPSKFHGY O88871 334 1
GABAB2RECPTR7 Length of motif = 20 Motif number = 7
GABAB2 receptor motif VII - 1
PCODE ST INT
KTLQRAMETLHASSRHQRIQ O75899 367 9
KTLQRAMETLHASSRHQRIQ O88871 366 9
GABAB2RECPTR8 Length of motif = 20 Motif number = 8
GABAB2 receptor motif VIII - 1
PCODE ST INT
FRNGERMGTIKFTQFQDSRE O75899 417 30
FRNGERMGTIKFTQFQDSRE O88871 416 30
GABAB2RECPTR9 Length of motif = 21 Motif number = 9
GABAB2 receptor motif IX - 1
PCODE ST INT
YNAVADTLEIINDTIRFQGSE O75899 442 5
YNAVADTLEIINDTIRFQGSE O88871 441 5
GABAB2RECPTR10 Length of motif = 20 Motif number = 10
GABAB2 receptor motif X - 1
PCODE ST INT
PDAATQNRRFQFTQNQKKED O75899 751 288
PDAATQNRRFQFTQNQKKED O88871 750 288
GABAB2RECPTR11 Length of motif = 25 Motif number = 11
GABAB2 receptor motif XI - 1
PCODE ST INT
RLEGLQSENHRLRMKITELDKDLEE O75899 787 16
RLEGLQSENHRLRMKITELDKDLEE O88871 786 16
GABAB2RECPTR12 Length of motif = 21 Motif number = 12
GABAB2 receptor motif XII - 1
PCODE ST INT
KAILKNHLDQNPQLQWNTTEP O75899 851 39
KAILKNHLDQNPQLQWNTTEP O88871 850 39
GABAB2RECPTR13 Length of motif = 21 Motif number = 13
GABAB2 receptor motif XIII - 1
PCODE ST INT
DASCVSPCVSPTASPRHRHVP O75899 911 39
DASCVSPCVSPTASPRHRHVP O88871 910 39
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