WORKLIST ENTRIES (1):

LEUZIPPRFOS View alignment View Structure     Fos transforming protein signature
 Type of fingerprint: COMPOUND with 5  elements
Links:
   PRINTS; PR00041 LEUZIPPRCREB; PR00043 LEUZIPPRJUN; PR00044 LEUZIPPRMYC
   INTERPRO; IPR000837
   PROSITE; PS00036 FOS_JUN_BASIC; PS00029 LEUCINE_ZIPPER

 Creation date 17-MAY-1993; UPDATE 10-JUN-1999

   1. BOHMANN, D., BOS, T.J., ADMON, A., NISHIMURA, T., VOGT, P.K. AND 
   TIJAN, R.
   Human proto-oncogene c-jun encodes a DNA-binding protein with structural
   and functional properties of transcription factor AP-1.
   SCIENCE 238 1386-1392 (1987).

   2. COHEN, D.R. AND CURRAN, T.
   Fra-1 - A serum-inducible, cellular imediate early gene that encodes a
   fos-related antigen.
   MOL.CELL BIOL. 8(5) 2063-2069 (1988).

   3. VAN STRAATEN, F., MULLER, R., CURRAN, T., VAN BEVEREN, C. AND VERMA, I.
   Complete nucleotide sequence of a human c-onc gene - deduced amino acid 
   sequence of the human c-fos protein.
   PROC.NATL.ACAD.SCI.U.S.A. 80(11) 3183-3187 (1983).

   Implicit in the growth regulatory functions of all proto-oncogenes is the 
   potential to induce abnormal cell growth [1] and cancer as a result of
   alterations in gene expression. This may be a qualitative or quantitative 
   alteration, the viral oncogenes activating this potential by transducing a 
   truncated or mutated form of the protein product, or by increasing 
   transcription of the proto-oncogene by the integration of a viral promoter 
   and enhancer sequence in its vicinity.
   
   Both the cellular and viral forms of the fos gene encode a phosphoprotein
   that is located in the nucleus of cells, and forms a noncovalent complex
   with several other proteins, a leucine zipper holding the dimer together. 
   The dimer is associated with chromatin and demonstrates specific and non-
   specific DNA-binding properties [2], the DNA being bound by a highly basic 
   area in the protein sequence immediately preceding the zipper domain.
   Expression of the fos gene is stimulated by mitogens, suggesting that the
   gene product is involved in cell growth [3], and may act as a nuclear
   signal in a more general sense.
  
   The 'leucine zipper' is a structure that is believed to mediate the
   function of several eukaryotic gene regulatory proteins. The zipper
   consists of a periodic repetition of leucine residues at every seventh
   position, and regions containing them appear to span 8 turns of alpha-
   helix. The leucine side chains that extend from one helix interact with
   those from a similar helix, hence facilitating dimerisation in the form
   of a coiled-coil. Leucine zippers are present in many gene regulatory
   proteins, including the CREB proteins, Jun/AP1 transcription factors,
   fos oncogene and fos-related proteins, C-myc, L-myc and N-myc oncogenes,
   and so on.
   
   LEUZIPPRFOS is a 5-element fingerprint that provides a signature for the 
   leucine zipper and DNA-binding domains characteristic of the fos oncogenes 
   and fos-related proteins. The fingerprint was derived from an initial 
   alignment of 6 sequences: motifs 2 and 3 span the highly basic DNA-
   binding domain, while motifs 4 and 5 encode the zipper region (cf.
   PROSITE patterns FOS_JUN_BASIC (PS00036) and LEUCINE_ZIPPER (PS00029)).
   Two iterations on OWL19.1 were required to reach convergence, at which
   point a true set comprising 14 sequences was identified. Several partial
   matches were also found: of those matching just 4 motifs, both are CREB 
   protein fragments that are highly similar to the DNA-binding and zipper
   domains of the fos gene products; those matching just 2 or 3 motifs are
   myosin heavy chains, which form coiled coils using a system similar to
   leucine zippers.
  
   An update on SPTR37_9f identified a true set of 24 sequences, and 6
   partial matches.

  SUMMARY INFORMATION
     24 codes involving  5 elements
      1 codes involving  4 elements
      3 codes involving  3 elements
      2 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
    5|  24   24   24   24   24  
    4|   0    1    1    1    1  
    3|   0    3    3    3    0  
    2|   0    1    2    1    0  
   --+--------------------------
     |   1    2    3    4    5  

True positives..
 FOS_HUMAN      O88479         FOS_MOUSE      FOS_RAT        
 FOS_CHICK      FOS_AVINK      FOSX_MSVFR     O56223         
 Q62592         FOS_MSVFB      FOS_FUGRU      FRA2_HUMAN     
 FOS_CYPCA      FOS_TETFL      FRA2_CHICK     Q91639         
 FRA2_MOUSE     FOSB_MOUSE     FOSB_HUMAN     FRA2_RAT       
 FRA1_RAT       FRA1_HUMAN     O35285         FRA1_MOUSE     
Subfamily:  Codes involving 4 elements
 Subfamily True positives..
 Q62738         
Subfamily:  Codes involving 3 elements
 Subfamily True positives..
 Q62281         ATF3_RAT       ATF3_MOUSE     
Subfamily:  Codes involving 2 elements
 Subfamily True positives..
 ATF3_HUMAN     FRA_DROME      


  PROTEIN TITLES
   FOS_HUMAN        P55-C-FOS PROTO-ONCOGENE PROTEIN (G0S7 PROTEIN) - HOMO SAPIE
   O88479           C-FOS PROTO-ONCOGENE PROTEIN - MESOCRICETUS AURATUS (GOLDEN 
   FOS_MOUSE        P55-C-FOS PROTO-ONCOGENE PROTEIN - MUS MUSCULUS (MOUSE).
   FOS_RAT          P55-C-FOS PROTO-ONCOGENE PROTEIN - RATTUS NORVEGICUS (RAT).
   FOS_CHICK        P55-C-FOS PROTO-ONCOGENE PROTEIN - GALLUS GALLUS (CHICKEN).
   FOS_AVINK        P55-V-FOS TRANSFORMING PROTEIN - AVIAN RETROVIRUS NK24.
   FOSX_MSVFR       V-FOS/FOX TRANSFORMING PROTEIN - FBR MURINE OSTEOSARCOMA VIR
   O56223           COMPLETE GENOME - MURINE OSTEOSARCOMA VIRUS.
   Q62592           FBR-MURINE OSTEOSARCOMA PROVIRUS GENOME - RATTUS NORVEGICUS 
   FOS_MSVFB        P55-V-FOS TRANSFORMING PROTEIN - FBJ MURINE OSTEOSARCOMA VIR
   FOS_FUGRU        P55-C-FOS PROTO-ONCOGENE PROTEIN - FUGU RUBRIPES (JAPANESE P
   FRA2_HUMAN       FOS-RELATED ANTIGEN 2 - HOMO SAPIENS (HUMAN).
   FOS_CYPCA        P55-C-FOS PROTO-ONCOGENE PROTEIN - CYPRINUS CARPIO (COMMON C
   FOS_TETFL        P55-C-FOS PROTO-ONCOGENE PROTEIN - TETRAODON FLUVIATILIS (PU
   FRA2_CHICK       FOS-RELATED ANTIGEN 2 - GALLUS GALLUS (CHICKEN).
   Q91639           FOS-RELATED ANTIGEN-2 - XENOPUS LAEVIS (AFRICAN CLAWED FROG)
   FRA2_MOUSE       FOS-RELATED ANTIGEN 2 - MUS MUSCULUS (MOUSE).
   FOSB_MOUSE       FOSB PROTEIN - MUS MUSCULUS (MOUSE).
   FOSB_HUMAN       FOSB PROTEIN (G0/G1 SWITCH REGULATORY PROTEIN 3) - HOMO SAPI
   FRA2_RAT         FOS-RELATED ANTIGEN 2 - RATTUS NORVEGICUS (RAT).
   FRA1_RAT         FOS-RELATED ANTIGEN 1 - RATTUS NORVEGICUS (RAT).
   FRA1_HUMAN       FOS-RELATED ANTIGEN 1 - HOMO SAPIENS (HUMAN).
   O35285           FOS-LIKE ANTIGEN 1 (FOS-RELATED ANTIGEN 1) - MUS MUSCULUS (M
   FRA1_MOUSE       FOS-RELATED ANTIGEN-1 - MUS MUSCULUS (MOUSE).
 
   Q62738           FOS-RELATED ANTIGEN 2 - RATTUS NORVEGICUS (RAT).
 
   Q62281           TI-241 - MUS MUSCULUS (MOUSE).
   ATF3_RAT         CYCLIC-AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-3 (ACTIVATING 
   ATF3_MOUSE       CYCLIC-AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-3 (ACTIVATING 
 
   ATF3_HUMAN       CYCLIC-AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-3 (ACTIVATING 
   FRA_DROME        TRANSCRIPTION FACTOR DFRA (FOS-RELATED ANTIGEN) (AP-1) (KAYA

SCAN HISTORY OWL19_1 2 100 NSINGLE OWL26_0 1 200 NSINGLE SPTR37_9f 2 67 NSINGLE INITIAL MOTIF SETS LEUZIPPRFOS1 Length of motif = 18 Motif number = 1 FOS Transforming protein motif I - 1 PCODE ST INT PTVTAISTSPDLQWLVQP FOS_AVINK 17 17 PTVTAISTSPDLQWLVQP FOS_HUMAN 62 62 PTETAISTSPDLQWLVQP FOSX_MSVFR 38 38 PTINAITTSQDLQWMVQP FRA2_CHICK 48 48 PSINAVSGSQELQWMVQP FRA1_RAT 41 41 PSINTMSGSQELQWMVQP FRA1_HUMAN 39 39 LEUZIPPRFOS2 Length of motif = 17 Motif number = 2 FOS Transforming protein motif II - 1 PCODE ST INT EQLSPEEEEKRRIRRER FOS_AVINK 84 49 EQLSPEEEEKRRIRRER FOS_HUMAN 130 50 EQLSPEEEVKRRIRRER FOSX_MSVFR 106 50 EQLSPEEEEKRRIRRER FRA2_CHICK 117 51 EQISPEEEERRRVRRER FRA1_RAT 100 41 EQISPEEEERRRVRRER FRA1_HUMAN 98 41 LEUZIPPRFOS3 Length of motif = 17 Motif number = 3 FOS Transforming protein motif III - 1 PCODE ST INT NKMAAAKCRNRRRELTD FOS_AVINK 101 0 NKMAAAKCRNRRRELTD FOS_HUMAN 147 0 NKMAAAKCRNRRRELTD FOSX_MSVFR 123 0 NKLAAAKCRNRRRELTE FRA2_CHICK 134 0 NKLAAAKCRNRRKELTD FRA1_RAT 117 0 NKLAAAKCRNRRKELTD FRA1_HUMAN 115 0 LEUZIPPRFOS4 Length of motif = 22 Motif number = 4 FOS Transforming protein motif IV - 1 PCODE ST INT LQAETDQLEEEKSALQAEIANL FOS_AVINK 119 1 LQAETDQLEDEKSALQTEIANL FOS_HUMAN 165 1 LQAETDQLEDEKSALQTEIANL FOSX_MSVFR 141 1 LQAETEVLEEEKSVLQKEIAEL FRA2_CHICK 152 1 LQAETDKLEDEKSGLQREIEEL FRA1_RAT 135 1 LQAETDKLEDEKSGLQREIEEL FRA1_HUMAN 133 1 LEUZIPPRFOS5 Length of motif = 24 Motif number = 5 FOS Transforming protein motif V - 1 PCODE ST INT LLKEKEKLEFILAAHRPACKMPEE FOS_AVINK 140 -1 LLKEKEKLEFILAAHRPACKIPDD FOS_HUMAN 186 -1 LLKEKEKLEFILAAHRPACKIPDD FOSX_MSVFR 162 -1 LQKEKEKLEFMLVAHSPVCKISPE FRA2_CHICK 173 -1 LQKQKERLELVLEAHRPICKIPEE FRA1_RAT 156 -1 LQKQKERLELVLEAHRPICKIPEG FRA1_HUMAN 154 -1 FINAL MOTIF SETS LEUZIPPRFOS1 Length of motif = 18 Motif number = 1 FOS Transforming protein motif I - 2 PCODE ST INT PTVTAISTSPDLQWLVQP FOS_HUMAN 62 62 PTVTAISTSPDLQWLVQP O88479 62 62 PTVTAISTSPDLQWLVQP FOS_MOUSE 62 62 PTVTAISTSPDLQWLVQP FOS_RAT 62 62 PTVTAISTSPDLQWLVQP FOS_AVINK 17 17 PTVTAISTSPDLQWLVQP FOS_CHICK 62 62 PTETAISTSPDLQWLVQP FOSX_MSVFR 38 38 PTETAISTSPDLQWLVQP O56223 347 347 PTETAISTSPDLQWLVQP Q62592 348 348 PTVTATSTSPDLQWLVQP FOS_MSVFB 62 62 PTVTAISTSPDLQWMVQP FOS_FUGRU 57 57 PTINAITTSQDLQWMVQP FRA2_HUMAN 49 49 PTVTAISSCPDLQWMVQP FOS_CYPCA 49 49 PTVTAISTSPDLQWMVQP FOS_TETFL 56 56 PTINAITTSQDLQWMVQP FRA2_CHICK 48 48 PTVNAITTSQDLQWMVQP Q91639 52 52 PTINAITTSQDLQWMVQP FRA2_MOUSE 49 49 PTVTAITTSQDLQWLVQP FOSB_HUMAN 56 56 PTVTAITTSQDLQWLVQP FOSB_MOUSE 56 56 TINAITTTSQDLQWMVQP FRA2_RAT 50 50 PSINAVSGSQELQWMVQP FRA1_RAT 41 41 PSINTMSGSQELQWMVQP FRA1_HUMAN 39 39 LVPSIDSSSQELHWMVQP O35285 39 39 FVPSIDSSSQELHWMVQP FRA1_MOUSE 39 39 LEUZIPPRFOS2 Length of motif = 17 Motif number = 2 FOS Transforming protein motif II - 2 PCODE ST INT EQLSPEEEEKRRIRRER FOS_HUMAN 130 50 EQLSPEEEEKRRIRRER O88479 130 50 EQLSPEEEEKRRIRRER FOS_MOUSE 130 50 EQLSPEEEEKRRIRRER FOS_RAT 130 50 EQLSPEEEEKRRIRRER FOS_AVINK 84 49 EQLSPEEEEKRRIRRER FOS_CHICK 129 49 EQLSPEEEVKRRIRRER FOSX_MSVFR 106 50 EQLSPEEEVKRRIRRER O56223 415 50 EQLSPEEEVKRRIRRER Q62592 416 50 EQLSPEEEEKRRIRRER FOS_MSVFB 130 50 EQTTPEEEEKKRIRRER FOS_FUGRU 114 39 EQLSPEEEEKRRIRRER FRA2_HUMAN 117 50 EQLSPEEEEKKRVRRER FOS_CYPCA 106 39 EQTTPEEEEKKRIRRER FOS_TETFL 113 39 EQLSPEEEEKRRIRRER FRA2_CHICK 117 51 EQLSPEEEEKRRVRRER Q91639 121 51 EQLSPEEEEKRRIRRER FRA2_MOUSE 117 50 ETLTPEEEEKRRVRRER FOSB_HUMAN 148 74 ETLTPEEEEKRRVRRER FOSB_MOUSE 148 74 EQLSPEEEEKRRIRRER FRA2_RAT 118 50 EQISPEEEERRRVRRER FRA1_RAT 100 41 EQISPEEEERRRVRRER FRA1_HUMAN 98 41 EQISPEEEERRRVRRER O35285 98 41 EQISPEEEERRRVRRER FRA1_MOUSE 98 41 LEUZIPPRFOS3 Length of motif = 17 Motif number = 3 FOS Transforming protein motif III - 2 PCODE ST INT NKMAAAKCRNRRRELTD FOS_HUMAN 147 0 NKMAAAKCRNRRRELTD O88479 147 0 NKMAAAKCRNRRRELTD FOS_MOUSE 147 0 NKMAAAKCRNRRRELTD FOS_RAT 147 0 NKMAAAKCRNRRRELTD FOS_AVINK 101 0 NKMAAAKCRNRRRELTD FOS_CHICK 146 0 NKMAAAKCRNRRRELTD FOSX_MSVFR 123 0 NKMAAAKCRNRRRELTD O56223 432 0 NKMAAAKCRNRRRELTD Q62592 433 0 NKMAAAKCRNRRRELTD FOS_MSVFB 147 0 NKQAAAKCRNRRRELTD FOS_FUGRU 131 0 NKLAAAKCRNRRRELTE FRA2_HUMAN 134 0 NKMAAAKCRNRRRELTD FOS_CYPCA 123 0 NKQAAAKCRNRRRELTD FOS_TETFL 130 0 NKLAAAKCRNRRRELTE FRA2_CHICK 134 0 NKLAAAKCRNRRRELTD Q91639 138 0 NKLAAAKCRNRRRELTE FRA2_MOUSE 134 0 NKLAAAKCRNRRRELTD FOSB_HUMAN 165 0 NKLAAAKCRNRRRELTD FOSB_MOUSE 165 0 NKLAAAKCRNRRRELTE FRA2_RAT 135 0 NKLAAAKCRNRRKELTD FRA1_RAT 117 0 NKLAAAKCRNRRKELTD FRA1_HUMAN 115 0 NKLAAAKCRNRRKELTD O35285 115 0 NKLAAAKCRNRRKELTD FRA1_MOUSE 115 0 LEUZIPPRFOS4 Length of motif = 22 Motif number = 4 FOS Transforming protein motif IV - 2 PCODE ST INT LQAETDQLEDEKSALQTEIANL FOS_HUMAN 165 1 LQAETDQLEDEKSALQTEIANL O88479 165 1 LQAETDQLEDEKSALQTEIANL FOS_MOUSE 165 1 LQAETDQLEDEKSALQTEIANL FOS_RAT 165 1 LQAETDQLEEEKSALQAEIANL FOS_AVINK 119 1 LQAETDQLEEEKSALQAEIANL FOS_CHICK 164 1 LQAETDQLEDEKSALQTEIANL FOSX_MSVFR 141 1 LQAETDQLEDEKSALQTEIANL O56223 450 1 LQAETDQLEDEKSALQTEIANL Q62592 451 1 LQAETDQLEDKKSALQTEIANL FOS_MSVFB 165 1 LQAETDQLEDEKSSLQNDIANL FOS_FUGRU 149 1 LQAETEELEEEKSGLQKEIAEL FRA2_HUMAN 152 1 LQAETDELEDEKSALQNDIANL FOS_CYPCA 141 1 LQAETDQLEAEKSSLQNDIANL FOS_TETFL 148 1 LQAETEVLEEEKSVLQKEIAEL FRA2_CHICK 152 1 LQAETEKLEQEKSGLQKEIADL Q91639 156 1 LQAETEELEEEKSGLQKEIAEL FRA2_MOUSE 152 1 LQAETDQLEEEKAELESEIAEL FOSB_HUMAN 183 1 LQAETDQLEEEKAELESEIAEL FOSB_MOUSE 183 1 LQTETEELEEEKSGLQKEIAEL FRA2_RAT 153 1 LQAETDKLEDEKSGLQREIEEL FRA1_RAT 135 1 LQAETDKLEDEKSGLQREIEEL FRA1_HUMAN 133 1 LQAETDKLEDEKSGLQREIEEL O35285 133 1 LQAETDKLEDEKSGLQREIEEL FRA1_MOUSE 133 1 LEUZIPPRFOS5 Length of motif = 24 Motif number = 5 FOS Transforming protein motif V - 2 PCODE ST INT LLKEKEKLEFILAAHRPACKIPDD FOS_HUMAN 186 -1 LLKEKEKLEFILAAHRPACKIPDD O88479 186 -1 LLKEKEKLEFILAAHRPACKIPDD FOS_MOUSE 186 -1 LLKEKEKLEFILAAHRPACKIPND FOS_RAT 186 -1 LLKEKEKLEFILAAHRPACKMPEE FOS_AVINK 140 -1 LLKEKEKLEFILAAHRPACKMPEE FOS_CHICK 185 -1 LLKEKEKLEFILAAHRPACKIPDD FOSX_MSVFR 162 -1 LLKEKEKLEFILAAHRPACKIPDD O56223 471 -1 LLKEKEKLEFILAAHRPACKIPDD Q62592 472 -1 LLKEKEKLEFILAAHRPACKIPDD FOS_MSVFB 186 -1 LLKEKERLEFILAAHQPICKIPSQ FOS_FUGRU 170 -1 LQKEKEKLEFMLVAHGPVCKISPE FRA2_HUMAN 173 -1 LLKEKERLEFILAAHKPICKIPSS FOS_CYPCA 162 -1 LLKEKERLEFILAAHQPICKIPSQ FOS_TETFL 169 -1 LQKEKEKLEFMLVAHSPVCKISPE FRA2_CHICK 173 -1 LQKEKDKLEFMLVAHSPVCKISTD Q91639 177 -1 LQKEKEKLEFMKVAHGPVCKISPE FRA2_MOUSE 173 -1 LQKEKERLEFVLVAHKPGCKIPYE FOSB_HUMAN 204 -1 LQKEKERLEFVLVAHKPGCKIPYE FOSB_MOUSE 204 -1 LQKEKEKLEFMLVAHGPVCKISPE FRA2_RAT 174 -1 LQKQKERLELVLEAHRPICKIPEE FRA1_RAT 156 -1 LQKQKERLELVLEAHRPICKIPEG FRA1_HUMAN 154 -1 LQKQKERLELVLEAHRPICKIPEG O35285 154 -1 LQKQKERLELVLEAHRLICKIPEG FRA1_MOUSE 154 -1

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