WORKLIST ENTRIES (1):

XPGRADSUPER View alignment View Structure     Xeroderma pigmentosum group G/yeast RAD superfamily signature
 Type of fingerprint: COMPOUND with 5  elements
Links:
   PRINTS; PR00851 XRODRMPGMNTB; PR00852 XRODRMPGMNTD; PR00066 XRODRMPGMNTG
   INTERPRO; IPR001532
   PROSITE; PS00841 XPG_1; PS00842 XPG_2 
   PFAM; PF00752 XPG_N; PF00867 XPG_I

 Creation date 08-MAR-1998; UPDATE 27-JUN-1999

   1. TANAKA, K. AND WOOD, R.D.
   Xeroderma pigmentosum and nucleotide excision-repair of DNA.
   TRENDS BIOCHEM.SCI. 19 83-86 (1994).

   2. SCHERLY, D., NOUSPIKEL, T., CORLET, J., UCLA, C., BAIROCH, A.
   AND CLARKSON, S.G.
   Complementation of the DNA repair defect in xeroderma pigmentosum
   group G cells by a human cDNA related to yeast RAD2.
   NATURE 363 182-185 (1993).

   3. CARR, A.M., SHELDRICK, K.S., MURRAY, J.M., AL-HARITHY, R., WATTS, F.Z.
   AND LEHMANN, A.R.
   Evolutionary conservation of excision repair in Schizosaccharomyces pombe - 
   evidence for a family of sequences related to the Saccharomyces cerevisiae
   rad2 gene.
   NUCLEIC ACIDS RES. 21 1345-1349 (1993). 

   4. O'DONOVAN, A., SCHERLY, D., CLARKSON, S.G. AND WOOD, R.D.
   Isolation of active recombinant XPG protein, a human DNA repair
   endonuclease.
   J.BIOL.CHEM. 269 15965-15968 (1994).
   
   5. O'DONOVAN, A., DAVIES, A.A., MOGGS, J.G., WEST, S.C. AND WOOD, R.D.
   XPG endonuclease makes the 3' incision in human DNA nucleotide excision
   repair.
   NATURE 371 432-435 (1994).
   
   6. HABRAKEN, Y., SUNG, P., PRAKASH, L. AND PRAKASH, S.
   Yeast excision repair gene RAD2 encodes a single-stranded DNA endonuclease.
   NATURE 366 365-368 (1993).

   Defects in DNA repair proteins can give rise, in humans, to the autosomal
   recessive disorders xeroderma pigmentosum (XP) and Cockayne's syndrome [1,2].
   XP is characterised by a high incidence of sunlight-induced skin cancer,
   the effect of skin-cell hypersensitivity to UV resulting from defects in
   the nucleotide excision pathway. Seven XP complementation groups have
   been identified: XP-A to XP-G. 
   
   XP-G is one of the most rare and phenotypically heterogeneous of XP, showing
   anything from slight to extreme dysfunction in DNA excision repair [3,4].
   XP-G can be corrected by a 133kDa nuclear protein, XPGC [1]. XPGC is an 
   acidic protein that confers normal UV resistance in expressing cells [4].
   It is a magnesium-dependent, single-strand DNA endonuclease that makes
   structure-specific endonucleolytic incisions in a DNA substrate containing
   a duplex region and single-stranded arms [4,5]. XPGC cleaves one strand of
   the duplex at the border with the single-stranded region [5].
   
   XPG belongs to a family of proteins that includes RAD2 from budding yeast
   and rad13 from fission yeast, which are single-stranded DNA endonucleases
   [5,6]; mouse and human FEN-1, a structure-specific endonuclease; RAD2 from 
   fission yeast and RAD27 from budding yeast; fission yeast exo1, a 5'->3'
   double-stranded DNA exonuclease that may act in a pathway that corrects
   mismatched base pairs; yeast DHS1, and yeast DIN7.
  
   Sequence analysis reveals that similarities within the family are largely
   confined to two well-conserved domains, the first of which is located at
   the N-terminal extremity (the N-region), the second lying towards the 
   C-terminus (the I-region). The I-region contains a perfectly conserved
   hexapeptide, EAEAQC, the Glu and Cys residues of which may be involved in
   the excision repair mechanism.
   
   XPGRADSUPER is a 5-element fingerprint that provides a signature for the
   XPG/RAD superfamily. The fingerprint was derived from an initial alignment
   of 17 sequences: the motifs were drawn from short conserved regions within 
   the N- and C-terminal portions of the alignment - motifs 1 and 2 lie within
   the N-domain, motif 2 including the region encoded by PROSITE pattern XPG_1
   (PS00841); and motifs 3-5 lie in the I domain, motif 3 including the region
   encoded by PROSITE pattern XPG_2 (PS00842), which contains a putative
   catalytic core pentapeptide. Two iterations on OWL30.0 were required to 
   reach convergence, at which point a true set comprising 23 sequences was
   identified. Several partial matches were also found: CELT12A25 is a
   C.elegans sequence that fails to match the first 2 motifs; and YA31_SCHPO,
   YEN1_YEAST and SCU13615 are yeast proteins that match only 2 motifs.
  
   An update on SPTR37_9f identified a true set of 32 sequences, and 2
   partial matches.

  SUMMARY INFORMATION
     32 codes involving  5 elements
      0 codes involving  4 elements
      0 codes involving  3 elements
      2 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
    5|  32   32   32   32   32  
    4|   0    0    0    0    0  
    3|   0    0    0    0    0  
    2|   0    0    2    2    0  
   --+--------------------------
     |   1    2    3    4    5  

True positives..
 FEN1_HUMAN     FEN1_MOUSE     P70054         P70040         
 Q61528         Q64248         XPG_MOUSE      O57351         
 XPG_HUMAN      XPG_XENLA      RAD2_SCHPO     O65251         
 RA27_YEAST     O59728         RA13_SCHPO     RAD2_YEAST     
 O50123         O60545         O75214         O75466         
 O29975         Q58839         EXO1_SCHPO     Q24557         
 Q24558         EXO1_YEAST     O27670         DIN7_YEAST     
 O44737         O62245         Q22418         YA31_SCHPO     
Subfamily:  Codes involving 2 elements
 Subfamily True positives..
 Q02463         YEN1_YEAST     


  PROTEIN TITLES
   FEN1_HUMAN       FLAP ENDONUCLEASE-1 (MATURATION FACTOR 1) (MF1) - HOMO SAPIE
   FEN1_MOUSE       FLAP ENDONUCLEASE-1 - MUS MUSCULUS (MOUSE).
   P70054           XFEN1B - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
   P70040           5' NUCLEASE XFEN1A - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
   Q61528           DNA-REPAIR PROTEIN COMPLEMENTING XP-G CELLS HOMOLOG (XERODER
   Q64248           DNA-REPAIR PROTEIN COMPLEMENTING XP-G CELLS HOMOLOG (XERODER
   XPG_MOUSE        DNA-REPAIR PROTEIN COMPLEMENTING XP-G CELLS HOMOLOG (XERODER
   O57351           FLAP ENDONUCLEASE 1 - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
   XPG_HUMAN        DNA-REPAIR PROTEIN COMPLEMENTING XP-G CELLS (XERODERMA PIGME
   XPG_XENLA        DNA-REPAIR PROTEIN COMPLEMENTING XP-G CELLS HOMOLOG (XERODER
   RAD2_SCHPO       DNA REPAIR PROTEIN RAD2 - SCHIZOSACCHAROMYCES POMBE (FISSION
   O65251           F21E10.3 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
   RA27_YEAST       STRUCTURE SPECIFIC ENDONUCLEASE RAD27 - SACCHAROMYCES CEREVI
   O59728           DNA REPAIR PROTEIN RAD13 - SCHIZOSACCHAROMYCES POMBE (FISSIO
   RA13_SCHPO       DNA REPAIR PROTEIN RAD13 - SCHIZOSACCHAROMYCES POMBE (FISSIO
   RAD2_YEAST       DNA REPAIR PROTEIN RAD2 - SACCHAROMYCES CEREVISIAE (BAKER'S 
   O50123           343AA LONG HYPOTHETICAL 5' NUCLEASE - PYROCOCCUS HORIKOSHII.
   O60545           PUTATIVE 5'-3' EXONUCLEASE HEX1 - HOMO SAPIENS (HUMAN).
   O75214           HEX1 - HOMO SAPIENS (HUMAN).
   O75466           EXONUCLEASE I - HOMO SAPIENS (HUMAN).
   O29975           DNA REPAIR PROTEIN RAD2 (RAD2) - ARCHAEOGLOBUS FULGIDUS.
   Q58839           HYPOTHETICAL PROTEIN MJ1444 - METHANOCOCCUS JANNASCHII.
   EXO1_SCHPO       EXONUCLEASE I (EXO I) - SCHIZOSACCHAROMYCES POMBE (FISSION Y
   Q24557           TOSCA - DROSOPHILA MELANOGASTER (FRUIT FLY).
   Q24558           TOSCA - DROSOPHILA MELANOGASTER (FRUIT FLY).
   EXO1_YEAST       EXONUCLEASE I (EXO I) (DHS1 PROTEIN) - SACCHAROMYCES CEREVIS
   O27670           DNA REPAIR PROTEIN RAD2 - METHANOBACTERIUM THERMOAUTOTROPHIC
   DIN7_YEAST       DNA-DAMAGE INDUCIBLE PROTEIN DIN7 - SACCHAROMYCES CEREVISIAE
   O44737           F57B10.6 PROTEIN - CAENORHABDITIS ELEGANS.
   O62245           F45G2.3 PROTEIN - CAENORHABDITIS ELEGANS.
   Q22418           SIMILAR TO S. CEREVISIAE DNA REPAIR PROTEIN RAD2 - CAENORHAB
   YA31_SCHPO       HYPOTHETICAL 57.8 KD PROTEIN C18B11.01C IN CHROMOSOME I - SC
 
   Q02463           UNKNOWN ORF 3' TO GLN3 - SACCHAROMYCES CEREVISIAE (BAKER'S Y
   YEN1_YEAST       HYPOTHETICAL 87.4 KD PROTEIN IN GLN3-SAH1 INTERGENIC REGION 

SCAN HISTORY OWL30_0 2 50 NSINGLE SPTR37_9f 4 34 NSINGLE INITIAL MOTIF SETS XPGRADSUPER1 Length of motif = 15 Motif number = 1 Xeroderma pigmentosa group G/RAD protein motif I - 1 PCODE ST INT GKILAVDISIWLNQA XPG_HUMAN 24 24 GKVLAVDISIWLNQA XPG_MOUSE 24 24 GKILAVDISIWLNQA XPG_XENLA 24 24 GKILAVDISIWLNQA A54439 24 24 GKILAVDISIWLNQA I58009 24 24 GKVLAVDISIWLNQA A57650 24 24 GKVLAVDISIWLNQA MMU40796 24 24 GRKVAIDASMSLYQF RA27_YEAST 28 28 GRKVAIDASMSLYQF RAD2_SCHPO 28 28 GRKVAVDASMCIYQF XLU68141 28 28 GRKVAIDASMSIYQF FEN1_HUMAN 28 28 NKRLAIDASIWIYQF RA13_SCHPO 24 24 DKRMAVDASIWIYQF RAD2_YEAST 24 24 GKKVAIDGMNALYQF C64480 21 21 GEVLAIDGYAWLHRA EXO1_YEAST 24 24 GKTLGVDGYVWLHKA EXO1_SCHPO 24 24 YQTLAIDGYAWLHRA DIN7_YEAST 24 24 XPGRADSUPER2 Length of motif = 20 Motif number = 2 Xeroderma pigmentosa group G/RAD protein motif II - 1 PCODE ST INT PIFVFDGDAPLLKKQTLVKR XPG_HUMAN 72 33 PIFVFDGDAPLLKKQTLAKR XPG_MOUSE 72 33 PIFVFDGEAPLLKRQTLAKR XPG_XENLA 72 33 PIFVFDGDAPLLKKQTLVKR A54439 72 33 PIFVFDGDAPLLKKQTLVKR I58009 72 33 PIFVFDGDAPLLKKQTLAKR A57650 72 33 PIFVFDGDAPLLKKQTLAKR MMU40796 72 33 PCYVFDGKPPDLKSHELTKR RA27_YEAST 82 39 PCFVFDGKPPTLKSGELAKR RAD2_SCHPO 82 39 PVYVFDGKPPQMKSGELAKR XLU68141 81 38 PVYVFDGKPPQLKSGELAKR FEN1_HUMAN 81 38 PVFVFDGGAPSLKRQTIQKR RA13_SCHPO 72 33 PVFVFDGGVPVLKRETIRQR RAD2_YEAST 72 33 PIWVFDGEPPKLKEKTRKVR C64480 75 39 PYLVFDGDAIPVKKSTESKR EXO1_YEAST 73 34 PLIVFDGGPLPCKASTEQKR EXO1_SCHPO 73 34 PYIVFDGDSLFVKNHTETRR DIN7_YEAST 73 34 XPGRADSUPER3 Length of motif = 18 Motif number = 3 Xeroderma pigmentosa group G/RAD protein motif III - 1 PCODE ST INT LRLFGIPYIQAPMEAEAQ XPG_HUMAN 776 684 LRLFGVPYIQAPMEAEAQ XPG_MOUSE 789 697 LQLFGIPYIVAPMEAEAQ XPG_XENLA 809 717 LRLFGIPYIQAPMEAEAQ A54439 776 684 LRLFGIPYIQAPMEAEAQ I58009 776 684 LRLFGVPYIQAPMEAEAQ A57650 775 683 LRLFGVPYIQAPMEAEAQ MMU40796 775 683 LGLMGIPYIIAPTEAEAQ RA27_YEAST 143 41 LELMGIPFVNAPCEAEAQ RAD2_SCHPO 146 44 LSLMGIPYVDAPCEAEAT XLU68141 145 44 LSLMGIPYLDAPSEAEAS FEN1_HUMAN 145 44 LRLFGLPYIVAPQEAEAQ RA13_SCHPO 765 673 LSRFGIPYITAPMEAEAQ RAD2_YEAST 779 687 LSLMGIPYVEAPSEGEAQ C64480 139 44 CKLNGIRYIVAPFEADSQ EXO1_YEAST 137 44 LREHGIESIVAPYEADAQ EXO1_SCHPO 137 44 CKLHSIPYIVAPFEADPQ DIN7_YEAST 137 44 XPGRADSUPER4 Length of motif = 21 Motif number = 4 Xeroderma pigmentosa group G/RAD protein motif IV - 1 PCODE ST INT LDLTDQTSGTITDDSDIWLFG XPG_HUMAN 797 3 LDLSDQTSGTITDDSDIWLFG XPG_MOUSE 810 3 LDLTDQTSGTITDDSDIWLFG XPG_XENLA 830 3 LDLTDQTSGTITDDSDIWLFG A54439 797 3 LDLTDQTSGTITDDSDIWLFG I58009 797 3 LDLSDQTSGTITDDSDIWLFG A57650 796 3 LDLSDQTSGTITDDSDIWLFG MMU40796 796 3 LAKKGKVYAAASEDMDTLCYR RA27_YEAST 164 3 LARSGKVYAAASEDMDTLCFQ RAD2_SCHPO 167 3 LVKAGKVYAAATEDMDALTFG XLU68141 166 3 LVKAGKVYAAATEDMDCLTFG FEN1_HUMAN 166 3 LLELKLVDGIVTDDSDVFLFG RA13_SCHPO 786 3 LLQLNLVDGIITDDSDVFLFG RAD2_YEAST 800 3 MAKKGDVWAVVSQDYDALLYG C64480 160 3 LEQKNIVQGIISEDSDLLVFG EXO1_YEAST 158 3 LEKENIIDGIITEDSDMLVFG EXO1_SCHPO 158 3 LEKMGLIQGIISEDSDLLVFG DIN7_YEAST 158 3 XPGRADSUPER5 Length of motif = 16 Motif number = 5 Xeroderma pigmentosa group G/RAD protein motif V - 1 PCODE ST INT LINLAYLLGSDYTEGI XPG_HUMAN 851 33 LINLAYLLGSDYTEGI XPG_MOUSE 864 33 LINLAYLLGSDYTEGI XPG_XENLA 884 33 LINLAYLLGSDYTEGI A54439 851 33 LINLAYLLGSDYTGNT I58009 851 33 LINLAYLLGSDYTEGI A57650 850 33 LINLAYLLGSDYTEGI MMU40796 850 33 FVDLCIMLGCDYCESI RA27_YEAST 221 36 FVDLCILLGCDYCEPI RAD2_SCHPO 224 36 FVDLCILLGSDYCETI XLU68141 223 36 FVDLCILLGSDYCESI FEN1_HUMAN 223 36 LIKLAHLLGSDYTMGL RA13_SCHPO 840 33 MIELAQLLGSDYTNGL RAD2_YEAST 854 33 LIDIAIFMGTDYNPGG C64480 214 33 IITMVCLSGCDYTNGI EXO1_YEAST 217 38 LRHMAIFSGCDYTDGV EXO1_SCHPO 215 36 FRNLVCLAGCDYTSGI DIN7_YEAST 217 38 FINAL MOTIF SETS XPGRADSUPER1 Length of motif = 15 Motif number = 1 Xeroderma pigmentosa group G/RAD protein motif I - 4 PCODE ST INT GRKVAIDASMSIYQF FEN1_HUMAN 28 28 GRKVAIDASMSIYQF FEN1_MOUSE 28 28 GRKVAVDASMCIYQF P70054 28 28 GRKVAVDASMCIYQF P70040 28 28 GKVLAVDISIWLNQA Q61528 24 24 GKVLAVDISIWLNQA Q64248 24 24 GKVLAVDISIWLNQA XPG_MOUSE 24 24 GRKVAIDASMCIYQF O57351 28 28 GKILAVDISIWLNQA XPG_HUMAN 24 24 GKILAVDISIWLNQA XPG_XENLA 24 24 GRKVAIDASMSLYQF RAD2_SCHPO 28 28 GRKIAVDASMSIYQF O65251 28 28 GRKVAIDASMSLYQF RA27_YEAST 28 28 NKRLAIDASIWIYQF O59728 24 24 NKRLAIDASIWIYQF RA13_SCHPO 24 24 DKRMAVDASIWIYQF RAD2_YEAST 24 24 GKKIAIDALNAIYQF O50123 21 21 GQVVAVDTYCWLHKG O60545 24 24 GQVVAVDTYCWLHKG O75214 24 24 GQVVAVDTYCWLHKG O75466 24 24 GKKIAVDAFNTLYQF O29975 21 21 GKKVAIDGMNALYQF Q58839 21 21 GKTLGVDGYVWLHKA EXO1_SCHPO 24 24 GSTVAVDTYCWLHKG Q24557 24 24 GSTVAVDTYCWLHKG Q24558 24 24 GEVLAIDGYAWLHRA EXO1_YEAST 24 24 GRTVAVDAANTLYQF O27670 21 21 YQTLAIDGYAWLHRA DIN7_YEAST 24 24 GKKLAIDVSIWIYQA O44737 24 24 GKSVAIDVSCLLHRG O62245 672 672 DKTLSIDGHIWLYES Q22418 24 24 YPVLAVDGNLLLYRF YA31_SCHPO 30 30 XPGRADSUPER2 Length of motif = 20 Motif number = 2 Xeroderma pigmentosa group G/RAD protein motif II - 4 PCODE ST INT PVYVFDGKPPQLKSGELAKR FEN1_HUMAN 81 38 PVYVFDGKPPQLKSGELAKR FEN1_MOUSE 79 36 PVYVFDGKPPQMKSGELAKR P70054 81 38 PVYVFDGKPPQMKSGELAKR P70040 81 38 PIFVFDGDAPLLKKQTLAKR Q61528 72 33 PIFVFDGDAPLLKKQTLAKR Q64248 72 33 PIFVFDGDAPLLKKQTLAKR XPG_MOUSE 72 33 PVYVFDGKPPQMKSGELAKR O57351 81 38 PIFVFDGDAPLLKKQTLVKR XPG_HUMAN 72 33 PIFVFDGEAPLLKRQTLAKR XPG_XENLA 72 33 PCFVFDGKPPTLKSGELAKR RAD2_SCHPO 82 39 PVYVFDGKPPELKRQELAKR O65251 115 72 PCYVFDGKPPDLKSHELTKR RA27_YEAST 82 39 PVFVFDGGAPSLKRQTIQKR O59728 72 33 PVFVFDGGAPSLKRQTIQKR RA13_SCHPO 72 33 PVFVFDGGVPVLKRETIRQR RAD2_YEAST 72 33 PAYVFDGKPPEFKRKELEKR O50123 75 39 PILVFDGCTLPSKKEVERSR O60545 73 34 PILVFDGCTLPSKKEVERSR O75214 73 34 PILVFDGCTLPSKKEVERSR O75466 73 34 PVFVFDGEPPEFKKAEIEER O29975 75 39 PIWVFDGEPPKLKEKTRKVR Q58839 75 39 PLIVFDGGPLPCKASTEQKR EXO1_SCHPO 73 34 PILVFDGQHLPAKALTEKRR Q24557 73 34 PILVFDGQHLPAKALTEKRR Q24558 73 34 PYLVFDGDAIPVKKSTESKR EXO1_YEAST 73 34 VIYVFDGRSHHLKGETVSRR O27670 75 39 PYIVFDGDSLFVKNHTETRR DIN7_YEAST 73 34 PVFVFDGPQVPPLKRQVLEA O44737 68 29 VVMVFDGRPLPAKKGTNEER O62245 721 34 PIVVFDNINASSSAHESKDQ Q22418 71 32 PIVVFDNLKPNDFKAEEHEK YA31_SCHPO 76 31 XPGRADSUPER3 Length of motif = 18 Motif number = 3 Xeroderma pigmentosa group G/RAD protein motif III - 4 PCODE ST INT LSLMGIPYLDAPSEAEAS FEN1_HUMAN 145 44 LSLMGIPYLDAPSEAEAS FEN1_MOUSE 143 44 LSLMGIPYVDAPCEAEAT P70054 145 44 LTLMGIPYVDAPCEAEAT P70040 145 44 LRLFGVPYIQAPMEAEAQ Q61528 775 683 LRLFGVPYIQAPMEAEAQ Q64248 775 683 LRLFGVPYIQAPMEAEAQ XPG_MOUSE 789 697 LTLMGIPYVDAPCEAEAT O57351 145 44 LRLFGIPYIQAPMEAEAQ XPG_HUMAN 776 684 LQLFGIPYIVAPMEAEAQ XPG_XENLA 809 717 LELMGIPFVNAPCEAEAQ RAD2_SCHPO 146 44 LRLMGVPVVEATSEAEAQ O65251 179 44 LGLMGIPYIIAPTEAEAQ RA27_YEAST 143 41 LRLFGLPYIVAPQEAEAQ O59728 764 672 LRLFGLPYIVAPQEAEAQ RA13_SCHPO 765 673 LSRFGIPYITAPMEAEAQ RAD2_YEAST 779 687 LQLMGIPIIQAPSEGEAQ O50123 139 44 ARSQGVDCLVAPYEADAQ O60545 137 44 ARSQGVDCLVAPYEADAQ O75214 137 44 ARSQGVDCLVAPYEADAQ O75466 137 44 LSYMGIPFVDAPSEGEAQ O29975 138 43 LSLMGIPYVEAPSEGEAQ Q58839 139 44 LREHGIESIVAPYEADAQ EXO1_SCHPO 137 44 CRSRNVDCIVAPYEADAQ Q24557 137 44 CRSRNVDCIVAPYEADAQ Q24558 137 44 CKLNGIRYIVAPFEADSQ EXO1_YEAST 137 44 LELLGIPYVQAPGEGEAQ O27670 139 44 CKLHSIPYIVAPFEADPQ DIN7_YEAST 137 44 LTNAGIPWIESPGEAEAQ O44737 485 397 RSMTNVDIVVAPYEADAQ O62245 786 45 LTELGIKVIIAPGDGEAQ Q22418 120 29 LKILGIPASFSPIGVEAE YA31_SCHPO 285 189 XPGRADSUPER4 Length of motif = 21 Motif number = 4 Xeroderma pigmentosa group G/RAD protein motif IV - 4 PCODE ST INT LVKAGKVYAAATEDMDCLTFG FEN1_HUMAN 166 3 LAKAGKVYAAATEDMDCLTFG FEN1_MOUSE 164 3 LVKAGKVYAAATEDMDALTFG P70054 166 3 LVKAGKVYAAATEDMDALTFG P70040 166 3 LDLSDQTSGTITDDSDIWLFG Q61528 796 3 LDLSDQTSGTITDDSDIWLFG Q64248 796 3 LDLSDQTSGTITDDSDIWLFG XPG_MOUSE 810 3 LVKAGKVYAAATEDMDALTFG O57351 166 3 LDLTDQTSGTITDDSDIWLFG XPG_HUMAN 797 3 LDLTDQTSGTITDDSDIWLFG XPG_XENLA 830 3 LARSGKVYAAASEDMDTLCFQ RAD2_SCHPO 167 3 LCKSGKVYGVASEDMDSLTFG O65251 200 3 LAKKGKVYAAASEDMDTLCYR RA27_YEAST 164 3 LLELKLVDGIVTDDSDVFLFG O59728 785 3 LLELKLVDGIVTDDSDVFLFG RA13_SCHPO 786 3 LLQLNLVDGIITDDSDVFLFG RAD2_YEAST 800 3 MASKGDVYASASQDYDSLLFG O50123 160 3 LNKAGIVQAIITEDSDLLAFG O60545 158 3 LNKAGIVQAIITEDSDLLAFG O75214 158 3 LNKAGIVQAIITEDSDLLAFG O75466 158 3 MAAKGDVEYTGSQDYDSLLFG O29975 159 3 MAKKGDVWAVVSQDYDALLYG Q58839 160 3 LEKENIIDGIITEDSDMLVFG EXO1_SCHPO 158 3 LNRADVAQYIITEDSDLTLFG Q24557 158 3 LNRADVAQYIITEDSDLTLFG Q24558 158 3 LEQKNIVQGIISEDSDLLVFG EXO1_YEAST 158 3 MVKMGDAWAVASQDYDCLLFG O27670 160 3 LEKMGLIQGIISEDSDLLVFG DIN7_YEAST 158 3 LERLGLVDGVVSDDSDVWAFG O44737 506 3 LVQEKLVDAVITEDSDLIVFG O62245 807 3 LEDLGVTSGCITTDFDYFLFG Q22418 141 3 ISQNNLAYAVATQDTDVLLLG YA31_SCHPO 308 5 XPGRADSUPER5 Length of motif = 16 Motif number = 5 Xeroderma pigmentosa group G/RAD protein motif V - 4 PCODE ST INT FVDLCILLGSDYCESI FEN1_HUMAN 223 36 FVDLCILLGSDYCESI FEN1_MOUSE 221 36 FVDLCILLGSDYCETI P70054 223 36 FVDLCILLGSDYCETI P70040 223 36 LINLAYLLGSDYTEGI Q61528 850 33 LINLAYLLGSDYTEGI Q64248 850 33 LINLAYLLGSDYTEGI XPG_MOUSE 864 33 FVDLCILLGSDYCETI O57351 223 36 LINLAYLLGSDYTEGI XPG_HUMAN 851 33 LINLAYLLGSDYTEGI XPG_XENLA 884 33 FVDLCILLGCDYCEPI RAD2_SCHPO 224 36 FIDLCILSGCDYCDSI O65251 257 36 FVDLCIMLGCDYCESI RA27_YEAST 221 36 LIKLAHLLGSDYTMGL O59728 839 33 LIKLAHLLGSDYTMGL RA13_SCHPO 840 33 MIELAQLLGSDYTNGL RAD2_YEAST 854 33 LIELAILVGTDYNPGG O50123 226 45 FRYMCILSGCDYLSSL O60545 215 36 FRYMCILSGCDYLSSL O75214 215 36 FRYMCILSGCDYLSSL O75466 215 36 LIDIAILVGTDYNEGV O29975 225 45 LIDIAIFMGTDYNPGG Q58839 214 33 LRHMAIFSGCDYTDGV EXO1_SCHPO 215 36 FRRMCILSGCDYLDSL Q24557 216 37 FRRMCILSGCDYLDSL Q24558 216 37 IITMVCLSGCDYTNGI EXO1_YEAST 217 38 LVDMALLVGTDFNEGV O27670 216 35 FRNLVCLAGCDYTSGI DIN7_YEAST 217 38 YISIALLSGGDYCAGL O44737 565 38 FRRICILSGCDYLQAG O62245 868 40 LISTAILLGCDYFQRG Q22418 202 40 FQDYCLMCGTDFTSRI YA31_SCHPO 365 36

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