WORKLIST ENTRIES (1):

GABAB2RECPTR View alignment     Metabotropic gamma-aminobutyric acid type B2 receptor signature
 Type of fingerprint: COMPOUND with 13 elements
Links:
   PRINTS; PR00237 GPCRRHODOPSN; PR00247 GPCRCAMP; PR00249 GPCRSECRETIN
   PRINTS; PR00250 GPCRSTE2; PR00899 GPCRSTE3; PR00251 BACTRLOPSIN
   PRINTS; PR00592 CASENSINGR; PR00593 MTABOTROPICR
   PRINTS; PR01176 GABABRECEPTR; PR01177 GABAB1RECPTR 
   INTERPRO; IPR002457

 Creation date 18-SEP-1999

   1. KAUPMANN, K., HUGGEL, K., HEID, J., FLOR, P.J., BISCHOFF, S., MICKEL, S.J.,
   MCMASTER, G., ANGST, C., BITTIGER, H., FROESTL, W. AND BETTLER, B.
   Expression cloning of GABA(B) receptors uncovers similarity to metabotropic
   glutamate receptors.
   NATURE 386 239-246 (1997). 

   2. KAUPMANN, K., SCHULER, V., MOSBACHER., J, BISCHOFF, S., BITTIGER, H.,
   HEID, J., FROESTL, W., LEONHARD, S., PFAFF, T., KARSCHIN, A. AND BETTLER, B.
   Human gamma-aminobutyric acid type B receptors are differentially expressed
   and regulate inwardly rectifying K+ channels.
   PROC.NATL.ACAD.SCI.U.S.A. 95(25) 14991-14996 (1998),

   3. WHITE, J.H., WISE, A., MAIN, M.J., GREEN, A., FRASER, N.J., DISNEY, G.H.,
   BARNES, A.A., EMSON, P., FOORD, S.M. AND MARSHALL, F.H.
   Heterodimerization is required for the formation of a functional GABA(B)
   receptor.
   NATURE 396 679-82 (1998).

   GABA (gamma-amino-butyric acid) is the principal inhibitory neurotransmitter
   in the brain, and signals through ionotropic (GABA(A)/GABA(C)) and
   metabotropic (GABA(B)) receptor systems [1]. The GABA(B) receptors have 
   been cloned, and photoaffinity labelling experiments suggest that they
   correspond to two highly conserved receptor forms in the vertebrate nervous
   system [1]. 
  
   GABA(B) receptors are involved in the fine tuning of inhibitory synaptic
   transmission [2]. Presynaptic receptors inhibit neurotransmitter release by
   down-regulating high-voltage activated Ca2+ channels, while postsynaptic 
   receptors decrease neuronal excitability by activating a prominent inwardly
   rectifying K+ (Kir) conductance that underlies the late inhibitory post-
   synaptic potentials [2]. GABA(B) receptors negatively couple to adenylyl
   cyclase and show sequence similarity to the metabotropic receptors for the
   excitatory neurotransmitter L-glutamate. 
   
   A new subtype of the GABA(B) receptor (GABA(B)R2) has been identified by
   EST database mining [3]. Yeast two-hybrid screening has shown that the new
   subtype forms heterodimers with GABA(B)R1 via an interaction at their
   intracellular C-terminal tails [3]. On expression with GABA(B)R2 in HEK293T
   cells, GABA(B)R1 is terminally glycosylated and expressed at the cell 
   surface. Co-expression of the receptors produces a fully functional GABA(B)
   receptor at the cell surface; this receptor binds GABA with a high affinity
   equivalent to that of the endogenous brain receptor [3]. Such results
   indicate that, in vivo, functional brain GABA(B) receptors may be hetero-
   dimers of GABA(B)R1 and GABA(B)R2.
  
   GABAB2RECPTR is a 13-element fingerprint that provides a signature for 
   type 2 GABA(B) receptors. The fingerprint was derived from an initial 
   alignment of 2 sequences: the motifs were drawn from conserved regions 
   spanning virtually the full alignment length, focusing on those sections 
   that characterise the type 2 receptors but distinguish them from the rest
   of the GABA(B) receptor family. A single iteration on SPTR37_10f was 
   required to reach convergence, no further sequences being identified
   beyond the starting set. 

  SUMMARY INFORMATION
      2 codes involving 13 elements
      0 codes involving 12 elements
      0 codes involving 11 elements
      0 codes involving 10 elements
      0 codes involving  9 elements
      0 codes involving  8 elements
      0 codes involving  7 elements
      0 codes involving  6 elements
      0 codes involving  5 elements
      0 codes involving  4 elements
      0 codes involving  3 elements
      0 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
   13|   2    2    2    2    2    2    2    2    2    2    2    2    2  
   12|   0    0    0    0    0    0    0    0    0    0    0    0    0  
   11|   0    0    0    0    0    0    0    0    0    0    0    0    0  
   10|   0    0    0    0    0    0    0    0    0    0    0    0    0  
    9|   0    0    0    0    0    0    0    0    0    0    0    0    0  
    8|   0    0    0    0    0    0    0    0    0    0    0    0    0  
    7|   0    0    0    0    0    0    0    0    0    0    0    0    0  
    6|   0    0    0    0    0    0    0    0    0    0    0    0    0  
    5|   0    0    0    0    0    0    0    0    0    0    0    0    0  
    4|   0    0    0    0    0    0    0    0    0    0    0    0    0  
    3|   0    0    0    0    0    0    0    0    0    0    0    0    0  
    2|   0    0    0    0    0    0    0    0    0    0    0    0    0  
   --+------------------------------------------------------------------
     |   1    2    3    4    5    6    7    8    9   10   11   12   13  

True positives..
 O75899         O88871         


  PROTEIN TITLES
   O75899           GABA-B RECEPTOR - HOMO SAPIENS (HUMAN).
   O88871           GABA-B RECEPTOR GB2 - RATTUS NORVEGICUS (RAT).

SCAN HISTORY SPTR37_10f 1 40 NSINGLE INITIAL MOTIF SETS GABAB2RECPTR1 Length of motif = 19 Motif number = 1 GABAB2 receptor motif I - 1 PCODE ST INT LAPGAWGWARGAPRPPPSS O75899 35 35 LAPGAWGWTRGAPRPPPSS O88871 34 34 GABAB2RECPTR2 Length of motif = 17 Motif number = 2 GABAB2 receptor motif II - 1 PCODE ST INT PLTKEVAKGSIGRGVLP O75899 63 9 PLTKEVAKGSIGRGVLP O88871 62 9 GABAB2RECPTR3 Length of motif = 18 Motif number = 3 GABAB2 receptor motif III - 1 PCODE ST INT QIRNESLLRPYFLDLRLY O75899 87 7 QIRNESLLRPYFLDLRLY O88871 86 7 GABAB2RECPTR4 Length of motif = 21 Motif number = 4 GABAB2 receptor motif IV - 1 PCODE ST INT WEQVHTEANSSRCLRKNLLAA O75899 290 185 WEQVHVEANSSRCLRRSLLAA O88871 289 185 GABAB2RECPTR5 Length of motif = 20 Motif number = 5 GABAB2 receptor motif V - 1 PCODE ST INT YIGVDFEPLSSKQIKTISGK O75899 314 3 YIGVDFEPLSSKQIKTISGK O88871 313 3 GABAB2RECPTR6 Length of motif = 23 Motif number = 6 GABAB2 receptor motif VI - 1 PCODE ST INT PQQYEREYNNKRSGVGPSKFHGY O75899 335 1 PQQFEREYNSKRSGVGPSKFHGY O88871 334 1 GABAB2RECPTR7 Length of motif = 20 Motif number = 7 GABAB2 receptor motif VII - 1 PCODE ST INT KTLQRAMETLHASSRHQRIQ O75899 367 9 KTLQRAMETLHASSRHQRIQ O88871 366 9 GABAB2RECPTR8 Length of motif = 20 Motif number = 8 GABAB2 receptor motif VIII - 1 PCODE ST INT FRNGERMGTIKFTQFQDSRE O75899 417 30 FRNGERMGTIKFTQFQDSRE O88871 416 30 GABAB2RECPTR9 Length of motif = 21 Motif number = 9 GABAB2 receptor motif IX - 1 PCODE ST INT YNAVADTLEIINDTIRFQGSE O75899 442 5 YNAVADTLEIINDTIRFQGSE O88871 441 5 GABAB2RECPTR10 Length of motif = 20 Motif number = 10 GABAB2 receptor motif X - 1 PCODE ST INT PDAATQNRRFQFTQNQKKED O75899 751 288 PDAATQNRRFQFTQNQKKED O88871 750 288 GABAB2RECPTR11 Length of motif = 25 Motif number = 11 GABAB2 receptor motif XI - 1 PCODE ST INT RLEGLQSENHRLRMKITELDKDLEE O75899 787 16 RLEGLQSENHRLRMKITELDKDLEE O88871 786 16 GABAB2RECPTR12 Length of motif = 21 Motif number = 12 GABAB2 receptor motif XII - 1 PCODE ST INT KAILKNHLDQNPQLQWNTTEP O75899 851 39 KAILKNHLDQNPQLQWNTTEP O88871 850 39 GABAB2RECPTR13 Length of motif = 21 Motif number = 13 GABAB2 receptor motif XIII - 1 PCODE ST INT DASCVSPCVSPTASPRHRHVP O75899 911 39 DASCVSPCVSPTASPRHRHVP O88871 910 39 FINAL MOTIF SETS GABAB2RECPTR1 Length of motif = 19 Motif number = 1 GABAB2 receptor motif I - 1 PCODE ST INT LAPGAWGWARGAPRPPPSS O75899 35 35 LAPGAWGWTRGAPRPPPSS O88871 34 34 GABAB2RECPTR2 Length of motif = 17 Motif number = 2 GABAB2 receptor motif II - 1 PCODE ST INT PLTKEVAKGSIGRGVLP O75899 63 9 PLTKEVAKGSIGRGVLP O88871 62 9 GABAB2RECPTR3 Length of motif = 18 Motif number = 3 GABAB2 receptor motif III - 1 PCODE ST INT QIRNESLLRPYFLDLRLY O75899 87 7 QIRNESLLRPYFLDLRLY O88871 86 7 GABAB2RECPTR4 Length of motif = 21 Motif number = 4 GABAB2 receptor motif IV - 1 PCODE ST INT WEQVHTEANSSRCLRKNLLAA O75899 290 185 WEQVHVEANSSRCLRRSLLAA O88871 289 185 GABAB2RECPTR5 Length of motif = 20 Motif number = 5 GABAB2 receptor motif V - 1 PCODE ST INT YIGVDFEPLSSKQIKTISGK O75899 314 3 YIGVDFEPLSSKQIKTISGK O88871 313 3 GABAB2RECPTR6 Length of motif = 23 Motif number = 6 GABAB2 receptor motif VI - 1 PCODE ST INT PQQYEREYNNKRSGVGPSKFHGY O75899 335 1 PQQFEREYNSKRSGVGPSKFHGY O88871 334 1 GABAB2RECPTR7 Length of motif = 20 Motif number = 7 GABAB2 receptor motif VII - 1 PCODE ST INT KTLQRAMETLHASSRHQRIQ O75899 367 9 KTLQRAMETLHASSRHQRIQ O88871 366 9 GABAB2RECPTR8 Length of motif = 20 Motif number = 8 GABAB2 receptor motif VIII - 1 PCODE ST INT FRNGERMGTIKFTQFQDSRE O75899 417 30 FRNGERMGTIKFTQFQDSRE O88871 416 30 GABAB2RECPTR9 Length of motif = 21 Motif number = 9 GABAB2 receptor motif IX - 1 PCODE ST INT YNAVADTLEIINDTIRFQGSE O75899 442 5 YNAVADTLEIINDTIRFQGSE O88871 441 5 GABAB2RECPTR10 Length of motif = 20 Motif number = 10 GABAB2 receptor motif X - 1 PCODE ST INT PDAATQNRRFQFTQNQKKED O75899 751 288 PDAATQNRRFQFTQNQKKED O88871 750 288 GABAB2RECPTR11 Length of motif = 25 Motif number = 11 GABAB2 receptor motif XI - 1 PCODE ST INT RLEGLQSENHRLRMKITELDKDLEE O75899 787 16 RLEGLQSENHRLRMKITELDKDLEE O88871 786 16 GABAB2RECPTR12 Length of motif = 21 Motif number = 12 GABAB2 receptor motif XII - 1 PCODE ST INT KAILKNHLDQNPQLQWNTTEP O75899 851 39 KAILKNHLDQNPQLQWNTTEP O88871 850 39 GABAB2RECPTR13 Length of motif = 21 Motif number = 13 GABAB2 receptor motif XIII - 1 PCODE ST INT DASCVSPCVSPTASPRHRHVP O75899 911 39 DASCVSPCVSPTASPRHRHVP O88871 910 39

User query: Display/Full Code "GABAB2RECPTR"