WORKLIST ENTRIES (1):
GPCRSECRETIN View alignment Secretin-like GPCR superfamily signature
Type of fingerprint: COMPOUND with 7 elements
Links:
PRINTS; PR00237 GPCRRHODOPSN; PR00247 GPCRCAMP; PR00248 GPCRMGR
PRINTS; PR00250 GPCRSTE2; PR00899 GPCRSTE3; PR00251 BACTRLOPSIN
PRINTS; PR01694 BAIPRECURSOR; PR01350 CTRFAMILY; PR01278 CD97PROTEIN
PRINTS; PR01279 CRFRECEPTOR; PR01127 DIUHORMONER; PR01128 EMR1HORMONER
PRINTS; PR01352 GHRHRECEPTOR; PR01129 GIPRECEPTOR; PR01353 GLUCAGNFAMLY
PRINTS; PR01695 IGHEPTARCPTR; PR01444 LATROPHILIN; PR00393 PTRHORMONER
PRINTS; PR00490 SECRETINR; PR00491 VASOACTVEIPR; PR01422 GPR56ORPHANR
INTERPRO; IPR000832
PROSITE; PS00649 G_PROTEIN_RECEP_F2_1; PS00650 G_PROTEIN_RECEP_F2_2
PFAM; PF00002 7tm_2
Creation date 27-JUL-1992; UPDATE 19-JUN-1999
1. ATTWOOD, T.K. AND FINDLAY, J.B.C.
Fingerprinting G protein-coupled receptors.
PROTEIN ENG. 7(2) 195-203 (1994).
2. ISHIHARA T., NAKAMURA S., KAZIRO, Y., TAKAHASHI, T., TAKAHASHI, K.
AND NAGATA, S.
Molecular cloning and expression of a cDNA encoding the secretin receptor
EMBO J. 10 1635-1641 (1991).
3. LIN, H.Y., HARRIS, T.L., FLANNERY, M.S., ARUFFO, A., KAJI, E.H.,
GORN, A., KOLAKOWSKI, L.F., LODISH, H.F. AND GOLDRING, S.R.
Expression cloning of adenylate cyclase-coupled calcitonin receptor
SCIENCE 254 1022-1024 (1991).
4. JUEPPNER, H., ABOU-SAMRA, A.-B., FREEMAN, M., KONG, X.F.,
SCHIPANI, E., RICHARDS, J., KOLALOWSKI, L.F., HOCK, J., POTTS, J.T.,
KRONENBERG, H.M. AND SEGRE, G.E.
A G protein linked receptor for parathyroid hormone and parathyroid
hormone-related peptide.
SCIENCE 254 1024-1026 (1991).
5. ISHIHARA, T., SHIGEMOTO, R., MORI, K., TAKAHASHI, K. AND NAGATA, S.
Functional expression and tissue distribution of a novel receptor for
vasoactive intestinal polypeptide.
NEURON 8(4) 811-819 (1992).
G protein-coupled receptors (GPCRs) constitute a vast protein family that
encompasses a wide range of functions (including various autocrine, para-
crine and endocrine processes). They show considerable diversity at the
sequence level, on the basis of which they can be separated into distinct
groups. We use the term clan to describe the GPCRs, as they embrace a group
of families for which there are indications of evolutionary relationship,
but between which there is no statistically significant similarity in
sequence [1]. The currently known clan members include the rhodopsin-like
GPCRs, the secretin-like GPCRs, the cAMP receptors, the fungal mating
pheromone receptors, and the metabotropic glutamate receptor family.
The secretin-like GPCRs include secretin [2], calcitonin [3], parathyroid
hormone/parathyroid hormone-related peptides [4] and vasoactive intestinal
peptide [5], all of which activate adenylyl cyclase and the phosphatidyl-
inositol-calcium pathway. The amino acid sequences of the receptors contain
high proportions of hydrophobic residues grouped into 7 domains, in a
manner reminiscent of the rhodopsins and other receptors believed to inter-
act with G proteins. However, while a similar 3D framework has been
proposed to account for this, there is no significant sequence similarity
between these families: the secretin-like receptors thus bear their own
unique '7TM' signature.
GPCRSECRETIN is a 7-element fingerprint that provides a signature for the
secretin-like GPCR superfamily. The fingerprint was derived from an initial
alignment of 4 sequences: the motifs encode the 7 hydrophobic, membrane-
spanning regions (cf. PROSITE pattern PS00650 G_PROTEIN_RECEP_F2_2). A
single iteration on OWL17.0 was required to reach convergence, no further
sequences being identified beyond the starting set.
An update on SPTR37_9f identified a true set of 59 sequences, and 15
partial matches.
SUMMARY INFORMATION
59 codes involving 7 elements
0 codes involving 6 elements
1 codes involving 5 elements
2 codes involving 4 elements
1 codes involving 3 elements
11 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
7| 59 59 59 59 59 59 59
6| 0 0 0 0 0 0 0
5| 1 0 1 1 1 0 1
4| 0 1 2 2 2 1 0
3| 1 0 1 0 1 0 0
2| 8 0 10 3 0 0 1
--+------------------------------------
| 1 2 3 4 5 6 7
True positives..
VIPR_RAT SCRC_RAT SCRC_HUMAN PACR_RAT
PACR_MOUSE PACR_HUMAN O73769 PACR_BOVIN
SCRC_RABIT VIPR_HUMAN VIPR_PIG VIPS_HUMAN
PTRR_HUMAN PTRR_DIDMA PTRR_PIG VIPR_CARAU
VIPS_MOUSE VIPS_RAT PTRR_MOUSE PTRR_RAT
O73768 GIPR_RAT GIPR_HUMAN GIPR_MESAU
GLR_RAT GLPR_RAT GLR_MOUSE GLPR_MOUSE
GLR_HUMAN GLPR_HUMAN CRFR_MOUSE CRFR_SHEEP
CRFR_HUMAN CRFR_RAT CRFR_XENLA CRF2_RAT
PTR2_HUMAN GRFR_PIG Q99431 O43461
CRF2_HUMAN GRFR_HUMAN PTH2_RAT GRFR_RAT
CRF2_MOUSE GRFR_MOUSE CRFR_CHICK CRF2_XENLA
CALR_CAVPO CALR_HUMAN CALR_RABIT CALR_RAT
CALR_MOUSE CALR_PIG DIHR_MANSE CGRR_HUMAN
CGRR_RAT DIHR_ACHDO Q93245
Subfamily: Codes involving 5 elements
Subfamily True positives..
YQ44_CAEEL
Subfamily: Codes involving 4 elements
Subfamily True positives..
Q98955 YOW3_CAEEL
Subfamily: Codes involving 3 elements
Subfamily True positives..
EMR1_HUMAN
Subfamily: Codes involving 2 elements
Subfamily True positives..
Q10922 EMR1_MOUSE O88929 O88928
O88927 O88926 O88925 O88924
CD97_HUMAN O00718
PROTEIN TITLES
VIPR_RAT VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 1 PRECURSOR (VIP-
SCRC_RAT SECRETIN RECEPTOR PRECURSOR (SCT-R) - RATTUS NORVEGICUS (RAT
SCRC_HUMAN SECRETIN RECEPTOR PRECURSOR (SCT-R) - HOMO SAPIENS (HUMAN).
PACR_RAT PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE TYPE IA R
PACR_MOUSE PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE TYPE I RE
PACR_HUMAN PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE TYPE I RE
O73769 PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE TYPE 1 RE
PACR_BOVIN PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE TYPE I RE
SCRC_RABIT SECRETIN RECEPTOR PRECURSOR (SCT-R) - ORYCTOLAGUS CUNICULUS
VIPR_HUMAN VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 1 PRECURSOR (VIP-
VIPR_PIG VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 1 PRECURSOR (VIP-
VIPS_HUMAN VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2 PRECURSOR (VIP-
PTRR_HUMAN PARATHYROID HORMONE/PARATHYROID HORMONE-RELATED PEPTIDE RECE
PTRR_DIDMA PARATHYROID HORMONE/PARATHYROID HORMONE-RELATED PEPTIDE RECE
PTRR_PIG PARATHYROID HORMONE/PARATHYROID HORMONE-RELATED PEPTIDE RECE
VIPR_CARAU VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR (VIP-R) (VIP RECE
VIPS_MOUSE VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2 PRECURSOR (VIP-
VIPS_RAT VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2 PRECURSOR (VIP-
PTRR_MOUSE PARATHYROID HORMONE/PARATHYROID HORMONE-RELATED PEPTIDE RECE
PTRR_RAT PARATHYROID HORMONE/PARATHYROID HORMONE-RELATED PEPTIDE RECE
O73768 GROWTH-HORMONE RELEASING HORMONE-LIKE PEPTIDE RECEPTOR - CAR
GIPR_RAT GASTRIC INHIBITORY POLYPEPTIDE RECEPTOR PRECURSOR (GIP-R) (G
GIPR_HUMAN GASTRIC INHIBITORY POLYPEPTIDE RECEPTOR PRECURSOR (GIP-R) (G
GIPR_MESAU GASTRIC INHIBITORY POLYPEPTIDE RECEPTOR PRECURSOR (GIP-R) (G
GLR_RAT GLUCAGON RECEPTOR PRECURSOR (GL-R) - RATTUS NORVEGICUS (RAT)
GLPR_RAT GLUCAGON-LIKE PEPTIDE 1 RECEPTOR PRECURSOR (GLP-1 RECEPTOR)
GLR_MOUSE GLUCAGON RECEPTOR PRECURSOR (GL-R) - MUS MUSCULUS (MOUSE).
GLPR_MOUSE GLUCAGON-LIKE PEPTIDE 1 RECEPTOR PRECURSOR (GLP-1 RECEPTOR)
GLR_HUMAN GLUCAGON RECEPTOR PRECURSOR (GL-R) - HOMO SAPIENS (HUMAN).
GLPR_HUMAN GLUCAGON-LIKE PEPTIDE 1 RECEPTOR PRECURSOR (GLP-1 RECEPTOR)
CRFR_MOUSE CORTICOTROPIN RELEASING FACTOR RECEPTOR 1 PRECURSOR (CRF-R)
CRFR_SHEEP CORTICOTROPIN RELEASING FACTOR RECEPTOR 1 PRECURSOR (CRF-R)
CRFR_HUMAN CORTICOTROPIN RELEASING FACTOR RECEPTOR 1 PRECURSOR (CRF-R)
CRFR_RAT CORTICOTROPIN RELEASING FACTOR RECEPTOR 1 PRECURSOR (CRF-R)
CRFR_XENLA CORTICOTROPIN RELEASING FACTOR RECEPTOR 1 PRECURSOR (CRF-R)
CRF2_RAT CORTICOTROPIN RELEASING FACTOR RECEPTOR 2 PRECURSOR (CRF-R)
PTR2_HUMAN PARATHYROID HORMONE RECEPTOR PRECURSOR (PTH2 RECEPTOR) - HOM
GRFR_PIG GROWTH HORMONE-RELEASING HORMONE RECEPTOR PRECURSOR (GHRH RE
Q99431 CORTICOTROPIN RELEASING HORMONE RECEPTOR TYPE 2 BETA ISOFORM
O43461 CORTICOTROPIN RELEASING HORMONE RECEPTOR TYPE 2 GAMMA ISOFOR
CRF2_HUMAN CORTICOTROPIN RELEASING FACTOR RECEPTOR 2 PRECURSOR (CRF-R)
GRFR_HUMAN GROWTH HORMONE-RELEASING HORMONE RECEPTOR PRECURSOR (GHRH RE
PTH2_RAT PARATHYROID HORMONE RECEPTOR PRECURSOR (PTH2 RECEPTOR) - RAT
GRFR_RAT GROWTH HORMONE-RELEASING HORMONE RECEPTOR PRECURSOR (GHRH RE
CRF2_MOUSE CORTICOTROPIN RELEASING FACTOR RECEPTOR 2 PRECURSOR (CRF-R)
GRFR_MOUSE GROWTH HORMONE-RELEASING HORMONE RECEPTOR PRECURSOR (GHRH RE
CRFR_CHICK CORTICOTROPIN RELEASING FACTOR RECEPTOR 1 PRECURSOR (CRF-R)
CRF2_XENLA CORTICOTROPIN RELEASING FACTOR RECEPTOR 2 PRECURSOR (CRF-R)
CALR_CAVPO CALCITONIN RECEPTOR PRECURSOR (CT-R) - CAVIA PORCELLUS (GUIN
CALR_HUMAN CALCITONIN RECEPTOR PRECURSOR (CT-R) - HOMO SAPIENS (HUMAN).
CALR_RABIT CALCITONIN RECEPTOR PRECURSOR (CT-R) - ORYCTOLAGUS CUNICULUS
CALR_RAT CALCITONIN RECEPTOR PRECURSOR (CT-R) (C1A/C1B) - RATTUS NORV
CALR_MOUSE CALCITONIN RECEPTOR PRECURSOR (CT-R) - MUS MUSCULUS (MOUSE).
CALR_PIG CALCITONIN RECEPTOR PRECURSOR (CT-R) - SUS SCROFA (PIG).
DIHR_MANSE DIURETIC HORMONE RECEPTOR (DH-R) - MANDUCA SEXTA (TOBACCO HA
CGRR_HUMAN CALCITONIN GENE-RELATED PEPTIDE TYPE 1 RECEPTOR PRECURSOR (C
CGRR_RAT CALCITONIN GENE-RELATED PEPTIDE TYPE 1 RECEPTOR PRECURSOR (C
DIHR_ACHDO DIURETIC HORMONE RECEPTOR PRECURSOR (DH-R) - ACHETA DOMESTIC
Q93245 C18B12B.1.
YQ44_CAEEL PROBABLE G PROTEIN-COUPLED RECEPTOR C13B9.4 IN CHROMOSOME II
Q98955 GLUCAGON RECEPTOR - MELEAGRIS GALLOPAVO (COMMON TURKEY).
YOW3_CAEEL PROBABLE G PROTEIN-COUPLED RECEPTOR ZK643.3 - CAENORHABDITIS
EMR1_HUMAN CELL SURFACE GLYCOPROTEIN EMR1 PRECURSOR (EMR1 HORMONE RECEP
Q10922 HYPOTHETICAL 174.3 KD PROTEIN B0286.2 IN CHROMOSOME II - CAE
EMR1_MOUSE CELL SURFACE GLYCOPROTEIN EMR1 PRECURSOR (EMR1 HORMONE RECEP
O88929 CL3BC - RATTUS NORVEGICUS (RAT).
O88928 CL3BB - RATTUS NORVEGICUS (RAT).
O88927 CL3BA - RATTUS NORVEGICUS (RAT).
O88926 CL3AC - RATTUS NORVEGICUS (RAT).
O88925 CL3AB - RATTUS NORVEGICUS (RAT).
O88924 CL3AA - RATTUS NORVEGICUS (RAT).
CD97_HUMAN LEUCOCYTE ANTIGEN CD97 PRECURSOR - HOMO SAPIENS (HUMAN).
O00718 CD97 - HOMO SAPIENS (HUMAN).
SCAN HISTORY
OWL17_0 1 50 NSINGLE
OWL18_0 1 50 NSINGLE
OWL19_1 1 50 NSINGLE
OWL20_1 1 50 NSINGLE
OWL21_1 1 100 NSINGLE
OWL23_2 2 100 NSINGLE
OWL28_0 1 200 NSINGLE
SPTR37_9f 3 80 NSINGLE
INITIAL MOTIF SETS
GPCRSECRETIN1 Length of motif = 25 Motif number = 1
Secretin motif I - 1
PCODE ST INT
MIYTVGYSMSLASLTVAVLILAYFR PTRR_RAT 189 189
MIYTVGYSISLGSLTVAVLILGYFR PTRR_DIDMA 186 186
VMYTVGYSSSLAMLLVALSILCSFR SCRC_RAT 144 144
YLAIVGHSLSIFTLVISLGIFVFFR CALR_HUMAN 150 150
GPCRSECRETIN2 Length of motif = 25 Motif number = 2
Secretin motif II - 1
PCODE ST INT
YIHMHMFLSFMLRAASIFVKDAVLY PTRR_RAT 221 7
YIHMHLFVSFMLRAVSIFIKDAVLY PTRR_DIDMA 218 7
YIHMHLFVSFILRALSNFIKDAVLF SCRC_RAT 176 7
TLHKNMFLTYILNSMIIIIHLVEVV CALR_HUMAN 198 23
GPCRSECRETIN3 Length of motif = 24 Motif number = 3
Secretin motif III - 1
PCODE ST INT
VAVTFFLYFLATNYYWILVEGLYL PTRR_RAT 283 37
VAVTVFLYFLTTNYYWILVEGLYL PTRR_DIDMA 277 34
LVMIFFQYCIMANYAWLLVEGLYL SCRC_RAT 217 16
ILHFFHQYMMACNYFWMLCEGIYL CALR_HUMAN 237 14
GPCRSECRETIN4 Length of motif = 26 Motif number = 4
Secretin motif IV - 1
PCODE ST INT
LWGFTIFGWGLPAVFVAVWVGVRATL PTRR_RAT 321 14
LWGFTLFGWGLPAVFVAVWVTVRATL PTRR_DIDMA 315 14
LQAFVLLGWGSPAIFVALWAITRHFL SCRC_RAT 255 14
LRWYYLLGWGFPLVPTTIHAITRAVY CALR_HUMAN 275 14
GPCRSECRETIN5 Length of motif = 26 Motif number = 5
Secretin motif V - 1
PCODE ST INT
WIIQVPILASVVLNFILFINIIRVLA PTRR_RAT 361 14
WIIQVPILAAIVVNFILFINIIRVLA PTRR_DIDMA 355 14
WVIRGPVILSILINFIFFINILRILM SCRC_RAT 296 15
YIIHGPVMAALVVNFFFLLNIVRVLV CALR_HUMAN 315 14
GPCRSECRETIN6 Length of motif = 21 Motif number = 6
Secretin motif VI - 1
PCODE ST INT
LLRSTLVLVPLFGVHYTVFMA PTRR_RAT 406 19
LLKSTLVLMPLFGVHYIVFMA PTRR_DIDMA 400 19
LAKSTLLLIPLFGIHYIVFAF SCRC_RAT 340 18
AVKATMILVPLLGIQFVVFPW CALR_HUMAN 357 16
GPCRSECRETIN7 Length of motif = 22 Motif number = 7
Secretin motif VII - 1
PCODE ST INT
MHYEMLFNSFQGFFVAIIYCFC PTRR_RAT 441 14
MHYEMLFNSFQGFFVAIIYCFC PTRR_DIDMA 435 14
LFFELALGSFQGLVVAVLYCFL SCRC_RAT 370 9
DYVMHSLIHFQGFFVATIYCFC CALR_HUMAN 389 11
FINAL MOTIF SETS
GPCRSECRETIN1 Length of motif = 25 Motif number = 1
Secretin motif I - 3
PCODE ST INT
TGYTIGYSLSLASLLVAMAILSLFR VIPR_RAT 145 145
VMYTVGYSSSLAMLLVALSILCSFR SCRC_RAT 144 144
VMYTVGYSSSLVMLLVALGILCAFR SCRC_HUMAN 144 144
ALYTVGYSTSLATLTTAMVILCRFR PACR_RAT 154 154
ALYTVGYSTSLVTLTTAMVILCRFR PACR_MOUSE 155 155
ALYTVGYSTSLVTLTTAMVILCRFR PACR_HUMAN 155 155
ALYTVGYSTSLVSLTTAMVILCRFR O73769 147 147
ALYTVGYSTSLVTLTTAMVILCRFR PACR_BOVIN 172 172
VMYTVGYSSSLVMLLVALGILCAFR SCRC_RABIT 140 140
TGYTIGYGLSLATLLVATAILSLFR VIPR_HUMAN 144 144
TGYTIGYSLSLAALLVATAILSLFR VIPR_PIG 145 145
AIYTLGYSVSLMSLATGSIILCLFR VIPS_HUMAN 128 128
MIYTVGYSVSLASLTVAVLILAYFR PTRR_HUMAN 189 189
MIYTVGYSISLGSLTVAVLILGYFR PTRR_DIDMA 186 186
MIYTVGYSVSLASLTVAVLILAYFR PTRR_PIG 185 185
IGYTIGHSVSLISLTTAIVILCMSR VIPR_CARAU 105 105
AIYTLGYSVSLMSLTTGSIIICLFR VIPS_MOUSE 127 127
AIYTLGYSVSLMSLTTGSIIICLFR VIPS_RAT 127 127
MIYTVGYSMSLASLTVAVLILAYFR PTRR_MOUSE 189 189
MIYTVGYSMSLASLTVAVLILAYFR PTRR_RAT 189 189
QLYTAGYATSLISLITAVIIFTCFR O73768 138 138
VVYTVGYSLSLATLLLALLILSLFR GIPR_RAT 136 136
VMYTVGYSLSLATLLLALLILSLFR GIPR_HUMAN 139 139
VVYTVGYSLSLGTLLLALLILSLFR GIPR_MESAU 136 136
VMYTVGYSLSLGALLLALVILLGLR GLR_RAT 144 144
IIYTVGYALSFSALVIASAILVSFR GLPR_RAT 146 146
VMYTVGYSLSLGALLLALVILLGLR GLR_MOUSE 144 144
IIYTVGYALSFSALVIASAILVGFR GLPR_MOUSE 146 146
VMYTVGYSLSLGALLLALAILGGLS GLR_HUMAN 143 143
IIYTVGYALSFSALVIASAILLGFR GLPR_HUMAN 146 146
IINYLGHCISLVALLVAFVLFLRLR CRFR_MOUSE 121 121
IINYLGHCISLAALLVAFVLFLRLR CRFR_SHEEP 121 121
IINYLGHCISLVALLVAFVLFLRLR CRFR_HUMAN 121 121
IINYLGHCISLVALLVAFVLFLRLR CRFR_RAT 121 121
VINFLGHSISLCALLVAFILFLRLR CRFR_XENLA 121 121
IINYLGHCVSVVALVAAFLLFLVLR CRF2_RAT 118 118
VMYTVGYSISFGSLAVAILIIGYFR PTR2_HUMAN 146 146
IVYTTGHSVSAVALFVAIAILVALR GRFR_PIG 131 131
VVNYLGHCVSVAALVAAFLLFLALR Q99431 145 145
VVNYLGHCVSVAALVAAFLLFLALR O43461 104 104
VVNYLGHCVSVAALVAAFLLFLALR CRF2_HUMAN 118 118
IIYTVGHSISIVALFVAITILVALR GRFR_HUMAN 131 131
ILYTVGYSISFGSLAVAILIIGYFR PTH2_RAT 144 144
IIYTTGHSISIVALCVAIAILVALR GRFR_RAT 131 131
IVNYLGHCVSVVALVAAFLLFLVLR CRF2_MOUSE 138 138
IIYTTGHSISIVALCVAIAILVALR GRFR_MOUSE 131 131
IINYLGHCVSLGTLLVAFVLFMRLR CRFR_CHICK 126 126
IINYLGHCISILALVIAFLLFLCLR CRF2_XENLA 120 120
YLAIVGHSMSIITLVVSLGIFVYFR CALR_CAVPO 150 150
YLAIVGHSLSIFTLVISLGIFVFFR CALR_HUMAN 150 150
YLAIVGHSLSIFTLVISLGIFKCFR CALR_RABIT 150 150
YLALVGHSMSIAALIASMGIFLFFK CALR_RAT 150 150
YLALVGHSLSIAALVASMLIFWIFK CALR_MOUSE 150 150
YLAIVGHSLSILTLLISLGIFMFLR CALR_PIG 151 151
LIYLAGYSLSLAVLSLAVFVFLYFK DIHR_MANSE 88 88
YLTIIGHGLSIASLLISLGIFFYFK CGRR_HUMAN 143 143
YLTIIGHGLSIASLIISLIIFFYFK CGRR_RAT 143 143
FVFFVGFCLSLVAIAVAIWIFLYFK DIHR_ACHDO 135 135
SVSLTLSFVSVILLVAAIVLFSIFD Q93245 40 40
GPCRSECRETIN2 Length of motif = 25 Motif number = 2
Secretin motif II - 3
PCODE ST INT
YIHMHLFMSFILRATAVFIKDMALF VIPR_RAT 177 7
YIHMHLFVSFILRALSNFIKDAVLF SCRC_RAT 176 7
YIHMHLFVSFILRALSNFIKDAVLF SCRC_HUMAN 176 7
FIHMNLFVSFMLRAISVFIKDWILY PACR_RAT 186 7
FIHMNLFVSFMLRAISVFIKDWILY PACR_MOUSE 187 7
FIHMNLFVSFMLRAISVFIKDWILY PACR_HUMAN 187 7
FIHMNLFVSFMLRAISVFIKDGVLY O73769 179 7
FIHMNLFVSFMLRAISVFIKDWILY PACR_BOVIN 204 7
YIHMHLFLSFILRALSNFIKDAVLF SCRC_RABIT 172 7
YIHMHLFISFILRAAAVFIKDLALF VIPR_HUMAN 176 7
YIHMHLFISFILRATAVFIKDLALF VIPR_PIG 177 7
YIHLNLFLSFILRAISVLVKDDVLY VIPS_HUMAN 160 7
YIHMHLFLSFMLRAVSIFVKDAVLY PTRR_HUMAN 221 7
YIHMHLFVSFMLRAVSIFIKDAVLY PTRR_DIDMA 218 7
YIHMHLFLSFMLRAVSIFVKDAVLY PTRR_PIG 217 7
YIHMHLFVSFILKAIAVFVKDAVLY VIPR_CARAU 137 7
YIHLNLFLSFMLRAISVLVKDSVLY VIPS_MOUSE 159 7
YIHLNLFLSFMLRAISVLVKDSVLY VIPS_RAT 159 7
YIHMHMFLSFMLRAASIFVKDAVLY PTRR_MOUSE 221 7
YIHMHMFLSFMLRAASIFVKDAVLY PTRR_RAT 221 7
YIHINLFVSFILRATAVFIKDAVLF O73768 170 7
YIHMNLFTSFMLRAGAILTRDQLLP GIPR_RAT 168 7
YIHINLFTSFMLRAAAILSRDRLLP GIPR_HUMAN 171 7
YIHMNVFLSFMLRAVAILTRDRLLP GIPR_MESAU 168 7
YIHGNLFASFVLKAGSVLVIDWLLK GLR_RAT 176 7
YIHLNLFASFILRALSVFIKDAALK GLPR_RAT 178 7
YIHGNLFASFVLKAGSVLVIDWLLK GLR_MOUSE 176 7
YIHLNLFASFILRALSVFIKDAALK GLPR_MOUSE 178 7
AIHANLFASFVLKASSVLVIDGLLR GLR_HUMAN 175 7
YIHLNLFASFILRALSVFIKDAALK GLPR_HUMAN 178 7
IIHWNLISAFILRNATWFVVQLTVS CRFR_MOUSE 153 7
IIHWNLISAFILRNATWFVVQLTMS CRFR_SHEEP 153 7
IIHWNLISAFILRNATWFVVQLTMS CRFR_HUMAN 182 36
IIHWNLISAFILRNATWFVVQLTVS CRFR_RAT 153 7
IIHWNLITAFILRNVTWFVMQLTLS CRFR_XENLA 153 7
VIHWNLITTFILRNITWFLLQLIDH CRF2_RAT 150 7
YIHMHLFVSFMLRATSIFVKDRVVH PTR2_HUMAN 178 7
YIHSQLFATFILKAGAVFLKDAALF GRFR_PIG 163 7
VIHWNLITTFILRNVMWFLLQLVDH Q99431 177 7
VIHWNLITTFILRNVMWFLLQLVDH O43461 136 7
VIHWNLITTFILRNVMWFLLQLVDH CRF2_HUMAN 150 7
YVHTQLFTTFILKAGAVFLKDAALF GRFR_HUMAN 163 7
YIHLHLFVSFMLRAXSIFVKDRVAQ PTH2_RAT 176 7
YIHTQLFATFILKASAVFLKDAAVF GRFR_RAT 163 7
VIHWNLITTFILRNIAWFLLQLIDH CRF2_MOUSE 170 7
YIHTQLFATFILKASAVFLKDAAIF GRFR_MOUSE 163 7
IIHWNLITAFILRNATWFVVQLTMN CRFR_CHICK 158 7
IIHWNLITTFILRNIMWFLLQMIDH CRF2_XENLA 152 7
TLHKNMFLTYILNSMIIIIHLVEVV CALR_CAVPO 182 7
TLHKNMFLTYILNSMIIIIHLVEVV CALR_HUMAN 198 23
TLHKNMFLTYILNSMIIIIHLVEVV CALR_RABIT 182 7
TLHKNMFLTYILNSIIIIIHLVEVV CALR_RAT 182 7
TLHKHMFLTYILNSIIIIIHLVEVV CALR_MOUSE 182 7
TLHKNMFLTYVLNSIIIIVHLVVIV CALR_PIG 199 23
TIHTNLMSTYILSACSWILNLVLQN DIHR_MANSE 120 7
TLHKNLFFSFVCNSVVTIIHLTAVA CGRR_HUMAN 175 7
TLHKNLFFSFVCNSIVTIIHLTAVA CGRR_RAT 175 7
TIHTNLMATYICNDATWIISAVVQE DIHR_ACHDO 167 7
SIHKNLATAFVFRFAVLAIWTIVQT Q93245 91 26
GPCRSECRETIN3 Length of motif = 24 Motif number = 3
Secretin motif III - 3
PCODE ST INT
AAVVFFQYCVMANFFWLLVEGLYL VIPR_RAT 218 16
LVMIFFQYCIMANYAWLLVEGLYL SCRC_RAT 217 16
LVMVLFQYCIMANYSWLLVEGLYL SCRC_HUMAN 217 16
AVMVFFHYCVVSNYFWLFIEGLYL PACR_RAT 227 16
AVMVFFHYCVVSNYFWLFIEGLYL PACR_MOUSE 228 16
AVMVFFHYCVVSNYFWLFIEGLYL PACR_HUMAN 228 16
AVMVFFHYCVMSNYFWLFIEGLYL O73769 220 16
AVMVFFHYCVVSNYFWLFIEGLYL PACR_BOVIN 245 16
LVMVFFQYCIMANYAWLLVEGLYL SCRC_RABIT 213 16
AAMVFFQYCVMANFFWLLVEGLYL VIPR_HUMAN 217 16
AAVVLFQYCVMANFFWLLVEGLYL VIPR_PIG 218 16
LSLVFLQYCIMANFFWLLVEGLYL VIPS_HUMAN 204 19
VAVTFFLYFLATNYYWILVEGLYL PTRR_HUMAN 283 37
VAVTVFLYFLTTNYYWILVEGLYL PTRR_DIDMA 277 34
VAVTFFLYFLATNYYWILVEGLYL PTRR_PIG 278 36
AVIVFFQYCIMASFFWLLVEGLYL VIPR_CARAU 179 17
LSLVFFQYCIMANFYWLLVEGLYL VIPS_MOUSE 203 19
LSLVFFQYCIMANFYWLLVEGLYL VIPS_RAT 203 19
VAVTFFLYFLATNYYWILVEGLYL PTRR_MOUSE 283 37
VAVTFFLYFLATNYYWILVEGLYL PTRR_RAT 283 37
TAVTFFQFCILTNYFWLLVEGLYL O73768 211 16
TAQILTQYCVGANYTWLLVEGVYL GIPR_RAT 215 22
TAQIVTQYCVGANYTWLLVEGVYL GIPR_HUMAN 218 22
TAQIVTQYCVGANYTWLLVEGVYL GIPR_MESAU 215 22
VATVIMQYGIIANYCWLLVEGVYL GLR_RAT 227 26
LVFLLMQYCVAANYYWLLVEGVYL GLPR_RAT 228 25
VATVIMQYGIIPNYCWLLVEGVYL GLR_MOUSE 227 26
LVFLLMQYCVAANYYWLLVEGVYL GLPR_MOUSE 228 25
VAAVFMQYGIVANYCWLLVEGLYL GLR_HUMAN 226 26
LVFLLMQYCVAANYYWLLVEGVYL GLPR_HUMAN 228 25
LVTAAYNYFHVTNFFWMFGEGCYL CRFR_MOUSE 190 12
LVTAAYNYFHVTNFFWMFGEGCYL CRFR_SHEEP 190 12
LVTAAYNYFHVTNFFWMFGEGCYL CRFR_HUMAN 219 12
LVTAAYNYFHVTNFFWMFGEGCYL CRFR_RAT 190 12
LVTIAHNYFYVTNFFWMFGEGCYL CRFR_XENLA 190 12
CVTTIFNYFVVTNFFWMFVEGCYL CRF2_RAT 186 11
IAVVMFIYFLATNYYWILVEGLYL PTR2_HUMAN 238 35
VSVATSHFATMTNFSWLLAEAVYL GRFR_PIG 204 16
CITTIFNYFVVTNFFWMFVEGCYL Q99431 213 11
CITTIFNYFVVTNFFWMFVEGCYL O43461 172 11
CITTIFNYFVVTNFFWMFVEGCYL CRF2_HUMAN 186 11
VSVAASHFATMTNFSWLLAEAVYL GRFR_HUMAN 204 16
IAVVMFIYFLATNYYWILVEGLYL PTH2_RAT 236 35
VSVAVSHFATMTNFSWLLAEAVYL GRFR_RAT 204 16
CITTIFNYFVVTNFFWMFVEGCYL CRF2_MOUSE 206 11
VSVAISHLATMTNFSWLLAEAVYL GRFR_MOUSE 204 16
LVTAAYNYFHVTNFFWMFGEGCYL CRFR_CHICK 195 12
CITTIYNYFVVTNFFWMFVEGCYL CRF2_XENLA 188 11
ILHFFHQYMMACNYFWMLCEGIYL CALR_CAVPO 221 14
ILHFFHQYMMACNYFWMLCEGIYL CALR_HUMAN 237 14
VLHFFHQYMMSCNYFWMLCEGIYL CALR_RABIT 221 14
ILHFFHQYMMACNYFWMLCEGIYL CALR_RAT 258 51
VLHFLHQYMMSCNYFWMLCEGIYL CALR_MOUSE 258 51
VLHFFHQYMMSCNYFWMLCEGVYL CALR_PIG 238 14
ILVICMNYFYLTNFFWMLVEGLYL DIHR_MANSE 158 13
VSQFIHLYLMGCNYFWMLCEGIYL CGRR_HUMAN 214 14
VSQFIHLYLMGCNYFWMLCEGIYL CGRR_RAT 214 14
VLAVLMHYFYLTNFFWMFVEGLYL DIHR_ACHDO 201 9
AILWFVIYFNVASVMWMLIEGAFL Q93245 139 23
GPCRSECRETIN4 Length of motif = 26 Motif number = 4
Secretin motif IV - 3
PCODE ST INT
FWGYILIGWGVPSVFITIWTVVRIYF VIPR_RAT 256 14
LQAFVLLGWGSPAIFVALWAITRHFL SCRC_RAT 255 14
LQGFVAFGWGSPAIFVALWAIARHFL SCRC_HUMAN 255 14
FYWYTIIGWGTPTVCVTVWAVLRLYF PACR_RAT 265 14
FYWYTIIGWGTPTVCVTVWAVLRLYF PACR_MOUSE 266 14
FYWYTIIGWGTPTVCVTVWATLRLYF PACR_HUMAN 266 14
FYWYTIIGWGTPTICVTIWAVLRLHF O73769 258 14
FYWYIIIGWGTPTVCVSVWAMLRLYF PACR_BOVIN 283 14
LQGFVVLGWGSPAMFVTSWAVTRHFL SCRC_RABIT 251 14
FWGYILIGWGVPSTFTMVWTIARIHF VIPR_HUMAN 255 14
FWGYIFVGWGVPSTFIMVWTVVRIHF VIPR_PIG 256 14
FLAYLLIGWGLPTVCIGAWTAARLYL VIPS_HUMAN 241 13
LWGFTVFGWGLPAVFVAVWVSVRATL PTRR_HUMAN 321 14
LWGFTLFGWGLPAVFVAVWVTVRATL PTRR_DIDMA 315 14
LWGFTVFGWGLPAIFVAVWVSVRATL PTRR_PIG 316 14
FWWYILIGWGGPTIFIMAWSFAKAYF VIPR_CARAU 217 14
FLAYLLIGWGIPSVCIGAWTATRLSL VIPS_MOUSE 240 13
FLAYLLIGWGIPSVCIGAWIATRLSL VIPS_RAT 240 13
LWGFTIFGWGLPAVFVAVWVGVRATL PTRR_MOUSE 321 14
LWGFTIFGWGLPAVFVAVWVGVRATL PTRR_RAT 321 14
FWWYILIGWGVPSVVLIVWVLTRQFY O73768 249 14
FRCYLLLGWGAPALFVIPWVIVRYLY GIPR_RAT 253 14
FRYYLLLGWGAPALFVIPWVIVRYLY GIPR_HUMAN 256 14
FRCYLLLGWGAPALFVIPWVIVRYLL GIPR_MESAU 253 14
FSLYLCIGWGSPLLFVIPWVVVKCLF GLR_RAT 265 14
FKLYLSIGWGVPLLFVIPWGIVKYLY GLPR_RAT 266 14
FSLYLGIGWGAPLLFVIPWVVVKCLF GLR_MOUSE 265 14
FKLYLSIGWGVPLLFVIPWGIVKYLY GLPR_MOUSE 266 14
FSLYLGIGWGAPMLFVVPWAVVKCLF GLR_HUMAN 264 14
FRLYVSIGWGVPLLFVVPWGIVKYLY GLPR_HUMAN 266 14
KWMFVCIGWGVPFPIIVAWAIGKLYY CRFR_MOUSE 228 14
KWMFICIGWGVPFPIIVAWAIGKLYY CRFR_SHEEP 228 14
KWMFICIGWGVPFPIIVAWAIGKLYY CRFR_HUMAN 257 14
KWMFVCIGWGVPFPIIVAWAIGKLHY CRFR_RAT 228 14
KWMFICIGWCIPFPIIVAWAIGKLYY CRFR_XENLA 228 14
KWLFLFIGWCIPCPIIVAWAVGKLYY CRF2_RAT 224 14
LWGFILIGWGFPAAFVAAWAVARATL PTR2_HUMAN 276 14
FWWLVLAGWGLPLLFTGTWVGCKLAF GRFR_PIG 242 14
KCLFLFIGWCIPFPIIVAWAIGKLYY Q99431 251 14
KCLFLFIGWCIPFPIIVAWAIGKLYY O43461 210 14
KCLFLFIGWCIPFPIIVAWAIGKLYY CRF2_HUMAN 224 14
FWWLVLAGWGLPVLFTGTWVSCKLAF GRFR_HUMAN 242 14
LWGFILIGWGFPAVFVVAWAVARATL PTH2_RAT 274 14
FWWLVLAGWGLPVLCTGTWVGCKLAF GRFR_RAT 242 14
KWLFLFIGWCIPCPIIIAWAVGKLYY CRF2_MOUSE 244 14
FWWLVLAGWGLPVLCTGTWVGCKHSF GRFR_MOUSE 242 14
KWMFICIGWCIPFPIIVAWAIGKLYY CRFR_CHICK 233 14
KWVFLFIGWCIPSPIIVTWAICKLFY CRF2_XENLA 226 14
LRWYYLLGWGFPLVPTTIHAITRALY CALR_CAVPO 259 14
LRWYYLLGWGFPLVPTTIHAITRAVY CALR_HUMAN 275 14
LRWYYLLGWGFPLVPTTIHAITRAIY CALR_RABIT 259 14
LRWYYLLGWGFPIVPTIIHAITRAVY CALR_RAT 296 14
LRWYYLLGWGFPIVPTIIHAITRALY CALR_MOUSE 296 14
LWWYHVLGWGFPLIPTTAHAITRAVL CALR_PIG 276 14
LKVYTTIGWGAPAVFITIWVISRCFV DIHR_MANSE 196 14
LMWYYFLGWGFPLIPACIHAIARSLY CGRR_HUMAN 252 14
LMWYYFLGWGFPLLPACIHAIARSLY CGRR_RAT 252 14
LQIYIIIGWGIPGVIVVTWAIIKHLG DIHR_ACHDO 239 14
WSLYLACGWGVPFVVVTAWALVHQYI Q93245 178 15
GPCRSECRETIN5 Length of motif = 26 Motif number = 5
Secretin motif V - 3
PCODE ST INT
WIIKAPILLSILVNFVLFICIIRILV VIPR_RAT 297 15
WVIRGPVILSILINFIFFINILRILM SCRC_RAT 296 15
WIIRGPVILSILINFILFINILRILM SCRC_HUMAN 296 15
WVIKGPVVGSIMVNFVLFIGIIIILV PACR_RAT 306 15
WVIKGPVVGSIMVNFVLFIGIIIILV PACR_MOUSE 307 15
WVIKGPVVGSIMVNFVLFIGIIVILV PACR_HUMAN 307 15
WVIKGPVVASIMINFVLFIGIIIILV O73769 299 15
WVIKGPVVGSIMVNFVLFIGIIVILV PACR_BOVIN 324 15
WVIRGPVILSILINFILFINILRILT SCRC_RABIT 292 15
WIIKGPILTSILVNFILFICIIRILL VIPR_HUMAN 295 14
WIIKAPILASILVNFILFIRIIGILV VIPR_PIG 296 14
WVIRIPILISIIVNFVLFISIIRILL VIPS_HUMAN 282 15
WIIQVPILASIVLNFILFINIVRVLA PTRR_HUMAN 361 14
WIIQVPILAAIVVNFILFINIIRVLA PTRR_DIDMA 355 14
WIIQVPILASIVLNFILFINIVRVLA PTRR_PIG 356 14
WIIKTPILASILMNFILFICIIRILR VIPR_CARAU 259 16
WVIRMPILISIVVNFALFISIVRILL VIPS_MOUSE 281 15
WVIRMPILISIVVNFALFISIVRILL VIPS_RAT 281 15
WIIQVPILASVVLNFILFINIIRVLA PTRR_MOUSE 361 14
WIIQVPILASVVLNFILFINIIRVLA PTRR_RAT 361 14
WIIKGPITVSLIANIIIFLNVIRILV O73768 290 15
WIIRTPILITILINFLIFIRILGILV GIPR_RAT 294 15
WIIRTPILMTILINFLIFIRILGILL GIPR_HUMAN 297 15
WIIRTPILITILINFFIFIRILGILV GIPR_MESAU 294 15
WILRIPVLLAILINFFIFVRIIHLLV GLR_RAT 306 15
LIIRLPILFAIGVNFLVFIRVICIVI GLPR_RAT 307 15
WILRIPVFLALLINFFIFVHIIQLLV GLR_MOUSE 306 15
LIIRLPILFAIGVNFLIFIRVICIVV GLPR_MOUSE 307 15
WILRFPVFLAILINFFIFVRIVQLLV GLR_HUMAN 305 15
LIIRLPILFAIGVNFLIFVRVICIVV GLPR_HUMAN 307 15
YIYQGPMILVLLINFIFLFNIVRILM CRFR_MOUSE 270 16
YIYQGPMILVLLINFIFLFNIVRILM CRFR_SHEEP 270 16
YIYQGPMILVLLINFIFLFNIVRILM CRFR_HUMAN 299 16
YIYQGPMILVLLINFIFLFNIVRILM CRFR_RAT 270 16
FIYQGPVILVLLINFIFLFNIVRILM CRFR_XENLA 270 16
YIYQGPIILVLLINFVFLFNIVRILM CRF2_RAT 266 16
WIYQAPILAAIGLNFILFLNTVRVLA PTR2_HUMAN 316 14
WIIKGPIVLSVGVNFGLFLNIIRILL GRFR_PIG 283 15
YIYQGPIILVLLINFVFLFNIVRILM Q99431 293 16
YIYQGPIILVLLINFVFLFNIVRILM O43461 252 16
YIYQGPIILVLLINFVFLFNIVRILM CRF2_HUMAN 266 16
WIIKGPIVLSVGVNFGLFLNIIRILV GRFR_HUMAN 283 15
WIYXXPILAAIGLNFILFLNTVRVLA PTH2_RAT 313 13
WIIKGPIVLSVGVNFGLFLNIICILL GRFR_RAT 283 15
YIYQGPVMLVLLINFVFLFNIVRILM CRF2_MOUSE 286 16
WIIKGPIVLSVGVNFGLFLNIICILL GRFR_MOUSE 283 15
YIYQGPMILVLLINFIFLFNIVRILM CRFR_CHICK 275 16
YIYQGRVILVLLINFVFLFNIVRILM CRF2_XENLA 268 16
YIIHGPVMVALVVNFFFLLNIVRVLV CALR_CAVPO 299 14
YIIHGPVMAALVVNFFFLLNIVRVLV CALR_HUMAN 315 14
YIIHGPVMAALVVNFFFLLNIVRVLV CALR_RABIT 299 14
YIIHGPVMAALVVNFFFLLNIVRVLV CALR_RAT 336 14
YIIHGPVMVALVVNFFFLLNIVRVLV CALR_MOUSE 336 14
YIIHGPVMAALVVNFFFLLNILRVLV CALR_PIG 316 14
WIHKAPALVGLALNLFFLIRIMWVLI DIHR_MANSE 251 29
YIIHGPICAALLVNLFFLLNIVRVLI CGRR_HUMAN 292 14
YIIHGPICAALLVNLFFLLNIVRVLI CGRR_RAT 292 14
WIHQAPVITVLAVNLVFLFSIMWVLI DIHR_ACHDO 294 29
WILAGTMGSALIMNLIFLLMIVVILV Q93245 223 19
GPCRSECRETIN6 Length of motif = 21 Motif number = 6
Secretin motif VI - 3
PCODE ST INT
LAKSTLLLIPLFGIHYVMFAF VIPR_RAT 341 18
LAKSTLLLIPLFGIHYIVFAF SCRC_RAT 340 18
LARSTLLLIPLFGIHYIVFAF SCRC_HUMAN 340 18
LARSTLLLIPLFGIHYTVFAF PACR_RAT 406 74
LARSTLLLIPLFGIHYTVFAF PACR_MOUSE 379 46
LARSTLLLIPLFGIHYTVFAF PACR_HUMAN 351 18
LARSTLLLIPLFGIHYTVFAF O73769 343 18
LARSTLLLIPLFGIHYTVFAF PACR_BOVIN 396 46
LARSTLLLIPLFGVHYIVFVF SCRC_RABIT 336 18
LARSTLLLIPLFGVHYIMFAF VIPR_HUMAN 339 18
LAKSTLLLIPLFGVHYIMFAF VIPR_PIG 340 18
LAKSTLLLIPLFGVHYMVFAV VIPS_HUMAN 326 18
LLKSTLVLMPLFGVHYIVFMA PTRR_HUMAN 406 19
LLKSTLVLMPLFGVHYIVFMA PTRR_DIDMA 400 19
LLKSTLVLMPLFGVHYIVFMA PTRR_PIG 401 19
LAKSTLLLIPLFGINFIIFAF VIPR_CARAU 303 18
LAKSTLLLIPLFGVHYMVFAA VIPS_MOUSE 325 18
LAKSTLLLIPLFGVHYMVFAA VIPS_RAT 325 18
LLRSTLVLVPLFGVHYTVFMA PTRR_MOUSE 406 19
LLRSTLVLVPLFGVHYTVFMA PTRR_RAT 406 19
LAKSTLFLIPLFGMHYTLFAF O73768 334 18
LARSTLTLMPLLGVHEVVFAP GIPR_RAT 336 16
LARSTLTLVPLLGVHEVVFAP GIPR_HUMAN 339 16
LARSTLTLVPLLGVHEVVFAP GIPR_MESAU 336 16
LARSTLTLIPLLGVHEVVFAF GLR_RAT 348 16
LAKSTLTLIPLLGTHEVIFAF GLPR_RAT 349 16
LARSTLTLIPLLGVHEVVFAF GLR_MOUSE 348 16
LAKSTLTLIPLLGTHEVIFAF GLPR_MOUSE 349 16
LAKSTLTLIPLLGVHEVVFAF GLR_HUMAN 347 16
LAKSTLTLIPLLGTHEVIFAF GLPR_HUMAN 349 16
AVKATLVLLPLLGITYMLFFV CRFR_MOUSE 312 16
AVKATLVLLPLLGITYMLFFV CRFR_SHEEP 312 16
AVKATLVLLPLLGITYMLFFV CRFR_HUMAN 341 16
AVKATLVLLPLLGITYMLFFV CRFR_RAT 312 16
AVKATLVLLPLLGITYMLFFV CRFR_XENLA 312 16
AVKATLVLLPLLGITYMLFFV CRF2_RAT 308 16
LAKSTLVLVLVFGVHYIVFVC PTR2_HUMAN 361 19
LSKSTLLLIPLFGIHYVIFNF GRFR_PIG 327 18
AVKATLVLLPLLGITYMLFFV Q99431 335 16
AVKATLVLLPLLGITYMLFFV O43461 294 16
AVKATLVLLPLLGITYMLFFV CRF2_HUMAN 308 16
LSKSTLFLIPLFGIHYIIFNF GRFR_HUMAN 327 18
LAKSTLVLVLVFGVHYIVFIC PTH2_RAT 358 19
LSKSTLLLIPLFGIHYIIFNF GRFR_RAT 368 59
AVKATLVLLPLLGITYMLFFV CRF2_MOUSE 328 16
LSKSTLLLIPLFGIHYIIFNF GRFR_MOUSE 327 18
AVKATLVLLSLLGITYMLFFV CRFR_CHICK 317 16
AVKATLVLLPLLGITYMLFFV CRF2_XENLA 310 16
AVKATMILVPLLGIQFVVFPW CALR_CAVPO 341 16
AVKATMILVPLLGIQFVVFPW CALR_HUMAN 357 16
AVKATMILVPLLGIQFVVFPW CALR_RABIT 341 16
AVKATMVLVPLLGIQFVVFPW CALR_RAT 378 16
AVKATMVLVPLLGIQFVVFPW CALR_MOUSE 378 16
AVRATLILVPLLGVQFVVLPW CALR_PIG 358 16
ATKALLVLIPLLGITNLLVLC DIHR_MANSE 293 16
AVRATLILVPLLGIEFVLIPW CGRR_HUMAN 334 16
AVRATLILVPLLGIEFVLFPW CGRR_RAT 334 16
ATKALLVLFPLLGITYILMMQ DIHR_ACHDO 336 16
TIKATLLLVPLLGISNIPLFY Q93245 265 16
GPCRSECRETIN7 Length of motif = 22 Motif number = 7
Secretin motif VII - 3
PCODE ST INT
MVFELVVGSFQGFVVAILYCFL VIPR_RAT 372 10
LFFELALGSFQGLVVAVLYCFL SCRC_RAT 370 9
LFFELALGSFQGLVVAVLYCFL SCRC_HUMAN 370 9
LVFELGLGSFQGFVVAVLYCFL PACR_RAT 437 10
LVFELGLGSFQGFVVAVLYCFL PACR_MOUSE 410 10
LVFELGLGSFQGFVVAVLYCFL PACR_HUMAN 382 10
LVFELGLGSFQGFVVAVLYCFL O73769 374 10
LVFELGLGSFQGFVVAVLYCFL PACR_BOVIN 427 10
LFFELALGSFQGLVVAVLYCFL SCRC_RABIT 366 9
MVFELVVGSFQGFVVAILYCFL VIPR_HUMAN 370 10
MVFELIVGSFQGCVVAILYCFL VIPR_PIG 371 10
ILFELCLGSFQGLVVAVLYCFL VIPS_HUMAN 357 10
MHYEMLFNSFQGFFVAIIYCFC PTRR_HUMAN 441 14
MHYEMLFNSFQGFFVAIIYCFC PTRR_DIDMA 435 14
MHYEMLFNSFQGFFVAIIYCFC PTRR_PIG 436 14
LVFDLILGSFQGFVVAVLYCFL VIPR_CARAU 334 10
ILFELCVGSFQGLVVAVLYCFL VIPS_MOUSE 356 10
ILFELCVGSFQGLVVAVLYCFL VIPS_RAT 356 10
MHYEMLFNSFQGFFVAIIYCFC PTRR_MOUSE 441 14
MHYEMLFNSFQGFFVAIIYCFC PTRR_RAT 441 14
FYIELGLGSFQGFVVALLYCFL O73768 365 10
LAFEIFLSSFQGFLVSVLYCFI GIPR_RAT 371 14
LGFEIFLSSFQGFLVSVLYCFI GIPR_HUMAN 374 14
LAFEIFLSSFQGFLVSVLYCFI GIPR_MESAU 371 14
LFFDLFFSSFQGLLVAVLYCFL GLR_RAT 383 14
LFTELSFTSFQGFMVAVLYCFV GLPR_RAT 384 14
LFFDLFLSSFQGLLVAVLYCFL GLR_MOUSE 383 14
LFTELSFTSFQGLMVAILYCFV GLPR_MOUSE 384 14
LFFDLFLSSFQGLLVAVLYCFL GLR_HUMAN 382 14
LFTELSFTSFQGLMVAILYCFV GLPR_HUMAN 384 14
IYFNSFLESFQGFFVSVFYCFL CRFR_MOUSE 345 12
IYFNSFLESFQGFFVSVFYCFL CRFR_SHEEP 345 12
IYFNSFLESFQGFFVSVFYCFL CRFR_HUMAN 374 12
IYFNSFLESFQGFFVSVFYCFL CRFR_RAT 345 12
IYFNSFLQSFQGFFVSVFYCFL CRFR_XENLA 345 12
IYFNSFLQSFQGFFVSVFYCFF CRF2_RAT 341 12
MHCELFFNSFQGFFVSIIYCYC PTR2_HUMAN 395 13
LPLELGLGSFQGFIVAILYCFL GRFR_PIG 358 10
IYFNSFLQSFQGFFVSVFYCFF Q99431 368 12
IYFNSFLQSFQGFFVSVFYCFF O43461 327 12
IYFNSFLQSFQGFFVSVFYCFF CRF2_HUMAN 341 12
LPLELGLGSFQGFIVAILYCFL GRFR_HUMAN 358 10
MHCELFFNSFQGFFVSIVYCYC PTH2_RAT 392 13
LPLELGLGSFQGFVVAVLYCFL GRFR_RAT 399 10
IYFNSFLQSFQGFFVSVFYCFF CRF2_MOUSE 361 12
VPLELGLGSFQGFIVAVLYCFL GRFR_MOUSE 358 10
IYFNSFLESFQGFFVSVFYCFL CRFR_CHICK 350 12
IYFNSFLQSFQGFFVSVFYCFL CRF2_XENLA 343 12
DYFMHSLIHFQGFFVATIYCFC CALR_CAVPO 373 11
DYVMHSLIHFQGFFVATIYCFC CALR_HUMAN 389 11
DYLMHSLIHFQGFFVATIYCFC CALR_RABIT 373 11
DYLMHSLIHFQGFFVATIYCFC CALR_RAT 410 11
DYLMHSLIHFQGFFVATIYCFC CALR_MOUSE 410 11
DYVVHSLIHFQGFFVAIIYCFC CALR_PIG 390 11
DYTRALMLSTQGFTVALFYCFM DIHR_MANSE 326 12
DYIMHILMHFQGLLVSTIFCFF CGRR_HUMAN 366 11
DYVMHILMHYQGLLVSTIFCFF CGRR_RAT 366 11
RNAQALLLSLQGFTVALFYCFL DIHR_ACHDO 368 11
MLGSAILQHSQGIFIAVLYCFL Q93245 295 9
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