WORKLIST ENTRIES (1):
NRPEPTIDEYR View alignment View Structure Neuropeptide Y receptor signature
Type of fingerprint: COMPOUND with 5 elements
Links:
PRINTS; PR00237 GPCRRHODOPSN; PR00247 GPCRCAMP; PR00248 GPCRMGR
PRINTS; PR00249 GPCRSECRETIN; PR00250 GPCRSTE2; PR00899 GPCRSTE3
PRINTS; PR00251 BACTRLOPSIN
PRINTS; PR01013 NRPEPTIDEY1R; PR01014 NRPEPTIDEY2R; PR01015 NRPEPTIDEY4R
PRINTS; PR01016 NRPEPTIDEY5R; PR01017 NRPEPTIDEY6R
INTERPRO; IPR000611
Creation date 30-NOV-1998; UPDATE 03-JUL-1999
1. ATTWOOD, T.K. AND FINDLAY, J.B.C.
Fingerprinting G protein-coupled receptors.
PROTEIN ENG. 7(2) 195-203 (1994).
2. ATTWOOD, T.K. AND FINDLAY, J.B.C.
G protein-coupled receptor fingerprints.
7TM, VOLUME 2, EDS. G.VRIEND AND B.BYWATER (1993).
3. BIRNBAUMER, L.
G proteins in signal transduction.
ANNU.REV.PHARMACOL.TOXICOL. 30 675-705 (1990).
4. CASEY, P.J. AND GILMAN, A.G.
G protein involvement in receptor-effector coupling.
J.BIOL.CHEM. 263(6) 2577-2580 (1988).
5. ATTWOOD, T.K. AND FINDLAY, J.B.C.
Design of a discriminating fingerprint for G protein-coupled receptors.
PROTEIN ENG. 6(2) 167-176 (1993).
6. WATSON, S. AND ARKINSTALL, S.
Neuropeptide Y.
IN THE G PROTEIN-LINKED RECEPTOR FACTSBOOK, ACADEMIC PRESS, 1994, PP.194-198.
G protein-coupled receptors (GPCRs) constitute a vast protein family that
encompasses a wide range of functions (including various autocrine, para-
crine and endocrine processes). They show considerable diversity at the
sequence level, on the basis of which they can be separated into distinct
groups. We use the term clan to describe the GPCRs, as they embrace a group
of families for which there are indications of evolutionary relationship,
but between which there is no statistically significant similarity in
sequence [1,2]. The currently known clan members include the rhodopsin-like
GPCRs, the secretin-like GPCRs, the cAMP receptors, the fungal mating
pheromone receptors, and the metabotropic glutamate receptor family.
The rhodopsin-like GPCRs themselves represent a widespread protein family
that includes hormone, neurotransmitter and light receptors, all of
which transduce extracellular signals through interaction with guanine
nucleotide-binding (G) proteins. Although their activating ligands vary
widely in structure and character, the amino acid sequences of the
receptors are very similar and are believed to adopt a common structural
framework comprising 7 transmembrane (TM) helices [3-5].
Neuropeptide Y (NPY) is one of the most abundant peptides in mammalian
brain, inducing a variety of behavioural effects (e.g., stimulation of food
intake, anxiety, facilitation of learning and memory, and regulation of the
cardiovascular and neuroendocrine systems) [6]. In the periphery, NPY
stimulates vascular smooth muscle contraction and modulates hormone
secretion. NPY has been implicated in the pathophysiology of hypertension,
congestive heart failure, affective disorders and appetite regulation [6].
NRPEPTIDEYR is a 5-element fingerprint that provides a signature for
neuropeptide Y receptors. The fingerprint was derived from an initial
alignment of 11 sequences: the motifs were drawn from conserved sections
within either loop or TM regions, focusing on those areas of the alignment
that characterise the neuropeptide Y receptors but distinguish them from the
rest of the rhodopsin-like GPCR superfamily - motif 1 spans the first
cytoplasmic loop; motif 2 spans the first external loop; motif 3 encodes
the N-terminal portion of TM domain 3; motif 4 spans the central portion
of TM domain 7; and motif 5 lies at the C-terminus. Two iterations on
OWL30.2 were required to reach convergence, at which point a true set
comprising 20 sequences was identified. Several partial matches were also
found, all of which are superfamily members that match two motifs.
An update on SPTR37_9f identified a true set of 22 sequences, and 9
partial matches.
SUMMARY INFORMATION
22 codes involving 5 elements
0 codes involving 4 elements
2 codes involving 3 elements
7 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
5| 22 22 22 22 22
4| 0 0 0 0 0
3| 2 2 2 0 0
2| 4 3 4 0 3
--+--------------------------
| 1 2 3 4 5
True positives..
NY1R_XENLA NY1R_RAT NY1R_MOUSE NY1R_HUMAN
NY1R_CANFA O73734 NY6R_MOUSE O57463
NY4R_MOUSE NY6R_RABIT NY4R_RAT O73733
NY4R_HUMAN O35380 NY5R_RAT NY5R_MOUSE
NY5R_HUMAN NY5R_CANFA NY2R_PIG NY2R_MOUSE
NY2R_HUMAN NY2R_BOVIN
Subfamily: Codes involving 3 elements
Subfamily True positives..
Q99647 Q99463
Subfamily: Codes involving 2 elements
Subfamily True positives..
SSR1_HUMAN SSR1_RAT SSR1_MOUSE CCKR_CAVPO
CCKR_HUMAN CCKR_RAT O08786
PROTEIN TITLES
NY1R_XENLA NEUROPEPTIDE Y RECEPTOR TYPE 1 (NPY1-R) - XENOPUS LAEVIS (AF
NY1R_RAT NEUROPEPTIDE Y RECEPTOR TYPE 1 (NPY1-R) (FC5) - RATTUS NORVE
NY1R_MOUSE NEUROPEPTIDE Y RECEPTOR TYPE 1 (NPY1-R) - MUS MUSCULUS (MOUS
NY1R_HUMAN NEUROPEPTIDE Y RECEPTOR TYPE 1 (NPY1-R) - HOMO SAPIENS (HUMA
NY1R_CANFA NEUROPEPTIDE Y RECEPTOR TYPE 1 (NPY1-R) - CANIS FAMILIARIS (
O73734 NEUROPEPTIDE Y/PEPTIDE YY RECEPTOR YC - BRACHYDANIO RERIO (Z
NY6R_MOUSE NEUROPEPTIDE Y RECEPTOR TYPE 6 (NPY6-R) (PANCREATIC POLYPEPT
O57463 NEUROPEPTIDE Y /PEPTIDE YY RECEPTOR YB - BRACHYDANIO RERIO (
NY4R_MOUSE NEUROPEPTIDE Y RECEPTOR TYPE 4 (NPY4-R) (PANCREATIC POLYPEPT
NY6R_RABIT NEUROPEPTIDE Y RECEPTOR TYPE 6 (NPY6-R) - ORYCTOLAGUS CUNICU
NY4R_RAT NEUROPEPTIDE Y RECEPTOR TYPE 4 (NPY4-R) (PANCREATIC POLYPEPT
O73733 NEUROPEPTIDE Y/PEPTIDE YY RECEPTOR YA - BRACHYDANIO RERIO (Z
NY4R_HUMAN NEUROPEPTIDE Y RECEPTOR TYPE 4 (NPY4-R) (PANCREATIC POLYPEPT
O35380 NEUROPEPTIDE Y Y5 RECEPTOR - MUS MUSCULUS (MOUSE).
NY5R_RAT NEUROPEPTIDE Y RECEPTOR TYPE 5 (NPY5-R) (Y5 RECEPTOR) - RATT
NY5R_MOUSE NEUROPEPTIDE Y RECEPTOR TYPE 5 (NPY5-R) (Y5 RECEPTOR) - MUS
NY5R_HUMAN NEUROPEPTIDE Y RECEPTOR TYPE 5 (NPY5-R) (Y5 RECEPTOR) (NPYY5
NY5R_CANFA NEUROPEPTIDE Y RECEPTOR TYPE 5 (NPY5-R) (Y5 RECEPTOR) (NPYY5
NY2R_PIG NEUROPEPTIDE Y RECEPTOR TYPE 2 (NPY2-R) - SUS SCROFA (PIG).
NY2R_MOUSE NEUROPEPTIDE Y RECEPTOR TYPE 2 (NPY2-R) - MUS MUSCULUS (MOUS
NY2R_HUMAN NEUROPEPTIDE Y RECEPTOR TYPE 2 (NPY2-R) - HOMO SAPIENS (HUMA
NY2R_BOVIN NEUROPEPTIDE Y RECEPTOR TYPE 2 (NPY2-R) - BOS TAURUS (BOVINE
Q99647 TRUNCATED PANCREATIC POLYPEPTIDE RECEPTOR PP2 - HOMO SAPIENS
Q99463 Y6 ENCODING PROTEIN - HOMO SAPIENS (HUMAN).
SSR1_HUMAN SOMATOSTATIN RECEPTOR TYPE 1 (SS1R) (SRIF-2) - HOMO SAPIENS
SSR1_RAT SOMATOSTATIN RECEPTOR TYPE 1 (SS1R) (SRIF-2) - RATTUS NORVEG
SSR1_MOUSE SOMATOSTATIN RECEPTOR TYPE 1 (SS1R) (SRIF-2) - MUS MUSCULUS
CCKR_CAVPO CHOLECYSTOKININ TYPE A RECEPTOR (CCK-A RECEPTOR) (CCK-AR) -
CCKR_HUMAN CHOLECYSTOKININ TYPE A RECEPTOR (CCK-A RECEPTOR) (CCK-AR) -
CCKR_RAT CHOLECYSTOKININ TYPE A RECEPTOR (CCK-A RECEPTOR) (CCK-AR) -
O08786 CHOLECYSTOKININ A RECEPTOR (CHOLECYSTOKININ TYPE-A RECEPTOR)
SCAN HISTORY
OWL30_2 2 100 NSINGLE
SPTR37_9f 2 50 NSINGLE
INITIAL MOTIF SETS
NRPEPTIDEYR1 Length of motif = 13 Motif number = 1
Neuropeptide Y receptor motif I - 1
PCODE ST INT
KQKEMRNVTNILI NY1R_HUMAN 67 67
KQKEMRNVTNILI NY1R_MOUSE 66 66
KQKEMRNVTNILI NY1R_RAT 66 66
KQKEMRNVTNILI NY1R_XENLA 62 62
RQKEKANVTNLLI NY4R_HUMAN 68 68
RQKEKSNVTNLLI NY4R_MOUSE 68 68
RQKEKSNVTNLLI NY4R_RAT 68 68
KFKSMRTVTNFFI NY2R_HUMAN 77 77
KFKSMRTVTNFFI NY2R_BOVIN 80 80
KKRNQKTTVNFLI NY5R_RAT 79 79
KKRNQKTTVNFLI NY5R_HUMAN 78 78
NRPEPTIDEYR2 Length of motif = 13 Motif number = 2
Neuropeptide Y receptor motif II - 1
PCODE ST INT
TFVYTLMDHWVFG NY1R_HUMAN 97 17
TFVYTLMDHWVFG NY1R_MOUSE 96 17
TFVYTLMDHWVFG NY1R_RAT 96 17
TLIYTLMDHWIFG NY1R_XENLA 92 17
TAVYTIMDYWIFG NY4R_HUMAN 98 17
TVTYTIMDYWIFG NY4R_MOUSE 98 17
TVTYTIMDYWIFG NY4R_RAT 98 17
TLTYTLMGEWKMG NY2R_HUMAN 107 17
TLTYTLMGEWKMG NY2R_BOVIN 110 17
TLTSVLLDQWMFG NY5R_RAT 109 17
TLTSVLLDQWMFG NY5R_HUMAN 108 17
NRPEPTIDEYR3 Length of motif = 16 Motif number = 3
Neuropeptide Y receptor motif III - 1
PCODE ST INT
QCVSITVSIFSLVLIA NY1R_HUMAN 120 10
QCVSITVSIFSLVLIA NY1R_MOUSE 119 10
QCVSITVSIFSLVLIA NY1R_RAT 119 10
QCVSVTVSIFSLVLIA NY1R_XENLA 115 10
QCMSVTVSILSLVLVA NY4R_HUMAN 121 10
QCMSVTVSILSLVLVA NY4R_MOUSE 121 10
QCMSVTVSILSLVLVA NY4R_RAT 121 10
QGLAVQVSTITLTVIA NY2R_HUMAN 130 10
QGLAVQVSTITLTVIA NY2R_BOVIN 133 10
QCVSVLVSTLILISIA NY5R_RAT 132 10
QCVSVLVSTLILISIA NY5R_HUMAN 131 10
NRPEPTIDEYR4 Length of motif = 10 Motif number = 4
Neuropeptide Y receptor motif IV - 1
PCODE ST INT
LTAMISTCVN NY1R_HUMAN 307 171
LTAMISTCVN NY1R_MOUSE 306 171
LTAMISTCVN NY1R_RAT 306 171
LTAMISTCVN NY1R_XENLA 302 171
LLAMASTCVN NY4R_HUMAN 309 172
LLAMASTCVN NY4R_MOUSE 309 172
LFAMASTCVN NY4R_RAT 309 172
IIAMCSTFAN NY2R_HUMAN 312 166
IIAMCSTFAN NY2R_BOVIN 315 166
LLGMMSCCLN NY5R_RAT 422 274
LLGMMSCCLN NY5R_HUMAN 422 275
NRPEPTIDEYR5 Length of motif = 14 Motif number = 5
Neuropeptide Y receptor motif V - 1
PCODE ST INT
IFYGFLNKNFQRDL NY1R_HUMAN 318 1
IFYGFLNKNFQRDL NY1R_MOUSE 317 1
IFYGFLNKNFQRDL NY1R_RAT 317 1
IFYGFLNKNFQRDL NY1R_XENLA 313 1
FIYGFLNTNFKKEI NY4R_HUMAN 320 1
FIYGFLNINFKKDI NY4R_MOUSE 320 1
FIYGFLNINFKKDI NY4R_RAT 320 1
LLYGWMNSNYRKAF NY2R_HUMAN 323 1
LLYGWMNSNYRKAF NY2R_BOVIN 326 1
ILYGFLNNGIKADL NY5R_RAT 433 1
ILYGFLNNGIKADL NY5R_HUMAN 433 1
FINAL MOTIF SETS
NRPEPTIDEYR1 Length of motif = 13 Motif number = 1
Neuropeptide Y receptor motif I - 2
PCODE ST INT
KQKEMRNVTNILI NY1R_XENLA 62 62
KQKEMRNVTNILI NY1R_RAT 66 66
KQKEMRNVTNILI NY1R_MOUSE 66 66
KQKEMRNVTNILI NY1R_HUMAN 67 67
KQKEMRNVTNILI NY1R_CANFA 66 66
RQKEMRNVTNILI O73734 57 57
KQREAQNVTNILI NY6R_MOUSE 63 63
RQKEMRNVTNIFI O57463 52 52
RQKEKSNVTNLLI NY4R_MOUSE 68 68
KQREAQNVTNILI NY6R_RABIT 63 63
RQKEKSNVTNLLI NY4R_RAT 68 68
HQRDPPNVTSILI O73733 69 69
RQKEKANVTNLLI NY4R_HUMAN 68 68
KKRNQKTTVNFLI O35380 89 89
KKRNQKTTVNFLI NY5R_RAT 79 79
KKRNQKTTVNFLI NY5R_MOUSE 89 89
KKRNQKTTVNFLI NY5R_HUMAN 78 78
RKRNQKTMVNFLI NY5R_CANFA 68 68
KFKSMRTVTNFFI NY2R_PIG 78 78
KFKSMRTVTNFFI NY2R_MOUSE 81 81
KFKSMRTVTNFFI NY2R_HUMAN 77 77
KFKSMRTVTNFFI NY2R_BOVIN 80 80
NRPEPTIDEYR2 Length of motif = 13 Motif number = 2
Neuropeptide Y receptor motif II - 2
PCODE ST INT
TLIYTLMDHWIFG NY1R_XENLA 92 17
TFVYTLMDHWVFG NY1R_RAT 96 17
TFVYTLMDHWVFG NY1R_MOUSE 96 17
TFVYTLMDHWVFG NY1R_HUMAN 97 17
TFVYTLMDHWVFG NY1R_CANFA 96 17
TVIYTLMDRWILG O73734 87 17
TVIYTLMDHWVFG NY6R_MOUSE 93 17
TIIYTLMDRWILG O57463 82 17
TVTYTIMDYWIFG NY4R_MOUSE 98 17
TAIYTLMDRWIFG NY6R_RABIT 93 17
TVTYTIMDYWIFG NY4R_RAT 98 17
TVVYTLMDHWIFG O73733 99 17
TAVYTIMDYWIFG NY4R_HUMAN 98 17
TLTSVLLDQWMFG O35380 119 17
TLTSVLLDQWMFG NY5R_RAT 109 17
TLTSVLLDQWMFG NY5R_MOUSE 119 17
TLTSVLLDQWMFG NY5R_HUMAN 108 17
TLTSVLLDQWMFG NY5R_CANFA 98 17
TLTYTLMGEWKMG NY2R_PIG 108 17
TLTYTLMGEWKMG NY2R_MOUSE 111 17
TLTYTLMGEWKMG NY2R_HUMAN 107 17
TLTYTLMGEWKMG NY2R_BOVIN 110 17
NRPEPTIDEYR3 Length of motif = 16 Motif number = 3
Neuropeptide Y receptor motif III - 2
PCODE ST INT
QCVSVTVSIFSLVLIA NY1R_XENLA 115 10
QCVSITVSIFSLVLIA NY1R_RAT 119 10
QCVSITVSIFSLVLIA NY1R_MOUSE 119 10
QCVSITVSIFSLVLIA NY1R_HUMAN 120 10
QCVSITVSIFSLVLIA NY1R_CANFA 119 10
QCMSVTVSIFSLVLIA O73734 110 10
QSVSVSVSIFSLVLIA NY6R_MOUSE 116 10
QCMSVTVSIFSMVLIA O57463 105 10
QCMSVTVSILSLVLVA NY4R_MOUSE 121 10
QSVSISVSIFSLVLIA NY6R_RABIT 116 10
QCMSVTVSILSLVLVA NY4R_RAT 121 10
QCVSVTVSVLSLVLIA O73733 122 10
QCMSVTVSILSLVLVA NY4R_HUMAN 121 10
QCVSVLVSTLILISIA O35380 142 10
QCVSVLVSTLILISIA NY5R_RAT 132 10
QCVSVLVSTLILISIA NY5R_MOUSE 142 10
QCVSVLVSTLILISIA NY5R_HUMAN 131 10
QCVSVLVSTLILISIA NY5R_CANFA 121 10
QGLAVQVSTITLTVIA NY2R_PIG 131 10
QGLAVQVSTITLTVIA NY2R_MOUSE 134 10
QGLAVQVSTITLTVIA NY2R_HUMAN 130 10
QGLAVQVSTITLTVIA NY2R_BOVIN 133 10
NRPEPTIDEYR4 Length of motif = 10 Motif number = 4
Neuropeptide Y receptor motif IV - 2
PCODE ST INT
LTAMISTCVN NY1R_XENLA 302 171
LTAMISTCVN NY1R_RAT 306 171
LTAMISTCVN NY1R_MOUSE 306 171
LTAMISTCVN NY1R_HUMAN 307 171
LTAMISTCVN NY1R_CANFA 306 171
LTAMASTCVN O73734 300 174
LIAMVSTCIN NY6R_MOUSE 305 173
LTAMASTCVN O57463 295 174
LLAMASTCVN NY4R_MOUSE 309 172
LVAMVSTCIN NY6R_RABIT 305 173
LFAMASTCVN NY4R_RAT 309 172
LLAMSSTCVN O73733 313 175
LLAMASTCVN NY4R_HUMAN 309 172
LLGMMSCCLN O35380 432 274
LLGMMSCCLN NY5R_RAT 422 274
LLGMMSCCLN NY5R_MOUSE 432 274
LLGMMSCCLN NY5R_HUMAN 422 275
LLGMMSCCLN NY5R_CANFA 412 275
IIAMCSTFAN NY2R_PIG 314 167
IIAMCSTFAN NY2R_MOUSE 316 166
IIAMCSTFAN NY2R_HUMAN 312 166
IIAMCSTFAN NY2R_BOVIN 315 166
NRPEPTIDEYR5 Length of motif = 14 Motif number = 5
Neuropeptide Y receptor motif V - 2
PCODE ST INT
IFYGFLNKNFQRDL NY1R_XENLA 313 1
IFYGFLNKNFQRDL NY1R_RAT 317 1
IFYGFLNKNFQRDL NY1R_MOUSE 317 1
IFYGFLNKNFQRDL NY1R_HUMAN 318 1
IFYGFLNKNFQRDL NY1R_CANFA 317 1
VVYGFLNTNFQKEL O73734 311 1
LFYGFLNKNFQKDL NY6R_MOUSE 316 1
VIYGFLNNNFQKEL O57463 306 1
FIYGFLNINFKKDI NY4R_MOUSE 320 1
LFYGFLNRNFQKDL NY6R_RABIT 316 1
FIYGFLNINFKKDI NY4R_RAT 320 1
IIYGFLNSNFRKDV O73733 324 1
FIYGFLNTNFKKEI NY4R_HUMAN 320 1
ILYGFLNNGIKADL O35380 443 1
ILYGFLNNGIKADL NY5R_RAT 433 1
ILYGFLNNGIKADL NY5R_MOUSE 443 1
ILYGFLNNGIKADL NY5R_HUMAN 433 1
ILYGFLNNGIKADL NY5R_CANFA 423 1
LLYGWMNSNYRKAF NY2R_PIG 325 1
LLYGWMNSNYRKAF NY2R_MOUSE 327 1
LLYGWMNSNYRKAF NY2R_HUMAN 323 1
LLYGWMNSNYRKAF NY2R_BOVIN 326 1
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