WORKLIST ENTRIES (1):
TRNSRECEPTRP View alignment Transient receptor potential family signature
Type of fingerprint: COMPOUND with 3 elements
Links:
PRINTS; PR00167 CACHANNEL
PRINTS; PR01642 TRPCHANNEL1; PR01643 TRPCHANNEL2; PR01644 TRPCHANNEL3
PRINTS; PR01645 TRPCHANNEL4; PR01646 TRPCHANNEL5; PR01647 TRPCHANNEL6
PRINTS; PR01648 TRPCHANNEL7
INTERPRO; IPR002153
Creation date 04-MAR-1999; UPDATE 10-JUN-1999
1. ZHU, X., JIANG, M., PEYTON, M., BOULAY, G., HURST, R., STEFANI, E.
AND BIRNBAUMER, L.
Trp, a novel mammalian gene family essential for agonist-activated
capacitative Ca2+ entry.
CELL 85 661-671 (1996).
2. BOULAY, G., ZHU, X., PEYTON, M., JIANG, M., HURST, R., STEFANI, E.
AND BIRNBAUMER, L.
Cloning and expression of a novel mammalian homolog of Drosophila transient
receptor potential (Trp) involved in calcium entry secondary to activation
of receptors coupled by the Gq class of G protein.
J.BIOL.CHEM. 272 29672-29680 (1997).
Transient receptor potential (Trp) and related proteins are thought to be
Ca2+ ion channel subunits that mediate capacitative Ca2+ entry in response
to a range of external and internal cell stimuli. Such Ca2+ entry is thought
to be an essential component of cellular responses to many hormones and
growth factors, and acts to replenish intracellular Ca2+ stores that have
been emptied through the action of inositol triphosphate (IP3) and other
agents. In non-excitable cells, i.e. those that lack voltage-gated Ca2+
channels, such as hepatocytes, this mode of Ca2+ entry is thought to be an
important step in generating the oscillations of intracellular Ca2+
concentration that characterise their response to stimulatory agents [1].
Studies on the visual transduction system in Drosophila led to the molecular
cloning of Trp and the cDNA of a related protein, Trp-like, which show
similarity to voltage gated Ca2+ channels in the regions known as S3 through
S6, including the S5-S6 linker that forms the ion-selective channel pore [2].
This provided evidence that Trp and/or related proteins might form mammalian
capacitative Ca2+ entry channels. They have varying lengths (usually 800-1000
amino acid residues), and hydropathy analyses suggest that they have six or
more transmebrane (TM) regions, flanked by cytosolic N- and C-termini.
TRNSRECEPTRP is a 3-element fingerprint that provides a signature for the
transient receptor potential family and related proteins. The fingerprint
was derived from an initial alignment of 26 sequences: the motifs were
drawn from the central hydrophobic region of the molecules containing the
putative TM domains. Two iterations on OWL31.1 were required to reach
convergence, at which point a true set comprising 27 sequences was
identified. A single partial match was also found, a TRP-like protein
fragment from Mus musculus that matches motifs 1 and 2.
An update on SPTR37_9f identified a true set of 17 sequences.
SUMMARY INFORMATION
17 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
3| 17 17 17
2| 0 0 0
--+----------------
| 1 2 3
True positives..
O62852 O35119 P79100 O18784
O18785 O35722 Q61056 TRP1_HUMAN
O44872 Q61143 O46129 Q13507
Q94447 O62826 TRPL_DROME TRP_DROME
YN52_CAEEL
PROTEIN TITLES
O62852 CAPACITATIVE CALCIUM ENTRY CHANNEL 2 - ORYCTOLAGUS CUNICULUS
O35119 TRANSIENT RECEPTOR POTENTIAL - RATTUS NORVEGICUS (RAT).
P79100 CAPACITATIVE CALCIUM ENTRY CHANNEL 1 (CAPACITATIVE CALCIUM E
O18784 TRP-1A - BOS TAURUS (BOVINE).
O18785 TRP-1B - BOS TAURUS (BOVINE).
O35722 TRANSIENT RECEPTOR PROTEIN 1 (MTRP1 BETA) - MUS MUSCULUS (MO
Q61056 TRANSIENT RECEPTOR PROTEIN 1 (FRAGMENT) - MUS MUSCULUS (MOUS
TRP1_HUMAN TRP-1 PROTEIN (TRPC1 PROTEIN) - HOMO SAPIENS (HUMAN).
O44872 R06B10.4 PROTEIN - CAENORHABDITIS ELEGANS.
Q61143 CALCIUM ENTRY CHANNEL - MUS MUSCULUS (MOUSE).
O46129 TRP-LIKE PROTEIN - LOLIGO FORBESI (NORTHERN EUROPEAN SQUID).
Q13507 TRANSIENT RECEPTOR POTENTIAL RELATED CHANNEL 3 PROTEIN - HOM
Q94447 TRP PROTEIN - CALLIPHORA VICINA (BLUE BLOWFLY) (CALLIPHORA E
O62826 TYROSINE-RELATED PROTEIN 2 - BOS TAURUS (BOVINE).
TRPL_DROME TRANSIENT-RECEPTOR-POTENTIAL LIKE PROTEIN - DROSOPHILA MELAN
TRP_DROME TRANSIENT-RECEPTOR-POTENTIAL PROTEIN - DROSOPHILA MELANOGAST
YN52_CAEEL HYPOTHETICAL 95.6 KD PROTEIN ZC21.2 IN CHROMOSOME III - CAEN
SCAN HISTORY
OWL31_1 2 200 NSINGLE
SPTR37_9f 2 18 NSINGLE
INITIAL MOTIF SETS
TRNSRECEPTRP1 Length of motif = 22 Motif number = 1
Transient receptor potential protein motif I - 1
PCODE ST INT
GVYNVTMVIVLLNMLIAMINSS MMU49069 708 708
GVYNVTMVIVLLNMLIAMINSS AF080394 709 709
GIYNVTMVVVLLNMLIAMINSS HSY13758 652 652
GSYSVINIIVLLNMLIAMMSNS TRP_DROME 643 643
GSYSVINIIVLLNMLIAMMSNS DROTRPC 642 642
GSYSVINIIVLLNMLIAMMSNS CVTRP 640 640
GTYNVISLVVLLNMLIAMMNNS AB008889 580 580
GTYNVISLVVLLNMLIAMMNNS BTCCE1 604 604
GTYNVISLVVLLNMLIAMMNNS MMU50921 602 602
GTYNVISLVVLLNMLIAMMNNS MMU50922 602 602
GTYNVISLVVLLNMLIAMMNNS AF029983 606 606
GTYNVISLVVLLNMLIAMMNNS MMAJ6204 606 606
GTYNVISLVVLLNMLIAMMNNS OCAJ6203 606 606
GTYNVISLVVLLNMLIAMMNNS AF029983 606 606
GTYNVISLVVLLNMLIAMMNNS BTA224862 91 91
GIFTIVMVIVLLNMLIAMITNS BTA6304 164 164
GTYNVVVVIVLTKLLVAMLHKS AF012900 627 627
GTYNVVVVIVLTKLLVAMLHKS TRP1_HUMAN 627 627
GTYNVVVVIVLTKLLVAMLHKS MMU73625 643 643
GTYNVVVVIVLTKLLVAMLHKS AF012901 593 593
GTYNVVVVIVLTKLLVAMLHKS MMU95167 609 609
GTYNVVVVIVLTKLLVAMLHKS I38361 644 644
GSYSVINVIVLLNLLIAMMSNS TRPL_DROME 650 650
GIYNVTMVVVLLNMLIAMINSS JC5807 634 634
GSYSMIAIIILLNLLIAMMSNS LFAJ3320 606 606
IMYHCTSIIVLLNMLIAMMSHS YN52_CAEEL 662 662
TRNSRECEPTRP2 Length of motif = 14 Motif number = 2
Transient receptor potential protein motif II - 1
PCODE ST INT
FQEIEDDADVEWKF MMU49069 730 0
FQEIEDDADVEWKF AF080394 731 0
YQEIEDDSDVEWKF HSY13758 674 0
YQIISERADTEWKF TRP_DROME 665 0
YQIISERADTEWKF DROTRPC 664 0
YQIISERADVEWKF CVTRP 662 0
YQLIADHADIEWKF AB008889 602 0
YQLIADHADIEWKF BTCCE1 626 0
YQLIADHADIEWKF MMU50921 624 0
YQLIADHADIEWKF MMU50922 624 0
YQLIADHADIEWKF AF029983 628 0
YQLIADHADIEWKF MMAJ6204 628 0
YQLIADHADIEWKF OCAJ6203 628 0
YQLIADHADIEWKF AF029983 628 0
YQLIADHADIEWKF BTA224862 113 0
FQKIEDAADVEWKF BTA6304 186 0
FQLIANHEDKEWKF AF012900 649 0
FQLIANHEDKEWKF TRP1_HUMAN 649 0
FQLIANHEDKEWKF MMU73625 665 0
FQLIANHEDKEWKF AF012901 615 0
FQLIANHEDKEWKF MMU95167 631 0
FQLIANHEDKEWKF I38361 666 0
YAMIDEHSDTEWKF TRPL_DROME 672 0
YQEIEDDSDVEWKF JC5807 656 0
YQLIYSQADEEWKF LFAJ3320 628 0
FQIINDHADLEWKF YN52_CAEEL 684 0
TRNSRECEPTRP3 Length of motif = 14 Motif number = 3
Transient receptor potential protein motif III - 1
PCODE ST INT
TLPVPFNLVPSPKS MMU49069 758 14
TLPVPFNLVPSPKS AF080394 759 14
TLPPPFSLVPSPKS HSY13758 702 14
TIPPPFNLCPNMKM TRP_DROME 693 14
TIPPPFNLCPNMKM DROTRPC 692 14
TVPPPFNMFPSVKL CVTRP 690 14
TLPTPFNVIPSPKS AB008889 630 14
TLPTPFNVIPSPKS BTCCE1 654 14
TLPTPFNVIPSPKS MMU50921 652 14
TLPTPFNVIPSPKS MMU50922 652 14
TLPPPFNIIPSPKS AF029983 656 14
TLPPPFNIIPSPKS MMAJ6204 656 14
TLPPPFNIIPSPKS OCAJ6203 656 14
TLPPPFNIIPSPKS AF029983 656 14
TLPTPFNVIPSPKS BTA224862 141 14
TLPVPFNILPSPKA BTA6304 214 14
TLPPPFNIIPSPKT AF012900 677 14
TLPPPFNIIPSPKT TRP1_HUMAN 677 14
TLPPPFNIIPSPKT MMU73625 693 14
TLPPPFNIIPSPKT AF012901 643 14
TLPPPFNIIPSPKT MMU95167 659 14
TLPPPFNIIPSPKT I38361 694 14
TLPPPFNVLPSVKW TRPL_DROME 700 14
TLPPPLVPCPKSFV JC5807 684 14
TVPPPFNIIPSPKS LFAJ3320 656 14
SLPPPFNIIVTPKS YN52_CAEEL 712 14
FINAL MOTIF SETS
TRNSRECEPTRP1 Length of motif = 22 Motif number = 1
Transient receptor potential protein motif I - 2
PCODE ST INT
GTYNVISLVVLLNMLIAMMNNS O62852 606 606
GTYNVISLVVLLNMLIAMMNNS O35119 580 580
GTYNVISLVVLLNMLIAMMNNS P79100 604 604
GTYNVVVVIVLTKLLVAMLHKS O18784 627 627
GTYNVVVVIVLTKLLVAMLHKS O18785 593 593
GTYNVVVVIVLTKLLVAMLHKS O35722 609 609
GTYNVVVVIVLTKLLVAMLHKS Q61056 627 627
GTYNVVVVIVLTKLLVAMLHKS TRP1_HUMAN 627 627
GSYCCCSIIVLLNMLIAMMSNS O44872 660 660
GVYNVTMVIVLLNMLIAMINSS Q61143 708 708
GSYSMIAIIILLNLLIAMMSNS O46129 606 606
GIYNVTMVVVLLNMLIAMINSS Q13507 652 652
GSYSVINIIVLLNMLIAMMSNS Q94447 640 640
GIFTIVMVIVLLNMLIAMITNS O62826 164 164
GSYSVINVIVLLNLLIAMMSNS TRPL_DROME 650 650
GSYSVINIIVLLNMLIAMMSNS TRP_DROME 643 643
IMYHCTSIIVLLNMLIAMMSHS YN52_CAEEL 662 662
TRNSRECEPTRP2 Length of motif = 14 Motif number = 2
Transient receptor potential protein motif II - 2
PCODE ST INT
YQLIADHADIEWKF O62852 628 0
YQLIADHADIEWKF O35119 602 0
YQLIADHADIEWKF P79100 626 0
FQLIANHEDKEWKF O18784 649 0
FQLIANHEDKEWKF O18785 615 0
FQLIANHEDKEWKF O35722 631 0
FQLIANHEDKEWKF Q61056 649 0
FQLIANHEDKEWKF TRP1_HUMAN 649 0
YQYISDQADIEWKF O44872 682 0
FQEIEDDADVEWKF Q61143 730 0
YQLIYSQADEEWKF O46129 628 0
YQEIEDDSDVEWKF Q13507 674 0
YQIISERADVEWKF Q94447 662 0
FQKIEDAADVEWKF O62826 186 0
YAMIDEHSDTEWKF TRPL_DROME 672 0
YQIISERADTEWKF TRP_DROME 665 0
FQIINDHADLEWKF YN52_CAEEL 684 0
TRNSRECEPTRP3 Length of motif = 14 Motif number = 3
Transient receptor potential protein motif III - 2
PCODE ST INT
TLPPPFNIIPSPKS O62852 656 14
TLPTPFNVIPSPKS O35119 630 14
TLPTPFNVIPSPKS P79100 654 14
TLPPPFNIIPSPKT O18784 677 14
TLPPPFNIIPSPKT O18785 643 14
TLPPPFNIIPSPKT O35722 659 14
TLPPPFNIIPSPKT Q61056 677 14
TLPPPFNIIPSPKT TRP1_HUMAN 677 14
TLPPPFNIVPSPKS O44872 710 14
TLPVPFNLVPSPKS Q61143 758 14
TVPPPFNIIPSPKS O46129 656 14
TLPPPFSLVPSPKS Q13507 702 14
TVPPPFNMFPSVKL Q94447 690 14
TLPVPFNILPSPKA O62826 214 14
TLPPPFNVLPSVKW TRPL_DROME 700 14
TIPPPFNLCPNMKM TRP_DROME 693 14
SLPPPFNIIVTPKS YN52_CAEEL 712 14
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