WORKLIST ENTRIES (1):
INHIBINA View alignment View Structure Inhibin alpha chain signature
Type of fingerprint: COMPOUND with 8 elements
Links:
PRINTS; PR00670 INHIBINBA; PR00671 INHIBINBB; PR00672 INHIBINBC
INTERPRO; IPR002405
PROSITE; PS00250 TGF_BETA
Creation date 05-MAR-1997; UPDATE 07-JUN-1999
1. MAYO, K.E., CERELLI, G.M., SPIESS, J., RIVIER, J., ROSENFELD, M.G.,
EVANS, R.M. AND VALE, W.
Inhibin A-subunit cDNAs from porcine ovary and human placenta.
PROC.NATL.ACAD.SCI.U.S.A. 83(16) 5849-5853 (1986).
2. MASON, A.J., HAYFLICK, J.S., LING, N., ESCH, F., UENO, N., YING, S.Y.,
GUILLEMIN, R., NIALL, H. AND SEEBURG, P.H.
Complementary DNA sequences of ovarian follicular fluid inhibin show
precursor structure and homology with transforming growth factor-beta.
NATURE 318 659-663 (1985).
Inhibin is a gonadal glycopeptide that preferentially suppresses pituitary
secretion of follitropin (follicle-stimulating hormone) [1]. It is a
heterodimeric protein, linked by one or more disulphide bonds: inhibin A is
a dimer of alpha and beta-A chains; and inhibin B is a dimer of alpha and
beta-B. Inhibins belong to a gene family that also includes transforming
growth factor-beta (TGF-beta) [2].
INHIBINA is an 8-element fingerprint that provides a signature for inhibin
alpha subunits. The fingerprint was derived from an initial alignment of
13 sequences: the motifs were drawn from the C-terminal two-thirds of the
alignment, motifs 2,3 and 5-8 each containing conserved Cys residues, which
are involved in inter- and intra-chain disulphide bond formation. A single
iteration on OWL29.1 was required to reach convergence, no further sequences
being identified beyond the starting set. Numerous partial matches were
found: all are members of the TGF-beta family that match motifs 5 and 6,
which contain 2 of the conserved cysteines (cf. PROSITE pattern TGF_BETA
(PS00250)).
An update on SPTR37_9f identified a true set of 8 sequences.
SUMMARY INFORMATION
8 codes involving 8 elements
0 codes involving 7 elements
0 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
8| 8 8 8 8 8 8 8 8
7| 0 0 0 0 0 0 0 0
6| 0 0 0 0 0 0 0 0
5| 0 0 0 0 0 0 0 0
4| 0 0 0 0 0 0 0 0
3| 0 0 0 0 0 0 0 0
2| 0 0 0 0 0 0 0 0
--+-----------------------------------------
| 1 2 3 4 5 6 7 8
True positives..
IHA_PIG IHA_HORSE IHA_BOVIN IHA_RAT
IHA_MOUSE IHA_HUMAN O77755 IHA_CHICK
PROTEIN TITLES
IHA_PIG INHIBIN ALPHA CHAIN PRECURSOR - SUS SCROFA (PIG).
IHA_HORSE INHIBIN ALPHA CHAIN PRECURSOR - EQUUS CABALLUS (HORSE).
IHA_BOVIN INHIBIN ALPHA CHAIN PRECURSOR - BOS TAURUS (BOVINE).
IHA_RAT INHIBIN ALPHA CHAIN PRECURSOR - RATTUS NORVEGICUS (RAT).
IHA_MOUSE INHIBIN ALPHA CHAIN PRECURSOR - MUS MUSCULUS (MOUSE).
IHA_HUMAN INHIBIN ALPHA CHAIN PRECURSOR - HOMO SAPIENS (HUMAN).
O77755 INHIBIN ALPHA CHAIN PRECURSOR - TRICHOSURUS VULPECULA (BRUSH
IHA_CHICK INHIBIN ALPHA CHAIN PRECURSOR - GALLUS GALLUS (CHICKEN).
SCAN HISTORY
OWL29_1 1 65 NSINGLE
SPTR37_9f 2 9 NSINGLE
INITIAL MOTIF SETS
INHIBINA1 Length of motif = 25 Motif number = 1
Inhibin A motif I - 1
PCODE ST INT
GLFTYVFQPSQHTRSRQVTSAQLWF IHA_BOVIN 103 103
GLFTYVFQPSQHTRSRQVTSAQLWF IHA_SHEEP 8 8
GLFTYVFRPSQHIRSHQVTSAQLWF IHA_MOUSE 110 110
GLFTYVFRPSQHIRSHQVTSAQLWF IHA_RAT 110 110
GLFTYVFRPSQHIRSHQVTSAQLWF MMINAS 62 62
GLFTYVFRPSQHIRSHQVTSAQLWF MUSINHIB02 110 110
GLFTYVFRPSQHTHSRQVTSAQLWF SSINHAR 107 107
GLFTYVFRPSQHTRSRQVASAQLWF IHA_PIG 107 107
GLFRYMFRPSQHTRSRQVTSAQLWF IHA_HUMAN 109 109
GLFTYMFRPSQHMRSRQVTSAHLWF IHA_HORSE 110 110
GLFTYMFRPSQHMRSRQVTSAHLWF ECU21219 13 13
GIFTYLFQPSAHALSRTLTSAQLWF IHA_CHICK 101 101
GIFTYLFQPSAHALSRTLTSAQLWF GGU48438 102 102
INHIBINA2 Length of motif = 17 Motif number = 2
Inhibin A motif II - 1
PCODE ST INT
PLLTHPVLALLLRCPLC IHA_BOVIN 181 53
PLLTHPVLALLLRCPLC IHA_SHEEP 86 53
PLLTHPILVLLLRCPLC IHA_MOUSE 188 53
PLLTHPILVLLLRCPLC IHA_RAT 188 53
PLLTHPILVLLLRCPLC MMINAS 140 53
PLLTHPILVLLLRCPLC MUSINHIB02 188 53
PLLTHPVLVLLLRCPLC SSINHAR 185 53
PLLTHPVLVLLLRCPLC IHA_PIG 185 53
SLLTHPVLVLLLRCPLC IHA_HUMAN 187 53
PLLTHPVLVLLLRCPLC IHA_HORSE 188 53
PLLTHPVLVLLLRCPLC ECU21219 91 53
PQLAQPLFVLLVRCPGC IHA_CHICK 173 47
PQLAQPLFVLLVRCPGC GGU48438 174 47
INHIBINA3 Length of motif = 18 Motif number = 3
Inhibin A motif III - 1
PCODE ST INT
CSTRPEATPFLVAHTRAK IHA_BOVIN 199 1
CSARPEATPFLVAHTRAK IHA_SHEEP 104 1
CSGRPETTPFLVAHTRAR IHA_MOUSE 206 1
CSGRPETTPFLVAHTRAR IHA_RAT 206 1
CSGRPETTPFLVAHTRAR MMINAS 158 1
CSGRPETTPFLVAHTRAR MUSINHIB02 206 1
CSARPEATPFLVAHTRAR SSINHAR 203 1
CSARPEATPFLVAHTRAR IHA_PIG 203 1
CSARPEATPFLVAHTRTR IHA_HUMAN 205 1
CSARPEATPFLVAHTRAR IHA_HORSE 206 1
CSARPEATPFLVAHTRAR ECU21219 109 1
CLADGDKMPFLVATTRAK IHA_CHICK 191 1
CLADGDKMPFLVATTRAK GGU48438 192 1
INHIBINA4 Length of motif = 20 Motif number = 4
Inhibin A motif IV - 1
PCODE ST INT
PWSPAALRLLQRPPEEPAAH IHA_BOVIN 234 17
PWSPAALRLLQRPPEEPAAH IHA_SHEEP 139 17
PWSPAALRLLQRPPEEPAAH IHA_MOUSE 241 17
PWSPAALRLLQRPPEEPSAH IHA_RAT 241 17
PWSPAALRLLQRPPEEPAAH MMINAS 193 17
PWSPAALRLLQRPPEEPAAH MUSINHIB02 241 17
PWSPAALRLLQRPPEEPAVH SSINHAR 238 17
PWSPAALRLLQRPPEEPAVH IHA_PIG 238 17
PWSPSALRLLQRPPEEPAAH IHA_HUMAN 240 17
PWSPAALRLLQRPPEEPAAH IHA_HORSE 241 17
PWSPAALRLLQRPPEEPAAH ECU21219 144 17
PWSPGALSLLQRPSEDVAAH IHA_CHICK 219 10
PWSPAALSLLQRPSEDVAAH GGU48438 220 10
INHIBINA5 Length of motif = 18 Motif number = 5
Inhibin A motif V - 1
PCODE ST INT
CHRAALNISFQELGWDRW IHA_BOVIN 256 2
CHRAALNISFQELGWDRW IHA_SHEEP 161 2
CHRAALNISFQELGWDRW IHA_MOUSE 263 2
CHRAALNISFQELGWDRW IHA_RAT 263 2
CHRAALNISFQELGWDRW MMINAS 215 2
CHRAALNISFQELGWDRW MUSINHIB02 263 2
CHRASLNISFQELGWDRW SSINHAR 260 2
CHRASLNISFQELGWDRW IHA_PIG 260 2
CHRVALNISFQELGWERW IHA_HUMAN 262 2
CHRAALNISFQELGWDRW IHA_HORSE 263 2
CHRAALNISFQELGWDRW ECU21219 166 2
CRRASLNISFEELGWDNW IHA_CHICK 241 2
CRRASLNISFEELGWDNW GGU48438 242 2
INHIBINA6 Length of motif = 18 Motif number = 6
Inhibin A motif VI - 1
PCODE ST INT
WIVHPPSFIFYYCHGGCG IHA_BOVIN 273 -1
WIVHPPSFIFYYCHGGCG IHA_SHEEP 178 -1
WIVHPPSFIFHYCHGSCG IHA_MOUSE 280 -1
WIVHPPSFIFHYCHGSCG IHA_RAT 280 -1
WIVHPPSFIFHYCHGSCG MMINAS 232 -1
WIVHPPSFIFHYCHGSCG MUSINHIB02 280 -1
WIVHPPSFIFHYCHGGCG SSINHAR 277 -1
WIVHPPSFIFHYCHGGCG IHA_PIG 277 -1
WIVYPPSFIFHYCHGGCG IHA_HUMAN 279 -1
WIVHPRSFIFHYCHGGCG IHA_HORSE 280 -1
WIVHPRSFIFHYCHGGCG ECU21219 183 -1
WIVHPSSFVFHYCHGNCA IHA_CHICK 258 -1
WIVHPSSFVFHYCHGNCA GGU48438 259 -1
INHIBINA7 Length of motif = 20 Motif number = 7
Inhibin A motif VII - 1
PCODE ST INT
GAQPCCAALPGTMRPLHVRT IHA_BOVIN 317 26
GAQACCAALPGTMRPLRVRT IHA_SHEEP 222 26
GAKPCCAALPGSMTSLRVRT IHA_MOUSE 323 25
GAKPCCAALPGSMRSLRVRT IHA_RAT 323 25
GAKPCCAALPGSMRSLRVRT MMINAS 275 25
GAKPCCAALPGSMRSLRVRT MUSINHIB02 323 25
GAQPCCAALPGTMRSLRVRT SSINHAR 321 26
GAQPCCAALPGTMRSLRVRT IHA_PIG 321 26
GAQPCCAALPGTMRPLHVRT IHA_HUMAN 323 26
GAQPCCAALPGTMRPLRVRT IHA_HORSE 324 26
GAQPCCAALPGTMRPLRVRT ECU21219 227 26
GVQLCCAALPGTMRSLRVRT IHA_CHICK 285 9
GVQLCCAALPGTMRSLRVRT GGU48438 286 9
INHIBINA8 Length of motif = 22 Motif number = 8
Inhibin A motif VIII - 1
PCODE ST INT
SDGGYSFKYEMVPNLLTQHCAC IHA_BOVIN 338 1
SDGGYSFKYEMVPNLLTQHCAC IHA_SHEEP 243 1
SDGGYSFKYEMVPNLITQHCAC IHA_MOUSE 344 1
SDGGYSFKYEMVPNLITQHCAC IHA_RAT 344 1
SDGGYSFKYEMVPNLITQHCAC MMINAS 296 1
SDGGYSFKYEMVPNLITQHCAC MUSINHIB02 344 1
SDGGYSFKYETVPNLLTQHCAC SSINHAR 342 1
SDGGYSFKYETVPNLLTQHCAC IHA_PIG 342 1
SDGGYSFKYETVPNLLTQHCAC IHA_HUMAN 344 1
SDGGYSFKYEIVPNLLTQHCAC IHA_HORSE 345 1
SDGGYSFKYEIVPNLLTQHCAC ECU21219 248 1
SDGGYSFKYETVPNILAQDCTC IHA_CHICK 306 1
SDGGYSFKYETVPNILAQDCTC GGU48438 307 1
FINAL MOTIF SETS
INHIBINA1 Length of motif = 25 Motif number = 1
Inhibin A motif I - 2
PCODE ST INT
GLFTYVFRPSQHTRSRQVASAQLWF IHA_PIG 107 107
GLFTYMFRPSQHMRSRQVTSAHLWF IHA_HORSE 110 110
GLFTYVFQPSQHTRSRQVTSAQLWF IHA_BOVIN 103 103
GLFTYVFRPSQHIRSHQVTSAQLWF IHA_RAT 110 110
GLFTYVFRPSQHIRSHQVTSAQLWF IHA_MOUSE 110 110
GLFRYMFRPSQHTRSRQVTSAQLWF IHA_HUMAN 109 109
GLFTYTFRPSLHTRSRQVTAAQLWF O77755 107 107
GIFTYLFQPSAHALSRTLTSAQLWF IHA_CHICK 102 102
INHIBINA2 Length of motif = 17 Motif number = 2
Inhibin A motif II - 2
PCODE ST INT
PLLTHPVLVLLLRCPLC IHA_PIG 185 53
PLLTHPVLVLLLRCPLC IHA_HORSE 188 53
PLLTHPVLALLLRCPLC IHA_BOVIN 181 53
PLLTHPILVLLLRCPLC IHA_RAT 188 53
PLLTHPILVLLLRCPLC IHA_MOUSE 188 53
SLLTHPVLVLLLRCPLC IHA_HUMAN 187 53
TLLTRPLLVLLLRCPNC O77755 185 53
PQLAQPLFVLLVRCPGC IHA_CHICK 174 47
INHIBINA3 Length of motif = 18 Motif number = 3
Inhibin A motif III - 2
PCODE ST INT
CSARPEATPFLVAHTRAR IHA_PIG 203 1
CSARPEATPFLVAHTRAR IHA_HORSE 206 1
CSTRPEATPFLVAHTRAK IHA_BOVIN 199 1
CSGRPETTPFLVAHTRAR IHA_RAT 206 1
CSGRPETTPFLVAHTRAR IHA_MOUSE 206 1
CSARPEATPFLVAHTRTR IHA_HUMAN 205 1
CPAQLDATPFLVAHTRAR O77755 203 1
CLADGDKMPFLVATTRAK IHA_CHICK 192 1
INHIBINA4 Length of motif = 20 Motif number = 4
Inhibin A motif IV - 2
PCODE ST INT
PWSPAALRLLQRPPEEPAVH IHA_PIG 238 17
PWSPAALRLLQRPPEEPAAH IHA_HORSE 241 17
PWSPAALRLLQRPPEEPAAH IHA_BOVIN 234 17
PWSPAALRLLQRPPEEPSAH IHA_RAT 241 17
PWSPAALRLLQRPPEEPAAH IHA_MOUSE 241 17
PWSPSALRLLQRPPEEPAAH IHA_HUMAN 240 17
PWSPAALRLLQRPSEDPAAH O77755 238 17
PWSPAALSLLQRPSEDVAAH IHA_CHICK 220 10
INHIBINA5 Length of motif = 18 Motif number = 5
Inhibin A motif V - 2
PCODE ST INT
CHRASLNISFQELGWDRW IHA_PIG 260 2
CHRAALNISFQELGWDRW IHA_HORSE 263 2
CHRAALNISFQELGWDRW IHA_BOVIN 256 2
CHRAALNISFQELGWDRW IHA_RAT 263 2
CHRAALNISFQELGWDRW IHA_MOUSE 263 2
CHRVALNISFQELGWERW IHA_HUMAN 262 2
CHRAALNISFQELGWDQW O77755 260 2
CRRASLNISFEELGWDNW IHA_CHICK 242 2
INHIBINA6 Length of motif = 18 Motif number = 6
Inhibin A motif VI - 2
PCODE ST INT
WIVHPPSFIFHYCHGGCG IHA_PIG 277 -1
WIVHPRSFIFHYCHGGCG IHA_HORSE 280 -1
WIVHPPSFIFYYCHGGCG IHA_BOVIN 273 -1
WIVHPPSFIFHYCHGSCG IHA_RAT 280 -1
WIVHPPSFIFHYCHGSCG IHA_MOUSE 280 -1
WIVYPPSFIFHYCHGGCG IHA_HUMAN 279 -1
WIVHPPSFIFHYCHGGCG O77755 277 -1
WIVHPSSFVFHYCHGNCA IHA_CHICK 259 -1
INHIBINA7 Length of motif = 20 Motif number = 7
Inhibin A motif VII - 2
PCODE ST INT
GAQPCCAALPGTMRSLRVRT IHA_PIG 321 26
GAQPCCAALPGTMRPLRVRT IHA_HORSE 324 26
GAQPCCAALPGTMRPLHVRT IHA_BOVIN 317 26
GAKPCCAALPGSMRSLRVRT IHA_RAT 323 25
GAKPCCAALPGSMTSLRVRT IHA_MOUSE 323 25
GAQPCCAALPGTMRPLHVRT IHA_HUMAN 323 26
GSRPCCAAMPSTMRPLRVRT O77755 318 23
GVQLCCAALPGTMRSLRVRT IHA_CHICK 286 9
INHIBINA8 Length of motif = 22 Motif number = 8
Inhibin A motif VIII - 2
PCODE ST INT
SDGGYSFKYETVPNLLTQHCAC IHA_PIG 342 1
SDGGYSFKYEIVPNLLTQHCAC IHA_HORSE 345 1
SDGGYSFKYEMVPNLLTQHCAC IHA_BOVIN 338 1
SDGGYSFKYEMVPNLITQHCAC IHA_RAT 344 1
SDGGYSFKYEMVPNLITQHCAC IHA_MOUSE 344 1
SDGGYSFKYETVPNLLTQHCAC IHA_HUMAN 344 1
SDGGYSFKYEIVPNLLTQHCAC O77755 339 1
SDGGYSFKYETVPNILAQDCTC IHA_CHICK 307 1
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