WORKLIST ENTRIES (1):
RABAPTIN View alignment Rabaptin signature
Type of fingerprint: COMPOUND with 12 elements
Links:
Creation date 30-OCT-2000
1. NISHIMUNE, H., UYEDA, A., NOGAWA, M., FUJIMORI, K. AND TAGUCHI, T.
Neurocrescin: a novel neurite-outgrowth factor secreted by muscle after
denervation.
NEUROREPORT 8 3649-3654 (1997).
2. STENMARK, H., VITALE, G., ULLRICH, O. AND ZERIAL, M.
Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic
membrane fusion.
CELL 83 423-432 (1995).
Regeneration of injured axons at neuromuscular junctions has been assumed
to be regulated by extra-cellular factors that promote neurite outgrowth.
A novel neurite outgrowth factor from chick denervated skeletal muscle has
been cloned and characterised. The protein, termed neurocrescin (rabaptin),
has been shown to be secreted in an activity-dependent fashion [1].
Rabaptin is a 100kDa coiled-coil protein that interacts with the GTP form
of the small GTPase Rab5, a potent regulator of endocytic transport [2]. It
is mainly cytosolic, but a fraction co-localises with Rab5 to early
endosomes [2]. Rab5 recruits rabaptin-5 to purified early endosomes in a
GTP-dependent manner, demonstrating functional similarities with other
members of the Ras superfamily [2]. Immunodepletion of rabaptin-5 from
cytosol strongly inhibits Rab5-dependent early endosome fusion. Thus,
rabaptin-5 is a Rab effector required for membrane docking and fusion [2].
RABAPTIN is a 12-element fingerprint that provides a signature for
rabaptins. The fingerprint was derived from an initial alignment of 6
sequences: the motifs were drawn largely from hydrophobic segments spanning
virtually the full alignment length. A single iteration on SPTR39_14f was
required to reach convergence, no further sequences being identified beyond
the starting set. A single partial match was found, Q62835, a fos-related
antigen from Rattus norvegicus that matches motifs 2, 3, 8 and 11.
SUMMARY INFORMATION
6 codes involving 12 elements
0 codes involving 11 elements
0 codes involving 10 elements
0 codes involving 9 elements
0 codes involving 8 elements
0 codes involving 7 elements
0 codes involving 6 elements
0 codes involving 5 elements
1 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
12| 6 6 6 6 6 6 6 6 6 6 6 6
11| 0 0 0 0 0 0 0 0 0 0 0 0
10| 0 0 0 0 0 0 0 0 0 0 0 0
9| 0 0 0 0 0 0 0 0 0 0 0 0
8| 0 0 0 0 0 0 0 0 0 0 0 0
7| 0 0 0 0 0 0 0 0 0 0 0 0
6| 0 0 0 0 0 0 0 0 0 0 0 0
5| 0 0 0 0 0 0 0 0 0 0 0 0
4| 0 1 1 0 0 0 0 1 0 0 1 0
3| 0 0 0 0 0 0 0 0 0 0 0 0
2| 0 0 0 0 0 0 0 0 0 0 0 0
--+-------------------------------------------------------------
| 1 2 3 4 5 6 7 8 9 10 11 12
True positives..
O35550 O35551 Q15276 O95369
P70609 O42351
Subfamily: Codes involving 4 elements
Subfamily True positives..
Q62835
PROTEIN TITLES
O35550 RAT RABAPTIN-5 - Rattus norvegicus (Rat).
O35551 MOUSE RABAPTIN-5 (NEUROCRESCIN) - Mus musculus (Mouse).
Q15276 RABAPTIN-5 - Homo sapiens (Human).
O95369 RABAPTIN-4 - Homo sapiens (Human).
P70609 RABAPTIN - Rattus norvegicus (Rat).
O42351 CHICKEN RABAPTIN-5 (NEUROCRESCIN) - Gallus gallus (Chicken).
Q62835 FOS-RELATED ANTIGEN - Rattus norvegicus (Rat).
SCAN HISTORY
SPTR39_14f 1 50 NSINGLE
INITIAL MOTIF SETS
RABAPTIN1 Length of motif = 20 Motif number = 1
Rabaptin motif I - 1
PCODE ST INT
DVSLQQRVAELEKINAEFLR O95369 11 11
DVSLQQRVAELEKINAEFLR Q15276 11 11
DVALLQRVAELEKVNAEFLR O42351 11 11
DVSLQQRVAELEKINAEFLR O35551 11 11
DVSLQQRVAELEKINAEFLR P70609 11 11
DVSLQQRVAELEKINAEFLR O35550 11 11
RABAPTIN2 Length of motif = 18 Motif number = 2
Rabaptin motif II - 1
PCODE ST INT
LWEAQAEMENIKAIATVS O95369 78 47
LWEAQAEMENIKAIATVS Q15276 78 47
LMEAHAEMENIKAIATVS O42351 78 47
LWEAQAEMENIKAIATVS O35551 78 47
LSEAQADMENIKAIATVS P70609 78 47
LWEAQAEMENIKAIATVS O35550 78 47
RABAPTIN3 Length of motif = 19 Motif number = 3
Rabaptin motif III - 1
PCODE ST INT
AEKLRSVVMPMEKEIAALK O95369 181 85
AEKLRSVVMPMEKEIAALK Q15276 181 85
AEKLRSVVMPMEKEIAALK O42351 181 85
AEKLRSVVMPMEKEIAALK O35551 181 85
AEKLRSVVMPMEKEIAALK P70609 181 85
AEKLRSVVMPMEKEIAALK O35550 181 85
RABAPTIN4 Length of motif = 22 Motif number = 4
Rabaptin motif IV - 1
PCODE ST INT
CRTDLEMYVAVLNTQKSVLQED O95369 230 30
CRTDLEMYVAVLNTQKSVLQED Q15276 230 30
CRTDLEMYVAVLNTQKSVLQED O42351 230 30
CRTDLEMYVAVLNTQKSVLQED O35551 230 30
CRTDLEMYVAVLNTQKSVLQED P70609 230 30
CRTDLEMYVAVLNTQKSVLQED O35550 230 30
RABAPTIN5 Length of motif = 18 Motif number = 5
Rabaptin motif V - 1
PCODE ST INT
HLDSTRGSVHSLDAGLLL O95369 367 115
HLDSTRGSVHSLDAGLLL Q15276 367 115
HLNSTHSSVHSLDADLLL O42351 365 113
HLDSTHGSVHSLDADLML O35551 367 115
HLDSTHGSVHSLDADLLL P70609 367 115
HLDSTHGSVHSLDADLLL O35550 367 115
RABAPTIN6 Length of motif = 19 Motif number = 6
Rabaptin motif VI - 1
PCODE ST INT
LQSKALGYNYKAKSAGNLD O95369 417 32
LQSKALGYNYKAKSAGNLD Q15276 417 32
LQSKALGYNNKAKSAGNLD O42351 415 32
LQSKALGYNYKAKSAGNLD O35551 417 32
LQSKALGYNYKAKSAGNLD P70609 417 32
LQSKALGYNYKAKSAGNLD O35550 417 32
RABAPTIN7 Length of motif = 21 Motif number = 7
Rabaptin motif VII - 1
PCODE ST INT
SENFDTASLGSLQMPSGFMLT O95369 449 13
SENFDTASLGSLQMPSGFMLT Q15276 449 13
SENYDTASLGSLQMPSGFMLT O42351 447 13
SENFDTVSLGSLQMPSGFMLT O35551 449 13
SENFDTVSLESLQMPSGFMLT P70609 449 13
SENFDTVSLGSLQMPSGFMLT O35550 449 13
RABAPTIN8 Length of motif = 21 Motif number = 8
Rabaptin motif VIII - 1
PCODE ST INT
RAIKAMTPEQEETASLLSSVT O95369 474 4
RAIKAMTPEQEETASLLSSVT Q15276 474 4
KAIKAMTPEQEETASLLSSVT O42351 472 4
RAIKAMTPEQEETASLLSSVT O35551 474 4
RAIKAMTPEQEETASLLSSVT P70609 474 4
RAIKAMTPEQEETASLLSSVT O35550 474 4
RABAPTIN9 Length of motif = 21 Motif number = 9
Rabaptin motif IX - 1
PCODE ST INT
SAYVSPSGYRLVSETEWNLLQ O95369 499 4
SAYVSPSGYRLVSETEWNLLQ Q15276 499 4
SAYVSPSGYRLVSETEWNLLQ O42351 497 4
SAYVSPSGYRLVSETEWNLLQ O35551 499 4
SAYVSPSGYRLVSETEWNLLQ P70609 499 4
SAYVSPSGYRLVSETEWNLLQ O35550 499 4
RABAPTIN10 Length of motif = 17 Motif number = 10
Rabaptin motif X - 1
PCODE ST INT
QISALVLRAQASEILLE O95369 595 75
QISALVLRAQASEILLE Q15276 595 75
QISLLMVKCQKSENFLN O42351 593 75
QISALVLRAQASEVLLE O35551 595 75
QISALVLRAQASEVLLE P70609 595 75
QISALVLRAQASEVLLE O35550 595 75
RABAPTIN11 Length of motif = 23 Motif number = 11
Rabaptin motif XI - 1
PCODE ST INT
VQEQMAVLMQSREQVSEELVRLQ O95369 624 12
VQEQMAVLMQSREQVSEELVRLQ Q15276 624 12
VQEQMAVLTQSREQVSEELVRLQ O42351 622 12
VQEQMAVLMQSREQVSEELVRLQ O35551 624 12
VQEQMAVLMQSREQVSEELVRLQ P70609 624 12
VQEQMAVLMQSREQVSEELVRLQ O35550 624 12
RABAPTIN12 Length of motif = 21 Motif number = 12
Rabaptin motif XII - 1
PCODE ST INT
ALRELVLKYREDIINVRTAAD O95369 676 29
ALRELVLKYREDIINVRTAAD Q15276 676 29
ELRELILKYREDIISVRTAAD O42351 674 29
VLRELVLKYRENIVHVRTAAD O35551 676 29
VLRELVLKYRENIVHVRTAAD P70609 676 29
VLRELVLKYRENIVHVRTAAD O35550 676 29
FINAL MOTIF SETS
RABAPTIN1 Length of motif = 20 Motif number = 1
Rabaptin motif I - 1
PCODE ST INT
DVSLQQRVAELEKINAEFLR O35550 11 11
DVSLQQRVAELEKINAEFLR O35551 11 11
DVSLQQRVAELEKINAEFLR O95369 11 11
DVSLQQRVAELEKINAEFLR Q15276 11 11
DVSLQQRVAELEKINAEFLR P70609 11 11
DVALLQRVAELEKVNAEFLR O42351 11 11
RABAPTIN2 Length of motif = 18 Motif number = 2
Rabaptin motif II - 1
PCODE ST INT
LWEAQAEMENIKAIATVS O35550 78 47
LWEAQAEMENIKAIATVS O35551 78 47
LWEAQAEMENIKAIATVS O95369 78 47
LWEAQAEMENIKAIATVS Q15276 78 47
LSEAQADMENIKAIATVS P70609 78 47
LMEAHAEMENIKAIATVS O42351 78 47
RABAPTIN3 Length of motif = 19 Motif number = 3
Rabaptin motif III - 1
PCODE ST INT
AEKLRSVVMPMEKEIAALK O35550 181 85
AEKLRSVVMPMEKEIAALK O35551 181 85
AEKLRSVVMPMEKEIAALK O95369 181 85
AEKLRSVVMPMEKEIAALK Q15276 181 85
AEKLRSVVMPMEKEIAALK P70609 181 85
AEKLRSVVMPMEKEIAALK O42351 181 85
RABAPTIN4 Length of motif = 22 Motif number = 4
Rabaptin motif IV - 1
PCODE ST INT
CRTDLEMYVAVLNTQKSVLQED O35550 230 30
CRTDLEMYVAVLNTQKSVLQED O35551 230 30
CRTDLEMYVAVLNTQKSVLQED O95369 230 30
CRTDLEMYVAVLNTQKSVLQED Q15276 230 30
CRTDLEMYVAVLNTQKSVLQED P70609 230 30
CRTDLEMYVAVLNTQKSVLQED O42351 230 30
RABAPTIN5 Length of motif = 18 Motif number = 5
Rabaptin motif V - 1
PCODE ST INT
HLDSTHGSVHSLDADLLL O35550 367 115
HLDSTHGSVHSLDADLML O35551 367 115
HLDSTRGSVHSLDAGLLL O95369 367 115
HLDSTRGSVHSLDAGLLL Q15276 367 115
HLDSTHGSVHSLDADLLL P70609 367 115
HLNSTHSSVHSLDADLLL O42351 365 113
RABAPTIN6 Length of motif = 19 Motif number = 6
Rabaptin motif VI - 1
PCODE ST INT
LQSKALGYNYKAKSAGNLD O35550 417 32
LQSKALGYNYKAKSAGNLD O35551 417 32
LQSKALGYNYKAKSAGNLD O95369 417 32
LQSKALGYNYKAKSAGNLD Q15276 417 32
LQSKALGYNYKAKSAGNLD P70609 417 32
LQSKALGYNNKAKSAGNLD O42351 415 32
RABAPTIN7 Length of motif = 21 Motif number = 7
Rabaptin motif VII - 1
PCODE ST INT
SENFDTVSLGSLQMPSGFMLT O35550 449 13
SENFDTVSLGSLQMPSGFMLT O35551 449 13
SENFDTASLGSLQMPSGFMLT O95369 449 13
SENFDTASLGSLQMPSGFMLT Q15276 449 13
SENFDTVSLESLQMPSGFMLT P70609 449 13
SENYDTASLGSLQMPSGFMLT O42351 447 13
RABAPTIN8 Length of motif = 21 Motif number = 8
Rabaptin motif VIII - 1
PCODE ST INT
RAIKAMTPEQEETASLLSSVT O35550 474 4
RAIKAMTPEQEETASLLSSVT O35551 474 4
RAIKAMTPEQEETASLLSSVT O95369 474 4
RAIKAMTPEQEETASLLSSVT Q15276 474 4
RAIKAMTPEQEETASLLSSVT P70609 474 4
KAIKAMTPEQEETASLLSSVT O42351 472 4
RABAPTIN9 Length of motif = 21 Motif number = 9
Rabaptin motif IX - 1
PCODE ST INT
SAYVSPSGYRLVSETEWNLLQ O35550 499 4
SAYVSPSGYRLVSETEWNLLQ O35551 499 4
SAYVSPSGYRLVSETEWNLLQ O95369 499 4
SAYVSPSGYRLVSETEWNLLQ Q15276 499 4
SAYVSPSGYRLVSETEWNLLQ P70609 499 4
SAYVSPSGYRLVSETEWNLLQ O42351 497 4
RABAPTIN10 Length of motif = 17 Motif number = 10
Rabaptin motif X - 1
PCODE ST INT
QISALVLRAQASEVLLE O35550 595 75
QISALVLRAQASEVLLE O35551 595 75
QISALVLRAQASEILLE O95369 595 75
QISALVLRAQASEILLE Q15276 595 75
QISALVLRAQASEVLLE P70609 595 75
QISLLMVKCQKSENFLN O42351 593 75
RABAPTIN11 Length of motif = 23 Motif number = 11
Rabaptin motif XI - 1
PCODE ST INT
VQEQMAVLMQSREQVSEELVRLQ O35550 624 12
VQEQMAVLMQSREQVSEELVRLQ O35551 624 12
VQEQMAVLMQSREQVSEELVRLQ O95369 624 12
VQEQMAVLMQSREQVSEELVRLQ Q15276 624 12
VQEQMAVLMQSREQVSEELVRLQ P70609 624 12
VQEQMAVLTQSREQVSEELVRLQ O42351 622 12
RABAPTIN12 Length of motif = 21 Motif number = 12
Rabaptin motif XII - 1
PCODE ST INT
VLRELVLKYRENIVHVRTAAD O35550 676 29
VLRELVLKYRENIVHVRTAAD O35551 676 29
ALRELVLKYREDIINVRTAAD O95369 676 29
ALRELVLKYREDIINVRTAAD Q15276 676 29
VLRELVLKYRENIVHVRTAAD P70609 676 29
ELRELILKYREDIISVRTAAD O42351 674 29
User query: Display/Full Code "RABAPTIN"