WORKLIST ENTRIES (1):

KCHANNEL View alignment View Structure        Potassium channel signature
 Type of fingerprint: COMPOUND with 8  elements
Links:
   PRINTS; PR00170 NACHANNEL; PR00167 CACHANNEL; PR00168 ISKCHANNEL
   PRINTS; PR01095 TASKCHANNEL; PR01096 TWIK1CHANNEL; PR01499 TREKCHANNEL
   PRINTS; PR01449 BKCHANNELA; PR01450 BKCHANNELB; PR01451 SKCHANNEL
   PRINTS; PR01459 KCNQCHANNEL; PR01463 EAGCHANLFMLY; PR01491 KVCHANNEL
   PRINTS; PR01320 KIRCHANNEL
   INTERPRO; IPR001622

 Creation date 09-MAR-1993; UPDATE 10-JUN-1999

   1. PERNEY, T.M. AND KACZMAREK, L.K.
   The molecular biology of K+ channels. 
   CURR.OPIN.CELL BIOL. 3 663-670 (1991).

   2. LUNEAU, C., WIEDMAN, R., SMITH, J.S. AND WILLIAMS, J.B.
   Shaw-like rat brain potassium channel cDNAs with divergent 3' ends.
   FEBS LETT. 288 163-167 (1991).

   3. TEMPEL, B.L., JAN, Y.N. AND JAN, L.Y.
   Cloning of a probable potassium channel gene from mouse brain.
   NATURE 332 837-839 (1988).

   4. STUEHMER, W., RUPPERSBERG, J.P., SCHROERTER, K.H., SAKMANN, B., STOCKER,
   M., GIESE, K.P., PERSCHKE, A., BAUMANN, A. AND PONGS, O.
   Molecular basis of functional diversity of voltage gated potassium channels
   in mammalian brain.
   EMBO J. 8(11) 3225-3244 (1989).

   5. SCHWARZ, T.L., TEMPEL, B.L., PAPAZIAN, D.M., JAN, Y.N. AND JAN, L.Y.
   Multiple potassium channel components are produced by alternative splicing
   at the Shaker locus in Drosophila.
   NATURE 331 137-142 (1988).

   6. ATTALI, B., ROMEY, G., HONORE, E., SCHMIDALLIANA, A., MATTEI, M.G., 
   LESAGE, F., RICARD, P., BARHANIN, J. AND LAZDUNSKI, M.
   Cloning, functional expression, and regulation of two K+ channels in human
   T-lymphocytes.
   J.BIOL.CHEM. 267(12) 8650-8657 (1992).

   Potassium channels are the most diverse group of the ion channel family
   (possibly as a result of gene duplication and alternative splicing of the 
   genes [1,2]). They are important in shaping the action potential, and in
   neuronal excitability and plasticity [3]. The potassium channel family is 
   composed of several functionally distinct isoforms, which can be broadly
   separated into 2 groups [4]: the first is the practically non-inactivating 
   "delayed" group, the second the rapidly inactivating "transient" group.
   These are all highly similar proteins, with possibly only small amino acid 
   changes causing the diversity of the voltage-dependent gating mechanism,
   channel conductance and toxin binding properties.
   
   Members of the potassium channel family vary in several ways: some open in 
   response to depolarisation of the plasma membrane; others open in response 
   to hyperpolarisation or an increase in intracellular calcium concentration;
   some can be regulated by binding of a transmitter, together with 
   intracellular kinases; and others are regulated by GTP-binding proteins or 
   other second messengers [5]. They are also involved in T-cell activation, 
   and may have a role in target cell lysis by cytotoxic T-lymphocytes [6].
  
   Potassium channels are transmembrane (TM) proteins that contain 6 membrane-
   spanning alpha-helical segments, 5 of which are hydrophobic, the other 
   being positively charged. The charged segment is believed to be localised 
   within a cluster formed by the hydrophobic helices: it is postulated that 
   it may constitute the voltage sensor region, possibly moving outward on 
   depolarisation, causing a conformational change. The 6-helix bundle is a 
   common structural motif in sodium channels (in which it is repeated 4 times
   within the sequence to form a 24-helix bundle), and in calcium channels 
   (where it also forms a 24-helix bundle, which itself is tightly bound 
   to 3 different subunits).
   
   KCHANNEL is an 8-element fingerprint that provides a signature for the 
   potassium channels. The fingerprint was derived from an initial alignment 
   of 16 sequences: motifs 1 and 2 were drawn from the cytoplasmic region 
   preceding the TM domains; motifs 3, 5, 6 and 8 encode loops between TM
   domains 1 and 2, 3 and 4, 4 and 5, and 5 and 6 respectively; motifs 4 and
   7 encode TM domains 2 and 5. Two iterations on OWL19.1 were required to
   reach convergence, at which point a true set comprising 56 sequences was
   identified. 
  
   An update on SPTR37_9f identified a true set of 97 sequences, and 15
   partial matches.

  SUMMARY INFORMATION
     97 codes involving  8 elements
      1 codes involving  7 elements
      0 codes involving  6 elements
      0 codes involving  5 elements
      0 codes involving  4 elements
      2 codes involving  3 elements
     12 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
    8|  97   97   97   97   97   97   97   97  
    7|   1    1    1    1    1    0    1    1  
    6|   0    0    0    0    0    0    0    0  
    5|   0    0    0    0    0    0    0    0  
    4|   0    0    0    0    0    0    0    0  
    3|   0    0    2    1    0    0    2    1  
    2|   0    0   12    0    0    0   12    0  
   --+-----------------------------------------
     |   1    2    3    4    5    6    7    8  

True positives..
 Q61923         CIK6_RAT       CIK6_HUMAN     CIK3_HUMAN     
 CIK3_RAT       CIK2_HUMAN     CIK2_MOUSE     CIK5_RABIT     
 P79197         CIK5_HUMAN     CIK5_RAT       CIK1_HUMAN     
 CIK1_MOUSE     CIK1_RAT       CIK3_MOUSE     Q91781         
 CIK4_RAT       CIK4_MUSPF     CIK4_BOVIN     CIK5_MOUSE     
 Q28656         CIK4_HUMAN     CIK2_XENLA     CIK4_MOUSE     
 Q28293         O61335         Q16968         CIK2_DROME     
 CIK4_DROME     CIK1_DROME     O70259         Q16322         
 Q25376         Q26597         Q28649         Q91592         
 CIKB_HUMAN     CIKB_RAT       Q91593         CIKA_HUMAN     
 Q14193         Q03717         O18868         CIKA_RAT       
 Q95167         O18476         CIKE_RAT       CIKD_MOUSE     
 CIKD_RAT       CIKD_HUMAN     O76805         CIKF_MOUSE     
 CIKF_RAT       CIKB_DROME     Q26095         CIKG_HUMAN     
 CIKG_RAT       CIKW_DROME     CIKL_DROME     Q26040         
 O08723         O60576         O60577         P70622         
 Q63286         O75671         Q03719         Q62897         
 Q63881         Q99249         Q26041         O62350         
 O76457         Q26094         Q09658         Q22012         
 P91784         O57662         O54900         O88759         
 O43651         P97557         Q60565         Q19464         
 O43527         O35174         O76266         O43652         
 O35173         O88758         O43528         Q16976         
 O73606         P91783         Q09937         P91256         
 Q18351         
Subfamily:  Codes involving 7 elements
 Subfamily True positives..
 Q20381         
Subfamily:  Codes involving 3 elements
 Subfamily True positives..
 O73925         Q18147         
Subfamily:  Codes involving 2 elements
 Subfamily True positives..
 CIK9_HUMAN     O60607         O00347         CIK9_MOUSE     
 Q99454         O88943         O75580         O43796         
 O43526         Y139_METJA     Q21584         O88944         


  PROTEIN TITLES
   Q61923           MURINE POTASSIUM CHANNEL PROTEIN - MUS MUSCULUS (MOUSE).
   CIK6_RAT         VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV1.6 (RCK2) (KV2) -
   CIK6_HUMAN       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV1.6 (HBK2) - HOMO 
   CIK3_HUMAN       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV1.3 (HPCN3) (HGK5)
   CIK3_RAT         VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV1.3 (RGK5) (RCK3) 
   CIK2_HUMAN       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV1.2 (RBK2) (HBK5) 
   CIK2_MOUSE       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV1.2 (RBK2) (RCK5) 
   CIK5_RABIT       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV1.5 - ORYCTOLAGUS 
   P79197           K+ CHANNEL KV1.5 - MUSTELA PUTORIUS FURO (FERRET).
   CIK5_HUMAN       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV1.5 (HK2) (HPCN1) 
   CIK5_RAT         VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV1.5 (KV1) (RCK7) -
   CIK1_HUMAN       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV1.1 (HUKI) (HBK1) 
   CIK1_MOUSE       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV1.1 (MK1) (MBK1) -
   CIK1_RAT         VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV1.1 (IA) (RBK1) (R
   CIK3_MOUSE       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV1.3 (MK3) - MUS MU
   Q91781           POTASSIUM CHANNEL - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
   CIK4_RAT         VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV1.4 (RCK4) (RHK1) 
   CIK4_MUSPF       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV1.4 (FK1) - MUSTEL
   CIK4_BOVIN       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV1.4 (BAK4) - BOS T
   CIK5_MOUSE       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV1.5 (KV1-5) - MUS 
   Q28656           GLIBENCLAMIDE-SENSITIVE VOLTAGE-GATED POTASSIUM CHANNEL - OR
   CIK4_HUMAN       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV1.4 (HK1) (HPCN2) 
   CIK2_XENLA       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV1.2 (XSHA2) - XENO
   CIK4_MOUSE       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV1.4 - MUS MUSCULUS
   Q28293           DELAYED RECTIFIER K+ CHANNEL - CANIS FAMILIARIS (DOG).
   O61335           POTASSIUM CHANNEL - PANULIRUS INTERRUPTUS (CALIFORNIA SPINY 
   Q16968           POTASSIUM CHANNEL - APLYSIA CALIFORNICA (CALIFORNIA SEA HARE
   CIK2_DROME       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN, LATE POPULATION (SH
   CIK4_DROME       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN, LARVAL (SHAKER-EPSI
   CIK1_DROME       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN, ADULT (SHAKER-ALPHA
   O70259           VOLTAGE-GATED POTASSIUM CHANNEL KV1.7 - MUS MUSCULUS (MOUSE)
   Q16322           CYCLIC GMP GATED POTASSIUM CHANNEL - HOMO SAPIENS (HUMAN).
   Q25376           VOLTAGE-DEPENDENT POTASSIUM CHANNEL SQKV1A - LOLIGO OPALESCE
   Q26597           POTASSIUM CHANNEL PROTEIN - SCHISTOSOMA MANSONI (BLOOD FLUKE
   Q28649           CGMP-GATED POTASSIUM CHANNEL - ORYCTOLAGUS CUNICULUS (RABBIT
   Q91592           POTASSIUM CHANNEL ALPHA SUBUNIT KV2.2 - XENOPUS LAEVIS (AFRI
   CIKB_HUMAN       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV2.2 - HOMO SAPIENS
   CIKB_RAT         VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV2.2 (CDRK) - RATTU
   Q91593           POTASSIUM CHANNEL ALPHA SUBUNIT KV2.1 - XENOPUS LAEVIS (AFRI
   CIKA_HUMAN       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV2.1 (DHK1) - HOMO 
   Q14193           H-DRK1 K(+) CHANNEL - HOMO SAPIENS (HUMAN).
   Q03717           POTASSIUM VOLTAGE GATED CHANNEL, SHAB-RELATED SUBFAMILY, MEM
   O18868           DELAYED RECTIFIER POTASSIUM CHANNEL KV2.1 - SUS SCROFA (PIG)
   CIKA_RAT         VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV2.1 (DRK1) - RATTU
   Q95167           DELAYED RECTIFIER POTASSIUM CHANNEL PROTEIN - CANIS FAMILIAR
   O18476           KV2 VOLTAGE-GATED POTASSIUM CHANNEL - LOLIGO PEALEII (LONGFI
   CIKE_RAT         VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV3.2 (KSHIIIA) - RA
   CIKD_MOUSE       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV3.1 (KV4) (NGK2) -
   CIKD_RAT         VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV3.1 (KV4) (NGK2) (
   CIKD_HUMAN       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV3.1 (KV4) (NGK2) -
   O76805           DELAYED RECTIFIER POTASSIUM CHANNEL - DROSOPHILA MELANOGASTE
   CIKF_MOUSE       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV3.3 (KSHIIID) - MU
   CIKF_RAT         VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV3.3 (KSHIIID) - RA
   CIKB_DROME       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN SHAB (SHAB11) - DROS
   Q26095           POTASSIUM CHANNEL HOMOLOG - POLYORCHIS PENICILLATUS (HYDROME
   CIKG_HUMAN       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV3.4 (KSHIIIC) - HO
   CIKG_RAT         VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KV3.4 (RAW3) - RATTU
   CIKW_DROME       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN SHAW (SHAW2) - DROSO
   CIKL_DROME       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN SHAL (SHAL2) - DROSO
   Q26040           SHAL 1 POTASSIUM CHANNEL - PANULIRUS INTERRUPTUS (CALIFORNIA
   O08723           KV4.3 - RATTUS NORVEGICUS (RAT).
   O60576           KV4.3 POTASSIUM CHANNEL SHORT SPLICE VARIANT - HOMO SAPIENS 
   O60577           KV4.3 POTASSIUM CHANNEL LONG SPLICE VARIANT - HOMO SAPIENS (
   P70622           KV4.3 POTASSIUM CHANNEL - RATTUS NORVEGICUS (RAT).
   Q63286           VOLTAGE-GATED K+ CHANNEL - RATTUS NORVEGICUS (RAT).
   O75671           SHAL-TYPE POTASSIUM CHANNEL - HOMO SAPIENS (HUMAN).
   Q03719           POTASSIUM VOLTAGE GATED CHANNEL, SHAL-RELATED FAMILY, MEMBER
   Q62897           SHAL-RELATED POTASSIUM CHANNEL KV4.3 - RATTUS NORVEGICUS (RA
   Q63881           SHAL1 - RATTUS NORVEGICUS (RAT).
   Q99249           POTASSIUM CHANNEL PROTEIN RK5 - RATTUS NORVEGICUS (RAT).
   Q26041           SHAW POTASSIUM CHANNEL - PANULIRUS INTERRUPTUS (CALIFORNIA S
   O62350           EGL-36 PROTEIN - CAENORHABDITIS ELEGANS.
   O76457           SHAW POTASSIUM CHANNEL KV3.1A - APLYSIA CALIFORNICA (CALIFOR
   Q26094           POTASSIUM CHANNEL HOMOLOG - POLYORCHIS PENICILLATUS (HYDROME
   Q09658           PUTATIVE POTASSIUM CHANNEL PROTEIN ZK1321.2 IN CHROMOSOME II
   Q22012           R186.5 PROTEIN - CAENORHABDITIS ELEGANS.
   P91784           POTASSIUM CHANNEL ALPHA SUBUNIT - POLYORCHIS PENICILLATUS (H
   O57662           POTASSIUM CHANNEL XKV4.3 - XENOPUS LAEVIS (AFRICAN CLAWED FR
   O54900           SHAB-RELATED DELAYED-RECTIFIER K+ CHANNEL - RATTUS NORVEGICU
   O88759           POTASSIUM CHANNEL, ALPHA SUBUNIT - RATTUS NORVEGICUS (RAT).
   O43651           SHAB-RELATED DELAYED-RECTIFIER K+ CHANNEL ALPHA SUBUNIT - HO
   P97557           NEURONAL POTASSIUM CHANNEL - RATTUS NORVEGICUS (RAT).
   Q60565           POTASSIUM CHANNEL KV8.1 - MESOCRICETUS AURATUS (GOLDEN HAMST
   Q19464           F14F11.1 PROTEIN - CAENORHABDITIS ELEGANS.
   O43527           POTASSIUM CHANNEL - HOMO SAPIENS (HUMAN).
   O35174           K+ VOLTAGE-GATED CHANNEL, SUBFAMILY S, 2 (POTASSIUM CHANNEL 
   O76266           VOLTAGE-GATED POTASSIUM-CHANNEL LKV1 - HIRUDO MEDICINALIS (M
   O43652           DELAYED-RECTIFIER K+ CHANNEL ALPHA SUBUNIT - HOMO SAPIENS (H
   O35173           K+ VOLTAGE-GATED CHANNEL, SUBFAMILY S, 1 (POTASSIUM CHANNEL 
   O88758           POTASSIUM CHANNEL, ALPHA SUBUNIT - RATTUS NORVEGICUS (RAT).
   O43528           POTASSIUM CHANNEL - HOMO SAPIENS (HUMAN).
   Q16976           NONINACTIVATING POTASSIUM CHANNEL - APLYSIA CALIFORNICA (CAL
   O73606           SHAB-LIKE VOLTAGE-GATED POTASSIUM CHANNEL CKV6.2 - GALLUS GA
   P91783           POTASSIUM CHANNEL GAMMA SUBUNIT - POLYORCHIS PENICILLATUS (H
   Q09937           HYPOTHETICAL 53.8 KD PROTEIN C53C9.3 IN CHROMOSOME X - CAENO
   P91256           EXP-2 PROTEIN - CAENORHABDITIS ELEGANS.
   Q18351           C32C4.1 PROTEIN - CAENORHABDITIS ELEGANS.
 
   Q20381           SIMILAR TO POTASSIUM CHANNEL PROTEIN. NCBI GI: 1123042 - CAE
 
   O73925           KVLQT POTASSIUM CHANNEL - SQUALUS ACANTHIAS (SPINY DOGFISH).
   Q18147           HYPOTHETICAL 83.8 KD PROTEIN C25B8.1 IN CHROMOSOME X - CAENO
 
   CIK9_HUMAN       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KQT-LIKE 1 (KV1.9) -
   O60607           SLOW DELAYED RECTIFIER CHANNEL SUBUNIT - HOMO SAPIENS (HUMAN
   O00347           KIDNEY AND CARDIAC VOLTAGE DEPENDENT K+ CHANNEL (VOLTAGE-GAT
   CIK9_MOUSE       VOLTAGE-GATED POTASSIUM CHANNEL PROTEIN KQT-LIKE 1 (KV1.9) -
   Q99454           HNSPC - HOMO SAPIENS (HUMAN).
   O88943           POTASSIUM CHANNEL - RATTUS NORVEGICUS (RAT).
   O75580           NEURONAL DELAYED-RECTIFIER VOLTAGE-GATED POTASSIUM CHANNEL S
   O43796           VOLTAGE GATED POTASSIUM CHANNEL - HOMO SAPIENS (HUMAN).
   O43526           POTASSIUM CHANNEL - HOMO SAPIENS (HUMAN).
   Y139_METJA       HYPOTHETICAL PROTEIN MJ0139 - METHANOCOCCUS JANNASCHII.
   Q21584           CODED FOR BY C. ELEGANS CDNA YK25B9.3 - CAENORHABDITIS ELEGA
   O88944           POTASSIUM CHANNEL - RATTUS NORVEGICUS (RAT).

SCAN HISTORY OWL19_1 2 100 NSINGLE OWL25_3 2 100 NSINGLE SPTR37_9f 2 129 NSINGLE INITIAL MOTIF SETS KCHANNEL1 Length of motif = 20 Motif number = 1 K+ channel motif I - 1 PCODE ST INT EYFFDRNRPSFDAILYYYQS CIK1_RAT 79 79 EYFFDRNRPSFDAILYYYQS CIK2_RAT 75 75 EYFFDRNRPSFDAILYYYQS CIK3_RAT 96 96 EYFFDRNRPSFDAILYYYQS CIK4_RAT 220 220 EYFFDRNRPSFDAILYYYQS CIK6_RAT 83 83 EYFFDRNRPSFDAILYYYQS RATRGK5 96 96 EYFFDRSRPSFDAILYYYQS CIK1_DROME 139 139 EYFFDRSRPSFDAILYYYQS CIK2_DROME 127 127 EYFFDRSRPSFDAILYYYQS CIK4_DROME 139 139 EYFFDRHPKSFSSILNFYRT CIKB_DROME 328 328 EYFFDRHPGVFAQVLNYYRT CIKW_DROME 52 52 EYFFDRDPDIFRHILNYYRT CIKL_DROME 82 82 EYFFDRHPGAFTSILNFYRT CIKA_RAT 78 78 EFFFDRHPGVFAYVLNYYRT CIKE_RAT 101 101 EFFFDRHPGVFAYVLNYYRT CIKF_RAT 101 101 EFFFDRHPGVFAYVLNYYRT CIKG_RAT 101 101 KCHANNEL2 Length of motif = 29 Motif number = 2 K+ channel motif II - 1 PCODE ST INT PESSGPARVIAIVSVMVILISIVIFCLET CIK1_RAT 160 61 PESSGPARIIAIVSVMVILISIVSFCLET CIK2_RAT 156 61 PESSGPARGIAIVSVLVILISIVIFCLET CIK3_RAT 177 61 PESSSPARGIAIVSVLVILISIVIFCLET CIK4_RAT 302 62 PESSGPARGIAIVSVLVILISIVIFCLET CIK6_RAT 167 64 PESSRPARGIAIVSVLVILISIVIFCLET RATRGK5 177 61 PESSQAARVVAIISVFVILLSIVIFCLET CIK1_DROME 220 61 PESSQAARVVAIISVFVILLSIVIFCLET CIK2_DROME 208 61 PESSQAARVVAIISVFVILLSIVIFCLET CIK4_DROME 220 61 PNTSFAARVIAVISILFIVLSTIALTLNT CIKB_DROME 428 80 PYSSNAAKTIGVVSVFFICISILSFCLKT CIKW_DROME 167 95 PHTSTSALVFYYVTGFFIAVSVMANVVET CIKL_DROME 178 76 PNSSVAAKILAIISIMFIVLSTIALSLNT CIKA_RAT 178 80 PYSSRAARFIAFASLFFILVSITTFCLET CIKE_RAT 222 101 PYSSRAARFIAFASLFFILVSITTFCLET CIKF_RAT 222 101 PYSSRAARFIAFASLFFILVSITTFCLET CIKG_RAT 222 101 KCHANNEL3 Length of motif = 24 Motif number = 3 K+ channel motif III - 1 PCODE ST INT IVETLCIIWFSFELVVRFFACPSK CIK1_RAT 223 34 IVETLCIIWFSFEFLVRFFACPSK CIK2_RAT 224 39 VVETLCIIWFSFELLVRFFACPSK CIK3_RAT 247 41 IVETVCIVWFSFEFVVRCFACPSQ CIK4_RAT 375 44 LVETLCIVWFTFELLVRFSACPSK CIK6_RAT 266 70 VVETLCIIWFSFELLVRFFACPSK RATRGK5 247 41 LIETLCIIWFTFELTVRFLACPNK CIK1_DROME 281 32 LIETLCIIWFTFELTVRFLACPNK CIK2_DROME 269 32 LIETLCIIWFTFELTVRFLACPNK CIK4_DROME 281 32 MVEAVCITWFTLEYILRFSSSPDK CIKB_DROME 476 19 YIECVCNAWFTFEILVRFISSPNK CIKW_DROME 233 37 CLDTACVMIFTAEYLLRLFAAPDR CIKL_DROME 231 24 HVEAVCIAWFTMEYLLRFLSSPKK CIKA_RAT 227 20 YVEGVCVVWFTFEFLVRIVFSPNK CIKE_RAT 284 33 YVEGVCVVWFTFEFLVRIVFSPNK CIKF_RAT 284 33 YVEGVCVVWFTFEFLVRIVFSPNK CIKG_RAT 284 33 KCHANNEL4 Length of motif = 21 Motif number = 4 K+ channel motif IV - 1 PCODE ST INT FFKNIMNFIDIVAIIPYFITL CIK1_RAT 249 2 FFTNIMNIIDIVAIIPYFITL CIK2_RAT 250 2 FSRNIMNLIDIVAIIPYFITL CIK3_RAT 273 2 FFKNIMNIIDIVSILPYFITL CIK4_RAT 401 2 FFRNIMNIIDLVAIFPYFITL CIK6_RAT 292 2 FSRNIMNLIDIVAIIPYFITL RATRGK5 273 2 FCRDVMNVIDIIAIIPYFITL CIK1_DROME 307 2 FCRDVMNVIDIIAIIPYFITL CIK2_DROME 295 2 FCRDVMNVIDIIAIIPYFITL CIK4_DROME 307 2 FFKGGLNIIDLLAILPYFVSL CIKB_DROME 502 2 FIKSSVNIIDYIATLSFYIDL CIKW_DROME 259 2 FVRSVMSIIDVVAIMPYYIGL CIKL_DROME 257 2 FFKGPLNAIDLLAILPYYVTI CIKA_RAT 253 2 FIKNLLNIIDFVAILPFYLEV CIKE_RAT 310 2 FIKNLLNIIDFVAILPFYLEV CIKF_RAT 310 2 FIKNLLNIIDFVAILPFYLEV CIKG_RAT 310 2 KCHANNEL5 Length of motif = 27 Motif number = 5 K+ channel motif V - 1 PCODE ST INT LVRVFRIFKLSRHSKGLQILGQTLKAS CIK1_RAT 296 26 LVRVFRIFKLSRHSKGLQILGQTLKAS CIK2_RAT 298 27 LVRVFRIFKLSRHSKGLQILGQTLKAS CIK3_RAT 318 24 LVRVFRIFKLSRHSKGLQILGHTLRAS CIK4_RAT 450 28 LVRVFRIFKLSRHSKGLQILGKTLQAS CIK6_RAT 347 34 LVRVFRIFKLSRHSKGLQILGQTLKAS RATRGK5 318 24 LVRVFRIFKLSRHSKGLQILGRTLKAS CIK1_DROME 366 38 LVRVFRIFKLSRHSKGLQILGRTLKAS CIK2_DROME 354 38 LVRVFRIFKLSRHSKGLQILGRTLKAS CIK4_DROME 366 38 IMRILRVLKLARHSTGLQSLGFTLRNS CIKB_DROME 547 24 IIRIMRLFKLTRHSSGLKILIQTFRAS CIKW_DROME 299 19 VFRVFRIFKFSRHSQGLRILGYTLKSC CIKL_DROME 294 16 IMRILRILKLARHSTGLQSLGFTLRRS CIKA_RAT 297 23 FVRILRIFKLTRHFVGLRVLGHTLRAS CIKE_RAT 352 21 FVRILRIFKLTRHFVGLRVLGHTLRAS CIKF_RAT 352 21 FVRILRIFKLTRHFVGLRVLGHTLRAS CIKG_RAT 352 21 KCHANNEL6 Length of motif = 24 Motif number = 6 K+ channel motif VI - 1 PCODE ST INT ELGLLIFFLFIGVILFSSAVYFAE CIK1_RAT 325 2 ELGLLIFFLFIGVILFSSAVYFAE CIK2_RAT 327 2 ELGLLIFFLFIGVILFSSAVYFAE CIK3_RAT 347 2 ELGLLIFFLFIGVILFSSAVYFAE CIK4_RAT 479 2 ELGLLIFFLFIGVILFSSAVYFAE CIK6_RAT 376 2 ELGLLIFFLFIGVILFSSAVYFAE RATRGK5 347 2 ELGLLIFFLFIGVVLFSSAVYFAE CIK1_DROME 395 2 ELGLLIFFLFIGVVLFSSAVYFAE CIK2_DROME 383 2 ELGLLIFFLFIGVVLFSSAVYFAE CIK4_DROME 395 2 ELGLLMLFLAMGVLIFSSLAYFAE CIKB_DROME 576 2 ELTLLVFFLVLGIVIFASLVYYAE CIKW_DROME 328 2 ELGFLVFSLAMAIIIFATVMFYAE CIKL_DROME 323 2 ELGLLILFLAMGIMIFSSLVFFAE CIKA_RAT 326 2 EFLLLIIFLALGVLIFATMIYYAE CIKE_RAT 381 2 EFLLLIIFLALGVLIFATMIYYAE CIKF_RAT 381 2 EFLLLIIFLALGVLIFATMIYYAE CIKG_RAT 381 2 KCHANNEL7 Length of motif = 23 Motif number = 7 K+ channel motif VII - 1 PCODE ST INT FSSIPDAFWWAVVSMTTVGYGDM CIK1_RAT 356 7 FPSIPDAFWWAVVSMTTVGYGDM CIK2_RAT 358 7 FNSIPDAFWWAVVTMTTVGYGDM CIK3_RAT 378 7 FQSIPDAFWWAVVTMTTVGYGDM CIK4_RAT 510 7 FPSIPDAFWWAVVTMTTVGYGDM CIK6_RAT 407 7 FNSIPDAFWWAVVTMTTVGYGDM RATRGK5 378 7 FKSIPDAFWWAVVTMTTVGYGDM CIK1_DROME 426 7 FKSIPDAFWWAVVTMTTVGYGDM CIK2_DROME 414 7 FKSIPDAFWWAVVTMTTVGYGDM CIK4_DROME 426 7 FVSIPEAFWWAGITMTTVGYGDI CIKB_DROME 607 7 FNSIPLGLWWALVTMTTVGYGDM CIKW_DROME 361 9 FTSIPAAFWYTIVTMTTLGYGDM CIKL_DROME 354 7 FKSIPASFWWATITMTTVGYGDI CIKA_RAT 357 7 FKNIPIGFWWAVVTMTTLGYGDM CIKE_RAT 421 16 FKNIPIGFWWAVVTMTTLGYGDM CIKF_RAT 421 16 FKNIPIGFWWAVVTMTTLGYGDM CIKG_RAT 421 16 KCHANNEL8 Length of motif = 27 Motif number = 8 K+ channel motif VIII - 1 PCODE ST INT GKIVGSLCAIAGVLTIALPVPVIVSNF CIK1_RAT 385 6 GKIVGSLCAIAGVLTIALPVPVIVSNF CIK2_RAT 387 6 GKIVGSLCAIAGVLTIALPVPVIVSNF CIK3_RAT 407 6 GKIVGSLCAIAGVLTIALPVPVIVSNF CIK4_RAT 539 6 GKIVGSLCAIAGVLTIALPVPVIVSNF CIK6_RAT 436 6 GKIVGSLCAIAGVLTIALPVPVILSNF RATRGK5 407 6 GKIVGSLCVVAGVLTIALPVPVIVSNF CIK1_DROME 455 6 GKIVGSLCAIAGVLTIALPVPVIVSNF CIK2_DROME 443 6 GKIVGSLCAIAGVLTIALPVPVIVSNF CIK4_DROME 455 6 GKVIGTVCCICGVLVVALPIPIIVNNF CIKB_DROME 636 6 GMFVGALCALAGVLTIALPVPVIVSNF CIKW_DROME 390 6 GKIVGGVCSLSGVLVIALPVPVIVSNF CIKL_DROME 383 6 GKIVGGLCCIAGVLVIALPIPIIVNNF CIKA_RAT 386 6 GMLVGALCALAGVLTIAMPVPVIVNNF CIKE_RAT 450 6 GMLVGALCALAGVLTIAMPVPVIANNF CIKF_RAT 450 6 GMLVGALCALAGVLTIAMPVPVIVNNF CIKG_RAT 450 6 FINAL MOTIF SETS KCHANNEL1 Length of motif = 20 Motif number = 1 K+ channel motif I - 2 PCODE ST INT EYFFDRNRPSFDAILYYYQS CIK6_HUMAN 83 83 EYFFDRNRPSFDAILYYYQS CIK6_RAT 83 83 EYFFDRNRPSFDAILYYYQS Q61923 83 83 EYFFDRNRPSFDAILYYYQS CIK3_HUMAN 94 94 EYFFDRNRPSFDAILYYYQS CIK3_RAT 96 96 EYFFDRNRPSFDAILYYYQS CIK2_HUMAN 75 75 EYFFDRNRPSFDAILYYYQS CIK2_MOUSE 75 75 EYFFDRNRPSFDGILYYYQS CIK5_RABIT 146 146 EYFFDRNRPSFDGILYYYQS P79197 151 151 EYFFDRNRPSFDGILYYYQS CIK5_HUMAN 162 162 EYFFDRNRPSFDGILYYYQS CIK5_RAT 153 153 EYFFDRNRPSFDAILYYYQS CIK1_HUMAN 79 79 EYFFDRNRPSFDAILYYYQS CIK1_MOUSE 79 79 EYFFDRNRPSFDAILYYYQS CIK1_RAT 79 79 EYFFDRNRPSFDAILYYYQS CIK3_MOUSE 99 99 EYFFDRNRPSFDAILYYYQS Q91781 76 76 EYFFDRNRPSFDAILYYYQS CIK4_BOVIN 226 226 EYFFDRNRPSFDAILYYYQS CIK4_MUSPF 219 219 EYFFDRNRPSFDAILYYYQS CIK4_RAT 220 220 EYFFDRNRPSFDGILYYYQS CIK5_MOUSE 153 153 EYFFDRNRPSFDAILYYYQS Q28656 87 87 EYFFDRNRPSFDAILYYYQS CIK4_HUMAN 218 218 EYFFDRNRPSFDAILYFYQS CIK2_XENLA 75 75 EYFFDRNRPSFDAILYYYQS CIK4_MOUSE 219 219 EIFFVRNRPSFDAILYYYQS Q28293 75 75 EYFFDRNRPSFDAILYYYQS O61335 96 96 EYFFDRNRPSFDAILYFYQS Q16968 108 108 EYFFDRSRPSFDAILYYYQS CIK2_DROME 127 127 EYFFDRSRPSFDAILYYYQS CIK4_DROME 139 139 EYFFDRSRPSFDAILYYYQS CIK1_DROME 139 139 EYFFDRHRPSFDAVLYYYQS O70259 133 133 EYFFDRNRPSFDGILYYYQS Q16322 128 128 EYFFDGNRPSFDAILYFYHS Q25376 82 82 EYFFDRNRSSFDGILYFYQS Q26597 93 93 EYFFDRNRPSFDGILYYYQS Q28649 339 339 EYFFDRHPGAFTSILNFYRT Q91592 86 86 EYFFDRHPGAFTSILNFYRT CIKB_HUMAN 86 86 EYFFDRHPGAFTSILNFYRT CIKB_RAT 86 86 EYFFDRHPGAFTSILNFYRT Q91593 82 82 EYFFDRHPGAFTSILNFYRT CIKA_HUMAN 78 78 EYFFDRHPGAFTSILNFYRT Q14193 82 82 EYFFDRHPGAFTSILNFYRT Q03717 82 82 EYFFDRHPGAFTSILNFYRT O18868 82 82 EYFFDRHPGAFTSILNFYRT CIKA_RAT 78 78 EYFFDRHPGAFTSILNFYRT Q95167 86 86 EYFFDRHPRSFASILNFYRT O18476 274 274 EFFFDRHPGVFAYVLNYYRT CIKE_RAT 101 101 EFFFDRHPGVFAHILNYYRT CIKD_MOUSE 54 54 EFFFDRHPGVFAHILNYYRT CIKD_RAT 54 54 EFFFDRHPGVFAHILNYYRT CIKD_HUMAN 54 54 EYFFDRHPKSFSSILNFYRT O76805 328 328 EFFFDRHPGVFAYVLNYYRT CIKF_MOUSE 135 135 EFFFDRHPGVFAYVLNYYRT CIKF_RAT 136 136 EYFFDRHPKSFSSILNFYRT CIKB_DROME 328 328 EYFFDRHRKAFNGILYYYQS Q26095 96 96 EFFFDRHPGVFAYVLNYYRT CIKG_HUMAN 93 93 EFFFDRHPGVFAYVLNYYRT CIKG_RAT 94 94 EYFFDRHPGVFAQVLNYYRT CIKW_DROME 52 52 EYFFDRDPDIFRHILNYYRT CIKL_DROME 82 82 EYFFDRDPDIFRHILNYYRT Q26040 82 82 EYFFDRDPEVFRCVLNFYRT O08723 81 81 EYFFDRDPEVFRCVLNFYRT O60576 81 81 EYFFDRDPEVFRCVLNFYRT O60577 81 81 EYFFDRDPEVFRCVLNFYRT P70622 81 81 EYFFDRDPEVFRCVLNFYRT Q63286 81 81 EYFFDRDPDMFRHVLNFYRT O75671 81 81 EYFFDRDPDMFRHVLNFYRT Q03719 81 81 EYFFDRDPEVFRCVLNFYRT Q62897 81 81 QYFFDRDPDIFRHILNFYRT Q63881 82 82 QYFFDRDPDIFRHILNFYRT Q99249 82 82 EYFFDRHPGVFAQVLNYYRT Q26041 47 47 EYFFDRHPAVFAMILNYYRT O62350 79 79 EYFFDRHPGVFAQILNYYRS O76457 52 52 ELFFDRHRPTFESILYYYQS Q26094 85 85 EFFFDRHRTTFESILYIYQS Q09658 111 111 EYFFDRHPGVFAQILNYYRT Q22012 47 47 EYYFDRDPDLFRHILNYYRT P91784 85 85 EYFFDRDPEVFRSILNFYRT O57662 81 81 EYYFDRNPSLFRYVLNFYYT O54900 66 66 EYYFDRNPSLFRYVLNFYYT O88759 66 66 EYYFDRNPSLFRYVLNFYYT O43651 66 66 EYFFDRSSQAFRYVLHYYRT P97557 103 103 EYFFDRSSQAFRYVLHYYRT Q60565 104 104 EYFFDRHPGVFSMILNYYRT Q19464 47 47 EFYFDRDPDAFKCVIEVYYF O43527 76 76 EFYFDRNPELFPYVLHFYHT O35174 68 68 EYFFDRHRPTFEIVFAYFQY O76266 123 123 EFYFDRHPGFFLSLLHFYRT O43652 101 101 EFYFDRHPGFFLGLLHFYRT O35173 70 70 EFYFDRHPGFFLGLLHFYRT O88758 70 70 EFFFDRNPGAFGTILTFLRA O43528 114 114 EYFFDRHPSVFNSIIDFYRT Q16976 106 106 EFFFDRNPSAFRTIMTFLTA O73606 108 108 EYFFDRDPHIFRLILKFYKT P91783 78 78 EYYLERSAVLFDSIFKYYIS Q09937 132 132 AYYFQRSPTSFEAVFQYYAT P91256 146 146 EYYLERNAKLTDHVMDFFVT Q18351 79 79 KCHANNEL2 Length of motif = 29 Motif number = 2 K+ channel motif II - 2 PCODE ST INT PESSGPARGIAIVSVLVILISIVIFCLET CIK6_HUMAN 167 64 PESSGPARGIAIVSVLVILISIVIFCLET CIK6_RAT 167 64 PESSGPARGIAIVSVLVILISIVIFCLET Q61923 167 64 PESSGPARGIAIVSVLVILISIVIFCLET CIK3_HUMAN 175 61 PESSGPARGIAIVSVLVILISIVIFCLET CIK3_RAT 177 61 PESSGPARIIAIVSVMVILISIVSFCLET CIK2_HUMAN 156 61 PESSGPARIIAIVSVMVILISIVSFCLET CIK2_MOUSE 156 61 PESSGSARAIAIVSVLVILISIITFCLET CIK5_RABIT 227 61 PESSGSARGIAIVSVLVILISIITFCLET P79197 232 61 PESSGSARAIAIVSVLVILISIITFCLET CIK5_HUMAN 243 61 PESSGSARAIAIVSVLVILISIITFCLET CIK5_RAT 234 61 PESSGPARVIAIVSVMVILISIVIFCLET CIK1_HUMAN 160 61 PESSGPARVIAIVSVMVILISIVIFCLET CIK1_MOUSE 160 61 PESSGPARVIAIVSVMVILISIVIFCLET CIK1_RAT 160 61 PESSGPARGIAIVSVLVILISIVIFCLET CIK3_MOUSE 180 61 PESSGPARIIAIISVMVILISIVIFCLET Q91781 157 61 PESSSPARGIAIVSVLVILISIVIFCLET CIK4_BOVIN 308 62 PESSSPARGIAIVSVLVILISIVIFCLET CIK4_MUSPF 301 62 PESSSPARGIAIVSVLVILISIVIFCLET CIK4_RAT 302 62 PESSGSARAIAIVSVSVILISIITFCLET CIK5_MOUSE 234 61 PESSGPARGIAIVSVLVILISIVIFCLET Q28656 168 61 PESSDPARGIAIVSVLVILISIVIFCLET CIK4_HUMAN 300 62 PESSGPARIIAIISVTVILISIVSFCLET CIK2_XENLA 156 61 PESSSPARGIAIVSVLVILISIVIFCLET CIK4_MOUSE 301 62 PESSGPARIIAIVSVMVILISIVSFCLET Q28293 156 61 PESSQNARVVAIISVFVILLSIVIFCLET O61335 177 61 PESSAAARLCAIFSVVIILLSIVIFCLET Q16968 189 61 PESSQAARVVAIISVFVILLSIVIFCLET CIK2_DROME 208 61 PESSQAARVVAIISVFVILLSIVIFCLET CIK4_DROME 220 61 PESSQAARVVAIISVFVILLSIVIFCLET CIK1_DROME 220 61 PESSQAARVLAVVSVLVILVSIVVFCLET O70259 211 58 PESSSAARAVAVVSVLVVVISITIFCLET Q16322 209 61 PESSTPARVIAIVSVSVIVISIVTFCLET Q25376 163 61 PESSLAARILAIGSVFVILLSIIIFCLET Q26597 174 61 KGAPHAARTVAVVSVLVVVISITIFCLVT Q28649 422 63 PNSSVAAKVLAIISILFIVLSTIALSLNT Q91592 186 80 PNSSVAAKILAIVSILFIVLSTIALSLNT CIKB_HUMAN 186 80 PNSSVAAKILAIVSILFIVLSTIALSLNT CIKB_RAT 186 80 PNSSVAAKILAIISILFIVLSTIALSLNT Q91593 182 80 PNSSVAAKILAIISIMFIVLSTIALSLNT CIKA_HUMAN 178 80 PNSSVAAKILAIISIMFIVLSTIALSLNT Q14193 182 80 PNSSVAAKILAIISIMFIVLSTIALSLNT Q03717 182 80 PNSSVAAKILAIISIMFIVLSTIALSLNT O18868 182 80 PNSSVAAKILAIISIMFIVLSTIALSLNT CIKA_RAT 178 80 PNSSVAAKILAIVSNLFIVLSTIALSLNT Q95167 186 80 PTTSMAARVLAIVSILFVVLSTVALTLNT O18476 374 80 PYSSRAARFIAFASLFFILVSITTFCLET CIKE_RAT 222 101 PYSSRYARYVAFASLFFILVSITTFCLET CIKD_MOUSE 183 109 PYSSRYARYVAFASLFFILVSITTFCLET CIKD_RAT 183 109 PYSSRYARYVAFASLFFILVSITTFCLET CIKD_HUMAN 183 109 PNTSFAARVIAVISILFIVLSTIALTLNT O76805 428 80 PYSSRAARYVAFASLFFILISITTFCLET CIKF_MOUSE 283 128 PYSSRAARYVAFASLFFILISITTFCLET CIKF_RAT 284 128 PNTSFAARVIAVISILFIVLSTIALTLNT CIKB_DROME 428 80 PSSSIYAKIVAIISVLVILISIVVFCLET Q26095 175 59 PYSSRAARVVAFASLFFILVSITTFCLET CIKG_HUMAN 219 106 PYSSRAARVVAFASLFFILVSITTFCLET CIKG_RAT 220 106 PYSSNAAKTIGVVSVFFICISILSFCLKT CIKW_DROME 167 95 PHTSTSALVFYYVTGFFIAVSVMANVVET CIKL_DROME 178 76 PHTSTAALVFYYVTGFFIAVSVMANVVET Q26040 178 76 PHTSTLALVFYYVTGFFIAVSVITNVVET O08723 176 75 PHTSTLALVFYYVTGFFIAVSVITNVVET O60576 176 75 PHTSTLALVFYYVTGFFIAVSVITNVVET O60577 176 75 PHTSTLALVFYYVTGFFIAVSVITNVVET P70622 176 75 PHTSTLALVFYYVTGFFIAVSVITNVVET Q63286 176 75 PHTSTAALVFYYVTGFFIAVSVIANVVET O75671 179 78 PHTSTAALVFYYVTGFFIAVSVIANVVET Q03719 179 78 PHTSTLALVFYYVTGFFIAVSVITNVVET Q62897 176 75 PHTSTMALVFYYVTGFFIAVSVIANVVET Q63881 178 76 PHTSTMALVFYYVTGFFIAVSVIANVVET Q99249 178 76 PYSSQAAKVIGVISVFFICVSILSFCLKT Q26041 162 95 PYSSQAAKLIAGISVLFIFISIFSFCLKT O62350 197 98 PYSSTAAKIIAVISVFFIVISILSFCLKT O76457 167 95 PDSSNAAKIFAILSVVIIVVSLIMFVIET Q26094 167 62 PDSSLSARIIAFISIAVIALSIISFCWET Q09658 192 61 PNSSRSAQFIAAISVFFLITAIIVFCLKT Q22012 162 95 PQSTFLARILYYITGFFIAVSVGSTIIET P91784 195 90 PHTSTLALVFYYVTGFFIAVSVIANVVET O57662 176 75 PAYCLSAKLIAISSLSVVLASIVAMCVHS O54900 178 92 PAYCLSAKLIAISSLSVVLASIVAMCVHS O88759 178 92 PAYCLSAKLIAISSLSVVLASIVAMCVHS O43651 178 92 PGSSTAARIFGVISIIFVAVSIVNMALMS P97557 206 83 PGSSTAARIFGVISIIFVAVSIVNMALMS Q60565 207 83 PWSSKYARVISSLSVAFILASTCSFILKT Q19464 162 95 PESSCPARVVAELSFLLILVSSVVMCMDT O43527 175 79 PGYSVLSRVFSVLSILVVLGSIITMCLNS O35174 180 92 PETSATAYAVAFISVIMTTISIILFCVET O76266 203 60 PGYSLPSKLFSCVSISVVLASIAAMCIHS O43652 213 92 PGYSLPSKLFSCVSIGVVLASIAAMCIHS O35173 182 92 PGYSLPSKLFSCVSIGVVLASIAAMCIHS O88758 182 92 PHSGLPGKVFACLSVLFVTVTAVNLSVST O43528 220 86 PRTSRLAMIYGVTSFLFVVTSIAGFCLET Q16976 207 81 PHSGIPGKIFACISISFVAITAVSLCIST O73606 210 82 PTFSLAAKCFYYFSCLVITLSIVVNTVET P91783 166 68 GDGSLFSTLFTFGSITFVLISVIGLVLGS Q09937 221 69 PGSSMQAKAFELSSTLFVAISVMGLSFGT P91256 238 72 PQSSVFAAVFALLSVFFVFASVVGLILGS Q18351 175 76 KCHANNEL3 Length of motif = 24 Motif number = 3 K+ channel motif III - 2 PCODE ST INT LVETLCIVWFTFELLVRFSACPSK CIK6_HUMAN 265 69 LVETLCIVWFTFELLVRFSACPSK CIK6_RAT 266 70 LVETLCIVWFTFELLVRFSACPSK Q61923 265 69 VVETLCIIWFSFELLVRFFACPSK CIK3_HUMAN 245 41 VVETLCIIWFSFELLVRFFACPSK CIK3_RAT 247 41 IVETLCIIWFSFEFLVRFFACPSK CIK2_HUMAN 224 39 IVETLCIIWFSFEFLVRFFACPSK CIK2_MOUSE 224 39 IVETTCVIWFTFELLVRFFACPSK CIK5_RABIT 311 55 IVETTCVIWFTFELLVRFFACPSK P79197 315 54 IVETTCVIWFTFELLVRFFACPSK CIK5_HUMAN 326 54 IVETTCVIWFTFELLVRFFACPSK CIK5_RAT 317 54 IVETLCIIWFSFELVVRFFACPSK CIK1_HUMAN 223 34 IVETLCIIWFSFELVVRFFACPSK CIK1_MOUSE 223 34 IVETLCIIWFSFELVVRFFACPSK CIK1_RAT 223 34 VVETLCIIWFSFELLVRFFACPSK CIK3_MOUSE 250 41 VVETLCIIWFSFELVVRFFACPSK Q91781 217 31 IVETVCIVWFSFEFVVRCFACPSQ CIK4_BOVIN 381 44 IVETVCIVWFSFEFVVRCFACPSQ CIK4_MUSPF 374 44 IVETVCIVWFSFEFVVRCFACPSQ CIK4_RAT 375 44 IVETTCVIWFTFELLVRFFACPSK CIK5_MOUSE 317 54 VVETLCIIWFSFELLVRFFACPSK Q28656 238 41 IVETVCIVWFSFEFVVRCFACPSQ CIK4_HUMAN 373 44 IVETLCIIWFSFEFLVRFLACPSK CIK2_XENLA 224 39 IVETVCIVWFSFEFVVRCFACTSQ CIK4_MOUSE 374 44 IVETLCIIWFSFEFLVRFFACPSK Q28293 224 39 LIETICIVWFSTELLVRFFASPLK O61335 238 32 IIETCCIIWFTFELLVRFASCPEK Q16968 252 34 LIETLCIIWFTFELTVRFLACPNK CIK2_DROME 269 32 LIETLCIIWFTFELTVRFLACPNK CIK4_DROME 281 32 LIETLCIIWFTFELTVRFLACPNK CIK1_DROME 281 32 VVETLCICWFSFELLVHLVACPSK O70259 287 47 MVESTCIVWFTFELVLRFVVCPSK Q16322 273 35 IIETGCIIWFTMELLIRFASCPGK Q25376 220 28 IIETFCIVWFSCELLVRFASSPKK Q26597 240 37 MVESTCIVWFTLELVLRFVVCPSK Q28649 487 36 HVEAVCIAWFTMEYLLRFLSSPNK Q91592 235 20 HVEAVCIAWFTMEYLLRFLSSPNK CIKB_HUMAN 235 20 HVEAVCIAWFTMEYLLRFLSSPNK CIKB_RAT 235 20 HVEAVCIAWFTMEYLLRFLSSPNK Q91593 231 20 HVEAVCIAWFTMEYLLRFLSSPKK CIKA_HUMAN 227 20 HVEAVCIAWFTMEYLLRFLSSPKK Q14193 231 20 HVEAVCIAWFTMEYLLRFLSSPKK Q03717 231 20 HVEAVCIAWFTMEYLLRFLSSPKK O18868 231 20 HVEAVCIAWFTMEYLLRFLSSPKK CIKA_RAT 227 20 HVEAVCNAWFTMEYLLRFLSSPNK Q95167 235 20 IVEAVCIGWFTLEYLGRFWASPNK O18476 422 19 YVEGVCVVWFTFEFLVRIVFSPNK CIKE_RAT 284 33 YIEGVCVVWFTFEFLMRVVFCPNK CIKD_MOUSE 247 35 YIEGVCVVWFTFEFLMRVVFCPNK CIKD_RAT 247 35 YIEGVCVVWFTFEFLMRVIFCPNK CIKD_HUMAN 247 35 MVEAVCITWFTLEYILRFSASPDK O76805 476 19 YVEGVCVVWFTFEFLMRVTFCPDK CIKF_MOUSE 350 38 YVEGVCVVWFTFEFLMRVTFCPDK CIKF_RAT 351 38 MVEAVCITWFTLEYILRFSSSPDK CIKB_DROME 476 19 IINTICNSWFTLEYLLRLIASPNK Q26095 223 19 YIEGVCVLWFTLEFLVRIVCCPDT CIKG_HUMAN 283 35 YIEGVCVMWFTLEFLVRIVCCPDT CIKG_RAT 284 35 YIECVCNAWFTFEILVRFISSPNK CIKW_DROME 233 37 CLDTACVMIFTAEYLLRLFAAPDR CIKL_DROME 231 24 CGDTACVMIFTAEYLLRMFAAPDR Q26040 231 24 CLDTACVMIFTVEYLLRLFAAPSR O08723 228 23 CLDTACVMIFTGEYLLRLFAAPSR O60576 228 23 CLDTACVMIFTGEYLLRLFAAPSR O60577 228 23 CLDTACVMIFTVEYLLRLFAAPSR P70622 228 23 CLDTACVMIFTVEYLLRLFAAPSR Q63286 228 23 CMDTACVLIFTGEYLLRLFAAPSR O75671 233 25 CMDTACVLIFTGEYLLRLFAAPSR Q03719 233 25 CLDTACVMIFTVEYLLRLFAAPSR Q62897 228 23 CLDTACVMIFTVEYLLRLAAAPSR Q63881 231 24 CLDTACVMIFTVEYLLRLAAAPSR Q99249 231 24 YIECVCNTWFTFEILIRLIASPNK Q26041 228 37 QIEMLCNIWFTLELIIRFVFCPSK O62350 263 37 YIECASNAWFTFEIIIRFVVAPNK O76457 233 37 TVNTAVICWFTIEFILRLICCPNK Q26094 225 29 WIELMCILWFTIELILRFISCPCK Q09658 252 31 YIETICNIWFTIEILARFSSCPSR Q22012 236 45 NIEAVCVVVFTIEYLARLYSAPCR P91784 242 18 CLDTACVMIFTVEYLLRLFAAPSR O57662 228 23 GVEIACIAWFTGELAIRLVAAPSQ O54900 224 17 GVEIACIAWFTGELAIRLVAAPSQ O88759 224 17 GVEIACIAWFTGELAVRLAAAPCQ O43651 224 17 ILEYVCISWFTGEFILRFLCVKDR P97557 247 12 ILEYVCISWFTGEFILRFLCVKDR Q60565 248 12 YVDLICNIWFTIELLIRSLFCPSF Q19464 235 44 NVETACIGWFTLEYLLRLFSSPNK O43527 224 20 IVEHFGIAWFTFELVARFAVAPDF O35174 229 20 IIETICTAWFTFEAIVRFISCPNK O76266 254 22 RLEYFCIAWFSFEVSSRLLLAPST O43652 274 32 RLEYFCIAWFSFEVSSRLLLAPST O35173 243 32 RLEYFCIAWFSFEVSSRLLLAPST O88758 243 32 IVESVCVGWFSLEFLLRLIQAPSK O43528 270 21 TLDIICTVFFTLELILRFIFAPDK Q16976 270 34 VLETVCVAWFSFEFLLRSIQAENK O73606 260 21 VLDSACVTFFALEYMFRFYSTDNR P91783 220 25 YVETVCIIWFTVEFIVRLAVTPNR Q09937 288 38 FTERICIAFFTVEYCLRFFAAPRK P91256 308 41 ILEYICIGWFTFEYLVRFTIYPRK Q18351 262 58 KCHANNEL4 Length of motif = 21 Motif number = 4 K+ channel motif IV - 2 PCODE ST INT FFRNIMNIIDLVAIFPYFITL CIK6_HUMAN 291 2 FFRNIMNIIDLVAIFPYFITL CIK6_RAT 292 2 FFRNIMNIIDLVAIFPYFITL Q61923 291 2 FSRNIMNLIDIVAIIPYFITL CIK3_HUMAN 271 2 FSRNIMNLIDIVAIIPYFITL CIK3_RAT 273 2 FFTNIMNIIDIVAIIPYFITL CIK2_HUMAN 250 2 FFTNIMNIIDIVAIIPYFITL CIK2_MOUSE 250 2 FSRNIMNIIDIVAIFPYFITL CIK5_RABIT 337 2 FSRNIMNIIDVVAIFPYFITL P79197 341 2 FSRNIMNIIDVVAIFPYFITL CIK5_HUMAN 352 2 FSRNIMNIIDVVAIFPYFITL CIK5_RAT 343 2 FFKNIMNFIDIVAIIPYFITL CIK1_HUMAN 249 2 FFKNIMNFIDIVAIIPYFITL CIK1_MOUSE 249 2 FFKNIMNFIDIVAIIPYFITL CIK1_RAT 249 2 FSRNIMNLIDIVAIIPYFITL CIK3_MOUSE 276 2 FFKNIMNFIDIVAIIPYFITL Q91781 243 2 FFKNIMNIIDIVSILPYFITL CIK4_BOVIN 407 2 FFKNIMNIIDIVSILPYFITL CIK4_MUSPF 400 2 FFKNIMNIIDIVSILPYFITL CIK4_RAT 401 2 FSRNIMNIIDIVAIFPYFITL CIK5_MOUSE 343 2 FSRNIMNLIDIVAIIPYFITL Q28656 264 2 FFKNIMNIIDIVSILPYFITL CIK4_HUMAN 399 2 FFTNLMNIIDIVAIIPYFITL CIK2_XENLA 250 2 FFKNIMNIIDIVSILPYFITL CIK4_MOUSE 400 2 FFTNIMNIIDIVAIIPYFITL Q28293 250 2 FLKDVMNIIDIVAIIPYFITL O61335 264 2 FFKNIMNCIDIVAIIPYFITL Q16968 278 2 FCRDVMNVIDIIAIIPYFITL CIK2_DROME 295 2 FCRDVMNVIDIIAIIPYFITL CIK4_DROME 307 2 FCRDVMNVIDIIAIIPYFITL CIK1_DROME 307 2 FFKNVMNLIDFVAILPYFVAL O70259 313 2 FFRNIMNIIDIISIIPYFATL Q16322 299 2 FFKDSMNAIDVVSIMPYFITL Q25376 246 2 FFKVLMNVIDVVSIIPYFITL Q26597 266 2 FYRNIMNIIDIISIIPYFATL Q28649 513 2 FFKGPLNIIDLLAILPYYVTI Q91592 261 2 FFKGPLNVIDLLAILPYYVTI CIKB_HUMAN 261 2 FFKGPLNVIDLLAILPYYVTI CIKB_RAT 261 2 FFKGPLNVIDLLAILPYYVTI Q91593 257 2 FFKGPLNAIDLLAILPYYVTI CIKA_HUMAN 253 2 FFKGPLNAIDLLAILPYYVTI Q14193 257 2 FFKGPLNAIDLLAILPYYVTI Q03717 257 2 FFKGPLNAIDLLAILPYYVTI O18868 257 2 FFKGPLNAIDLLAILPYYVTI CIKA_RAT 253 2 FFKGPLNVIDLLAILPYYVTI Q95167 261 2 FFKGPLNIIDLLAILPYFISL O18476 448 2 FIKNLLNIIDFVAILPFYLEV CIKE_RAT 310 2 FIKNSLNIIDFVAILPFYLEV CIKD_MOUSE 273 2 FIKNSLNIIDFVAILPFYLEV CIKD_RAT 273 2 FIKNSLNIIDFVAILPFYLEV CIKD_HUMAN 273 2 FFKGGLNIIDLLAILPYFVSL O76805 502 2 FLKSSLNIIDCVAILPFYLEV CIKF_MOUSE 376 2 FLKSSLNIIDCVAILPFYLEV CIKF_RAT 377 2 FFKGGLNIIDLLAILPYFVSL CIKB_DROME 502 2 FVKSTLNIVDLVSIIPYYVTA Q26095 249 2 FVKNLLNIIDFVAILPFYLEV CIKG_HUMAN 309 2 FVKNLLNIIDFVAILPFYLEV CIKG_RAT 310 2 FIKSSVNIIDYIATLSFYIDL CIKW_DROME 259 2 FVRSVMSIIDVVAIMPYYIGL CIKL_DROME 257 2 FVRSVMSIIDVVAILPYYIGL Q26040 257 2 FIRSVMSIIDVVAIMPYYIGL O08723 254 2 FIRSVMSIIDVVAIMPYYIGL O60576 254 2 FIRSVMSIIDVVAIMPYYIGL O60577 254 2 FIRSVMSIIDVVAIMPYYIGL P70622 254 2 FIRSVMSIIDVVAIMPYYIGL Q63286 254 2 FLRSVMSLIDVVAILPYYIGL O75671 259 2 FLRSVMSLIDVVAILPYYIGL Q03719 259 2 FIRSVMSIIDVVAIMPYYIGL Q62897 254 2 FVRSVMSIIDVVAILPYYIGL Q63881 257 2 FVRSVMSIIDVVAILPYYIGL Q99249 257 2 FLKASVNMIDFIATLSFYVDI Q26041 254 2 FFKSPLNMIDLVATLSFYADA O62350 289 2 FLKAPVNIIDIVATLSFYLDF O76457 259 2 FFLNTGNIIDFLSILPYYLSL Q26094 251 2 FATSVLNIIDFVAIAPFFVNF Q09658 278 2 YLRAPVNIIDIVATLTFYIDL Q22012 262 2 HARISLSIIDVIAILPFYIGL P91784 268 2 SVMRSVMSIDVVAIMPYYIGL O57662 257 5 FWKNPLNIIDFVSIIPFYATL O54900 250 2 FWKNPLNIIDFVSIIPFYATL O88759 250 2 FWKNPLNIIDFVSIIPFYATL O43651 250 2 FLRKVPNIIDLLAILPFYITL P97557 273 2 FLRKVPNIIDLLAILPFYITL Q60565 274 2 FVRSPLTIIDVISTGAFFFES Q19464 261 2 FALSFMNIVDVLAILPFYVSL O43527 250 2 FFKNALNLIDLMSIVPFYITL O35174 255 2 FWFGFQNLIDVTAVVPYYVTL O76266 280 2 FFCHPLNLIDIVSVLPFYLTL O43652 300 2 FFCHPLNLIDIVSVLPFYLTL O35173 269 2 FFCHPLNLIDIVSVLPFYLTL O88758 269 2 FLRSPLTLIDLVAILPYYITL O43528 296 2 FIFSLMNVIDLLALVPLYVQV Q16976 296 2 FLKTPLNIIDILAILPFYISL O73606 286 2 YLKNVMSIIDILAILPFFVDL P91783 246 2 FLVGIMNIVDMIAIIPFYLEL Q09937 314 2 FALKPLNLVDLLAIVPFYLEL P91256 334 2 FVKKTLNIIDLSTILPFYLEI Q18351 288 2 KCHANNEL5 Length of motif = 27 Motif number = 5 K+ channel motif V - 2 PCODE ST INT LVRVFRIFKLSRHSKGLQILGKTLQAS CIK6_HUMAN 346 34 LVRVFRIFKLSRHSKGLQILGKTLQAS CIK6_RAT 347 34 LVRVFRIFKLSRHSKGLQILGKTLQAS Q61923 346 34 LVRVFRIFKLSRHSKGLQILGQTLKAS CIK3_HUMAN 316 24 LVRVFRIFKLSRHSKGLQILGQTLKAS CIK3_RAT 318 24 LVRVFRIFKLSRHSKGLQILGQTLKAS CIK2_HUMAN 298 27 LVRVFRIFKLSRHSKGLQILGQTLKAS CIK2_MOUSE 298 27 LVRVFRIFKLSRHSKGLQILGKTLQAS CIK5_RABIT 389 31 LVRVFRIFKLSRHSKGLQILGKTLQAS P79197 392 30 LVRVFRIFKLSRHSKGLQILGKTLQAS CIK5_HUMAN 404 31 LVRVFRIFKLSRHSKGLQILGKTLQAS CIK5_RAT 393 29 LVRVFRIFKLSRHSKGLQILGQTLKAS CIK1_HUMAN 296 26 LVRVFRIFKLSRHSKGLQILGQTLKAS CIK1_MOUSE 296 26 LVRVFRIFKLSRHSKGLQILGQTLKAS CIK1_RAT 296 26 LVRVFRIFKLSRHSKGLQILGQTLKAS CIK3_MOUSE 321 24 LVRVFRIFKLSRHSKGLQILGQTLKAS Q91781 290 26 LVRVFRIFKLSRHSKGLQILGHTLRAS CIK4_BOVIN 456 28 LVRVFRIFKLSRHSKGLQILGHTLRAS CIK4_MUSPF 449 28 LVRVFRIFKLSRHSKGLQILGHTLRAS CIK4_RAT 450 28 LVRVFRIFKLSRHSKGLQILGKTLQAS CIK5_MOUSE 393 29 LVRVFRIFKLSRHSKGLQILGQTLKAS Q28656 309 24 LVRVFRIFKLSRHSKGLQILGHTLRAS CIK4_HUMAN 448 28 LVRVFRIFKLSRHSKGLQILGQTLNAS CIK2_XENLA 298 27 LVRVFRIFKLSRHSKGLQILGHTLRAS CIK4_MOUSE 449 28 LVRVFRIFKLSRHSKGLQILGQTLKAS Q28293 298 27 LVRVFRIFKLSRHSKGLQILGRTLKAS O61335 324 39 LVRVFRIFKLSRHSKGLQILGQTLKAS Q16968 323 24 LVRVFRIFKLSRHSKGLQILGRTLKAS CIK2_DROME 354 38 LVRVFRIFKLSRHSKGLQILGRTLKAS CIK4_DROME 366 38 LVRVFRIFKLSRHSKGLQILGRTLKAS CIK1_DROME 366 38 LVRVFRIFKLSRHSKGLQILGQTLRAS O70259 358 24 LVRVFRIFKLSRHSKGLQILGQTLKAS Q16322 345 25 LVRVFRIFKLSRHSKGLQILGQTLKAS Q25376 292 25 LVRVFRIFKLSRHSKGLQILGQTLRAS Q26597 311 24 LVRVFRIFKLSRHSKGLQILGQTLKAS Q28649 559 25 IMRILRILKLARHSTGLQSLGFTLRRS Q91592 305 23 IMRILRILKLARHSTGLQSLGFTLRRS CIKB_HUMAN 305 23 IMRILRILKLARHSTGLQSLGFTLRRS CIKB_RAT 305 23 IMRILRILKLARHSTGLQSLGFTLRRS Q91593 301 23 IMRILRILKLARHSTGLQSLGFTLRRS CIKA_HUMAN 297 23 IMRILRILKLARHSTGLQSLGFTLRRS Q14193 301 23 IMRILRILKLARHSTGLQSLGFTLRRS Q03717 301 23 IMRILRILKLARHSTGLQSLGFTLRRS O18868 301 23 IMRILRILKLARHSTGLQSLGFTLRRS CIKA_RAT 297 23 IMRILRILKLARHSTGLQSLGFTLRRS Q95167 305 23 IMRVLRILKLARHSTGLQSLGYTLQRS O18476 493 24 FVRILRIFKLTRHFVGLRVLGHTLRAS CIKE_RAT 352 21 FVRILRIFKLTRHFVGLRVLGHTLRAS CIKD_MOUSE 315 21 FVRILRIFKLTRHFVGLRVLGHTLRAS CIKD_RAT 315 21 FVRILRIFKLTRHFVGLRVLGHTLRAS CIKD_HUMAN 315 21 IMRILRVLKLARHSTGLQSLGFTLRNS O76805 547 24 FVRILRIFKLTRHFVGLRVLGHTLRAS CIKF_MOUSE 418 21 FVRILRIFKLTRHFVGLRVLGHTLRAS CIKF_RAT 419 21 IMRILRVLKLARHSTGLQSLGFTLRNS CIKB_DROME 547 24 VIRVIRIFKLTRHSRGLHILANTISAS Q26095 287 17 IVRILRIFKLTRHFVGLRVLGHTLRAS CIKG_HUMAN 351 21 FVRILRIFKLTRHFVGLRVLGHTLRAS CIKG_RAT 352 21 IIRIMRLFKLTRHSSGLKILIQTFRAS CIKW_DROME 299 19 VFRVFRIFKFSRHSQGLRILGYTLKSC CIKL_DROME 294 16 VFRVFRIFKFSRHSQGLRILGYTLKSC Q26040 294 16 VFRVFRIFKFSRHSQGLRILGYTLKSC O08723 291 16 VFRVFRIFKFSRHSQGLRILGYTLKSC O60576 291 16 VFRVFRIFKFSRHSQGLRILGYTLKSC O60577 291 16 VFRVFRIFKFSRHSQGLRILGYTLKSC P70622 291 16 VFRVFRIFKFSRHSQGLRILGYTLKSC Q63286 291 16 VFRVFRIFKFSRHSQGLRILGYTLKSC O75671 296 16 VFRVFRIFKFSRHSQGLRILGYTLKSC Q03719 296 16 VFRVFRIFKFSRHSQGLRILGYTLKSC Q62897 291 16 VFRVFRIFKFSRHSQGLRILGYTLKSC Q63881 294 16 VFRVFRIFKFSRHSQGLRILGYTLKSC Q99249 294 16 IIRIMRLFKLTRHSSGLKILIQTFRAS Q26041 294 19 MIRIFRLFKLTQHHQGLQILIHTFRAS O62350 328 18 IIRIMRLCKLTRHSAGLKILIHTFKAS O76457 296 16 VIRVLRVFKLSRHSRGLQILGNTLKAS Q26094 286 14 LVRVFRVFKLSRHSVGLQILGKTFRSS Q09658 320 21 IIRIMRLFKLTHHNSGLKILMHTFRAS Q22012 298 15 VFRVFRIFKFSRHSKGLRILGSTLTSC P91784 304 15 VFRVFRIFKFSRHSQGLRILGYTLKSC O57662 295 17 LMRIFRILKLARHSVGLRSLGATLRHS O54900 294 23 LMRIFRILKLARHSVGLRSLGATLRHS O88759 294 23 LMRIFRILKLARHSVGLRSLGATLRHS O43651 294 23 LLRALRMLKLGRHSTGLRSLGMTITQC P97557 319 25 LLRALRMLKLGRHSTGLRSLGMTITQC Q60565 320 25 MICVLRLFKLTQHFSGLKILIQTFKAS Q19464 301 19 IMRIARIFKLARHSSGLQTLTYALKRS O43527 294 23 LMRIFRILKLARHSTGLRSLGATLKYS O35174 299 23 VIRLVRVFKLTKHSTGLQVLILTIKAS O76266 323 22 LMRIFRVLKLARHSTGLRSLGATLKHS O43652 346 25 LMRIFRVLKLARHSTGLRSLGATLKHS O35173 318 28 LMRIFRVLKLARHSTGLRSLGATLKHS O88758 318 28 ALRILYVMRLARHSLGLQTLGLTARRC O43528 347 30 IIRMFRIFHLVKHYQALKVLVYAIKAS Q16976 343 26 ALRILYVMRLARHSLGLQTLGLTVRRC O73606 340 33 SVRIIRVFKLARHSQRLRVLSSSIYRS P91783 288 21 VLRVVRILKLGRYSSGMRTFALTLKSS Q09937 361 26 VLRVIRIIKLGRFSSGLQTFGMTLQRS P91256 381 26 VLRMARVFKLARYSTSLQTFGHTLQSS Q18351 334 25 KCHANNEL6 Length of motif = 24 Motif number = 6 K+ channel motif VI - 2 PCODE ST INT ELGLLIFFLFIGVILFSSAVYFAE CIK6_HUMAN 375 2 ELGLLIFFLFIGVILFSSAVYFAE CIK6_RAT 376 2 ELGLLIFFLFIGVILFSSAVYFAE Q61923 375 2 ELGLLIFFLFIGVILFSSAVYFAE CIK3_HUMAN 345 2 ELGLLIFFLFIGVILFSSAVYFAE CIK3_RAT 347 2 ELGLLIFFLFIGVILFSSAVYFAE CIK2_HUMAN 327 2 ELGLLIFFLFIGVILFSSAVYFAE CIK2_MOUSE 327 2 ELGLLIFFLFIGVILFSSAVYFAE CIK5_RABIT 418 2 ELGLLIFFLFIGVILFSSAVYFAE P79197 421 2 ELGLLIFFLFIGVILFSSAVYFAE CIK5_HUMAN 433 2 ELGLLIFFLFIGVILFSSAVYFAE CIK5_RAT 422 2 ELGLLIFFLFIGVILFSSAVYFAE CIK1_HUMAN 325 2 ELGLLIFFLFIGVILFSSAVYFAE CIK1_MOUSE 325 2 ELGLLIFFLFIGVILFSSAVYFAE CIK1_RAT 325 2 ELGLLIFFLFIGVILFSSAAYFAE CIK3_MOUSE 350 2 ELGLLIFFLFIGVILFSSAVYFAE Q91781 319 2 ELGLLIFFLFIGVILFSSAVYFAE CIK4_BOVIN 485 2 ELGLLIFFLFIGVILFSSAVYFAE CIK4_MUSPF 478 2 ELGLLIFFLFIGVILFSSAVYFAE CIK4_RAT 479 2 ELGLLIFFLFIGVILFSSAVYFAE CIK5_MOUSE 422 2 DVGLLIFFLFIGVILFSSAVYFAE Q28656 338 2 ELGLLIFFLFIGVILFSSAVYFAE CIK4_HUMAN 477 2 ELGLLIFFLFIGVILFSSAVFFAE CIK2_XENLA 327 2 ELGLLIFFLFIGVILFSSAVYFAE CIK4_MOUSE 478 2 ELGLLIFFLFIGVILFSSAVYFAE Q28293 327 2 ELGLLIFFLFIGVVLFSSAVYFAE O61335 353 2 ELGLLIFFLFIGVILFSSAVYFAE Q16968 352 2 ELGLLIFFLFIGVVLFSSAVYFAE CIK2_DROME 383 2 ELGLLIFFLFIGVVLFSSAVYFAE CIK4_DROME 395 2 ELGLLIFFLFIGVVLFSSAVYFAE CIK1_DROME 395 2 ELGLLIFFLFIGVVLFSSAVYFAE O70259 387 2 ELGLLIFFLFIGVILFSSAVYFAE Q16322 374 2 ELGLLIFFLVIGVVLFSSAVYFAE Q25376 321 2 ELGLLVFFLLICVILFSSAVYFAE Q26597 340 2 ELGLLIFFLFIGVILFSSAVYFAE Q28649 588 2 ELGLLILFLAMGIMIFSSLVFFAE Q91592 334 2 ELGLLILFLAMGIMIFSSLVFFAE CIKB_HUMAN 334 2 ELGLLILFLAMGIMIFSSLVFFAE CIKB_RAT 334 2 ELGLLILFLAMGIMIFSSLVFFAE Q91593 330 2 ELGLLILFLAMGIMIFSSLVFFAE CIKA_HUMAN 326 2 ELGLLILFLAMGIMIFSSLVFFAE Q14193 330 2 ELGLLILFLAMGIMIFSSLVFFAE Q03717 330 2 ELGLLILFLAMGIMIFSSLVFFAE O18868 330 2 ELGLLILFLAMGIMIFSSLVFFAE CIKA_RAT 326 2 ELGLLILFLAMGIMIFSSLVFFAE Q95167 334 2 ELGLLMMFLAIGILLFSSLAYFAE O18476 522 2 EFLLLIIFLALGVLIFATMIYYAE CIKE_RAT 381 2 EFLLLIIFLALGVLIFATMIYYAE CIKD_MOUSE 344 2 EFLLLIIFLALGVLIFATMIYYAE CIKD_RAT 344 2 EFLLLIIFLALGVLIFATMIYYAE CIKD_HUMAN 344 2 ELGLLMLFLAMGVLIFSSLAYFAE O76805 576 2 EFLLLIIFLALGVLIFATMIYYAE CIKF_MOUSE 447 2 EFLLLIIFLALGVLIFATMIYYAE CIKF_RAT 448 2 ELGLLMLFLAMGVLIFSSLAYFAE CIKB_DROME 576 2 ELCMLVLFLAIGVVLFSSAAYYAE Q26095 316 2 EFLLLIIFLALGVLIFATMIYYAE CIKG_HUMAN 380 2 EFLLLIIFLALGVLIFATMIYYAE CIKG_RAT 381 2 ELTLLVFFLVLGIVIFASLVYYAE CIKW_DROME 328 2 ELGFLVFSLAMAIIIFATVMFYAE CIKL_DROME 323 2 ELGFLVFSLAMAIIIFATVMFYAE Q26040 323 2 ELGFLLFSLTMAIIIFATVMFYAE O08723 320 2 ELGFLLFSLTMAIIIFATVMFYAE O60576 320 2 ELGFLLFSLTMAIIIFATVMFYAE O60577 320 2 ELGFLLFSLTMAIIIFATVMFYAE P70622 320 2 ELGFLLFSLTMAIIIFATVMFYAE Q63286 320 2 ELGFLLFSLTMAIIIFATVMFYAE O75671 325 2 ELGFLLFSLTMAIIIFATVMFYAE Q03719 325 2 ELGFLLFSLTMAIIIFATVMFYAE Q62897 320 2 ELGFLLFSLTMAIIIFATVMFYAE Q63881 323 2 ELGFLLFSLTMAIIIFATVMFYAE Q99249 323 2 ELTLLVFFLVLGIVIFASLVYYAE Q26041 323 2 ELILLVFFLILGIVIFAALVYYAE O62350 357 2 ELILLIFFLVLGIVIFAALIYYAE O76457 325 2 ELMMLAFFLFVMILIFGSCVYYAE Q26094 315 2 EFCLLIFFMAIALVLFASGMYFAE Q09658 349 2 ELMLLVFFLVLGVVVFASLVYYAE Q22012 327 2 ELGFLLFSLSMAIIIFATVVFYVE P91784 333 2 ELGFLLFSLTMAIIIFATVMFYAE O57662 324 2 EVGLLLLFLSVGISIFSVLIYSVE O54900 323 2 EVGLLLLFLSVGISIFSVLIYSVE O88759 323 2 EVGLLLLFLSVGISIFSVLIYSVE O43651 323 2 EVGLLLLFLSVGISIFSTIEYFAE P97557 348 2 EVGLLLLFLSVGISIFSTIEYFAE Q60565 349 2 ELFLLVFFVILAIVIFAALVYYAE Q19464 330 2 ELGLLLMYLAVGIFVFSALGYTME O43527 323 2 EVGLLLLYLSVGISIFSVVAYTIE O35174 328 2 ELGLFLVVLLVCMLVYSSAIYYAE O76266 352 2 EVGILLLYLAVGVSVFSGVAYTAE O43652 375 2 EVGILLLYLAVGVSVFSGVAYTAE O35173 347 2 EVGILLLYLAVGVSVFSGVAYTAE O88758 347 2 EFGLLLLFLCVAIALFAPLLYVIE O43528 376 2 ELLMLFIFLLIGMLIFSTMIYYAE Q16976 372 2 EFGLLLLFLCVAMALFSPLVYLAE O73606 369 2 ELGFILFMYINVVVMFATCIFYAE P91783 317 2 QLGMMGMVLSTGVVFFSTLLYFVE Q09937 390 2 QLQMMTIVLLTGVVFFSTMIYFLE P91256 410 2 ELSMLSMFLITGIVFFSTIMYYLE Q18351 363 2 KCHANNEL7 Length of motif = 23 Motif number = 7 K+ channel motif VII - 2 PCODE ST INT FPSIPDAFWWAVVTMTTVGYGDM CIK6_HUMAN 406 7 FPSIPDAFWWAVVTMTTVGYGDM CIK6_RAT 407 7 FPSIPDAFWWAVVTMTTVGYGDM Q61923 406 7 FSSIPDAFWWAVVTMTTVGYGDM CIK3_HUMAN 376 7 FNSIPDAFWWAVVTMTTVGYGDM CIK3_RAT 378 7 FPSIPDAFWWAVVSMTTVGYGDM CIK2_HUMAN 358 7 FPSIPDAFWWAVVSMTTVGYGDM CIK2_MOUSE 358 7 FSSIPDAFWWAVVTMTTVGYGDM CIK5_RABIT 449 7 FSSIPDAFWWAVVTMTTVGYGDM P79197 452 7 FSSIPDAFWWAVVTMTTVGYGDM CIK5_HUMAN 464 7 FSSIPDAFWWAVVTMTTVGYGDM CIK5_RAT 453 7 FSSIPDAFWWAVVSMTTVGYGDM CIK1_HUMAN 356 7 FSSIPDAFWWAVVSMTTVGYGDM CIK1_MOUSE 356 7 FSSIPDAFWWAVVSMTTVGYGDM CIK1_RAT 356 7 FNSIPDAFWWAVVTMTTVGYGDM CIK3_MOUSE 381 7 FTSIPDAFWWAVVSMTTVGYGDM Q91781 350 7 FQSIPDAFWWAVVTMTTVGYGDM CIK4_BOVIN 516 7 FQSIPDAFWWAVVTMTTVGYGDM CIK4_MUSPF 509 7 FQSIPDAFWWAVVTMTTVGYGDM CIK4_RAT 510 7 LSSIPDAFWWAVVTMTTVGYGDM CIK5_MOUSE 453 7 FSSIPDAFWWAVVTMTTVGYGDM Q28656 369 7 FQSIPDAFWWAVVTMTTVGYGDM CIK4_HUMAN 508 7 FPSIPDAFWWAVVSMTTVGYGDM CIK2_XENLA 358 7 FQSIPDAFWWAVVTMTTVGYGDM CIK4_MOUSE 509 7 FPSIPDAFWWAVVSMTTVGYGDM Q28293 358 7 FKSIPDAFWWAVVTMTTVGYGDM O61335 384 7 FKSIPDAFWWAVVTMTTVGYGDM Q16968 383 7 FKSIPDAFWWAVVTMTTVGYGDM CIK2_DROME 414 7 FKSIPDAFWWAVVTMTTVGYGDM CIK4_DROME 426 7 FKSIPDAFWWAVVTMTTVGYGDM CIK1_DROME 426 7 FTSIPESFWWAVVTMTTVGYGDM O70259 418 7 FSSIPDGFWWAVVTMTTVGYGDM Q16322 405 7 FKSIPDSFWWAVVTMTTVGYGDM Q25376 352 7 FRSIPDGFWWAVVTMTTVGYGDM Q26597 371 7 FSSIPDGFWWAVVTMTTVGYGDM Q28649 619 7 FTSIPASFWWATITMTTVGYGDI Q91592 365 7 FTSIPASFWWATITMTTVGYGDI CIKB_HUMAN 365 7 FTSIPASFWWATITMTTVGYGDI CIKB_RAT 365 7 FKSIPASFWWATITMTTVGYGDI Q91593 361 7 FKSIPASFWWATITMTTVGYGDI CIKA_HUMAN 357 7 FKSIPASFWWATITMTTVGYGDI Q14193 361 7 FKSIPASFWWATITMTTVGYGDI Q03717 361 7 FKSIPASFWWATITMTTVGYGDI O18868 361 7 FKSIPASFWWATITMTTVGYGDI CIKA_RAT 357 7 FTSIPASFWWATITMTTVGYGDI Q95167 365 7 YVSIPETFWWAAITMTTVGYGDI O18476 553 7 FKNIPIGFWWAVVTMTTLGYGDM CIKE_RAT 421 16 FKNIPIGFWWAVVTMTTLGYGDM CIKD_MOUSE 384 16 FKNIPIGFWWAVVTMTTLGYGDM CIKD_RAT 384 16 FKNIPIGFWWAVVTMTTLGYGDM CIKD_HUMAN 384 16 FVSIPEAFWWAGITMTTVGYGDI O76805 607 7 FKNIPIGFWWAVVTMTTLGYGDM CIKF_MOUSE 487 16 FKNIPIGFWWAVVTMTTLGYGDM CIKF_RAT 488 16 FVSIPEAFWWAGITMTTVGYGDI CIKB_DROME 607 7 FKSIPHGFWWAVVTMTTVGYGDL Q26095 347 7 FKNIPIGFWWAVVTMTTLGYGDM CIKG_HUMAN 420 16 FKNIPIGFWWAVVTMTTLGYGDM CIKG_RAT 421 16 FNSIPLGLWWALVTMTTVGYGDM CIKW_DROME 361 9 FTSIPAAFWYTIVTMTTLGYGDM CIKL_DROME 354 7 FTSIPSAFWYTIVTMTTLGYGDM Q26040 354 7 FTSIPASFWYTIVTMTTLGYGDM O08723 351 7 FTSIPASFWYTIVTMTTLGYGDM O60576 351 7 FTSIPASFWYTIVTMTTLGYGDM O60577 351 7 FTSIPASFWYTIVTMTTLGYGDM P70622 351 7 FTSIPASFWYTIVTMTTLGYGDM Q63286 351 7 FTSIPAAFWYTIVTMTTLGYGDM O75671 356 7 FTSIPAAFWYTIVTMTTLGYGDM Q03719 356 7 FTSIPASFWYTIVTMTTLGYGDM Q62897 351 7 FTSIPAAFWYTIVTMTTLGYGDM Q63881 354 7 FTSIPAAFWYTIVTMTTLGYGDM Q99249 354 7 FNSIPLGLWWALVTMTTVGYGDM Q26041 356 9 FQSIPLGLWWAICTMTTVGYGDM O62350 390 9 FESIPVGLWWAIVTMTTVGYGDM O76457 358 9 FISIPSSFWWAIVTMTTVGYGDM Q26094 346 7 FTSIPASFWFVLVTMTTVGYGDL Q09658 380 7 FVSIPIGLWWAIVTMTTIGYGDI Q22012 360 9 FTSIPASFWYTIVTMTTLGYGDM P91784 364 7 FTSIPASFWYTIVTMTTLGYGDM O57662 355 7 LTSIPICWWWATISMTTVGYGDT O54900 354 7 LTSIPICWWWATISMTTVGYGDT O88759 354 7 LTSIPICWWWATISMTTVGYGDT O43651 354 7 FTSVPCAWWWATTSMTTVGYGDI P97557 379 7 FTSVPCAWWWATTSMTTVGYGDI Q60565 380 7 FTSIPLGLWWSLVTISTVGFGDM Q19464 363 9 FKNIPQSFWWAIITMTTVGYGDI O43527 354 7 LATIPACWWWATVSMTTVGYGDV O35174 358 6 IHSIPDAFWWAIITMTTVGYGDT O76266 383 7 FNTIPACWWWGTVSMTTVGYGDV O43652 405 6 FHTIPACWWWGTVSMTTVGYGDV O35173 376 5 FDTIPACWWWGTVSMTTVGYGDV O88758 376 5 FTSIPACYWWAVITMTTVDYGDM O43528 408 8 FSTIPMGFWWSIITMTTVGYGDV Q16976 406 10 FTSIPTSYWWAVISMTTVGYGDM O73606 401 8 FSSIPEAMWYTVVTTTTLGYGDV P91783 350 9 FTSIPAAFWWAIVTMTTVGYGDY Q09937 421 7 FTSIPAAYWWCIVTMTTVGYGDA P91256 441 7 FYSIPAGCWWCVVTMATVGYGDA Q18351 394 7 KCHANNEL8 Length of motif = 27 Motif number = 8 K+ channel motif VIII - 2 PCODE ST INT GKIVGSLCAIAGVLTIALPVPVIVSNF CIK6_HUMAN 435 6 GKIVGSLCAIAGVLTIALPVPVIVSNF CIK6_RAT 436 6 GKIVGSLCAIAGVLTIALPVPVIVSNF Q61923 435 6 GKIVGSLCAIAGVLTIALPVPVIVSNF CIK3_HUMAN 405 6 GKIVGSLCAIAGVLTIALPVPVIVSNF CIK3_RAT 407 6 GKIVGSLCAIAGVLTIALPVPVIVSNF CIK2_HUMAN 387 6 GKIVGSLCAIAGVLTIALPVPVIVSNF CIK2_MOUSE 387 6 GKIVGSLCAIAGVLTIALPVPVIVSNF CIK5_RABIT 478 6 GKIVGSLCAIAGVLTIALPVPVIVSNF P79197 481 6 GKIVGSLCAIAGVLTIALPVPVIVSNF CIK5_HUMAN 493 6 GKIVGSLCAIAGVLTIALPVPVIVSNF CIK5_RAT 482 6 GKIVGSLCAIAGVLTIALPVPVIVSNF CIK1_HUMAN 385 6 GKIVGSLCAIAGVLTIALPVPVIVSNF CIK1_MOUSE 385 6 GKIVGSLCAIAGVLTIALPVPVIVSNF CIK1_RAT 385 6 GKIVGSLCAIAGVLTIALPVPVIVSNF CIK3_MOUSE 410 6 GKIVGSLCAIAGVLTIALPVPVIVSNF Q91781 379 6 GKIVGSLCAIAGVLTIALPVPVIVSNF CIK4_BOVIN 545 6 GKIVGSLCAIAGVLTIALPVPVIVSNF CIK4_MUSPF 538 6 GKIVGSLCAIAGVLTIALPVPVIVSNF CIK4_RAT 539 6 GKIVGSLCAIAGVLTIALPVPVIVSNF CIK5_MOUSE 482 6 GKIVGSLCAIAGVLTIALPVPVIVSNF Q28656 398 6 GKIVGVLCAIAGVLTIALPVPVIVSNF CIK4_HUMAN 537 6 GKIVGSLCAIAGVLTIALPVPVIVSNF CIK2_XENLA 387 6 GKIVGSLCAIAGVLTIALPVPVIVSNF CIK4_MOUSE 538 6 GKIVGSLCAIAGVLTIALPVPVIVSNF Q28293 387 6 GKIVGSLCAIAGVLTIALPVPVIVSNF O61335 413 6 GKLVGSLCAIAGVLTIALPVPVIVSNF Q16968 412 6 GKIVGSLCAIAGVLTIALPVPVIVSNF CIK2_DROME 443 6 GKIVGSLCAIAGVLTIALPVPVIVSNF CIK4_DROME 455 6 GKIVGSLCVVAGVLTIALPVPVIVSNF CIK1_DROME 455 6 GKIVGSLCAIAGVLTISLPVPVIVSNF O70259 447 6 GKIVGTLCAIAGVLTIALPVPVIVSNF Q16322 434 6 GKLVGSLCAIAGVLTIALPVPVIVSNF Q25376 381 6 GKLIGSLCAIAGVLTIALPVPVIVSNF Q26597 400 6 GKIVGTLCAIAGVLTIALPVPVIVSNF Q28649 648 6 GKIIGGLCCIAGVLVIALPIPIIVNNF Q91592 394 6 GKIVGGLCCIAGVLVIALPIPIIVNNF CIKB_HUMAN 394 6 GKIVGGLCCIAGVLVIALPIPIIVNNF CIKB_RAT 394 6 GKIVGGLCCIAGVLVIALPIPIIVNNF Q91593 390 6 GKIVGGLCCIAGVLVIALPIPIIVNNF CIKA_HUMAN 386 6 GKIVGGLCCIAGVLVIALPIPIIVNNF Q14193 390 6 GKIVGGLCCIAGVLVIALPIPIIVNNF Q03717 390 6 GKIVGGLCCIAGVLVIALPIPIIVNNF O18868 390 6 GKIVGGLCCIAGVLVIALPIPIIVNNF CIKA_RAT 386 6 GKSVGGLCCIAGVLVIALPIPIIVPPF Q95167 394 6 GKVVGGVCCICGVLVVALPIPIIVNNF O18476 582 6 GMLVGALCALAGVLTIAMPVPVIVNNF CIKE_RAT 450 6 GMLVGALCALAGVLTIAMPVPVIVNNF CIKD_MOUSE 413 6 GMLVGALCALAGVLTIAMPVPVIVNNF CIKD_RAT 413 6 GMLVGALCALAGVLTIAMPVPVIVNNF CIKD_HUMAN 413 6 GKVIGTVCCICGVLVVALPIPIIVNNF O76805 636 6 GMLVGGLCALAGVLTIAMPVPVIVNNF CIKF_MOUSE 516 6 GMLVGALCALAGVLTIAMPVPVIVNNF CIKF_RAT 517 6 GKVIGTVCCICGVLVVALPIPIIVNNF CIKB_DROME 636 6 GKMVGALCAISGVLVIALPVPVIVSNF Q26095 376 6 GMLVGALCALAGVLTIAMPVPVIVNNF CIKG_HUMAN 449 6 GMLVGALCALAGVLTIAMPVPVIVNNF CIKG_RAT 450 6 GMFVGALCALAGVLTIALPVPVIVSNF CIKW_DROME 390 6 GKIVGGVCSLSGVLVIALPVPVIVSNF CIKL_DROME 383 6 GKIVGGVCSLSGVLVIALPVPVIVSNF Q26040 383 6 GKIFGSICSLSGVLVIALPVPVIVSNF O08723 380 6 GKIFGSICSLSGVLVIALPVPVIVSNF O60576 380 6 GKIFGSICSLSGVLVIALPVPVIVSNF O60577 380 6 GKIFGSICSLSGVLVIALPVPVIVSNF P70622 380 6 GKIFGSICSLSGVLVIALPVPVIVSNF Q63286 380 6 GKIFGSICSLSGVLVIALPVPVIVSNF O75671 385 6 GKIFGSICSLSGVLVIALPVPVIVSNF Q03719 385 6 GKIFGSICSLSGVLVIALPVPVIVTNF Q62897 380 6 GKIFGSICSLSGVLVIALPVPVIVSNF Q63881 383 6 GKIFGSICSLSGVLVIALPVPVIVSNF Q99249 383 6 GMFVGALCALAGVLTIALPVPVIVSNF Q26041 385 6 GRLVGSLCAVMGVLTIALPVPVIVSNF O62350 419 6 GMFVGALCALAGVLCIALPVPVIVSNF O76457 387 6 GQIVGSMAVVCGVLTIALPVPVVVSNF Q26094 375 6 GKVVGGMCAMIGVLTLALPVPIIVANF Q09658 409 6 GRLIGSICALAGVLTIALPVPVIVSNF Q22012 389 6 GKLVGSICSLSGVLVIALPVPVIVSNF P91784 393 6 KIFEFHLTSLSGVLVIALPDPVMVSNF O57662 385 7 GKIIASTCIICGILVVALPITIIFNKF O54900 383 6 GKIIASTCIICGILVVALPITIIFNKF O88759 383 6 GKLIASTCIICGILVVALPITIIFNKF O43651 383 6 GKIVAFMCILSGILVLALPIAIINDRF P97557 408 6 GKIVAFMCILSGILVLALPIAIINDRF Q60565 409 6 GMLVGSLCALMGVLTIALPVPVIVSNF Q19464 392 6 SKLNAAISFLCGVIAIALPIHPIINNF O43527 383 6 GKLTASACILAGILVVVLPITLIFNKF O35174 387 6 GKVIGAACAISGVLTLAMPVPILTGHF O76266 412 6 GKLAASGCILGGILVVALPITIIFNKF O43652 434 6 GKLAASGCILGGILVVALPITIIFNKF O35173 405 6 GKLAASGCILGGILVVALPITIIFNKF O88758 405 6 GQVVALSSILSGILLMAFPVTSIFHTF O43528 437 6 GYIVGTACSVSGVLLVALTIPVISNNF Q16976 435 6 GQVVALSSILSGILLMAFPVTSIFHTF O73606 430 6 GKLIGSMCCLMGVLVIALPVPIIQMKA P91783 379 6 GKLIASGAIISGVLVLALPITIIVDNF Q09937 450 6 GKIIASAAIMCGVLVLALPITIIVDNF P91256 470 6 GKLVATSTSICGIIVLAFPISMIVEKF Q18351 423 6

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